BR0314543A - Polypeptides implicated in spiramycin biosynthesis, nucleotide sequences encoding these polypeptides and their applications - Google Patents
Polypeptides implicated in spiramycin biosynthesis, nucleotide sequences encoding these polypeptides and their applicationsInfo
- Publication number
- BR0314543A BR0314543A BR0314543-3A BR0314543A BR0314543A BR 0314543 A BR0314543 A BR 0314543A BR 0314543 A BR0314543 A BR 0314543A BR 0314543 A BR0314543 A BR 0314543A
- Authority
- BR
- Brazil
- Prior art keywords
- polypeptides
- spiramycin
- genes
- relates
- biosynthesis
- Prior art date
Links
- ACTOXUHEUCPTEW-BWHGAVFKSA-N 2-[(4r,5s,6s,7r,9r,10r,11e,13e,16r)-6-[(2s,3r,4r,5s,6r)-5-[(2s,4r,5s,6s)-4,5-dihydroxy-4,6-dimethyloxan-2-yl]oxy-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-10-[(2s,5s,6r)-5-(dimethylamino)-6-methyloxan-2-yl]oxy-4-hydroxy-5-methoxy-9,16-dimethyl-2-o Chemical compound O([C@H]1/C=C/C=C/C[C@@H](C)OC(=O)C[C@@H](O)[C@@H]([C@H]([C@@H](CC=O)C[C@H]1C)O[C@H]1[C@@H]([C@H]([C@H](O[C@@H]2O[C@@H](C)[C@H](O)[C@](C)(O)C2)[C@@H](C)O1)N(C)C)O)OC)[C@@H]1CC[C@H](N(C)C)[C@@H](C)O1 ACTOXUHEUCPTEW-BWHGAVFKSA-N 0.000 title abstract 6
- 229920001184 polypeptide Polymers 0.000 title abstract 6
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 6
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 6
- 239000004187 Spiramycin Substances 0.000 title abstract 5
- 229930191512 spiramycin Natural products 0.000 title abstract 5
- 229960001294 spiramycin Drugs 0.000 title abstract 5
- 235000019372 spiramycin Nutrition 0.000 title abstract 5
- 230000015572 biosynthetic process Effects 0.000 title abstract 4
- 108091028043 Nucleic acid sequence Proteins 0.000 title 1
- 108090000623 proteins and genes Proteins 0.000 abstract 5
- 230000006696 biosynthetic metabolic pathway Effects 0.000 abstract 2
- 244000005700 microbiome Species 0.000 abstract 2
- ZPCCSZFPOXBNDL-LWXQEXJOSA-N Spiramycin-II Natural products CO[C@H]1[C@@H](CC(=O)O[C@H](C)CC=CC=C[C@H](O[C@H]2CC[C@@H]([C@@H](C)O2)N(C)C)[C@H](C)C[C@@H](CC=O)[C@@H]1O[C@@H]3O[C@H](C)[C@@H](O[C@H]4C[C@@](C)(O)[C@@H](O)[C@H](C)O4)[C@@H]([C@H]3O)N(C)C)OC(=O)C ZPCCSZFPOXBNDL-LWXQEXJOSA-N 0.000 abstract 1
- HSZLKTCKAYXVBX-VPIGJTHDSA-N Spiramycin-III Natural products CCC(=O)O[C@@H]1CC(=O)O[C@H](C)CC=CC=C[C@H](O[C@H]2CC[C@@H]([C@@H](C)O2)N(C)C)[C@H](C)C[C@H](CC=O)[C@H](O[C@@H]3O[C@H](C)[C@@H](O[C@H]4C[C@@](C)(O)[C@@H](O)[C@H](C)O4)[C@@H]([C@H]3O)N(C)C)[C@H]1OC HSZLKTCKAYXVBX-VPIGJTHDSA-N 0.000 abstract 1
- 239000003242 anti bacterial agent Substances 0.000 abstract 1
- 229940088710 antibiotic agent Drugs 0.000 abstract 1
- 238000010276 construction Methods 0.000 abstract 1
- DDQFXRYVNIPXRQ-UHFFFAOYSA-L cyclopenta-1,3-diene;dichlorozirconium(2+);1,2,3,5,5-pentamethylcyclopenta-1,3-diene Chemical compound Cl[Zr+2]Cl.C1C=CC=[C-]1.CC1=[C-]C(C)(C)C(C)=C1C DDQFXRYVNIPXRQ-UHFFFAOYSA-L 0.000 abstract 1
- 238000002955 isolation Methods 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- ACTOXUHEUCPTEW-ZOTSFZJCSA-N spiramycin I Natural products CO[C@H]1[C@H](O)CC(=O)O[C@H](C)CC=CC=C[C@H](O[C@H]2CC[C@@H]([C@@H](C)O2)N(C)C)[C@H](C)C[C@H](CC=O)[C@@H]1O[C@@H]3O[C@H](C)[C@@H](O[C@H]4C[C@@](C)(O)[C@@H](O)[C@H](C)O4)[C@@H]([C@H]3O)N(C)C ACTOXUHEUCPTEW-ZOTSFZJCSA-N 0.000 abstract 1
- ZPCCSZFPOXBNDL-RSMXASMKSA-N spiramycin II Chemical compound O([C@H]1/C=C/C=C/C[C@@H](C)OC(=O)C[C@H]([C@@H]([C@H]([C@@H](CC=O)C[C@H]1C)O[C@H]1[C@@H]([C@H]([C@H](O[C@@H]2O[C@@H](C)[C@H](O)[C@](C)(O)C2)[C@@H](C)O1)N(C)C)O)OC)OC(C)=O)[C@H]1CC[C@H](N(C)C)[C@H](C)O1 ZPCCSZFPOXBNDL-RSMXASMKSA-N 0.000 abstract 1
- 229950001955 spiramycin i Drugs 0.000 abstract 1
- 229950006796 spiramycin ii Drugs 0.000 abstract 1
- 229950003659 spiramycin iii Drugs 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/36—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Actinomyces; from Streptomyces (G)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
- C12N1/205—Bacterial isolates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/44—Preparation of O-glycosides, e.g. glucosides
- C12P19/60—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin
- C12P19/62—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin the hetero ring having eight or more ring members and only oxygen as ring hetero atoms, e.g. erythromycin, spiramycin, nystatin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
- C12R2001/465—Streptomyces
Landscapes
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Tropical Medicine & Parasitology (AREA)
- Virology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
"POLIPEPTìDEOS IMPLICADOS NA BIOSSìNTESE DAS ESPIRAMICINAS, SEQuêNCIAS NUCLEOTìDICAS CODIFICANDO ESSES POLIPEPTìDEOS E SUAS APLICAçõES". A presente invenção refere-se ao isolamento e à identificação de novos genes da via de biossíntese das espiramicinas e de novos polipeptídeos implicados nessa biossíntese. A invenção é também relativa a um processo de produção desses polipeptídeos. Ela é também relativa à utilização desses genes com a finalidade de aumentar as taxas de produção e a pureza da espiramicina produzida. A invenção refere-se notadamente a um microorganismo que produz a espiramicina I, mas que não produz a espiramicina II e III e a utilização desse microorganismo. A invenção refere-se também à utilização dos genes da via de biossíntese das espiramicinas para a construção de mutantes que podem levar à síntese de novos antibióticos ou a formas derivadas de espiramicinas. A invenção refere-se ainda às moléculas produzidas graças à expressão desses genes e das composições farmacologicamente ativas de uma molécula produzida graças à expressão desses genes."Polypeptides implicated in the BIOSYNTHESIS OF SPIRAMICINS, NUCLEOTIDIC SEQUENCES CODING THESE POLYPEPTIDES AND THEIR APPLICATIONS". The present invention relates to the isolation and identification of novel spiramycin biosynthesis pathway genes and novel polypeptides implicated in such biosynthesis. The invention also relates to a process for producing such polypeptides. It is also related to the use of these genes for the purpose of increasing production rates and purity of the produced spiramycin. The invention notably relates to a microorganism that produces spiramycin I but does not produce spiramycin II and III and the use of such microorganism. The invention also relates to the use of spiramycin biosynthesis pathway genes for the construction of mutants that may lead to the synthesis of new antibiotics or to spiramycin-derived forms. The invention further relates to molecules produced by the expression of these genes and the pharmacologically active compositions of a molecule produced by the expression of these genes.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0212489A FR2845394A1 (en) | 2002-10-08 | 2002-10-08 | New polynucleotides encoding proteins involved in spiramycin biosynthesis, useful for improving synthesis of macrolide antibiotics or for generating new hybrid macrolides |
| FR0302439A FR2851773A1 (en) | 2003-02-27 | 2003-02-27 | New polynucleotides encoding proteins involved in spiramycin biosynthesis, useful for improving synthesis of macrolide antibiotics or for generating new hybrid macrolides |
| US49349003P | 2003-08-07 | 2003-08-07 | |
| PCT/FR2003/002962 WO2004033689A2 (en) | 2002-10-08 | 2003-10-08 | Polypeptides involved in spiramycin biosynthesis, nucleotide sequences encoding said polypeptides and uses thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| BR0314543A true BR0314543A (en) | 2005-08-09 |
| BRPI0314543B1 BRPI0314543B1 (en) | 2016-06-14 |
| BRPI0314543B8 BRPI0314543B8 (en) | 2021-05-25 |
Family
ID=32096598
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0314543A BRPI0314543B8 (en) | 2002-10-08 | 2003-10-08 | host cells, recombinant DNA, their use, processes for the production of a polypeptide involved in the biosynthesis of spiramycins, the production of macrolides and the production of spiramycin(s), and macrolide-producing mutant transgenic microorganism |
Country Status (10)
| Country | Link |
|---|---|
| EP (1) | EP1551975A2 (en) |
| JP (1) | JP5042497B2 (en) |
| KR (1) | KR101110175B1 (en) |
| AU (1) | AU2003300479B2 (en) |
| BR (1) | BRPI0314543B8 (en) |
| CA (1) | CA2501445C (en) |
| IL (1) | IL167854A (en) |
| MX (1) | MXPA05002852A (en) |
| NO (1) | NO335995B1 (en) |
| WO (1) | WO2004033689A2 (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111349595A (en) * | 2018-12-20 | 2020-06-30 | 沈阳福洋医药科技有限公司 | Spiramycin-producing strain, rokitamycin-producing strain, construction method, application and method for improving product yield |
| WO2024074640A1 (en) * | 2022-10-07 | 2024-04-11 | Syngenta Crop Protection Ag | Fungicidal mixture comprising streptimidone and malonomicin |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5068189A (en) * | 1988-05-13 | 1991-11-26 | Eli Lilly And Company | Recombinant dna vectors encoding a 4"-o-isovaleryl acylase derived from a carbomycin biosynthetic gene, designated care, for use in streptomyces and other organisms |
| JP2749616B2 (en) | 1988-05-24 | 1998-05-13 | メルシャン株式会社 | Gene encoding 4 "acylase of macrolide antibiotic |
| US5098837A (en) * | 1988-06-07 | 1992-03-24 | Eli Lilly And Company | Macrolide biosynthetic genes for use in streptomyces and other organisms |
| US5322937A (en) | 1990-06-01 | 1994-06-21 | Mercian Corporation | Genes encoding a 3-acylation enzyme for macrolide antibiotics |
| US5514544A (en) * | 1991-07-26 | 1996-05-07 | Eli Lilly And Company | Activator gene for macrolide biosynthesis |
| JPH0638750A (en) * | 1991-08-09 | 1994-02-15 | Meiji Seika Kaisha Ltd | Enzyme for acylating 3-position of macrolide antibiotic and gene coding the same |
| JPH06121677A (en) * | 1992-01-23 | 1994-05-06 | Mercian Corp | Method for highly manifesting enzyme gene acylating macrolide antibiotic |
| CA2197524A1 (en) * | 1996-02-22 | 1997-08-22 | Bradley Stuart Dehoff | Polyketide synthase genes |
| CA2197160C (en) * | 1996-02-22 | 2007-05-01 | Stanley Gene Burgett | Platenolide synthase gene |
| JP2001511349A (en) * | 1997-07-25 | 2001-08-14 | ヘキスト・マリオン・ルセル | Genes for 6-deoxyhexose biosynthesis and transfer in Saccharopolysporaerythraea and Streptomycesantibioticus |
| ATE321139T1 (en) * | 2001-07-26 | 2006-04-15 | Ecopia Biosciences Inc | GENES AND PROTEINS FOR ROSARAMICIN BIOSYNTHESIS |
-
2003
- 2003-10-08 EP EP03807883A patent/EP1551975A2/en not_active Withdrawn
- 2003-10-08 AU AU2003300479A patent/AU2003300479B2/en not_active Expired
- 2003-10-08 BR BRPI0314543A patent/BRPI0314543B8/en not_active IP Right Cessation
- 2003-10-08 WO PCT/FR2003/002962 patent/WO2004033689A2/en active Application Filing
- 2003-10-08 MX MXPA05002852A patent/MXPA05002852A/en active IP Right Grant
- 2003-10-08 KR KR1020057006111A patent/KR101110175B1/en active IP Right Grant
- 2003-10-08 JP JP2005500990A patent/JP5042497B2/en not_active Expired - Lifetime
- 2003-10-08 CA CA2501445A patent/CA2501445C/en not_active Expired - Lifetime
-
2005
- 2005-04-04 IL IL167854A patent/IL167854A/en active IP Right Grant
- 2005-05-02 NO NO20052160A patent/NO335995B1/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| KR101110175B1 (en) | 2012-07-18 |
| JP2006501863A (en) | 2006-01-19 |
| JP5042497B2 (en) | 2012-10-03 |
| BRPI0314543B1 (en) | 2016-06-14 |
| EP1551975A2 (en) | 2005-07-13 |
| WO2004033689A2 (en) | 2004-04-22 |
| AU2003300479B2 (en) | 2009-12-10 |
| CA2501445A1 (en) | 2004-04-22 |
| MXPA05002852A (en) | 2005-10-05 |
| CA2501445C (en) | 2016-01-26 |
| AU2003300479A1 (en) | 2004-05-04 |
| NO335995B1 (en) | 2015-04-13 |
| WO2004033689A3 (en) | 2004-08-26 |
| NO20052160L (en) | 2005-06-02 |
| BRPI0314543B8 (en) | 2021-05-25 |
| KR20050084843A (en) | 2005-08-29 |
| IL167854A (en) | 2011-06-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
| B15K | Others concerning applications: alteration of classification |
Free format text: AS CLASSIFICACOES ANTERIORES ERAM: C12N 15/52 , C12N 9/00 , C12N 15/63 , C12N 1/21 , C07K 14/36 , C12P 19/62 Ipc: C12N 15/52 (2006.01), C07K 14/36 (2006.01), C12P 1 |
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| B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] |
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| B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
| B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
| B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
| B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 14/06/2016, OBSERVADAS AS CONDICOES LEGAIS. |
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| B16C | Correction of notification of the grant [chapter 16.3 patent gazette] |
Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 08/10/2003 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF |
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| B21F | Lapse acc. art. 78, item iv - on non-payment of the annual fees in time |
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| B24J | Lapse because of non-payment of annual fees (definitively: art 78 iv lpi, resolution 113/2013 art. 12) |
Free format text: EM VIRTUDE DA EXTINCAO PUBLICADA NA RPI 2795 DE 30-07-2024 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDA A EXTINCAO DA PATENTE E SEUS CERTIFICADOS, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |