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BR0308113A - Macrocyclic compounds useful as pharmaceutical substances - Google Patents

Macrocyclic compounds useful as pharmaceutical substances

Info

Publication number
BR0308113A
BR0308113A BR0308113-3A BR0308113A BR0308113A BR 0308113 A BR0308113 A BR 0308113A BR 0308113 A BR0308113 A BR 0308113A BR 0308113 A BR0308113 A BR 0308113A
Authority
BR
Brazil
Prior art keywords
pharmaceutical substances
macrocyclic compounds
compounds useful
present
disorders
Prior art date
Application number
BR0308113-3A
Other languages
Portuguese (pt)
Other versions
BRPI0308113B8 (en
BRPI0308113B1 (en
Inventor
Roch Boivin
Kenichi Chiba
Jesse Chow
Hong Du
Yoshihito Eguchi
Masanori Fujita
Masaki Goto
Fabian Gusovsky
Jean-Christophe Harmange
Atsushi Inoue
Yimin Jiang
Megumi Kawada
Takatoshi Kawai
Yoshiyuki Kawakami
Akifumi Kimura
Makoto Kotake
Yoshikazu Kuboi
Charles-Andre Lemelin
Xiang-Yi Li
Tomohiro Matsushima
Yoshiharu Mizui
Kenzo Muramoto
Hideki Sakurai
Yong-Chun Shen
Hiroshi Shirota
Mark Spyvee
Isao Tanaka
John Wang
Satoshi Yamamoto
Naoki Yoneda
Original Assignee
Eisai Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eisai Co Ltd filed Critical Eisai Co Ltd
Publication of BR0308113A publication Critical patent/BR0308113A/en
Publication of BRPI0308113B1 publication Critical patent/BRPI0308113B1/en
Publication of BRPI0308113B8 publication Critical patent/BRPI0308113B8/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
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    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
    • A61K31/36—Compounds containing methylenedioxyphenyl groups, e.g. sesamin
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Abstract

"COMPOSTOS MACROCìCLICOS úTEIS COMO SUBSTâNCIAS FARMACêUTICAS". A presente invenção provê compostos possuindo a fórmula (I) e, adicionalmente, provê, processos para síntese dos mesmos e para uso dos mesmos no tratamento de vários distúrbios incluindo distúrbios inflamatórios e autoimunes e distúrbios envolvendo malignidade ou angiogenese aumentada, onde R~ 1~-R~ 11~, X, Y, Z, e n são conforme definido aqui."USEFUL MACROCYCLIC COMPOUNDS AS PHARMACEUTICAL SUBSTANCES". The present invention provides compounds having formula (I) and additionally provides methods for synthesizing them and for use in the treatment of various disorders including inflammatory and autoimmune disorders and disorders involving malignancy or increased angiogenesis, where R 1 is present. -R ~ 11 ~, X, Y, Z, and n are as defined herein.

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ES2555307T3 (en) 2015-12-30
WO2003076424A1 (en) 2003-09-18
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BRPI0308113B8 (en) 2021-05-25
ZA200407156B (en) 2006-12-27
RU2004129755A (en) 2005-04-20
US8329742B2 (en) 2012-12-11
US20130196987A1 (en) 2013-08-01
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