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BR0314688A - Novos derivados de piperidina para utilização no tratamento de estados de doença mediados pela quimiocina - Google Patents

Novos derivados de piperidina para utilização no tratamento de estados de doença mediados pela quimiocina

Info

Publication number
BR0314688A
BR0314688A BR0314688-0A BR0314688A BR0314688A BR 0314688 A BR0314688 A BR 0314688A BR 0314688 A BR0314688 A BR 0314688A BR 0314688 A BR0314688 A BR 0314688A
Authority
BR
Brazil
Prior art keywords
treatment
mediated disease
disease states
piperidine derivatives
chemokine mediated
Prior art date
Application number
BR0314688-0A
Other languages
English (en)
Inventor
Christopher Luckhurst
Matthew Perry
Brian Springthorpe
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of BR0314688A publication Critical patent/BR0314688A/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
    • A—HUMAN NECESSITIES
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
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  • Virology (AREA)
  • Dermatology (AREA)
  • Diabetes (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Neurology (AREA)
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  • Communicable Diseases (AREA)
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  • Rheumatology (AREA)
  • Endocrinology (AREA)
  • Biomedical Technology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
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Abstract

"NOVOS DERIVADOS DE PIPERIDINA PARA UTILIZAçãO NO TRATAMENTO DE ESTADOS DE DOENçA MEDIADOS PELA QUIMIOCINA". A presente invenção proporciona um composto com a fórmula geral (I): em que os substituintes R^ 1^, R^ 2^, R^ a^, R^ c^, X, Y e Z são como definidos no relatório descritivo e/ou no quadro reivindicatório do presente pedido de patente. A presente invenção adicionalmente se refere a um processo para a preparação do referido composto de fórmula geral (I); a uma composição farmacêutica que compreende o composto de fórmula geral (I), ou um sal farmaceuticamente aceitável do mesmo ou um solvato do mesmo; e bem como à utilização de um composto de fórmula geral (I), ou um sal farmaceuticamente aceitável do mesmo ou um solvato do mesmo em terapia, e também na manufaturação de um medicamento para utilização em terapia; e em adição se refere a um método de tratamento de um estado de doença mediado por quimiocina (tal como CCR3) ou por H1 em um mamífero sofrendo da, ou em risco da, referida doença que compreende a administração a um mamífero em necessidade de tal tratamento de uma quantidade terapeuticamente efetiva de um composto de fórmula geral (I), ou um sal farmaceuticamente aceitável do mesmo ou um solvato do mesmo.
BR0314688-0A 2002-09-24 2003-09-12 Novos derivados de piperidina para utilização no tratamento de estados de doença mediados pela quimiocina BR0314688A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE0202838A SE0202838D0 (sv) 2002-09-24 2002-09-24 Chemical compounds
PCT/SE2003/001425 WO2004029041A1 (en) 2002-09-24 2003-09-12 Novel piperidine derivatives for use in the treatment of chemokine mediated disease states

Publications (1)

Publication Number Publication Date
BR0314688A true BR0314688A (pt) 2005-08-02

Family

ID=20289093

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0314688-0A BR0314688A (pt) 2002-09-24 2003-09-12 Novos derivados de piperidina para utilização no tratamento de estados de doença mediados pela quimiocina

Country Status (20)

Country Link
US (1) US20060040984A1 (pt)
EP (2) EP1546130B1 (pt)
JP (1) JP2006503066A (pt)
KR (1) KR20050052511A (pt)
CN (1) CN1684952A (pt)
AT (1) ATE368656T1 (pt)
AU (1) AU2003259004B2 (pt)
BR (1) BR0314688A (pt)
CA (1) CA2497280A1 (pt)
DE (1) DE60315323T2 (pt)
ES (1) ES2289354T3 (pt)
IS (1) IS7813A (pt)
MX (1) MXPA05003007A (pt)
NO (1) NO20051965L (pt)
NZ (1) NZ538527A (pt)
PL (1) PL376119A1 (pt)
RU (1) RU2005105053A (pt)
SE (1) SE0202838D0 (pt)
WO (1) WO2004029041A1 (pt)
ZA (1) ZA200502341B (pt)

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WO2003059965A1 (en) * 2002-01-10 2003-07-24 University Of Washington Hydrogels formed by non-covalent linkages
SE0200844D0 (sv) * 2002-03-19 2002-03-19 Astrazeneca Ab Chemical compounds
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WO2004029041A1 (en) 2004-04-08
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US20060040984A1 (en) 2006-02-23
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AU2003259004A1 (en) 2004-04-19
ATE368656T1 (de) 2007-08-15
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