BR0113189A - Métodos terapêuticos para tratar indivìduos com uma eritropoietina recombinante que possui atividade e efeitos colaterais reduzidos - Google Patents
Métodos terapêuticos para tratar indivìduos com uma eritropoietina recombinante que possui atividade e efeitos colaterais reduzidosInfo
- Publication number
- BR0113189A BR0113189A BR0113189-3A BR0113189A BR0113189A BR 0113189 A BR0113189 A BR 0113189A BR 0113189 A BR0113189 A BR 0113189A BR 0113189 A BR0113189 A BR 0113189A
- Authority
- BR
- Brazil
- Prior art keywords
- treatment
- side effects
- reduced
- recombinant erythropoietin
- erythropoietin
- Prior art date
Links
- OXCMYAYHXIHQOA-UHFFFAOYSA-N potassium;[2-butyl-5-chloro-3-[[4-[2-(1,2,4-triaza-3-azanidacyclopenta-1,4-dien-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol Chemical compound [K+].CCCCC1=NC(Cl)=C(CO)N1CC1=CC=C(C=2C(=CC=CC=2)C2=N[N-]N=N2)C=C1 OXCMYAYHXIHQOA-UHFFFAOYSA-N 0.000 title abstract 6
- 102000003951 Erythropoietin Human genes 0.000 title abstract 5
- 108090000394 Erythropoietin Proteins 0.000 title abstract 5
- 230000000694 effects Effects 0.000 title abstract 5
- 229940105423 erythropoietin Drugs 0.000 title abstract 5
- 238000002560 therapeutic procedure Methods 0.000 title abstract 2
- 238000011282 treatment Methods 0.000 abstract 6
- 206010020772 Hypertension Diseases 0.000 abstract 3
- 208000007536 Thrombosis Diseases 0.000 abstract 2
- 230000002411 adverse Effects 0.000 abstract 2
- 208000007502 anemia Diseases 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 230000001225 therapeutic effect Effects 0.000 abstract 2
- 241000699800 Cricetinae Species 0.000 abstract 1
- 241000699802 Cricetulus griseus Species 0.000 abstract 1
- 206010022086 Injection site pain Diseases 0.000 abstract 1
- 206010028813 Nausea Diseases 0.000 abstract 1
- 206010047095 Vascular pain Diseases 0.000 abstract 1
- 230000000747 cardiac effect Effects 0.000 abstract 1
- 238000002512 chemotherapy Methods 0.000 abstract 1
- 108010090921 epoetin omega Proteins 0.000 abstract 1
- 229950008767 epoetin omega Drugs 0.000 abstract 1
- 239000012634 fragment Substances 0.000 abstract 1
- 230000008693 nausea Effects 0.000 abstract 1
- 210000001672 ovary Anatomy 0.000 abstract 1
- 238000001959 radiotherapy Methods 0.000 abstract 1
- 210000002966 serum Anatomy 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1816—Erythropoietin [EPO]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Cardiology (AREA)
- Neurosurgery (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Diabetes (AREA)
- Psychiatry (AREA)
- Urology & Nephrology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Transplantation (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
Abstract
"MéTODOS TERAPêUTICOS PARA TRATAR INDIVìDUOS COM UMA ERITROPOIETINA RECOMBINANTE QUE POSSUI ATIVIDADE E EFEITOS COLATERAIS REDUZIDOS". A presente invenção refere-se a várias propriedades terapêuticas e métodos novos de tratamento utilizando a eritropoietina recombinante preparada através da expressão partindo do fragmento de restrição Apa I do DNA genómico humano da eritropoietina transformado em células renais de hamsters bebês (BHK) de acordo com a Patente U.S. N<0> 5.688.697 para Powell. é mostrado que esta eritropoietina recombinante denominada aqui como Epoetina Èmega possui várias qualidades inesperadas e superiores em relação as outras eritropoietinas recombinantes tais como as denominadas Epoetinas