Nothing Special   »   [go: up one dir, main page]

BR0311471A - anticorpo anti-cd16a, e, métodos de redução de uma resposta imune deletéria em um mamìfero e de tratamento de uma resposta imune deletéria em um mamìfero - Google Patents

anticorpo anti-cd16a, e, métodos de redução de uma resposta imune deletéria em um mamìfero e de tratamento de uma resposta imune deletéria em um mamìfero

Info

Publication number
BR0311471A
BR0311471A BRPI0311471-6A BR0311471A BR0311471A BR 0311471 A BR0311471 A BR 0311471A BR 0311471 A BR0311471 A BR 0311471A BR 0311471 A BR0311471 A BR 0311471A
Authority
BR
Brazil
Prior art keywords
immune response
mammal
deleterious immune
treating
reducing
Prior art date
Application number
BRPI0311471-6A
Other languages
English (en)
Inventor
Leslie S Johnson
Ling Huang
Hua Li
Nadine Tuaillon
Original Assignee
Macrogenics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Macrogenics Inc filed Critical Macrogenics Inc
Publication of BR0311471A publication Critical patent/BR0311471A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/283—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against Fc-receptors, e.g. CD16, CD32, CD64
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
    • C07K2317/41—Glycosylation, sialylation, or fucosylation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Hematology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

"ANTICORPO ANTI-CD16A, E, MéTODOS DE REDUçãO DE UMA RESPOSTA IMUNE DELETéRIA EM UM MAMìFERO E DE TRATAMENTO DE UMA RESPOSTA IMUNE DELETéRIA EM UM MAMìFERO". Proteínas ligantes de CD16A úteis para a redução de uma resposta imune deletéria são descritas. Em um aspecto, anticorpos anti-CD16A humanizados, opcionalmente faltantes de função efetora, são usados para o tratamento de distúrbios imunes tais como púrpura trombocitopênica idiopática e anemia hemolítica autoimune.
BRPI0311471-6A 2002-05-30 2003-05-29 anticorpo anti-cd16a, e, métodos de redução de uma resposta imune deletéria em um mamìfero e de tratamento de uma resposta imune deletéria em um mamìfero BR0311471A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US38468902P 2002-05-30 2002-05-30
US43932003P 2003-01-10 2003-01-10
PCT/US2003/017111 WO2003101485A1 (en) 2002-05-30 2003-05-29 Cd16a binding proteins and use for the treatment of immune disorders

Publications (1)

Publication Number Publication Date
BR0311471A true BR0311471A (pt) 2007-04-27

Family

ID=29715346

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0311471-6A BR0311471A (pt) 2002-05-30 2003-05-29 anticorpo anti-cd16a, e, métodos de redução de uma resposta imune deletéria em um mamìfero e de tratamento de uma resposta imune deletéria em um mamìfero

Country Status (10)

Country Link
US (4) US7351803B2 (pt)
EP (1) EP1513554B9 (pt)
JP (1) JP4524181B2 (pt)
AT (1) ATE483472T1 (pt)
AU (1) AU2003232456B2 (pt)
BR (1) BR0311471A (pt)
CA (1) CA2487932A1 (pt)
DE (1) DE60334453D1 (pt)
HK (1) HK1074991A1 (pt)
WO (1) WO2003101485A1 (pt)

