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BR0110258A - Cristal estável de derivado de tiazolidinadiona e processo para sua produção - Google Patents

Cristal estável de derivado de tiazolidinadiona e processo para sua produção

Info

Publication number
BR0110258A
BR0110258A BR0110258-3A BR0110258A BR0110258A BR 0110258 A BR0110258 A BR 0110258A BR 0110258 A BR0110258 A BR 0110258A BR 0110258 A BR0110258 A BR 0110258A
Authority
BR
Brazil
Prior art keywords
production
stable
crystal
derivative crystal
thiazolidinedione derivative
Prior art date
Application number
BR0110258-3A
Other languages
English (en)
Inventor
Michiro Ohnota
Kazuo Orita
Original Assignee
Kyorin Seiyaku Kk
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyorin Seiyaku Kk filed Critical Kyorin Seiyaku Kk
Publication of BR0110258A publication Critical patent/BR0110258A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/34—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C30—CRYSTAL GROWTH
    • C30B—SINGLE-CRYSTAL GROWTH; UNIDIRECTIONAL SOLIDIFICATION OF EUTECTIC MATERIAL OR UNIDIRECTIONAL DEMIXING OF EUTECTOID MATERIAL; REFINING BY ZONE-MELTING OF MATERIAL; PRODUCTION OF A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; SINGLE CRYSTALS OR HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; AFTER-TREATMENT OF SINGLE CRYSTALS OR A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; APPARATUS THEREFOR
    • C30B7/00—Single-crystal growth from solutions using solvents which are liquid at normal temperature, e.g. aqueous solutions

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Materials Engineering (AREA)
  • Metallurgy (AREA)
  • Obesity (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Endocrinology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

"CRISTAL ESTáVEL DE DERIVADO DE TIAZOLIDINADIONA E PROCESSO PARA SUA PRODUçãO". Um cristal homogêneo tendo excelente estabilidade, adequado para produção em escala industrial de 5-[(2,4-dioxotiazolidin-5-il)metil]-2-metóxi -N-[[4-(trifluorometil)fenil]metil]benzamida (KRP-297). O novo cristal de KRP-297 é produzido através da recristalização de um solvente alcoólico. é caracterizado por ter ângulos de difração (2<sym>) em pelo menos 9,7<198>, 15,0<198> e 22,5<198> em difratometria de raios X em pó.
BR0110258-3A 2000-04-25 2001-04-23 Cristal estável de derivado de tiazolidinadiona e processo para sua produção BR0110258A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2000124006 2000-04-25
PCT/JP2001/003450 WO2001081327A1 (fr) 2000-04-25 2001-04-23 Nouveau cristal stable de derive thiazolidinedione et son procede de production

Publications (1)

Publication Number Publication Date
BR0110258A true BR0110258A (pt) 2003-01-07

Family

ID=18634205

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0110258-3A BR0110258A (pt) 2000-04-25 2001-04-23 Cristal estável de derivado de tiazolidinadiona e processo para sua produção

Country Status (23)

Country Link
US (1) US6770133B2 (pt)
EP (1) EP1277745A4 (pt)
KR (1) KR20030007548A (pt)
CN (1) CN1426402A (pt)
AU (1) AU4882801A (pt)
BG (1) BG107200A (pt)
BR (1) BR0110258A (pt)
CA (1) CA2407349A1 (pt)
CZ (1) CZ20023502A3 (pt)
EA (1) EA004244B1 (pt)
EE (1) EE200200601A (pt)
HK (1) HK1053835A1 (pt)
HU (1) HUP0300475A3 (pt)
IL (1) IL152224A0 (pt)
IS (1) IS6586A (pt)
MA (1) MA25664A1 (pt)
MX (1) MXPA02010545A (pt)
NO (1) NO20025069L (pt)
PL (1) PL365533A1 (pt)
SK (1) SK15142002A3 (pt)
WO (1) WO2001081327A1 (pt)
YU (1) YU80302A (pt)
ZA (1) ZA200208293B (pt)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1253145B1 (en) * 2000-02-01 2006-09-20 Kyorin Pharmaceutical Co., Ltd. Alkali metal salt of thiazolidine-2,4-dione derivatives
WO2003062214A1 (fr) * 2002-01-23 2003-07-31 Kyorin Pharmaceutical Co., Ltd. Nouveau cristal stable de derive de benzylthiazolidinedione et procede de preparation de celui-ci
DE10308351A1 (de) 2003-02-27 2004-11-25 Aventis Pharma Deutschland Gmbh 1,3-substituierte Cycloalkylderivate mit sauren, meist heterocyclischen Gruppen, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
DE10308352A1 (de) 2003-02-27 2004-09-09 Aventis Pharma Deutschland Gmbh Arylcycloalkylderivate mit verzweigten Seitenketten, Verfahren zu ihrer Herstellung und ihre Anwendung als Arzneimittel
DE10308355A1 (de) 2003-02-27 2004-12-23 Aventis Pharma Deutschland Gmbh Aryl-cycloalkyl substituierte Alkansäurederivate, Verfahren zu ihrer Herstellung und ihre Anwendung als Arzneimittel
US7148246B2 (en) 2003-02-27 2006-12-12 Sanofi-Aventis Deutschland Gmbh Cycloalkyl derivatives having bioisosteric carboxylic acid groups, processes for their preparation and their use as pharmaceuticals
DE10308353A1 (de) 2003-02-27 2004-12-02 Aventis Pharma Deutschland Gmbh Diarylcycloalkylderivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
EP2428516A1 (en) 2003-11-19 2012-03-14 Metabasis Therapeutics, Inc. Novel phosphorus-containing thyromimetics
DE602004004631D1 (de) 2004-04-01 2007-03-22 Sanofi Aventis Deutschland Oxadiazolone, Verfahren zu ihrer Herstellung sowie ihre Verwendung als Pharmazeutika
DE102005026762A1 (de) 2005-06-09 2006-12-21 Sanofi-Aventis Deutschland Gmbh Azolopyridin-2-on-derivate als Inhibitoren von Lipasen und Phospholipasen
TWI383008B (zh) * 2005-08-17 2013-01-21 Nippon Catalytic Chem Ind 吸水性樹脂之製造方法及吸水性樹脂以及其利用
TW200838512A (en) 2007-02-08 2008-10-01 Daiichi Sankyo Co Ltd Crystalline forms of a thiazolidinedione compound and manufacturing methods thereof
US20120046364A1 (en) 2009-02-10 2012-02-23 Metabasis Therapeutics, Inc. Novel Sulfonic Acid-Containing Thyromimetics, and Methods for Their Use