Alfa e Beta que são preparadas partindo do DNA genómico ou do CDNA expresso em Ovário de Hamster Chinês (CHO) de acordo com as Patente U.S. N<0> 4.703.008 e 5.955.422 para Lin. As propriedades superiores da Epoetina Èmega incluem, mas não estão limitadas a uma potência muito maior, uma resposta muito mais rápida (isto é, sem latência), níveis no soro eficientes durante mais tempo, antigenicidade muito menor em indivíduos humanos, atividade terapêutica em indivíduos que não são capazes de responder às outras epoetinas, menos efeitos colaterais adversos tais como incidências de trombose, náusea reduzida, dor reduzida no local da injeção, redução na dor corporal e mais significativamente, a ausência ou risco reduzido de pressão sang³ínea aumentada ou hipertensão. Estas novas propriedades possibilitam novos métodos incluindo, o tratamento de anemia e o tratamento de estados de saúde sem ser anemia tal como fadiga e dor vascular, o tratamento em pacientes afetados de forma adversa pela hipertensão tais como pacientes com estados de saúde cardíacos ou em risco aumentado de trombose, o tratamento em unidades de oncologia com ou sem quimioterapia ou terapia com radiação e o tratamento com novos regimes de dosagem que incluem doses muito mais baixas e freq³ências de administração muito menores tão baixas quanto uma vez por semana ou menores.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/637,962 US7078376B1 (en) | 2000-08-11 | 2000-08-11 | Therapeutic methods for treating subjects with a recombinant erythropoietin having high activity and reduced side effects |
| PCT/EP2001/009209 WO2002014356A2 (en) | 2000-08-11 | 2001-08-09 | Therapeutic use of a recombinant erythropoietin having high activity and reduced side effects |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| BR0113189A true BR0113189A (pt) | 2003-09-16 |
| BRPI0113189B1 BRPI0113189B1 (pt) | 2015-07-07 |
Family
ID=24558080
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0113189-3A BRPI0113189B1 (pt) | 2000-08-11 | 2001-08-09 | Usos de epoetina ômega |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US7078376B1 (pt) |
| EP (2) | EP1317276B1 (pt) |
| JP (1) | JP5105687B2 (pt) |
| KR (2) | KR100885601B1 (pt) |
| CN (1) | CN100558744C (pt) |
| AT (2) | ATE555802T1 (pt) |
| AU (3) | AU2001291755B2 (pt) |
| BR (1) | BRPI0113189B1 (pt) |
| CA (2) | CA2418531C (pt) |
| CZ (1) | CZ304572B6 (pt) |
| DE (1) | DE60131286T2 (pt) |
| HU (1) | HUP0300740A3 (pt) |
| IL (3) | IL154170A0 (pt) |
| MX (1) | MXPA03001237A (pt) |
| NZ (2) | NZ524000A (pt) |
| PL (1) | PL364248A1 (pt) |
| RU (1) | RU2282460C2 (pt) |
| WO (1) | WO2002014356A2 (pt) |
Families Citing this family (114)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1329119C (en) * | 1988-03-29 | 1994-05-03 | Milton David Goldenberg | Cytotoxic therapy |
| US20030232010A2 (en) * | 1988-03-29 | 2003-12-18 | Immunomedics, Inc. | Improved cytotoxic therapy |
| DE10234192B4 (de) | 2002-07-26 | 2009-11-26 | Epoplus Gmbh Co.Kg | Verwendung von Erythropoetin |
| US7388079B2 (en) * | 2002-11-27 | 2008-06-17 | The Regents Of The University Of California | Delivery of pharmaceutical agents via the human insulin receptor |
| US7141544B2 (en) * | 2003-10-10 | 2006-11-28 | Baxter International, Inc. | Stabilization of pharmaceutical protein formulations with small peptides |