Families Citing this family (108)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2003232456B2 (en) * 2002-05-30 2009-06-04 Macrogenics, Inc. CD16A binding proteins and use for the treatment of immune disorders
AU2003233246B2 (en) * 2002-06-07 2008-04-10 The Macfarlane Burnet Institute For Medical Research And Public Health Ltd FcyRIIa transgenic animal model for autoimmune disease
JP2007525149A (ja) 2003-01-13 2007-09-06 マクロジェニクス，インコーポレーテッド 可溶性ＦｃγＲ融合タンパク質およびその使用法
DE602004029252D1 (de) * 2003-06-13 2010-11-04 Biogen Idec Inc Aglycosyl-anti-cd154 (cd40-ligand) antikörper und deren verwendungen
AU2011224032B2 (en) * 2003-06-13 2013-01-31 Biogen Ma Inc. Aglycosyl Anti-CD154 (CD40 Ligand) Antibodies and Uses Thereof
EP1664116A4 (en) 2003-08-22 2009-06-03 Biogen Idec Inc IMPROVED ANTIBODIES WITH CHANGED EFFECTOR FUNCTION AND MANUFACTURING METHOD THEREFOR
JP4691650B2 (ja) * 2004-03-04 2011-06-01 国立大学法人広島大学 ニワトリ型モノクローナル抗体の生産方法、および当該生産方法によって生産されるニワトリ型モノクローナル抗体
US20110142858A1 (en) * 2004-06-07 2011-06-16 Ramot At Tel Aviv University Ltd. Method of Passsive Immunization Against Disease or Disorder Charcterized by Amyloid Aggregation with Diminished Risk of Neuroinflammation
JP4839583B2 (ja) * 2004-07-15 2011-12-21 和光純薬工業株式会社 ＦｃγレセプターＩＩＩａに特異的な抗体およびそれを用いたＦｃγレセプターＩＩＩａの測定方法
US8647625B2 (en) * 2004-07-26 2014-02-11 Biogen Idec Ma Inc. Anti-CD154 antibodies
CA2591059C (en) 2004-12-28 2018-11-06 Innate Pharma Monoclonal antibodies against nkg2a
WO2006081171A1 (en) * 2005-01-24 2006-08-03 Amgen Inc. Humanized anti-amyloid antibody
WO2010080538A1 (en) 2008-12-19 2010-07-15 Macrogenics, Inc. Covalent diabodies and uses thereof
EP3479844B1 (en) 2005-04-15 2023-11-22 MacroGenics, Inc. Covalent diabodies and uses thereof
US9284375B2 (en) 2005-04-15 2016-03-15 Macrogenics, Inc. Covalent diabodies and uses thereof
US11254748B2 (en) 2005-04-15 2022-02-22 Macrogenics, Inc. Covalent diabodies and uses thereof
US9963510B2 (en) 2005-04-15 2018-05-08 Macrogenics, Inc. Covalent diabodies and uses thereof
WO2012018687A1 (en) 2010-08-02 2012-02-09 Macrogenics, Inc. Covalent diabodies and uses thereof
GB0510790D0 (en) * 2005-05-26 2005-06-29 Syngenta Crop Protection Ag Anti-CD16 binding molecules
JP2009500458A (ja) * 2005-07-11 2009-01-08 マクロジェニクス，インコーポレーテッド ヒト化抗ｃｄ１６ａ抗体を用いる自己免疫疾患の治療方法
WO2007106707A2 (en) * 2006-03-10 2007-09-20 Macrogenics, Inc. Identification and engineering of antibodies with variant heavy chains and methods of using same
EP2038306B1 (en) 2006-06-30 2014-12-03 Novo Nordisk A/S Anti-nkg2a antibodies and uses thereof
WO2009077483A1 (en) 2007-12-14 2009-06-25 Novo Nordisk A/S Antibodies against human nkg2d and uses thereof
PL2158221T3 (pl) 2007-06-21 2019-02-28 Macrogenics, Inc. Kowalencyjne diaciała i ich zastosowania
JP5620106B2 (ja) * 2007-10-24 2014-11-05 株式会社糖鎖工学研究所 増強されたエフェクター機能を有するポリペプチド
US8795667B2 (en) * 2007-12-19 2014-08-05 Macrogenics, Inc. Compositions for the prevention and treatment of smallpox
AU2008343855B2 (en) 2007-12-21 2013-08-15 Amgen Inc. Anti-amyloid antibodies and uses thereof
