BR0112338A - Composto, composição farmacêutica, e, uso de um composto - Google Patents
Composto, composição farmacêutica, e, uso de um compostoInfo
- Publication number
- BR0112338A BR0112338A BR0112338-6A BR0112338A BR0112338A BR 0112338 A BR0112338 A BR 0112338A BR 0112338 A BR0112338 A BR 0112338A BR 0112338 A BR0112338 A BR 0112338A
- Authority
- BR
- Brazil
- Prior art keywords
- compound
- pharmaceutical composition
- thrombin
- cyclohexyl
- cyclopentyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
"COMPOSTO, COMPOSIçãO FARMACêUTICA, E, USO DE UM COMPOSTO". A invenção refere-se a um composto tendo a fórmula (I) em que R~ 1~ é ciclopentila, ciclo-hexila ou uma alquila (3-4C) ramificada; R~ 2~ é ciclo-hexila ou fenila; R~ 3~ é H ou metila; e A é um anel de 4,5 ou 6 membros saturado, não substituído; ou um sal farmaceuticamente aceitável do mesmo. Os compostos da invenção tem atividade anticoagulante e podem ser usados no tratamento ou prevenção de doenças mediadas por trombina e associadas com trombina.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP00202491 | 2000-07-12 | ||
| PCT/EP2001/007887 WO2002004423A1 (en) | 2000-07-12 | 2001-07-09 | Thrombin inhibitors comprising an aminoisoquinoline group |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR0112338A true BR0112338A (pt) | 2003-07-22 |
Family
ID=8171793
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR0112338-6A BR0112338A (pt) | 2000-07-12 | 2001-07-09 | Composto, composição farmacêutica, e, uso de um composto |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US6642253B2 (pt) |
| EP (1) | EP1303491A1 (pt) |
| JP (1) | JP2004502759A (pt) |
| KR (1) | KR20030022270A (pt) |
| CN (1) | CN1441784A (pt) |
| AR (1) | AR029596A1 (pt) |
| AU (1) | AU2001278476A1 (pt) |
| BR (1) | BR0112338A (pt) |
| CA (1) | CA2413035A1 (pt) |
| CZ (1) | CZ200392A3 (pt) |
| EC (1) | ECSP034422A (pt) |
| HR (1) | HRP20030017A2 (pt) |
| HU (1) | HUP0301258A2 (pt) |
| IL (1) | IL153611A0 (pt) |
| MX (1) | MXPA03000337A (pt) |
| NO (1) | NO20030145D0 (pt) |
| NZ (1) | NZ523553A (pt) |
| PE (1) | PE20020209A1 (pt) |
| PL (1) | PL359787A1 (pt) |
| RU (1) | RU2003104017A (pt) |
| SK (1) | SK322003A3 (pt) |
| WO (1) | WO2002004423A1 (pt) |
| ZA (1) | ZA200300080B (pt) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HUP0400651A2 (hu) | 2000-11-07 | 2004-06-28 | Bristol-Myers Squibb Company | Szerin proteáz inhibitorokként alkalmazható savszármazékok és ezeket tartalmazó gyógyszerkészítmények |
| US6906192B2 (en) | 2000-11-07 | 2005-06-14 | Bristol Myers Squibb Company | Processes for the preparation of acid derivatives useful as serine protease inhibitors |
| TWI389899B (zh) * | 2006-08-08 | 2013-03-21 | Msd Oss Bv | 具口服活性之凝血酶抑制劑 |
| JP5318779B2 (ja) * | 2006-12-27 | 2013-10-16 | サノフイ | シクロアルキルアミン置換イソキノリン及びイソキノリノン誘導体 |
| US7927378B2 (en) * | 2007-03-05 | 2011-04-19 | Scussel Sbj Systems, Llc | Vacuum assisted prosthetic sleeve and socket |
| CN109810173B (zh) * | 2017-11-21 | 2020-11-27 | 首都医科大学 | 二氢异喹啉-3-甲酰-TARGD(aa)aa,其制备,抗静脉血栓活性和应用 |
| CN109810172B (zh) * | 2017-11-21 | 2021-01-01 | 首都医科大学 | 异喹啉-3-甲酰-PARGD(aa)aa,其制备,抗静脉血栓活性和应用 |
