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BR0104747A - Use of cationic supravital mitochondrial marking agent in the detection and extinction of cancerous epithelial cells - Google Patents

Use of cationic supravital mitochondrial marking agent in the detection and extinction of cancerous epithelial cells

Info

Publication number
BR0104747A
BR0104747A BR0104747-7A BR0104747A BR0104747A BR 0104747 A BR0104747 A BR 0104747A BR 0104747 A BR0104747 A BR 0104747A BR 0104747 A BR0104747 A BR 0104747A
Authority
BR
Brazil
Prior art keywords
epithelial cells
extinction
marking agent
cancerous epithelial
detection
Prior art date
Application number
BR0104747-7A
Other languages
Portuguese (pt)
Inventor
Samuel D Bernal
Douglas D Burkett
Ralph E Green
Seth D Rose
Original Assignee
Zila Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zila Inc filed Critical Zila Inc
Publication of BR0104747A publication Critical patent/BR0104747A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/30—Staining; Impregnating ; Fixation; Dehydration; Multistep processes for preparing samples of tissue, cell or nucleic acid material and the like for analysis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/006—Biological staining of tissues in vivo, e.g. methylene blue or toluidine blue O administered in the buccal area to detect epithelial cancer cells, dyes used for delineating tissues during surgery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Physics & Mathematics (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pathology (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Optics & Photonics (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

"USO DE AGENTE DE MARCAçãO MITOCONDRIAL SUPRAVITAL CATIÈNICO NA DETECçãO E EXTINçãO DE CéLULAS EPITELIAIS CANCEROSAS". Um método de diagnóstico para detectar células epiteliais cancerosas por marcação seletiva da mitocóndria das células cancerosas, mediante fornecimento ao epitélio de um agente de marcação mitocondrial supravital catiónico. A destruição seletiva de células epiteliais cancerosas na presença de células normais é realizada pelo fornecimento de um agente de marcação mitocondrial supravital catiónico às células epiteliais cancerosas. O agente de destruição pode também compreender o produto de reação do agente de marcação e de um medicamento quimioterapêutico contra o câncer ou em mistura com o medicamento."USE OF CATHYNICAL SUPRAVITAL MITOCHONDRIAL MARKING AGENT IN THE DETECTION AND EXTINCTION OF CANCER EPITHELIAL CELLS". A diagnostic method for detecting cancerous epithelial cells by selectively marking the cancer cell's mitochondria by supplying the epithelium with a cationic supravital mitochondrial marking agent. The selective destruction of cancerous epithelial cells in the presence of normal cells is accomplished by supplying a cationic supravital mitochondrial marking agent to the cancerous epithelial cells. The destructive agent may also comprise the reaction product of the labeling agent and a chemotherapeutic drug against cancer or in admixture with the drug.

BR0104747-7A 2000-02-28 2001-02-27 Use of cationic supravital mitochondrial marking agent in the detection and extinction of cancerous epithelial cells BR0104747A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PCT/US2000/005387 WO2001064110A1 (en) 2000-02-28 2000-02-28 Method for detecting and killing epithelial cancer cells
PCT/US2001/006318 WO2001064255A1 (en) 2000-02-28 2001-02-27 Method for detecting and killing epithelial cancer cells

Publications (1)

Publication Number Publication Date
BR0104747A true BR0104747A (en) 2002-09-17

Family

ID=21741108

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0104747-7A BR0104747A (en) 2000-02-28 2001-02-27 Use of cationic supravital mitochondrial marking agent in the detection and extinction of cancerous epithelial cells

Country Status (14)

Country Link
EP (1) EP1214101A4 (en)
JP (1) JP2003525044A (en)
KR (2) KR20080080681A (en)
CN (1) CN100544770C (en)
AU (2) AU2000237154A1 (en)
BR (1) BR0104747A (en)
CA (1) CA2370741A1 (en)
CZ (1) CZ20013861A3 (en)
IL (1) IL146141A0 (en)
MX (1) MXPA01010886A (en)
NO (1) NO20015242L (en)
NZ (1) NZ515202A (en)
RU (1) RU2226404C2 (en)
WO (2) WO2001064110A1 (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2000237154A1 (en) * 2000-02-28 2001-09-12 Zila, Inc. Method for detecting and killing epithelial cancer cells
NZ517445A (en) * 2000-06-30 2004-03-26 Zila Inc Rhodamine diagnostic agent and diagnostic methods for detection of epithelial cancer
CN1399563A (en) * 2000-09-26 2003-02-26 日拉公司 Method for early prediction of onset of invasive cancer
MXPA04002659A (en) * 2001-12-14 2004-06-18 Zila Inc Stain-directed molecular analysis for cancer prognosis and diagnosis.
US6929817B2 (en) 2002-05-14 2005-08-16 National Starch & Chemical Investment Holding Corporation Slowly digestible starch product
US7081261B2 (en) * 2002-05-14 2006-07-25 National Starch And Chemical Investment Holding Corporation Resistant starch prepared by isoamylase debranching of low amylose starch
US6890571B2 (en) 2002-05-14 2005-05-10 National Starch And Chemical Investment Holding Corporation Slowly digestible starch product
IL165516A0 (en) * 2002-06-04 2006-01-15 Zila Inc Toluidine blue o drug substance and use thereof for in vivo staining and chemotherapeutic treatment of dysplastic tissues
EP1799097A4 (en) * 2004-09-30 2009-05-06 Zila Biotechnology Inc Light-directed method for detecting and aiding further evaluation of abnormal mucosal tissue
WO2006072625A2 (en) 2005-01-06 2006-07-13 Novo Nordisk A/S Anti-kir combination treatments and methods
DK3932410T3 (en) 2009-07-15 2024-09-23 Nutricia Nv Blend of non-digestible oligosaccharides to stimulate the immune system
CN103185713B (en) * 2011-12-29 2015-12-09 闫文广 For the detection agent composition and method of making the same of epithelial neoplasms cell

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4321251A (en) * 1979-12-19 1982-03-23 The United States Of America As Represented By The Department Of Health And Human Services Detection of malignant lesions of the oral cavity utilizing toluidine blue rinse
US5194373A (en) * 1985-06-06 1993-03-16 Thomas Jefferson University Method of determining endothelial cell coverage of a prosthetic surface
US4816395A (en) * 1985-12-19 1989-03-28 Peralta Cancer Research Institute Method for predicting chemosensitivity of anti-cancer drugs
WO1993008847A1 (en) * 1991-10-31 1993-05-13 Ctm Associates, Inc. Biological stain composition, method of preparation and method of use for delineation of epitheleal cancer
CA2214829C (en) * 1996-01-16 2002-05-14 Edwin Pomerantz Methods and compositions for in-vivo detection of oral cancers and precancerous conditions
US6086852A (en) * 1997-11-13 2000-07-11 Zila, Inc. In vivo stain composition, process of manufacture, and methods of use to identify dysplastic tissue
EA006294B1 (en) * 1998-12-23 2005-10-27 Дж.Д.Сирл Энд Ко. Use a celecoxib and gemcitabine combination in a combined method for treating pancreas
AU2000237154A1 (en) * 2000-02-28 2001-09-12 Zila, Inc. Method for detecting and killing epithelial cancer cells
IL148429A0 (en) * 2000-07-20 2002-09-12 Zila Inc Improved diagnostic method for detecting dysplastic epithelial tissue
CN1399563A (en) * 2000-09-26 2003-02-26 日拉公司 Method for early prediction of onset of invasive cancer

Also Published As

Publication number Publication date
AU2000237154A1 (en) 2001-09-12
NO20015242D0 (en) 2001-10-26
AU4331601A (en) 2001-09-12
KR100907122B1 (en) 2009-07-09
IL146141A0 (en) 2002-07-25
KR20020000222A (en) 2002-01-05
CN1365288A (en) 2002-08-21
EP1214101A1 (en) 2002-06-19
WO2001064255A1 (en) 2001-09-07
MXPA01010886A (en) 2002-05-06
NO20015242L (en) 2001-11-29
KR20080080681A (en) 2008-09-04
CA2370741A1 (en) 2001-09-07
RU2226404C2 (en) 2004-04-10
CZ20013861A3 (en) 2002-08-14
AU785489B2 (en) 2007-11-15
CN100544770C (en) 2009-09-30
EP1214101A4 (en) 2005-04-13
JP2003525044A (en) 2003-08-26
WO2001064110A1 (en) 2001-09-07
NZ515202A (en) 2003-05-30

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Legal Events

Date Code Title Description
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: MANTIDO O INDEFERIMENTO UMA VEZ QUE NAO FOI APRESENTADO RECURSO DENTRO DO PRAZO LEGAL.