BR0112475B1 - N-óxido de derivados 4-fenil-piridina como antagonista de receptor nk1, seu medicamento, seu processo de preparação e seus usos - Google Patents

N-óxido de derivados 4-fenil-piridina como antagonista de receptor nk1, seu medicamento, seu processo de preparação e seus usos

Info

Publication number: BR0112475B1
Authority: BR; Brazil
Prior art keywords: phenyl; oxide; preparation process; medicinal product; pyridine derivatives
Prior art date: 2000-07-14

Application number

BRPI0112475-7B1A

Other languages

English (en)

Other versions

BRPI0112475B8 (pt

BR0112475A (pt

Inventor

Torsten Hoffmann

Sonia Maria Poli

Patrick Schnider

Andrew Sleight

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-07-14

Filing date

2001-07-09

Publication date

2013-10-15

2001-07-09 Application filed filed Critical

2003-07-29 Publication of BR0112475A publication Critical patent/BR0112475A/pt

2013-10-15 Publication of BR0112475B1 publication Critical patent/BR0112475B1/pt

2021-05-25 Publication of BRPI0112475B8 publication Critical patent/BRPI0112475B8/pt

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P25/06—Antimigraine agents
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Veterinary Medicine (AREA)
Life Sciences & Earth Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Immunology (AREA)
Pulmonology (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Psychiatry (AREA)
Addiction (AREA)
Urology & Nephrology (AREA)
Hospice & Palliative Care (AREA)
Dermatology (AREA)
Vascular Medicine (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Ophthalmology & Optometry (AREA)
Otolaryngology (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Pyridine Compounds (AREA)

BRPI0112475A 2000-07-14 2001-07-09 n-óxido de derivados 4-fenil-piridina como antagonista de receptor nk1, seu medicamento, seu processo de preparação e seus usos BRPI0112475B8 (pt)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP00115287		2000-07-14
PCT/EP2001/007850 WO2002006236A1 (en)	2000-07-14	2001-07-09	N-oxides as nk1 receptor antagonist prodrugs of 4-phenyl-pyridine derivatives

Publications (3)

Publication Number	Publication Date
BR0112475A BR0112475A (pt)	2003-07-29
BR0112475B1 true BR0112475B1 (pt)	2013-10-15
BRPI0112475B8 BRPI0112475B8 (pt)	2021-05-25

Family

ID=8169262

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BRPI0112475A BRPI0112475B8 (pt)	2000-07-14	2001-07-09	n-óxido de derivados 4-fenil-piridina como antagonista de receptor nk1, seu medicamento, seu processo de preparação e seus usos

Country Status (39)

Country	Link
US (4)	US6593472B2 (pt)
EP (1)	EP1303490B1 (pt)
JP (1)	JP3950044B2 (pt)
KR (1)	KR100501608B1 (pt)
CN (1)	CN1178917C (pt)
AR (1)	AR029717A1 (pt)
AT (1)	ATE400556T1 (pt)
AU (1)	AU7061901A (pt)
BR (1)	BRPI0112475B8 (pt)
CA (1)	CA2415890C (pt)
CY (1)	CY1108557T1 (pt)
CZ (1)	CZ303639B6 (pt)
DE (1)	DE60134749D1 (pt)
DK (1)	DK1303490T3 (pt)
EC (1)	ECSP034431A (pt)
EG (1)	EG24968A (pt)
ES (1)	ES2309075T3 (pt)
GT (1)	GT200100137A (pt)
HK (1)	HK1058198A1 (pt)
HR (1)	HRP20030003B1 (pt)
HU (1)	HU230316B1 (pt)
IL (2)	IL153834A0 (pt)
JO (1)	JO2372B1 (pt)
MA (1)	MA26929A1 (pt)
ME (1)	ME01311B (pt)
MX (1)	MXPA03000366A (pt)
MY (1)	MY154976A (pt)
NO (1)	NO324700B1 (pt)
NZ (1)	NZ523273A (pt)
PA (1)	PA8522001A1 (pt)
PE (1)	PE20020272A1 (pt)
PL (1)	PL205207B1 (pt)
PT (1)	PT1303490E (pt)
RS (1)	RS50932B (pt)
RU (1)	RU2266284C2 (pt)
SI (1)	SI1303490T1 (pt)
UY (1)	UY26839A1 (pt)
WO (1)	WO2002006236A1 (pt)
ZA (1)	ZA200210207B (pt)