| DE102004063927A1 (de) * | 2004-01-23 | 2005-12-15 | Epoplus Gmbh Co.Kg | Einsatz von niedrig dosiertem Erythropoietin zur Stimulation endothelialer Vorläuferzellen sowie zur Organregeneration und Progressionsverlangsamung von Endorganschäden |
| MXPA06011084A (es) * | 2004-03-26 | 2007-03-21 | Johnson & Johnson | Regimen de dosificacion en comunicacion para eritropoyetina. |
| US20050255112A1 (en) * | 2004-05-17 | 2005-11-17 | Lee Jong Y | Compositions and methods for preventing erythropoietin-associated hypertension |
| US20070037886A1 (en) * | 2005-04-26 | 2007-02-15 | Ajinomoto Co., Inc. | Bone marrow erythroid progenitor cell(s) differentiation inducer |
| US8053569B2 (en) * | 2005-10-07 | 2011-11-08 | Armagen Technologies, Inc. | Nucleic acids encoding and methods of producing fusion proteins |
| US8124095B2 (en) * | 2005-10-07 | 2012-02-28 | Armagen Technologies, Inc. | Fusion proteins for delivery of erythropoietin to the CNS |
| US8741260B2 (en) | 2005-10-07 | 2014-06-03 | Armagen Technologies, Inc. | Fusion proteins for delivery of GDNF to the CNS |
| US8497246B2 (en) | 2006-08-18 | 2013-07-30 | Armagen Technologies, Inc. | Methods for diagnosing and treating CNS disorders by trans-blood-brain barrier delivery of protein compositions |
| US20080064702A1 (en) * | 2006-09-08 | 2008-03-13 | Charalambos Antoniades | Use of folates for the prevention and treatment of vascular diseases |
| WO2008137066A1 (en) * | 2007-05-02 | 2008-11-13 | The Board Of Regents Of The University Of Oklahoma | Use of compacted nucleic acid nanoparticles in non-viral treatments of ocular diseases |
| US8974791B2 (en) | 2007-07-27 | 2015-03-10 | Armagen Technologies, Inc. | Methods and compositions for increasing α-L-iduronidase activity in the CNS |
| ES2750254T3 (es) | 2007-09-27 | 2020-03-25 | Amgen Inc | Formulaciones farmacéuticas |
| EP2219602A1 (en) | 2007-11-15 | 2010-08-25 | Amgen, Inc | Aqueous formulation of erythropoiesis stimulating protein stablised by antioxidants for parenteral administration |
| WO2009089039A1 (en) * | 2008-01-09 | 2009-07-16 | Cho Daniel J | Use of blood flow parameters to monitor or control the dosing of erythropoiesis-stimulating agents |
| CA2711826C (en) | 2008-01-25 | 2018-02-27 | Amgen Inc. | Ferroportin antibodies and methods of use |
| EP2816059A1 (en) | 2008-05-01 | 2014-12-24 | Amgen, Inc | Anti-hepcidin antibodies and methods of use |
| JP6018753B2 (ja) | 2008-11-13 | 2016-11-02 | ザ・ジェネラル・ホスピタル・コーポレイションＴｈｅ Ｇｅｎｅｒａｌ Ｈｏｓｐｉｔａｌ Ｃｏｒｐｏｒａｔｉｏｎ | Ｂｍｐ−６の調節によって鉄の恒常性を制御するための方法および組成物 |
| CA2748889A1 (en) | 2009-03-18 | 2010-09-23 | Armagen Technologies, Inc. | Compositions and methods for blood-brain barrier delivery of igg-decoy receptor fusion proteins |
| US8834874B2 (en) | 2009-10-09 | 2014-09-16 | Armagen Technologies, Inc. | Methods and compositions for increasing iduronate 2-sulfatase activity in the CNS |
| CA2778105C (en) | 2009-10-23 | 2019-04-02 | Amgen Inc. | Vial adapter and system |
| SG194370A1 (en) | 2010-06-07 | 2013-11-29 | Amgen Inc | Drug delivery device |
| US20120016686A1 (en) * | 2010-07-13 | 2012-01-19 | Cerner Innovation, Inc. | Inpatient blood management |
| ES2388395B1 (es) * | 2011-03-18 | 2013-10-01 | Dr Healthcare España, S. L. | Uso de la diaminooxidasa para el tratamiento o la prevención de la fibromialgia o la fatiga crónica. |
| US9480624B2 (en) | 2011-03-31 | 2016-11-01 | Amgen Inc. | Vial adapter and system |
| CA3021845C (en) | 2011-04-20 | 2022-03-29 | Amgen Inc. | Autoinjector apparatus |
| RS57589B1 (sr) | 2011-10-14 | 2018-11-30 | Amgen Inc | Uređaji za ubrizgavanje i postupak za sklapanje |
| ES2983576T3 (es) | 2011-12-02 | 2024-10-23 | Armagen Inc | Métodos y composiciones para aumentar la actividad arilsulfatasa en el SNC |
| SI3081249T1 (sl) | 2012-11-21 | 2021-03-31 | Amgen Inc. | Naprava za dajanje zdravila |
| US10092703B2 (en) | 2013-03-15 | 2018-10-09 | Amgen Inc. | Drug cassette, autoinjector, and autoinjector system |
| KR102218494B1 (ko) | 2013-03-15 | 2021-02-19 | 인트린식 라이프사이언시스, 엘엘씨 | 항-헵시딘 항체 및 그의 용도 |
| JP6643977B2 (ja) | 2013-03-15 | 2020-02-12 | アムゲン・インコーポレーテッド | 体輪郭に適応可能な自動注入機デバイス |
| TWI614041B (zh) | 2013-03-15 | 2018-02-11 | 安美基公司 | 用於注射器之匣盒 |
| BR112015024282B1 (pt) | 2013-03-22 | 2022-05-17 | Amgen Inc | Injetor e método de montagem do injetor |
| CA3168888A1 (en) | 2013-10-24 | 2015-04-30 | Amgen Inc. | Drug delivery system with temperature-sensitive control |
| US11097055B2 (en) | 2013-10-24 | 2021-08-24 | Amgen Inc. | Injector and method of assembly |
| WO2015119906A1 (en) | 2014-02-05 | 2015-08-13 | Amgen Inc. | Drug delivery system with electromagnetic field generator |
| MX2016014561A (es) | 2014-05-07 | 2017-06-21 | Amgen Inc | Autoinyetor con elementos reductores del shock. |
| EP3151883A1 (en) | 2014-06-03 | 2017-04-12 | Amgen Inc. | Devices and methods for assisting a user of a drug delivery device |
| WO2016049036A1 (en) | 2014-09-22 | 2016-03-31 | Intrinsic Lifesciences Llc | Humanized anti-hepcidin antibodies and uses thereof |
| US10695506B2 (en) | 2014-10-14 | 2020-06-30 | Amgen Inc. | Drug injection device with visual and audio indicators |
| MA40904A (fr) * | 2014-11-03 | 2017-09-12 | Hygeia Tech Inc | Compositions d'ester de phorbol et procédés pour traiter ou réduire la durée d'une cytopénie |
| JP6716566B2 (ja) | 2014-12-19 | 2020-07-01 | アムジエン・インコーポレーテツド | 近接センサ付き薬物送達装置 |
| ES2785311T3 (es) | 2014-12-19 | 2020-10-06 | Amgen Inc | Dispositivo de administración de fármacos con botón móvil o campo de interfaz de usuario |
| US10538589B2 (en) | 2015-01-14 | 2020-01-21 | Armagen Inc. | Methods and compositions for increasing N-acetylglucosaminidase (NAGLU) activity in the CNS using a fusion antibody comprising an anti-human insulin receptor antibody and NAGLU |
| US10583245B2 (en) | 2015-02-17 | 2020-03-10 | Amgen Inc. | Drug delivery device with vacuum assisted securement and/or feedback |
| WO2016138434A1 (en) | 2015-02-27 | 2016-09-01 | Amgen Inc. | Drug delivery device having a needle guard mechanism with a tunable threshold of resistance to needle guard movement |
| PE20180690A1 (es) | 2015-04-27 | 2018-04-23 | Intercept Pharmaceuticals Inc | Composiciones de acido obeticolico y metodos de uso |
| WO2017039786A1 (en) | 2015-09-02 | 2017-03-09 | Amgen Inc. | Syringe assembly adapter for a syringe |
| ES2755717T3 (es) | 2015-12-09 | 2020-04-23 | Amgen Inc | Autoinyector con tapa de señalización |
| US11154661B2 (en) | 2016-01-06 | 2021-10-26 | Amgen Inc. | Auto-injector with signaling electronics |
| WO2017160799A1 (en) | 2016-03-15 | 2017-09-21 | Amgen Inc. | Reducing probability of glass breakage in drug delivery devices |
| WO2017189089A1 (en) | 2016-04-29 | 2017-11-02 | Amgen Inc. | Drug delivery device with messaging label |
| US11389588B2 (en) | 2016-05-02 | 2022-07-19 | Amgen Inc. | Syringe adapter and guide for filling an on-body injector |
| MX2018013616A (es) | 2016-05-13 | 2019-02-21 | Amgen Inc | Montaje de cubierta protectora de vial. |
| WO2017200989A1 (en) | 2016-05-16 | 2017-11-23 | Amgen Inc. | Data encryption in medical devices with limited computational capability |
| WO2017209899A1 (en) | 2016-06-03 | 2017-12-07 | Amgen Inc. | Impact testing apparatuses and methods for drug delivery devices |
| EP3478342A1 (en) | 2016-07-01 | 2019-05-08 | Amgen Inc. | Drug delivery device having minimized risk of component fracture upon impact events |
| US20190328965A1 (en) | 2016-08-17 | 2019-10-31 | Amgen Inc. | Drug delivery device with placement detection |
| EP3532127A1 (en) | 2016-10-25 | 2019-09-04 | Amgen Inc. | On-body injector |
| WO2018136398A1 (en) | 2017-01-17 | 2018-07-26 | Amgen Inc. | Injection devices and related methods of use and assembly |
| EP3582825A1 (en) | 2017-02-17 | 2019-12-25 | Amgen Inc. | Drug delivery device with sterile fluid flowpath and related method of assembly |
| US11369736B2 (en) | 2017-02-17 | 2022-06-28 | Amgen Inc. | Cannula insertion and retraction mechanisms |
| CA3050927A1 (en) | 2017-03-06 | 2018-09-13 | Brian Stonecipher | Drug delivery device with activation prevention feature |
| AU2018230546B2 (en) | 2017-03-07 | 2024-03-21 | Amgen Inc. | Needle insertion by overpressure |
| IL268386B2 (en) | 2017-03-09 | 2023-11-01 | Amgen Inc | Insertion mechanism for a drug delivery device |
| WO2018172219A1 (en) | 2017-03-20 | 2018-09-27 | F. Hoffmann-La Roche Ag | Method for in vitro glycoengineering of an erythropoiesis stimulating protein |
| CN114588404B (zh) | 2017-03-28 | 2024-07-09 | 美国安进公司 | 柱塞杆和注射器组件系统以及方法 |
| CN110709121B (zh) | 2017-06-08 | 2022-06-24 | 安进公司 | 扭矩驱动式药物递送装置 |
| US11590294B2 (en) | 2017-06-08 | 2023-02-28 | Amgen Inc. | Syringe assembly for a drug delivery device and method of assembly |
| US11541183B2 (en) | 2017-06-22 | 2023-01-03 | Amgen Inc. | Device activation impact/shock reduction |
| MX2019015479A (es) | 2017-06-23 | 2020-02-20 | Amgen Inc | Dispositivo electronico de administracion de farmacos con tapa accionada por un conjunto de conmutador. |
| WO2019014014A1 (en) | 2017-07-14 | 2019-01-17 | Amgen Inc. | NEEDLE INSERTION-RETRACTING SYSTEM HAVING DOUBLE TORSION SPRING SYSTEM |
| MA49626A (fr) | 2017-07-21 | 2020-05-27 | Amgen Inc | Élément d'étanchéité perméable aux gaz pour récipient à médicament et procédés d'assemblage |
| WO2019022951A1 (en) | 2017-07-25 | 2019-01-31 | Amgen Inc. | DRUG DELIVERY DEVICE WITH GEAR MODULE AND ASSEMBLY METHOD THEREOF |
| EP3658206A1 (en) | 2017-07-25 | 2020-06-03 | Amgen Inc. | Drug delivery device with container access system and related method of assembly |
| WO2019032482A2 (en) | 2017-08-09 | 2019-02-14 | Amgen Inc. | HYDRAULIC-PNEUMATIC PRESSURE CHAMBER DELIVERY SYSTEM |
| WO2019036181A1 (en) | 2017-08-18 | 2019-02-21 | Amgen Inc. | BODY INJECTOR WITH STERILE ADHESIVE PATCH |
| US11103636B2 (en) | 2017-08-22 | 2021-08-31 | Amgen Inc. | Needle insertion mechanism for drug delivery device |
| MA50611A (fr) | 2017-10-04 | 2020-08-12 | Amgen Inc | Adaptateur d'écoulement destiné à un dispositif d'administration de médicament |
| EP4257164A3 (en) | 2017-10-06 | 2024-01-17 | Amgen Inc. | Drug delivery device with interlock assembly and related method of assembly |
| US11464903B2 (en) | 2017-10-09 | 2022-10-11 | Amgen Inc. | Drug delivery device with drive assembly and related method of assembly |
| EP3703778A1 (en) | 2017-11-03 | 2020-09-09 | Amgen Inc. | System and approaches for sterilizing a drug delivery device |