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4864028A (en) * 1983-09-14 1989-09-05 Alcon Laboratories, Inc. Spiro-tricyclicaromatic succinimide derivatives
CN1003445B (zh) * 1984-10-03 1989-03-01 武田药品工业株式会社 噻唑烷二酮衍生物，其制备方法和用途
AR240698A1 (es) * 1985-01-19 1990-09-28 Takeda Chemical Industries Ltd Procedimiento para preparar compuestos de 5-(4-(2-(5-etil-2-piridil)-etoxi)benzil)-2,4-tiazolidindiona y sus sales
JPH04270273A (ja) 1991-02-25 1992-09-25 Kyorin Pharmaceut Co Ltd チアゾリジン−２，４−ジオン誘導体とその塩及びその製造法
JP3053490B2 (ja) 1991-02-25 2000-06-19 杏林製薬株式会社 チアゾリジン−２，４−ジオン誘導体とその塩及び製造法
JP3644998B2 (ja) 1995-02-09 2005-05-11 塩野義製薬株式会社 ベンジリデン誘導体の結晶の選択的取得方法
US6147101A (en) * 1995-06-02 2000-11-14 Kyorin Pharmaceutical Co., Ltd. N-benzyldioxothiazolidylbenzamide derivatives and process for producing the same
US6001862A (en) * 1995-06-02 1999-12-14 Kyorin Pharameuticals Co., Ltd. N-benzyldioxothiazolidylbenzamide derivatives and processes for preparing the same
JP3144624B2 (ja) * 1995-06-02 2001-03-12 杏林製薬株式会社 Ｎ−ベンジルジオキソチアゾリジルベンズアミド誘導体及びその製造法
ZA971637B (en) * 1996-02-28 1997-09-25 Nissan Chemical Ind Ltd Thifluzamide with improved efficacy.
JPH101476A (ja) 1996-02-28 1998-01-06 Nissan Chem Ind Ltd 効力が向上したチフルザミド
GB9726566D0 (en) * 1997-12-16 1998-02-11 Smithkline Beecham Plc Novel pharmaceutical

Also Published As

Publication number Publication date
IL152224A0 (en) 2003-05-29
IS6586A (is) 2002-10-21
AU4882801A (en) 2001-11-07
NO20025069D0 (no) 2002-10-22
YU80302A (sh) 2005-11-28
SK15142002A3 (sk) 2003-04-01
EP1277745A1 (en) 2003-01-22
CN1426402A (zh) 2003-06-25
MA25664A1 (fr) 2002-12-31
EE200200601A (et) 2004-04-15
PL365533A1 (en) 2005-01-10
HUP0300475A3 (en) 2004-10-28
US20030101925A1 (en) 2003-06-05
BG107200A (bg) 2003-11-28
HUP0300475A2 (hu) 2003-06-28
NO20025069L (no) 2002-10-22
ZA200208293B (en) 2003-10-06
KR20030007548A (ko) 2003-01-23
EA004244B1 (ru) 2004-02-26
US6770133B2 (en) 2004-08-03
HK1053835A1 (zh) 2003-11-07
EP1277745A4 (en) 2004-09-15
MXPA02010545A (es) 2004-05-14
CA2407349A1 (en) 2002-10-24
WO2001081327A1 (fr) 2001-11-01
CZ20023502A3 (cs) 2003-06-18
EA200201055A1 (ru) 2003-06-26

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 5A, 6A E 7A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO PUBLICADO NA RPI 1963 DE 19.08.2008.