BR112014014652A2 - microrganismos modificados e métodos de fazer butadieno usando os mesmos - Google Patents
microrganismos modificados e métodos de fazer butadieno usando os mesmosInfo
- Publication number
- BR112014014652A2 BR112014014652A2 BR112014014652A BR112014014652A BR112014014652A2 BR 112014014652 A2 BR112014014652 A2 BR 112014014652A2 BR 112014014652 A BR112014014652 A BR 112014014652A BR 112014014652 A BR112014014652 A BR 112014014652A BR 112014014652 A2 BR112014014652 A2 BR 112014014652A2
- Authority
- BR
- Brazil
- Prior art keywords
- methods
- butadiene
- same
- microorganisms
- modified microorganisms
- Prior art date
Links
- KAKZBPTYRLMSJV-UHFFFAOYSA-N Butadiene Chemical compound C=CC=C KAKZBPTYRLMSJV-UHFFFAOYSA-N 0.000 title abstract 8
- 244000005700 microbiome Species 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 3
- 238000004519 manufacturing process Methods 0.000 abstract 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- 102000004190 Enzymes Human genes 0.000 abstract 1
- 108090000790 Enzymes Proteins 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 230000037361 pathway Effects 0.000 abstract 1
- 102000040430 polynucleotide Human genes 0.000 abstract 1
- 108091033319 polynucleotide Proteins 0.000 abstract 1
- 239000002157 polynucleotide Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P5/00—Preparation of hydrocarbons or halogenated hydrocarbons
- C12P5/02—Preparation of hydrocarbons or halogenated hydrocarbons acyclic
- C12P5/026—Unsaturated compounds, i.e. alkenes, alkynes or allenes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/88—Lyases (4.)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P5/00—Preparation of hydrocarbons or halogenated hydrocarbons
- C12P5/02—Preparation of hydrocarbons or halogenated hydrocarbons acyclic
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
- C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
- C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
- C12Y101/01001—Alcohol dehydrogenase (1.1.1.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y102/00—Oxidoreductases acting on the aldehyde or oxo group of donors (1.2)
- C12Y102/01—Oxidoreductases acting on the aldehyde or oxo group of donors (1.2) with NAD+ or NADP+ as acceptor (1.2.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y402/00—Carbon-oxygen lyases (4.2)
- C12Y402/01—Hydro-lyases (4.2.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y402/00—Carbon-oxygen lyases (4.2)
- C12Y402/01—Hydro-lyases (4.2.1)
- C12Y402/01127—Linalool dehydratase (4.2.1.127)
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
- Y02E50/00—Technologies for the production of fuel of non-fossil origin
- Y02E50/30—Fuel from waste, e.g. synthetic alcohol or diesel
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Enzymes And Modification Thereof (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
- Compositions Of Macromolecular Compounds (AREA)
Abstract
resumo microrganismos modificados e métodos de fazer butadieno usando os mesmos a presente invenção refere-se genericamente a microrganismos que compreendem um ou mais polinucleotideos que codificam para as enzimas em uma ou mais vias, que catalisam a conversão de uma fonte de carbono fermentável em butadieno. são também proporcionados métodos de utilização dos microrganismos em processos industriais, incluindo para utilização na produção de butadieno e produtos deles derivados.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161576788P | 2011-12-16 | 2011-12-16 | |