| JP2021501616A (ja) | 2017-11-06 | 2021-01-21 | アムジエン・インコーポレーテツド | 配置及び流量検出を備える薬物送達デバイス |
| MA50569A (fr) | 2017-11-06 | 2020-09-16 | Amgen Inc | Ensembles de remplissage-finition et procédés associés |
| US11191904B2 (en) | 2017-11-10 | 2021-12-07 | Amgen Inc. | Plungers for drug delivery devices |
| MA50903A (fr) | 2017-11-16 | 2021-05-12 | Amgen Inc | Auto-injecteur avec détection de décrochage et de point d'extrémité |
| JP7370969B2 (ja) | 2017-11-16 | 2023-10-30 | アムジエン・インコーポレーテツド | 薬物送達デバイスの扉ラッチ機構 |
| US10835685B2 (en) | 2018-05-30 | 2020-11-17 | Amgen Inc. | Thermal spring release mechanism for a drug delivery device |
| US11083840B2 (en) | 2018-06-01 | 2021-08-10 | Amgen Inc. | Modular fluid path assemblies for drug delivery devices |
| WO2020023220A1 (en) | 2018-07-24 | 2020-01-30 | Amgen Inc. | Hybrid drug delivery devices with tacky skin attachment portion and related method of preparation |
| CA3103681A1 (en) | 2018-07-24 | 2020-01-30 | Amgen Inc. | Delivery devices for administering drugs |
| WO2020023336A1 (en) | 2018-07-24 | 2020-01-30 | Amgen Inc. | Hybrid drug delivery devices with grip portion |
| MA53375A (fr) | 2018-07-24 | 2021-06-02 | Amgen Inc | Dispositifs d'administration pour l'administration de médicaments |
| US12109389B2 (en) | 2018-07-31 | 2024-10-08 | Amgen Inc. | Fluid path assembly for a drug delivery device |
| MA53724A (fr) | 2018-09-24 | 2021-12-29 | Amgen Inc | Systèmes et procédés de dosage interventionnel |
| CA3110371A1 (en) | 2018-09-28 | 2020-04-02 | Amgen Inc. | Muscle wire escapement activation assembly for a drug delivery device |
| MA53815A (fr) | 2018-10-02 | 2022-01-05 | Amgen Inc | Systèmes d'injection pour administration de médicament avec transmission de force interne |
| TW202408605A (zh) | 2018-10-05 | 2024-03-01 | 美商安進公司 | 具有劑量指示器之藥物遞送裝置 |
| MA53913A (fr) | 2018-10-15 | 2022-01-19 | Amgen Inc | Procédé d'assemblage de plate-forme pour dispositif d'administration de médicament |
| BR112021007016A2 (pt) | 2018-10-15 | 2021-07-13 | Amgen Inc. | dispositivo de administração de fármaco tendo mecanismo de amortecimento |
| TWI831847B (zh) | 2018-11-01 | 2024-02-11 | 美商安進公司 | 部分針頭縮回之藥物遞送裝置及其操作方法 |
| US20220031939A1 (en) | 2018-11-01 | 2022-02-03 | Amgen Inc. | Drug delivery devices with partial drug delivery member retraction |
| US11213620B2 (en) | 2018-11-01 | 2022-01-04 | Amgen Inc. | Drug delivery devices with partial drug delivery member retraction |
| JP7510952B2 (ja) | 2019-04-24 | 2024-07-04 | アムジエン・インコーポレーテツド | シリンジ滅菌確認アセンブリ及び方法 |
| CA3148261A1 (en) | 2019-08-23 | 2021-03-04 | Amgen Inc. | Drug delivery device with configurable needle shield engagement components and related methods |
| CU24704B1 (es) * | 2019-09-05 | 2024-04-08 | Ct Inmunologia Molecular | Método para la obtención de eritropoyetina humana recombinante hiposialilada para el tratamiento de alteraciones del sistema nervioso |
| RU2736206C1 (ru) * | 2020-02-10 | 2020-11-12 | Федеральное государственное бюджетное образовательное учреждение высшего образования "Ярославский государственный медицинский университет" Министерства здравоохранения Российской Федерации | Способ прогнозирования риска формирования тромбоза постоянного сосудистого доступа в период от 6 месяцев до 1 года у пациентов, находящихся на программном гемодиализе |
| KR20240011135A (ko) | 2021-05-21 | 2024-01-25 | 암젠 인크 | 약물 용기를 위한 충전 레시피를 최적화하는 방법 |