| CN109810174B (zh) * | 2017-11-21 | 2021-01-01 | 首都医科大学 | 异喹啉-3-甲酰-TARGD(aa)aa,其制备,抗静脉血栓活性和应用 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL123986A (en) * | 1997-04-24 | 2011-10-31 | Organon Nv | Medicinal compounds |
-
2001
- 2001-07-09 NZ NZ523553A patent/NZ523553A/en unknown
- 2001-07-09 AU AU2001278476A patent/AU2001278476A1/en not_active Abandoned
- 2001-07-09 PL PL35978701A patent/PL359787A1/xx not_active Application Discontinuation
- 2001-07-09 EP EP01956519A patent/EP1303491A1/en not_active Withdrawn
- 2001-07-09 JP JP2002509290A patent/JP2004502759A/ja not_active Withdrawn
- 2001-07-09 WO PCT/EP2001/007887 patent/WO2002004423A1/en not_active Application Discontinuation
- 2001-07-09 HU HU0301258A patent/HUP0301258A2/hu unknown
- 2001-07-09 KR KR10-2003-7000363A patent/KR20030022270A/ko not_active Application Discontinuation
- 2001-07-09 BR BR0112338-6A patent/BR0112338A/pt not_active IP Right Cessation
- 2001-07-09 CZ CZ200392A patent/CZ200392A3/cs unknown
- 2001-07-09 RU RU2003104017/04A patent/RU2003104017A/ru not_active Application Discontinuation
- 2001-07-09 CN CN01812607A patent/CN1441784A/zh active Pending
- 2001-07-09 IL IL15361101A patent/IL153611A0/xx unknown
- 2001-07-09 MX MXPA03000337A patent/MXPA03000337A/es unknown
- 2001-07-09 CA CA002413035A patent/CA2413035A1/en not_active Abandoned
- 2001-07-09 SK SK32-2003A patent/SK322003A3/sk not_active Application Discontinuation
- 2001-07-09 US US10/332,792 patent/US6642253B2/en not_active Expired - Fee Related
- 2001-07-10 PE PE2001000684A patent/PE20020209A1/es not_active Application Discontinuation
- 2001-07-11 AR ARP010103283A patent/AR029596A1/es not_active Application Discontinuation
-
2003
- 2003-01-03 ZA ZA200300080A patent/ZA200300080B/en unknown
- 2003-01-10 HR HR20030017A patent/HRP20030017A2/hr not_active Application Discontinuation
- 2003-01-10 EC EC2003004422A patent/ECSP034422A/es unknown
- 2003-01-10 NO NO20030145A patent/NO20030145D0/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| US20030166579A1 (en) | 2003-09-04 |
| JP2004502759A (ja) | 2004-01-29 |
| PL359787A1 (en) | 2004-09-06 |
| ZA200300080B (en) | 2004-04-05 |
| EP1303491A1 (en) | 2003-04-23 |
| NO20030145L (no) | 2003-01-10 |
| KR20030022270A (ko) | 2003-03-15 |
| CN1441784A (zh) | 2003-09-10 |
| WO2002004423A8 (en) | 2003-03-06 |
| AU2001278476A1 (en) | 2002-01-21 |
| IL153611A0 (en) | 2003-07-06 |
| CZ200392A3 (cs) | 2003-05-14 |
| NZ523553A (en) | 2004-04-30 |
| WO2002004423A9 (en) | 2003-05-15 |
| HRP20030017A2 (en) | 2003-04-30 |
| SK322003A3 (en) | 2003-06-03 |
| HUP0301258A2 (hu) | 2003-08-28 |
| NO20030145D0 (no) | 2003-01-10 |
| ECSP034422A (es) | 2003-03-10 |
| MXPA03000337A (es) | 2004-04-05 |
| PE20020209A1 (es) | 2002-03-19 |
| AR029596A1 (es) | 2003-07-02 |
| RU2003104017A (ru) | 2004-08-20 |
| WO2002004423A1 (en) | 2002-01-17 |
| CA2413035A1 (en) | 2002-01-17 |
| US6642253B2 (en) | 2003-11-04 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 5A,6A E 7A ANUIDADE |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO PUBLICADO NA RPI 1963 DE 19.08.2008. |