US61/576,788 | 2011-12-16 | ||
US201261606035P | 2012-03-02 | 2012-03-02 | |
US61/606,035 | 2012-03-02 | ||
PCT/US2012/070161 WO2013090915A1 (en) | 2011-12-16 | 2012-12-17 | Modified microorganisms and methods of making butadiene using same |
Publications (3)
Publication Number | Publication Date |
---|---|
BR112014014652A8 BR112014014652A8 (pt) | 2017-06-13 |
BR112014014652A2 true BR112014014652A2 (pt) | 2017-06-13 |
BR112014014652B1 BR112014014652B1 (pt) | 2021-07-13 |
Family
ID=48613275
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112014014652-7A BR112014014652B1 (pt) | 2011-12-16 | 2012-12-17 | Método de produção de butadieno e microrganismo geneticamente modificado |
Country Status (14)
Country | Link |
---|---|
US (3) | US9518273B2 (pt) |
EP (1) | EP2791342B1 (pt) |
JP (2) | JP6415326B2 (pt) |
KR (1) | KR20150068925A (pt) |
CN (2) | CN104471068A (pt) |
AU (1) | AU2012353654B2 (pt) |
BR (1) | BR112014014652B1 (pt) |
CA (1) | CA2859556C (pt) |
EC (1) | ECSP14007092A (pt) |
MX (1) | MX349910B (pt) |
PH (1) | PH12014501364A1 (pt) |
RU (1) | RU2639564C2 (pt) |
SG (1) | SG11201403276TA (pt) |
WO (1) | WO2013090915A1 (pt) |
Families Citing this family (31)
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BR112013032516A2 (pt) | 2011-06-17 | 2017-03-01 | Invista Tech Sarl | método de biosintetizar butadieno e método para produzir butadieno |
US9422578B2 (en) | 2011-06-17 | 2016-08-23 | Invista North America S.A.R.L. | Methods for biosynthesizing 1,3 butadiene |
JP5997938B2 (ja) * | 2012-05-31 | 2016-09-28 | 株式会社ブリヂストン | ブタジエン重合体の製造方法及びタイヤの製造方法 |
JP5997939B2 (ja) * | 2012-05-31 | 2016-09-28 | 株式会社ブリヂストン | 共役ジエン系重合体の製造方法 |
BR112014031894A2 (pt) * | 2012-06-18 | 2017-08-01 | Braskem Sa | método para co-produção de butadieno e 1-propanol e/ou 1, 2-propanodiol e, microrganismo |
BR112015011088A2 (pt) | 2012-11-28 | 2017-08-22 | Invista Tech Sarl | Método para sintetizar isobuteno e hospedeiro recombinante |
US20140206066A1 (en) * | 2013-01-18 | 2014-07-24 | Coskata, Inc. | Syntrophic co-culture of anaerobic microorganism for production of n-butanol from syngas |
BR112015020904A2 (pt) * | 2013-03-15 | 2017-10-10 | Genomatica Inc | microrganismos e métodos para produção de butadieno e compostos relacionados por assimilação de formiato |
US20150050708A1 (en) * | 2013-03-15 | 2015-02-19 | Genomatica, Inc. | Microorganisms and methods for producing butadiene and related compounds by formate assimilation |
US10294496B2 (en) | 2013-07-19 | 2019-05-21 | Invista North America S.A.R.L. | Methods for biosynthesizing 1,3 butadiene |
CN105683385A (zh) | 2013-08-05 | 2016-06-15 | 英威达技术有限责任公司 | 用于生物合成异戊二烯的方法 |
CN105683384A (zh) | 2013-08-05 | 2016-06-15 | 英威达技术有限责任公司 | 用于生物合成异丁烯的方法 |
US20150064760A1 (en) * | 2013-09-05 | 2015-03-05 | Braskem S.A. | Modified microorganism and methods of using same for producing butadiene and 1-propanol and/or 1,2-propanediol |
US10000744B2 (en) | 2013-09-23 | 2018-06-19 | Braskem S.A. | Engineered enzyme having acetoacetyl-CoA hydrolase activity, microorganisms comprising same, and methods of using same |
EP3155111A1 (en) | 2014-06-16 | 2017-04-19 | Invista Technologies S.à r.l. | Process for producing glutarate and glutaric acid methyl ester |
EP3167066A4 (en) | 2014-07-11 | 2018-03-07 | Genomatica, Inc. | Microorganisms and methods for the production of butadiene using acetyl-coa |
WO2016097293A1 (en) * | 2014-12-19 | 2016-06-23 | Global Bioenergies | Process for the enzymatic production of 1-butene from 2-pentenoyl-coa |
EP3273782B9 (en) | 2015-02-27 | 2022-07-13 | White Dog Labs, Inc. | Mixotrophic fermentation method for making acetone, isopropanol, and other bioproducts, and mixtures thereof |
EP3280808B1 (en) * | 2015-04-09 | 2020-09-16 | Genomatica, Inc. | Genetically engineered e. coli and methods for improved crotyl alcohol production |
CN108026214B (zh) * | 2015-05-30 | 2021-03-02 | 基因组股份公司 | 乙烯基异构酶-脱水酶、烯醇脱水酶、芳樟醇脱水酶和/或巴豆醇脱水酶及其制备和使用 |
WO2017022804A1 (ja) * | 2015-08-03 | 2017-02-09 | 国立研究開発法人理化学研究所 | ジホスホメバロン酸デカルボキシラーゼ変異体、及びそれを用いたオレフィン化合物の製造方法 |
US20190218578A1 (en) * | 2015-08-24 | 2019-07-18 | White Dog Labs, Inc. | Microbial organisms for converting acetyl-coa into crotyl alcohol and methods for producing crotyl alcohol |
CN109996865B (zh) | 2016-07-12 | 2023-02-03 | 布拉斯肯有限公司 | 通过烷醇的酶促脱水形成烯烃 |
KR101929631B1 (ko) | 2016-12-20 | 2018-12-14 | 서강대학교산학협력단 | 미생물 발효를 이용한 1,3-부타디엔의 제조 방법 |
US11162115B2 (en) | 2017-06-30 | 2021-11-02 | Inv Nylon Chemicals Americas, Llc | Methods, synthetic hosts and reagents for the biosynthesis of hydrocarbons |
WO2019006255A1 (en) | 2017-06-30 | 2019-01-03 | Invista North America S.A.R.L. | METHODS, MATERIALS, SYNTHETIC HOSTS AND REAGENTS FOR HYDROCARBON BIOSYNTHESIS AND DERIVATIVES |
US11505809B2 (en) | 2017-09-28 | 2022-11-22 | Inv Nylon Chemicals Americas Llc | Organisms and biosynthetic processes for hydrocarbon synthesis |
CN108690851B (zh) * | 2018-05-30 | 2020-11-06 | 青岛农业大学 | 一种丁二烯生产菌及其生产丁二烯的方法 |
CN108949788B (zh) * | 2018-07-10 | 2020-07-14 | 广东省微生物研究所(广东省微生物分析检测中心) | 番茄红素合成相关基因及其应用 |
CN109666683B (zh) * | 2019-02-27 | 2021-10-29 | 昆明理工大学 | 乙酰辅酶A乙酰转移酶基因RKAcaT2及其应用 |
CN110433619B (zh) * | 2019-09-05 | 2021-11-16 | 北京工商大学 | 杀鲑气单胞菌亚种在挥发性有机污染物降解方面的应用 |
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EP0402226A1 (en) | 1989-06-06 | 1990-12-12 | Institut National De La Recherche Agronomique | Transformation vectors for yeast yarrowia |
SE464472B (sv) | 1989-08-31 | 1991-04-29 | Aga Ab | Saett och anordning foer tillverkning av ihaaliga foeremaal av glas |
US5122469A (en) | 1990-10-03 | 1992-06-16 | Genentech, Inc. | Method for culturing Chinese hamster ovary cells to improve production of recombinant proteins |
DE102004054766A1 (de) * | 2004-11-12 | 2006-05-18 | Basf Ag | Verfahren zur Herstellung von Butadien aus n-Butan |
BRPI0719748A2 (pt) | 2006-12-01 | 2013-12-10 | Gevo Inc | Microrganismo modificados por engenharia para produzir n-butanol e métodos relacionados |
US7981647B2 (en) * | 2008-03-03 | 2011-07-19 | Joule Unlimited, Inc. | Engineered CO2 fixing microorganisms producing carbon-based products of interest |
EP2304040B1 (fr) * | 2008-07-04 | 2017-09-06 | Scientist of Fortune S.A. | Production d'alcenes par decarboxylation enzymatique d'acides 3-hydroxy-alcanoïques |
SG179048A1 (en) * | 2009-09-09 | 2012-04-27 | Genomatica Inc | Microorganisms and methods for the co-production of isopropanol with primary alcohols, diols and acids |