| WO2024094457A1 (en) | 2022-11-02 | 2024-05-10 | F. Hoffmann-La Roche Ag | Method for producing glycoprotein compositions |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4703008A (en) | 1983-12-13 | 1987-10-27 | Kiren-Amgen, Inc. | DNA sequences encoding erythropoietin |
| KR850004274A (ko) | 1983-12-13 | 1985-07-11 | 원본미기재 | 에리트로포이에틴의 제조방법 |
| DK173067B1 (da) * | 1986-06-27 | 1999-12-13 | Univ Washington | Humant erythropoietin-gen, fremgangsmåde til ekspression deraf i transficerede cellelinier, de transficerede cellelinier sa |
| US5661125A (en) * | 1992-08-06 | 1997-08-26 | Amgen, Inc. | Stable and preserved erythropoietin compositions |
| ZA975264B (en) | 1996-06-17 | 1997-12-17 | Smithkline Beecham Corp | Method for treating congestive heart failure. |
| DK1813624T3 (da) | 1998-10-23 | 2010-11-22 | Amgen Inc | Fremgangsmåder og sammensætninger til forebyggelse og behandling af anæmi |
| DE19857609A1 (de) | 1998-12-14 | 2000-06-15 | Hannelore Ehrenreich | Verwendung von Erythropoietin zur Behandlung von cerebralen Ischämien des Menschen |
| US20020037832A1 (en) | 2000-05-02 | 2002-03-28 | Soren Nielsen | Use of alpha-MSH and EPO for preventing or treating ischemic conditions |
| CA2407797A1 (en) | 2000-05-02 | 2001-11-08 | Action Pharma Aps | Methods for treatment of diseases associated with inflammation under non-ischemic conditions |
| CN1318084C (zh) | 2000-05-26 | 2007-05-30 | 奥索-麦克尼尔药品公司 | 神经保护肽 |
-
2000
- 2000-08-11 US US09/637,962 patent/US7078376B1/en not_active Expired - Lifetime
-
2001
- 2001-08-09 AT AT07075711T patent/ATE555802T1/de active
- 2001-08-09 AU AU2001291755A patent/AU2001291755B2/en not_active Ceased
- 2001-08-09 NZ NZ524000A patent/NZ524000A/en not_active IP Right Cessation
- 2001-08-09 IL IL15417001A patent/IL154170A0/xx unknown
- 2001-08-09 CN CNB018170021A patent/CN100558744C/zh not_active Expired - Fee Related
- 2001-08-09 JP JP2002519493A patent/JP5105687B2/ja not_active Expired - Fee Related
- 2001-08-09 AT AT01971896T patent/ATE377426T1/de not_active IP Right Cessation
- 2001-08-09 PL PL01364248A patent/PL364248A1/xx not_active IP Right Cessation
- 2001-08-09 CZ CZ2003-406A patent/CZ304572B6/cs not_active IP Right Cessation
- 2001-08-09 HU HU0300740A patent/HUP0300740A3/hu unknown
- 2001-08-09 DE DE60131286T patent/DE60131286T2/de not_active Expired - Lifetime
- 2001-08-09 MX MXPA03001237A patent/MXPA03001237A/es active IP Right Grant
- 2001-08-09 NZ NZ542370A patent/NZ542370A/en not_active IP Right Cessation
- 2001-08-09 AU AU9175501A patent/AU9175501A/xx active Pending
- 2001-08-09 EP EP01971896A patent/EP1317276B1/en not_active Expired - Lifetime
- 2001-08-09 RU RU2003106435/14A patent/RU2282460C2/ru not_active IP Right Cessation
- 2001-08-09 BR BRPI0113189-3A patent/BRPI0113189B1/pt not_active IP Right Cessation
- 2001-08-09 CA CA2418531A patent/CA2418531C/en not_active Expired - Fee Related
- 2001-08-09 KR KR1020087012026A patent/KR100885601B1/ko not_active IP Right Cessation
- 2001-08-09 KR KR1020037001938A patent/KR100887463B1/ko not_active IP Right Cessation
- 2001-08-09 EP EP07075711A patent/EP1994940B1/en not_active Expired - Lifetime
- 2001-08-09 CA CA2804958A patent/CA2804958A1/en not_active Abandoned
- 2001-08-09 WO PCT/EP2001/009209 patent/WO2002014356A2/en active Search and Examination
-
2003
- 2003-01-29 IL IL154170A patent/IL154170A/en not_active IP Right Cessation
-
2006
- 2006-08-17 AU AU2006203640A patent/AU2006203640B2/en not_active Ceased
-
2009
