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BR112014015424A2 - detecção de células derivadas de tecido do cordão umbilical humano - Google Patents

detecção de células derivadas de tecido do cordão umbilical humano

Info

Publication number
BR112014015424A2
BR112014015424A2 BR112014015424A BR112014015424A BR112014015424A2 BR 112014015424 A2 BR112014015424 A2 BR 112014015424A2 BR 112014015424 A BR112014015424 A BR 112014015424A BR 112014015424 A BR112014015424 A BR 112014015424A BR 112014015424 A2 BR112014015424 A2 BR 112014015424A2
Authority
BR
Brazil
Prior art keywords
hutc
positive markers
cells
pbmc
allogeneic therapeutic
Prior art date
Application number
BR112014015424A
Other languages
English (en)
Inventor
Kihm Anthony
Dorai Haimanti
L Favis Reyna
Rassnick Stefanie
Yao Xiang
Sun Yu
Original Assignee
Depuy Synthes Products Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Depuy Synthes Products Llc filed Critical Depuy Synthes Products Llc
Publication of BR112014015424A2 publication Critical patent/BR112014015424A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6888—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56966—Animal cells
    • G01N33/56972—White blood cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/70589—CD45

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Cell Biology (AREA)
  • Analytical Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Organic Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

abstract the invention relates to methods for detecting allogeneic therapeutic cells (such as human umbilical cord tissue-derived cells (hutc)) in blood. the methods includes the steps of identifying one or more one or more markers positive for allogeneic therapeutic cells (e.g. hutc) and one or more markers positive for human peripheral blood mononuclear cells (pbmc); providing a blood sample from a patient that has been treated with allogeneic therapeutic cells (e.g. hutc), analyzing the sample using an assay method to detect one or more markers positive for pbmc and one or more markers positive for allogeneic therapeutic cells (e.g. hutc); and distinguishing between the pbmc and one or more markers positive for allogeneic therapeutic cells (e.g. hutc). in one embodiment, the cells are hutc and the markers positive of hutc include cd10 and/or cd13 and the one or more markers positive for pbmc includes cd45. tradução do resumo resumo patente de invenção "detecção de células derivadas de tecido do cordão umbilical humano" a presente invenção refere-se a métodos para detectar células terapêuticas alogênicas (como células derivadas de tecido do cordão umbilical humano (hutc)) no sangue. os métodos incluem as etapas de identificar um ou mais marcadores positivos para células terapêuticas alogênicas (por exemplo,. hutc) e um ou mais marcadores positivos para células mononucleares de sangue periférico humano (pbmc); fornecer uma amostra de sangue de um paciente que foi tratado com células terapêutica alogênicas (por exemplo, hutc), analisar a amostra usando um método de teste para detectar um ou mais marcadores positivos para pbmc e um ou mais marcadores positivos para células terapêuticas alogênicas (por exemplo, hutc); e distinguir entre as pbmc e um ou mais marcadores positivos para células terapêuticas alogênicas (por exemplo, hutc). em uma modalidade, as células são hutc e os marcadores positivos de utc incluem cd10 e/ou cd13 e o um ou mais marcadores positivos para pbmc inclui cd45.
BR112014015424A 2011-12-23 2012-12-20 detecção de células derivadas de tecido do cordão umbilical humano BR112014015424A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161579710P 2011-12-23 2011-12-23
PCT/US2012/071072 WO2013096686A1 (en) 2011-12-23 2012-12-20 Detection of human umbilical cord tissue-derived cells

Publications (1)

Publication Number Publication Date
BR112014015424A2 true BR112014015424A2 (pt) 2018-05-22

Family

ID=47559711

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112014015424A BR112014015424A2 (pt) 2011-12-23 2012-12-20 detecção de células derivadas de tecido do cordão umbilical humano

Country Status (17)

Country Link
US (2) US9611513B2 (pt)
EP (1) EP2794854B1 (pt)
JP (1) JP6301263B2 (pt)
KR (1) KR101981450B1 (pt)
CN (1) CN104837987B (pt)
AU (1) AU2012358810B2 (pt)
BR (1) BR112014015424A2 (pt)
CA (1) CA2869681A1 (pt)
ES (1) ES2676556T3 (pt)
HK (2) HK1203550A1 (pt)
MX (1) MX362198B (pt)
PH (1) PH12014501445B1 (pt)
PL (1) PL2794854T3 (pt)
RU (1) RU2636220C2 (pt)
SG (1) SG11201403465PA (pt)
WO (1) WO2013096686A1 (pt)
ZA (1) ZA201405407B (pt)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112014015424A2 (pt) 2011-12-23 2018-05-22 Depuy Synthes Products Llc detecção de células derivadas de tecido do cordão umbilical humano
CN104678109A (zh) * 2015-03-06 2015-06-03 复旦大学附属中山医院 一种人源性的cd13可溶性蛋白的免疫组化试剂盒及其应用
CN105238751B (zh) * 2015-11-30 2021-07-23 深圳市合一康生物科技股份有限公司 一种脐带组织间充质干细胞的分离培养方法
JP7108537B2 (ja) 2016-04-27 2022-07-28 ロート製薬株式会社 Ｃｄ２０１、ｃｄ４６、ｃｄ５６、ｃｄ１４７及びｃｄ１６５からなる群より選択される少なくとも１種の細胞表面マーカーを発現する間葉系幹細胞及びその調製方法、並びに上記間葉系幹細胞を含む医薬組成物及びその調製方法
US20200264189A1 (en) * 2017-08-18 2020-08-20 University Of South Carolina Detection of Fumarate Ester-Derived Modification in a Test Sample

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