US8410326B2 (en) * | 2010-01-14 | 2013-04-02 | Wisconsin Alumni Research Foundation | Integrated process and apparatus to produce hydrocarbons from aqueous solutions of lactones, hydroxy-carboxylic acids, alkene-carboxylic acids, and/or alcohols |
CN106047782A (zh) | 2010-05-05 | 2016-10-26 | 基因组股份公司 | 用于丁二烯生物合成的微生物和方法 |
CA2806230A1 (en) * | 2010-07-26 | 2012-02-09 | Genomatica, Inc. | Microorganisms and methods for the biosynthesis of aromatics, 2,4-pentadienoate and 1,3-butadiene |
US9422578B2 (en) * | 2011-06-17 | 2016-08-23 | Invista North America S.A.R.L. | Methods for biosynthesizing 1,3 butadiene |
WO2015084633A1 (en) * | 2013-12-03 | 2015-06-11 | Genomatica, Inc. | Microorganisms and methods for improving product yields on methanol using acetyl-coa synthesis |
EP3167066A4 (en) * | 2014-07-11 | 2018-03-07 | Genomatica, Inc. | Microorganisms and methods for the production of butadiene using acetyl-coa |
-
2012
- 2012-12-17 WO PCT/US2012/070161 patent/WO2013090915A1/en active Application Filing
- 2012-12-17 SG SG11201403276TA patent/SG11201403276TA/en unknown
- 2012-12-17 CA CA2859556A patent/CA2859556C/en active Active
- 2012-12-17 MX MX2014007235A patent/MX349910B/es active IP Right Grant
- 2012-12-17 US US14/365,441 patent/US9518273B2/en active Active
- 2012-12-17 KR KR1020147019664A patent/KR20150068925A/ko not_active Application Discontinuation
- 2012-12-17 EP EP12857162.7A patent/EP2791342B1/en active Active
- 2012-12-17 RU RU2014129026A patent/RU2639564C2/ru active
- 2012-12-17 JP JP2014547551A patent/JP6415326B2/ja active Active
- 2012-12-17 AU AU2012353654A patent/AU2012353654B2/en active Active
- 2012-12-17 CN CN201280069265.6A patent/CN104471068A/zh active Pending
- 2012-12-17 CN CN202110110867.2A patent/CN112877370A/zh active Pending
- 2012-12-17 BR BR112014014652-7A patent/BR112014014652B1/pt active IP Right Grant
-
2014
- 2014-06-16 PH PH12014501364A patent/PH12014501364A1/en unknown
- 2014-06-27 EC ECIEPI20147092A patent/ECSP14007092A/es unknown
-
2015
- 2015-10-16 US US14/885,311 patent/US10059963B2/en active Active
-
2018
- 2018-06-07 JP JP2018109276A patent/JP2018134113A/ja active Pending
- 2018-07-23 US US16/042,594 patent/US10273505B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
KR20150068925A (ko) | 2015-06-22 |
SG11201403276TA (en) | 2014-10-30 |
BR112014014652B1 (pt) | 2021-07-13 |
WO2013090915A1 (en) | 2013-06-20 |
MX2014007235A (es) | 2015-04-13 |
ECSP14007092A (es) | 2015-06-30 |
CA2859556C (en) | 2022-01-11 |
JP2018134113A (ja) | 2018-08-30 |
BR112014014652A8 (pt) | 2017-06-13 |
AU2012353654A1 (en) | 2014-07-10 |
JP6415326B2 (ja) | 2018-10-31 |
EP2791342B1 (en) | 2020-04-29 |
RU2639564C2 (ru) | 2017-12-21 |
CN112877370A (zh) | 2021-06-01 |
AU2012353654A8 (en) | 2014-07-17 |
EP2791342A4 (en) | 2016-04-13 |
CA2859556A1 (en) | 2013-06-20 |
JP2015501659A (ja) | 2015-01-19 |
US20160032325A1 (en) | 2016-02-04 |
PH12014501364A1 (en) | 2014-09-22 |
US20180346936A1 (en) | 2018-12-06 |
US10059963B2 (en) | 2018-08-28 |
EP2791342A1 (en) | 2014-10-22 |
US20140370564A1 (en) | 2014-12-18 |
US20150152439A2 (en) | 2015-06-04 |
AU2012353654B2 (en) | 2016-09-29 |
US10273505B2 (en) | 2019-04-30 |
CN104471068A (zh) | 2015-03-25 |
US9518273B2 (en) | 2016-12-13 |
RU2014129026A (ru) | 2016-02-10 |
MX349910B (es) | 2017-08-17 |
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