- 2009-03-12 IL IL197584A patent/IL197584A/en not_active IP Right Cessation
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| BR0113189A (pt) | Métodos terapêuticos para tratar indivìduos com uma eritropoietina recombinante que possui atividade e efeitos colaterais reduzidos | |
| Salazar et al. | Systeniic (half-body) radiation therapy: Response and toxicity | |
| RU2003106435A (ru) | Терапевтические способы для лечения субъектов рекомбинантным эритропоэтином, имеющим высокую активность и уменьшенные побочные действия | |
| Rechthand et al. | Chronic demyelinating polyneuropathy in systemic lupus erythematosus | |
| NO20054526L (no) | Forebygging og behandling av brystkreft med 4-hydroxy tamoxifen | |
| Van Den Berg et al. | Effects of prophylactic treatment regimens in children with severe haemophilia: a comparison of different strategies | |
| Lee et al. | Prophylactic treatment in Sweden—overtreatment or optimal model? | |
| Bobamuratova et al. | Complex rehabilitation of patients with jaw fractures | |
| BR9807473A (pt) | Tratamentos de doença relacionados à citocina | |
| WO2002058720A3 (en) | Angiogenically effective unit dose of fgf-2 and method of use | |
| DE69921348D1 (de) | Fgf-2 angiogenische wirksame einheitdosis und ihrer verwendung | |
| RU2038102C1 (ru) | Способ лечения вибрационной болезни | |
| RU2794433C1 (ru) | Способ лечения больных с синдромом хронической усталости | |
| Tribolet et al. | A mass not so harmless | |
| KR20090103656A (ko) | 섬유근육통 치료제 | |
| RU2222319C2 (ru) | Способ регионарной лимфостимуляции и обезболивания при лимфедеме нижних конечностей | |
| RU2285533C2 (ru) | Способ введения хлористого кальция | |
| Blaser et al. | Intravenous phenytoin: a loading scheme for desired concentrations | |
| Unal et al. | Stereotactic Re-irradiation for Recurrent or Second Primary Head-and-Neck Cancer | |
| 赵耀东 et al. | Recent Progresses of Acupuncture Treatment of Cerebral Hemorrhage | |
| RU2446834C2 (ru) | Способ лечения пострадавших с сочетанной черепно-мозговой травмой | |
| SU1128953A1 (ru) | Способ лечени больных ожирением | |
| RU2218146C2 (ru) | Способ лечения больных артериальной гипертензией | |
| Lucas | Comprehensive management of haemophilia A and B | |
| Krestyashin et al. | About analgesia for infants during transcutaneous achillotomy at treatment of congenital clubfoot by ponseti method |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B25G | Requested change of headquarter approved |
Owner name: BAXTER HEALTHCARE SA (CH) Free format text: ENDERECO DO DEPOSITANTE ALTERADO CONFORME SOLICITADO NA PETICAO NO 020110115944/RJ DE 11/11/2011. |
|
| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
| B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] |
Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI |
|
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
| B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 07/07/2015, OBSERVADAS AS CONDICOES LEGAIS. |
|
| B21F | Lapse acc. art. 78, item iv - on non-payment of the annual fees in time |
Free format text: REFERENTE A 15A ANUIDADE. |
|
| B24J | Lapse because of non-payment of annual fees (definitively: art 78 iv lpi, resolution 113/2013 art. 12) |
Free format text: EM VIRTUDE DA EXTINCAO PUBLICADA NA RPI 2385 DE 20-09-2016 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDA A EXTINCAO DA PATENTE E SEUS CERTIFICADOS, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |