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BR0207776A - Derivado de esterol, lipossomos compreendendo o mesmo, método de carga dos referidos lipossomos e uso dos mesmos - Google Patents

Derivado de esterol, lipossomos compreendendo o mesmo, método de carga dos referidos lipossomos e uso dos mesmos

Info

Publication number
BR0207776A
BR0207776A BR0207776-0A BR0207776A BR0207776A BR 0207776 A BR0207776 A BR 0207776A BR 0207776 A BR0207776 A BR 0207776A BR 0207776 A BR0207776 A BR 0207776A
Authority
BR
Brazil
Prior art keywords
liposomes
loading
same
sterol
sterol derivative
Prior art date
Application number
BR0207776-0A
Other languages
English (en)
Inventor
Steffen Panzner
Gerold Endert
Stefan Fankhonel
Nasr El-Mokdad
Original Assignee
Novosom Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novosom Ag filed Critical Novosom Ag
Publication of BR0207776A publication Critical patent/BR0207776A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
    • A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers comprising non-phosphatidyl surfactants as bilayer-forming substances, e.g. cationic lipids or non-phosphatidyl liposomes coated or grafted with polymers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0055—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Dispersion Chemistry (AREA)
  • Biophysics (AREA)
  • Medicinal Preparation (AREA)
  • Steroid Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

"DERIVADO DE ESTEROL, LIPOSSOMOS COMPREENDENDO O MESMO, MéTODO DE CARGA DOS REFERIDOS LIPOSSOMOS E USO DOS MESMOS". Sugere-se um composto anfotérico baseado em um esqueleto de esterol, sendo as 3 posições do sistema de anéis substituídas por um ou mais grupos anfotéricos com um ponto isoelétrico de entre 4 e 9, assim como lisossomos contendo os referidos compostos.
BR0207776-0A 2001-02-21 2002-02-21 Derivado de esterol, lipossomos compreendendo o mesmo, método de carga dos referidos lipossomos e uso dos mesmos BR0207776A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10109898A DE10109898A1 (de) 2001-02-21 2001-02-21 Lipide mit veränderlicher Ladung
PCT/EP2002/001878 WO2002066489A2 (de) 2001-02-21 2002-02-21 Amphotere sterole und deren verwendung zur herstellung von ph- sensitiven liposemen

Publications (1)

Publication Number Publication Date
BR0207776A true BR0207776A (pt) 2004-03-23

Family

ID=7675951

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0207776-0A BR0207776A (pt) 2001-02-21 2002-02-21 Derivado de esterol, lipossomos compreendendo o mesmo, método de carga dos referidos lipossomos e uso dos mesmos

Country Status (10)

Country Link
US (3) US7312206B2 (pt)
EP (3) EP1806354A2 (pt)
JP (2) JP4470197B2 (pt)
CN (1) CN1231493C (pt)
AT (2) ATE364620T1 (pt)
AU (2) AU2002302364B2 (pt)
BR (1) BR0207776A (pt)
CA (1) CA2438910C (pt)
DE (3) DE10109898A1 (pt)
WO (2) WO2002066490A2 (pt)

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US8193246B2 (en) * 2006-12-19 2012-06-05 Marina Biotech, Inc. Lipids and lipid assemblies comprising transfection enhancer elements
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CA2754896C (en) 2009-03-09 2017-11-28 Molecular Express, Inc. Methods and compositions for liposomal formulation of antigens and uses thereof
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WO2012109495A1 (en) 2011-02-09 2012-08-16 Metabolic Solutions Development Company, Llc Cellular targets of thiazolidinediones
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EP2714971A4 (en) 2011-05-23 2015-01-21 Phylogica Ltd METHOD FOR DETERMINING, IDENTIFYING AND INSULATING CELL-PENETRATING PEPTIDES
GB201116248D0 (en) * 2011-09-20 2011-11-02 Glaxosmithkline Biolog Sa Liposome production using isopropanol
EP2879502B1 (en) 2012-07-30 2018-09-05 Matinas BioPharma Nanotechnologies, Inc. Cochleates made with soy phosphatidylserine
US10942184B2 (en) 2012-10-23 2021-03-09 Caris Science, Inc. Aptamers and uses thereof
JP6404822B2 (ja) 2012-10-23 2018-10-17 カリス ライフ サイエンシズ スウィッツァーランド ホールディングス ゲーエムベーハー アプタマーおよびその使用
EP2914742A1 (en) 2012-11-05 2015-09-09 Pronai Therapeutics, Inc. Methods of using biomarkers for the treatment of cancer by modulation of bcl2!expression
EP2935628B1 (en) 2012-12-19 2018-03-21 Caris Life Sciences Switzerland Holdings GmbH Compositions and methods for aptamer screening
US20170000715A1 (en) * 2014-01-29 2017-01-05 Humedix Co., Ltd. Pegylated 7-dehydrocholesterol derivatives
JP6399530B1 (ja) * 2017-09-04 2018-10-03 一丸ファルコス株式会社 ｐＨ感受性リポソーム
EP3679140B1 (en) 2017-09-08 2022-11-16 MiNA Therapeutics Limited Stabilized cebpa sarna compositions and methods of use
US11566246B2 (en) 2018-04-12 2023-01-31 Mina Therapeutics Limited SIRT1-saRNA compositions and methods of use
CA3101478A1 (en) * 2018-05-30 2019-12-05 Translate Bio, Inc. Vitamin cationic lipids
WO2020208361A1 (en) 2019-04-12 2020-10-15 Mina Therapeutics Limited Sirt1-sarna compositions and methods of use
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JP2024511092A (ja) 2021-03-26 2024-03-12 ミナ セラピューティクス リミテッド ＴＭＥＭ１７３ｓａＲＮＡ組成物及び使用方法
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Also Published As

Publication number Publication date
CA2438910A1 (en) 2002-08-29
CN1231493C (zh) 2005-12-14
ATE364620T1 (de) 2007-07-15
WO2002066490A2 (de) 2002-08-29
US20040120997A1 (en) 2004-06-24
JP2004525902A (ja) 2004-08-26
AU2002302364B2 (en) 2008-01-03
US7407947B2 (en) 2008-08-05
EP1363933B1 (de) 2009-05-06
WO2002066490A3 (de) 2003-04-24
JP4470197B2 (ja) 2010-06-02
US20040131666A1 (en) 2004-07-08
AU2002244726A1 (en) 2002-09-04
DE50213524D1 (de) 2009-06-18
EP1363932A2 (de) 2003-11-26
EP1363933A2 (de) 2003-11-26
EP1806354A2 (de) 2007-07-11
CN1492876A (zh) 2004-04-28
DE10109898A1 (de) 2002-09-05
WO2002066489A3 (de) 2003-01-03
US7312206B2 (en) 2007-12-25
ATE430759T1 (de) 2009-05-15
WO2002066489A2 (de) 2002-08-29
DE50210313D1 (de) 2007-07-26
US20080113017A1 (en) 2008-05-15
JP2004521917A (ja) 2004-07-22
EP1363932B1 (de) 2007-06-13
CA2438910C (en) 2009-10-13

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 8A E 9A ANUIDADE(S).

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2103 DE 26/04/2011.