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ATE400556T1 (de) *	2000-07-14	2008-07-15	Hoffmann La Roche	N-oxide als nk1-rezeptorantagonistenprodrugs von 4-phenylpyridinderivaten
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EP2797597B1 (en)	2011-12-28	2020-02-26	Global Blood Therapeutics, Inc.	Substituted heteroaryl aldehyde compounds and methods for their use in increasing tissue oxygenation
FI3738434T3 (fi)	2011-12-28	2023-11-20	Global Blood Therapeutics Inc	Välituotteita substituoitujen bentsaldehydiyhdisteiden saamiseksi ja menetelmiä niiden käyttöön kudosten hapetuksen lisäämiseksi
US9802900B2 (en)	2013-03-15	2017-10-31	Global Blood Therapeutics, Inc.	Bicyclic heteroaryl compounds and uses thereof for the modulation of hemoglobin
CA2903022C (en)	2013-03-15	2021-11-09	Global Blood Therapeutics, Inc.	Compounds and uses thereof for the modulation of hemoglobin
US10100043B2 (en)	2013-03-15	2018-10-16	Global Blood Therapeutics, Inc.	Substituted aldehyde compounds and methods for their use in increasing tissue oxygenation
CA2902711C (en)	2013-03-15	2021-07-06	Global Blood Therapeutics, Inc.	Substituted pyridinyl-6-methoxy-2-hydroxybenzaldehyde derivatives and pharmaceutical compositions thereof useful for the modulation of hemoglobin
US9422279B2 (en)	2013-03-15	2016-08-23	Global Blood Therapeutics, Inc.	Compounds and uses thereof for the modulation of hemoglobin
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CA2903220C (en)	2013-03-15	2023-01-24	Qing Xu	Aldehyde compounds and uses thereof for the modulation of hemoglobin
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RU2673084C2 (ru)	2013-11-08	2018-11-22	Киссеи Фармасьютикал Ко., Лтд.	Производное карбоксиметилпиперидина
EA202092627A1 (ru)	2013-11-18	2021-09-30	Глобал Блад Терапьютикс, Инк.	Соединения и их применения для модуляции гемоглобина
US10350098B2 (en) *	2013-12-20	2019-07-16	Volcano Corporation	Devices and methods for controlled endoluminal filter deployment
PE20201444A1 (es)	2014-02-07	2020-12-10	Global Blood Therapeutics Inc	Polimorfos cristalinos de la base libre de 2-hidroxi-6-((2-(1-isopropil-1h-pirazol-5-il)piridin-3-il)metoxi)benzaldehido
TWI649307B (zh)	2014-05-07	2019-02-01	日商橘生藥品工業股份有限公司	Cyclohexylpyridine derivative
CN106588899B (zh) *	2015-10-15	2019-11-15	江苏恒瑞医药股份有限公司	吡啶基取代的6-氧杂螺[4.5]癸烷类衍生物、其制备方法及其在医药上的应用
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TWI825524B (zh)	2016-05-12	2023-12-11	美商全球血液治療公司	用於合成2-羥基-6-((2-(1-異丙基-1h-吡唑-5-基)-吡啶-3-基)甲氧基)苯甲醛之方法
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2001
- 2001-07-09 AT AT01949475T patent/ATE400556T1/de active
- 2001-07-09 IL IL15383401A patent/IL153834A0/xx unknown
- 2001-07-09 NZ NZ523273A patent/NZ523273A/en not_active IP Right Cessation
- 2001-07-09 RU RU2003102612/04A patent/RU2266284C2/ru active
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- 2001-07-09 DE DE60134749T patent/DE60134749D1/de not_active Expired - Lifetime
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- 2001-07-09 KR KR10-2003-7000476A patent/KR100501608B1/ko active IP Right Grant
- 2001-07-09 WO PCT/EP2001/007850 patent/WO2002006236A1/en active IP Right Grant
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- 2001-07-09 CN CNB018128246A patent/CN1178917C/zh not_active Expired - Lifetime
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- 2001-07-09 PL PL365684A patent/PL205207B1/pl unknown
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2002
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2004
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Also Published As

Publication number	Publication date
YU603A (sh)	2006-01-16
US20040048901A1 (en)	2004-03-11
HRP20030003B1 (en)	2011-01-31
CN1441782A (zh)	2003-09-10
PA8522001A1 (es)	2002-04-25
NZ523273A (en)	2004-08-27
US6747026B2 (en)	2004-06-08
ME01311B (me)	2013-12-20
MXPA03000366A (es)	2003-05-27
UY26839A1 (es)	2002-01-31
PE20020272A1 (es)	2002-04-16
CZ303639B6 (cs)	2013-01-23
BRPI0112475B8 (pt)	2021-05-25
WO2002006236A1 (en)	2002-01-24
AR029717A1 (es)	2003-07-10
CA2415890C (en)	2009-04-07
US20020045642A1 (en)	2002-04-18
DK1303490T3 (da)	2008-08-25
NO20030154D0 (no)	2003-01-13
HUP0301311A2 (hu)	2003-08-28
US20030149039A1 (en)	2003-08-07
KR20030015387A (ko)	2003-02-20
CY1108557T1 (el)	2014-04-09
RU2266284C2 (ru)	2005-12-20
GT200100137A (es)	2002-05-16
CA2415890A1 (en)	2002-01-24
HU230316B1 (hu)	2016-01-28
NO324700B1 (no)	2007-12-03
IL153834A (en)	2008-11-03
EP1303490A1 (en)	2003-04-23
DE60134749D1 (de)	2008-08-21
PT1303490E (pt)	2008-09-04
KR100501608B1 (ko)	2005-07-18
PL205207B1 (pl)	2010-03-31
EG24968A (en)	2011-03-14
JP2004504301A (ja)	2004-02-12
AU7061901A (en)	2002-01-30
CN1178917C (zh)	2004-12-08
JO2372B1 (en)	2006-12-12
US6593472B2 (en)	2003-07-15
US6806370B2 (en)	2004-10-19
NO20030154L (no)	2003-01-13
ZA200210207B (en)	2004-03-17
EP1303490B1 (en)	2008-07-09
HK1058198A1 (en)	2004-05-07
IL153834A0 (en)	2003-07-31
ATE400556T1 (de)	2008-07-15
US20040014793A1 (en)	2004-01-22
ES2309075T3 (es)	2008-12-16
MY154976A (en)	2015-08-28
ECSP034431A (es)	2003-03-10
PL365684A1 (en)	2005-01-10
SI1303490T1 (sl)	2008-10-31
HRP20030003A2 (en)	2003-02-28
JP3950044B2 (ja)	2007-07-25
BR0112475A (pt)	2003-07-29
MA26929A1 (fr)	2004-12-20
US6897226B2 (en)	2005-05-24
RS50932B (sr)	2010-08-31

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BR0116505A (pt)	2004-02-03	Compostos ou um sal deste farmaceuticamente aceitável, composições farmacêuticas, método para tratar ou prevenir doenças ou distúrbios onde um antagonista de um receptor de orexina humano é requerido, e, processo para a fabricação de composições farmacêuticas para o tratamento de distúrbios associados com o papel da orexina, especialmente da obesidade e distúrbios do sono
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UY24560A1 (es)	2000-12-29	Derivados arilos de la pirimidina útiles como antagonistas 5ht2b selectivos
PT101038A (pt)	1994-02-28	Derivados de indano e indeno, seu processo de preparacao, composicoes farmaceuticas e seu uso como antagonistas do receptor de endotelina
BR0112711A (pt)	2003-05-20	Derivados de heteroarila e seus usos como medicamentos
EE05001B1 (et)	2008-04-15	Heterotsüklilised ühendid, meetod nende valmistamiseks, neid sisaldav ravimkoostis ning nende kasutamine ravis
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HUP0401047A3 (en)	2007-12-28	Triazolo[4,5-d]pyrimidine derivatives, their use as purinergic receptor antagonist and pharmaceutical compositions containing same
FR2809732B1 (fr)	2002-07-19	DERIVES DE 4(-2-PHENYLTHIAZOL-5-yl)-1,4-DIAZABICYCLO-[3.2.2] NONANE, LEUR PREPARATION ET LEUR APPLICATION ENTHERAPEUTIQUE
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PT1305319E (pt)	2006-08-31	Derivados de 4-fenil-piridina como antagonistas do receptor da neuroquinina-1
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