CA2712220A1 (en) 2008-01-24 2009-07-30 Novo Nordisk A/S Humanized anti-human nkg2a monoclonal antibody
ES2618292T3 (es) 2008-01-31 2017-06-21 Inserm - Institut National De La Sante Et De La Recherche Medicale Anticuerpos contra CD39 humano y uso de los mismos para inhibir la actividad de las células T reguladoras
US8802093B2 (en) 2008-04-02 2014-08-12 Macrogenics, Inc. HER2/neu-specific antibodies and methods of using same
ES2589912T3 (es) 2008-04-02 2016-11-17 Macrogenics, Inc. Anticuerpos específicos para el complejo BCR y procedimientos de uso de los mismos
CA2726845C (en) 2008-06-04 2017-09-26 Macrogenics, Inc. Antibodies with altered binding to fcrn and methods of using same
US8394924B2 (en) * 2008-10-23 2013-03-12 Massachusetts Institute Of Technology Directed engagement of activating Fc receptors
WO2010096394A2 (en) * 2009-02-17 2010-08-26 Redwood Biosciences, Inc. Aldehyde-tagged protein-based drug carriers and methods of use
PL2427212T3 (pl) * 2009-05-08 2018-02-28 Vaccinex, Inc. Przeciwciała anty cd-100 i sposoby ich zastosowania
ES2672121T3 (es) 2009-10-07 2018-06-12 Macrogenics, Inc. Polipéptidos que contienen región Fc que presentan una función efectora mejorada debido a alteraciones del grado de fucosilación, y métodos para su uso
US8802091B2 (en) 2010-03-04 2014-08-12 Macrogenics, Inc. Antibodies reactive with B7-H3 and uses thereof
PT2542256T (pt) 2010-03-04 2019-09-05 Macrogenics Inc Anticorpos reativos com b7-h3, fragmentos imunologicamente ativos dos mesmos e sua utilização
KR101862236B1 (ko) * 2010-09-02 2018-05-29 백시넥스 인코포레이티드 항-ｃｘｃｌ13 항체 및 이의 이용 방법
WO2012097333A2 (en) 2011-01-14 2012-07-19 Redwood Bioscience, Inc. Aldehyde-tagged immunoglobulin polypeptides and method of use thereof
SG195073A1 (en) 2011-05-21 2013-12-30 Macrogenics Inc Deimmunized serum-binding domains and their use for extending serum half-life
CA2836857C (en) 2011-05-21 2019-12-03 Macrogenics, Inc. Cd3-binding molecules capable of binding to human and non-human cd3
JP6395606B2 (ja) 2011-10-11 2018-09-26 バクシネックス インコーポレーティッド 血液脳関門透過性の調節のためのセマフォリン−４ｄ結合分子の使用
CN104520323B (zh) 2012-03-02 2018-05-04 瓦西尼斯公司 用于治疗b细胞介导的炎性疾病的方法
US9090709B2 (en) 2012-03-28 2015-07-28 Vaccinex, Inc. Anti-SEMA4D antibodies and epitopes
US10494440B2 (en) 2012-05-11 2019-12-03 Vaccinex, Inc. Use of semaphorin-4D binding molecules to promote neurogenesis following stroke
NZ710744A (en) 2013-01-31 2020-07-31 Vaccinex Inc Methods for increasing immunoglobulin a levels
US9487587B2 (en) 2013-03-05 2016-11-08 Macrogenics, Inc. Bispecific molecules that are immunoreactive with immune effector cells of a companion animal that express an activating receptor and cells that express B7-H3 and uses thereof
MX2015012709A (es) 2013-03-14 2016-05-31 Macrogenics Inc Moleculas biespecificas que son inmunorreactivas con celulas efectoras inmunes que expresan un receptor activador y un antigeno expresado por una celula infectada por un virus y usos de las mismas.
MX2015017485A (es) 2013-06-25 2016-03-31 Vaccinex Inc Uso de moleculas inhibidoras de semaforina-4d en combinacion con una terapia de modulacion inmune para inhibir crecimiento tumoral y metastasis.
UA116479C2 (uk) 2013-08-09 2018-03-26 Макродженікс, Інк. БІСПЕЦИФІЧНЕ МОНОВАЛЕНТНЕ Fc-ДІАТІЛО, ЯКЕ ОДНОЧАСНО ЗВ'ЯЗУЄ CD32B I CD79b, ТА ЙОГО ЗАСТОСУВАННЯ
US11384149B2 (en) 2013-08-09 2022-07-12 Macrogenics, Inc. Bi-specific monovalent Fc diabodies that are capable of binding CD32B and CD79b and uses thereof
EP2840091A1 (en) 2013-08-23 2015-02-25 MacroGenics, Inc. Bi-specific diabodies that are capable of binding gpA33 and CD3 and uses thereof
EP2839842A1 (en) 2013-08-23 2015-02-25 MacroGenics, Inc. Bi-specific monovalent diabodies that are capable of binding CD123 and CD3 and uses thereof
NZ630881A (en) 2013-10-10 2016-03-31 Vaccinex Inc Use of semaphorin-4d binding molecules for treatment of atherosclerosis
JP6417413B2 (ja) * 2013-10-17 2018-11-07 ナショナル ユニヴァーシティー オブ シンガポール 多様な腫瘍に対する抗体依存性細胞毒性を誘発するキメラ受容体
NZ630892A (en) 2013-10-21 2016-03-31 Vaccinex Inc Use of semaphorin-4d binding molecules for treating neurodegenerative disorders
EP3087095B1 (en) 2013-12-24 2019-08-07 argenx BVBA Fcrn antagonists and methods of use
ES2772817T3 (es) * 2014-04-10 2020-07-08 Obi Pharma Inc Anticuerpos de unión a antígenos de carbohidrato asociados a tumor, composiciones farmacéuticas y sus usos
WO2015184207A1 (en) 2014-05-29 2015-12-03 Macrogenics, Inc. Tri-specific binding molecules that specifically bind to multiple cancer antigens and methods of use thereof
RU2734771C2 (ru) 2014-09-16 2020-10-23 Иннейт Фарма Нейтрализация ингибиторных путей в лимфоцитах
CN107108721B (zh) 2014-09-29 2021-09-07 杜克大学 包含hiv-1包膜靶向臂的双特异性分子
PT3204417T (pt) 2014-10-10 2020-10-08 Innate Pharma Bloqueio de cd73
SG10202006685XA (en) 2014-10-23 2020-08-28 Innate Pharma Treatment of Cancers Using Anti-NKG2A Agents
HUE056775T2 (hu) 2015-03-09 2022-03-28 Argenx Bvba Eljárás Fc-tartalmú szerek szérum szintjeinek csökkentésére FcRn-antagonisták alkalmazásával
CN113604435A (zh) * 2015-03-27 2021-11-05 南克维斯特公司 用于治疗癌症的被遗传修饰的nk-92细胞和单克隆抗体
JP6913025B2 (ja) * 2015-04-13 2021-08-04 ファイザー・インク 治療抗体およびその使用
TWI773646B (zh) 2015-06-08 2022-08-11 美商宏觀基因股份有限公司 結合lag-3的分子和其使用方法
CN107709552B (zh) 2015-06-10 2022-05-13 南克维斯特公司 用于治疗癌症的修饰的nk-92细胞
TW201709929A (zh) 2015-06-12 2017-03-16 宏觀基因股份有限公司 治療癌症的聯合療法
US11130817B2 (en) 2015-10-12 2021-09-28 Innate Pharma CD73 blocking agents
EA201891178A1 (ru) 2015-12-14 2019-01-31 Макродженикс, Инк. Биспецифичные молекулы, обладающие иммунореактивностью в отношении pd-1 и ctla-4, и способы их применения
HUE054356T2 (hu) 2016-01-21 2021-09-28 Innate Pharma Gátlási reakcióutak semlegesítése limfocitákban
WO2017142928A1 (en) 2016-02-17 2017-08-24 Macrogenics, Inc. Ror1-binding molecules, and methods of use thereof
KR102398425B1 (ko) 2016-03-08 2022-05-16 이나뜨 파르마 에스.에이. Siglec 중화 항체
EP3912681A1 (en) 2016-03-14 2021-11-24 Orega Biotech Anti-cd39 antibodies
AU2017249435B2 (en) 2016-04-15 2024-05-02 Macrogenics, Inc. Novel B7-H3 binding molecules, antibody drug conjugates thereof and methods of use thereof
CA3019398A1 (en) 2016-04-26 2017-11-02 R.P. Scherer Technologies, Llc Antibody conjugates and methods of making and using the same
KR20190015520A (ko) 2016-06-07 2019-02-13 마크로제닉스, 인크. 조합 치료법
WO2018065552A1 (en) 2016-10-06 2018-04-12 Innate Pharma Anti-cd39 antibodies
WO2018083080A2 (en) 2016-11-04 2018-05-11 Innate Pharma Nkp46 ligand
MX2019007404A (es) 2016-12-23 2019-09-27 Macrogenics Inc Moleculas de union a adam9 y metodos de uso de las mismas.
EP3577138A1 (en) 2017-02-06 2019-12-11 Innate Pharma Immunomodulatory antibody drug conjugates binding to a human mica polypeptide
KR102584011B1 (ko) 2017-03-16 2023-09-27 이나뜨 파르마 에스.에이. 암 치료를 위한 조성물 및 방법
EP3652207A1 (en) 2017-07-10 2020-05-20 Innate Pharma Combination therapy using antibody to human siglec-9 and antibody to human nkg2a for treating cancer
EP3652208A1 (en) 2017-07-10 2020-05-20 Innate Pharma Siglec-9-neutralizing antibodies
CA3092522A1 (en) 2018-03-13 2019-09-19 Innate Pharma Treatment of head and neck cancer
IT201800004853A1 (it) 2018-04-24 2019-10-24 Metodi per trattare il cancro
EA202092696A1 (ru) 2018-05-15 2021-04-05 Медиммун Лимитед Лечение рака
DK3807316T3 (da) 2018-06-18 2024-07-29 Innate Pharma Sammensætninger og fremgangsmåder til behandling af cancer
KR20210030267A (ko) * 2018-07-10 2021-03-17 고쿠리츠다이가쿠호진 고베다이가쿠 항 SIRPα 항체
CN113164519A (zh) 2018-08-01 2021-07-23 南克维斯特公司 用于免疫疗法的基因修饰的包含归巢受体或细胞因子和嵌合抗原受体的四顺反子系统
WO2020035345A1 (en) 2018-08-14 2020-02-20 Innate Pharma Treatment of colorectal cancer by a combination of an anti-mica antibody and an anti-nkg2a antibody
US20200376135A1 (en) * 2018-10-23 2020-12-03 Magenta Therapeutics, Inc. Fc silenced antibody drug conjugates (adcs) and uses thereof
CA3120476A1 (en) 2018-12-26 2020-07-02 Innate Pharma Leucocyte immunoglobulin-like receptor neutralizing antibodies
GB2589049C (en) 2019-04-11 2024-02-21 argenx BV Anti-IgE antibodies
KR20220002959A (ko) 2019-04-23 2022-01-07 이나뜨 파르마 에스.에이. Cd73 차단 항체
EP3965816A1 (en) 2019-05-06 2022-03-16 MedImmune Limited Combination of monalizumab, durvalumab, chemotherapy and bevacizumab or cetuximab for the treatment of colorectal cancer
CN114126647A (zh) 2019-06-07 2022-03-01 阿尔金克斯有限公司 适用于皮下施用的FcRn抑制剂的药物制剂
EP4073117A1 (en) * 2019-12-10 2022-10-19 Institut Pasteur New antibody blocking human fcgriiia and fcgriiib
DK4087875T3 (da) 2020-01-08 2024-10-28 argenx BV Antagonister af human neonatal Fc-receptor (FcRn) til behandling af pemphigus-sygdomme
US11230699B2 (en) 2020-01-28 2022-01-25 Immunitybio, Inc. Chimeric antigen receptor-modified NK-92 cells targeting EGFR super-family receptors
EP4196500A2 (en) 2020-08-13 2023-06-21 Innate Pharma Cancer treatment methods using anti-cd73 antibodies
JP2024532886A (ja) * 2021-08-25 2024-09-10 ナンジン、ジェンスクリプト、バイオテック、カンパニー、リミテッド ヒトＣＤ１６ａに対する抗体及びその変異体
KR20240134139A (ko) 2021-12-20 2024-09-06 비토퀴놀 에스에이 항-갯과 인터루킨-31-수용체 a (il-31ra) 항체 및 이의 용도
CN114805592A (zh) * 2022-05-13 2022-07-29 南京吉盛澳玛生物医药有限公司 一种三特异性抗体的设计、制备及用途
WO2023227660A1 (en) 2022-05-25 2023-11-30 Innate Pharma Nectin-4 binding agents
WO2024165028A1 (en) * 2023-02-06 2024-08-15 Concept To Medicine Biotech Co., Ltd. Anti-cd16a antibodies and uses thereof

Family Cites Families (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4816567A (en) * 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US4946788A (en) * 1985-06-11 1990-08-07 Ciba-Geigy Corporation Purified immunoglobulin-related factor, novel monoclonal antibodies, hybridoma cell lines, processes and applications
US5225539A (en) * 1986-03-27 1993-07-06 Medical Research Council Recombinant altered antibodies and methods of making altered antibodies
US5985599A (en) * 1986-05-29 1999-11-16 The Austin Research Institute FC receptor for immunoglobulin
US4946778A (en) * 1987-09-21 1990-08-07 Genex Corporation Single polypeptide chain binding molecules
US5260203A (en) * 1986-09-02 1993-11-09 Enzon, Inc. Single polypeptide chain binding molecules
FR2611913B1 (fr) * 1987-02-24 1994-04-15 Khayat David Procede de dosage des recepteurs fc gamma solubles seriques, coffret de dosage correspondant et applications
EP0307434B2 (en) * 1987-03-18 1998-07-29 Scotgen Biopharmaceuticals, Inc. Altered antibodies
DE3856559T2 (de) * 1987-05-21 2004-04-29 Micromet Ag Multifunktionelle Proteine mit vorbestimmter Zielsetzung
JP2657221B2 (ja) * 1988-05-27 1997-09-24 アプライド・リサーチ・システムズ・エイアールエス・ホールディング・ナムローゼ・フェンノートシャップ ヒトＦｃγレセプター▲ＩＩＩ▼
IL162181A (en) * 1988-12-28 2006-04-10 Pdl Biopharma Inc A method of producing humanized immunoglubulin, and polynucleotides encoding the same
US5225538A (en) * 1989-02-23 1993-07-06 Genentech, Inc. Lymphocyte homing receptor/immunoglobulin fusion proteins
US5116964A (en) * 1989-02-23 1992-05-26 Genentech, Inc. Hybrid immunoglobulins
US5399493A (en) * 1989-06-15 1995-03-21 The Regents Of The University Of Michigan Methods and compositions for the optimization of human hematopoietic progenitor cell cultures
US5437994A (en) * 1989-06-15 1995-08-01 Regents Of The University Of Michigan Method for the ex vivo replication of stem cells, for the optimization of hematopoietic progenitor cell cultures, and for increasing the metabolism, GM-CSF secretion and/or IL-6 secretion of human stromal cells
US5545806A (en) * 1990-08-29 1996-08-13 Genpharm International, Inc. Ransgenic non-human animals for producing heterologous antibodies
DK0814159T3 (da) * 1990-08-29 2005-10-24 Genpharm Int Transgene, ikke-humane dyr, der er i stand til at danne heterologe antistoffer
US6027725A (en) * 1991-11-25 2000-02-22 Enzon, Inc. Multivalent antigen-binding proteins
EP0627932B1 (en) * 1992-11-04 2002-05-08 City Of Hope Antibody construct
CA2159510A1 (en) * 1993-04-08 1994-10-27 David A. Horne Method for the synthesis of 4- and/or 5-(di)substituted 2-aminoimidazoles from 2-aminoimidazoles and aldehydes
US5641863A (en) * 1993-09-30 1997-06-24 University Of Pennsylvania Chimeric IgG Fc receptors
DE69530763T2 (de) 1994-03-29 2004-02-26 Celltech Therapeutics Ltd., Slough Antikörper gegen e-selektin
DE19619068A1 (de) * 1996-05-13 1997-11-27 Siemens Ag Vorrichtung zur Überwachung des Transportprozesses von flachen Sendungen
US5834597A (en) * 1996-05-20 1998-11-10 Protein Design Labs, Inc. Mutated nonactivating IgG2 domains and anti CD3 antibodies incorporating the same
US6025158A (en) * 1997-02-21 2000-02-15 Genentech, Inc. Nucleic acids encoding humanized anti-IL-8 monoclonal antibodies
US6277375B1 (en) * 1997-03-03 2001-08-21 Board Of Regents, The University Of Texas System Immunoglobulin-like domains with increased half-lives
US6528624B1 (en) * 1998-04-02 2003-03-04 Genentech, Inc. Polypeptide variants
US6194551B1 (en) * 1998-04-02 2001-02-27 Genentech, Inc. Polypeptide variants
KR20060067983A (ko) 1999-01-15 2006-06-20 제넨테크, 인크. 효과기 기능이 변화된 폴리펩티드 변이체
US6737056B1 (en) * 1999-01-15 2004-05-18 Genentech, Inc. Polypeptide variants with altered effector function
AU2002245142B2 (en) 2000-12-14 2007-07-05 Genentech, Inc. Prokaryotically produced antibodies and uses thereof
AU2003232456B2 (en) * 2002-05-30 2009-06-04 Macrogenics, Inc. CD16A binding proteins and use for the treatment of immune disorders
JP2009500458A (ja) * 2005-07-11 2009-01-08 マクロジェニクス，インコーポレーテッド ヒト化抗ｃｄ１６ａ抗体を用いる自己免疫疾患の治療方法

Also Published As

Publication number Publication date
EP1513554B1 (en) 2010-10-06
EP1513554B9 (en) 2011-11-09
US7351803B2 (en) 2008-04-01
DE60334453D1 (de) 2010-11-18
WO2003101485A1 (en) 2003-12-11
CA2487932A1 (en) 2003-12-11
JP2005532342A (ja) 2005-10-27
US20110152504A1 (en) 2011-06-23
US7618628B2 (en) 2009-11-17
US7838635B2 (en) 2010-11-23
ATE483472T1 (de) 2010-10-15
US20040010124A1 (en) 2004-01-15
AU2003232456B2 (en) 2009-06-04
US20070244303A1 (en) 2007-10-18
HK1074991A1 (en) 2005-12-02
US20080050371A1 (en) 2008-02-28
AU2003232456A1 (en) 2003-12-19
EP1513554A1 (en) 2005-03-16
EP1513554A4 (en) 2006-06-28
JP4524181B2 (ja) 2010-08-11

Similar Documents

Publication Publication Date Title
BR0311471A (pt) anticorpo anti-cd16a, e, métodos de redução de uma resposta imune deletéria em um mamìfero e de tratamento de uma resposta imune deletéria em um mamìfero
MX2008000030A (es) Metodos para el tratamiento de enfermedad autoinmune utilizando anticuerpos anti-cd16a humanizados.
ATE480562T1 (de) Veränderung von fcrn-bindungsaffinitäten oder von serumhalbwertszeiten von antikörpern mittels mutagenese
MY163480A (en) Sclerostin binding agents
HK1074670A1 (en) Sets of digital antibodies directed against short epitopes, and methods using same
HK1200854A1 (en) Methods for antibody engineering
WO2006118772A3 (en) Fcrn antibodies and uses thereof
GEP20104991B (en) Antibodies that bind interleukin-4 receptor
EA200700136A1 (ru) Анти-cd154-антитела
GB0315450D0 (en) Biological products
EP3255063A3 (en) Antibodies to matrix metalloproteinase 9
WO2012027721A3 (en) Antibodies to matrix metalloproteinase 9
WO2005003169A3 (en) Modified antibody fab fragments
NZ594466A (en) Human monoclonal antibodies to protein tyrosine kinase 7 (PTK7) and methods for using anti-PTK7 antibodies
EP1476456A4 (en) COMPOSITIONS AND METHOD FOR SUBROGEN-ANTIBODY MODULATION OF AN IMMUNE RESPONSE AND TRANSPORT
DK1776387T3 (da) Angiogene og immunologiske anvendelser af anti-CD160-specifikke forbindelser, som kan fremstilles af de monoklonale antistoffer CL1-R2
IL172646A0 (en) Antibodies against interleukin -22 and uses therefor
TW200626614A (en) Human monoclonal antibodies to influenza M2 protein and methods of making and using same
WO2019060750A3 (en) A33 antibody compositions and methods of using the same in radioimmunotherapy
CR20220646A (es) Anticuerpos contra el sars-cov-2 y métodos de selección y uso de los mismos
PL378566A1 (pl) Ligandy dla białek wiążących TGF-beta i ich zastosowania
WO2019195623A3 (en) Heterodimeric antibodies that bind fibroblast activation protein
WO2020006374A3 (en) Anti-sirp-beta1 antibodies and methods of use thereof
WO2020172621A8 (en) Cd33 antibodies and methods of using the same to treat cancer
WO2005047328A3 (en) Antibodies against secretoryleukocyte protease inhibitor

Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 10A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2206 DE 16/04/2013.