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BR0016516A - Pirróis substituìdos - Google Patents

Pirróis substituìdos

Info

Publication number
BR0016516A
BR0016516A BR0016516-6A BR0016516A BR0016516A BR 0016516 A BR0016516 A BR 0016516A BR 0016516 A BR0016516 A BR 0016516A BR 0016516 A BR0016516 A BR 0016516A
Authority
BR
Brazil
Prior art keywords
replaced
pyrroles
disclosed
compounds
pirróis
Prior art date
Application number
BR0016516-6A
Other languages
English (en)
Inventor
Nader Fotouhi
Norman Kong
Allen John Lovey
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of BR0016516A publication Critical patent/BR0016516A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)

Abstract

"PIRRóIS SUBSTITUìDOS". Divulgado são pirróis substituídos tendo a fórmula (I), em que R^ 1^, R^ 2^, R^ 1'^ e R^ 2'^ são como definidos nas reivindicações e na descrição. Estes compostos e seus sais farmaceuticamente aceitáveis são úteis no tratamento e/ou controle de distúrbios proliferativos celulares, em particular câncer. Também divulgado são composições farmacêuticas contendo os compostos anteriores.
BR0016516-6A 1999-12-22 2000-12-21 Pirróis substituìdos BR0016516A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US17155799P 1999-12-22 1999-12-22
PCT/EP2000/013026 WO2001046178A2 (en) 1999-12-22 2000-12-21 Substituierte bisindolymaleimide

Publications (1)

Publication Number Publication Date
BR0016516A true BR0016516A (pt) 2002-09-17

Family

ID=22624198

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0016516-6A BR0016516A (pt) 1999-12-22 2000-12-21 Pirróis substituìdos

Country Status (28)

Country Link
US (1) US6281356B1 (pt)
EP (1) EP1242409A2 (pt)
JP (1) JP2003518112A (pt)
KR (1) KR100508741B1 (pt)
CN (1) CN1193027C (pt)
AR (1) AR027035A1 (pt)
AU (1) AU782920B2 (pt)
BR (1) BR0016516A (pt)
CA (1) CA2394852A1 (pt)
CO (1) CO5090902A1 (pt)
CZ (1) CZ20022492A3 (pt)
HK (1) HK1054382A1 (pt)
HR (1) HRP20020536A2 (pt)
HU (1) HUP0204572A3 (pt)
IL (1) IL150200A0 (pt)
JO (1) JO2199B1 (pt)
MA (1) MA26860A1 (pt)
MX (1) MXPA02006162A (pt)
MY (1) MY133682A (pt)
NO (1) NO20022927D0 (pt)
NZ (1) NZ519359A (pt)
PE (1) PE20011098A1 (pt)
PL (1) PL357603A1 (pt)
RU (1) RU2261862C2 (pt)
UY (1) UY26498A1 (pt)
WO (1) WO2001046178A2 (pt)
YU (1) YU46302A (pt)
ZA (1) ZA200204313B (pt)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030139373A1 (en) * 2001-11-20 2003-07-24 Breimer Lars Holger Method for cancer therapy
PE20040079A1 (es) 2002-04-03 2004-04-19 Novartis Ag Derivados de indolilmaleimida
GB0303319D0 (en) 2003-02-13 2003-03-19 Novartis Ag Organic compounds
US20140303121A1 (en) 2013-03-15 2014-10-09 Plexxikon Inc. Heterocyclic compounds and uses thereof
SG11201506687RA (en) 2013-03-15 2015-09-29 Plexxikon Inc Heterocyclic compounds and uses thereof
DK3272745T3 (da) 2016-07-21 2019-09-02 Inst Farmakologii Polskiej Akademii Nauk Imidazolylsubstituerede indolderivater, der binder 5-ht7-serotoninreceptor, og farmaceutiske sammensætninger deraf
CA3079029A1 (en) 2017-10-13 2019-04-18 Plexxikon Inc. Solid forms of a compound for modulating kinases

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SK278989B6 (sk) 1988-02-10 1998-05-06 F. Hoffmann-La Roche Ag Substituované pyroly, ich použitie na výrobu lieči
PT93947B (pt) * 1989-05-05 1996-11-29 Goedecke Ag Processo para a preparacao de novos derivados de maleinimidas e de composicoes farmaceuticas que os contem
US5380746A (en) 1989-05-05 1995-01-10 Goedecke Aktiengesellschaft Bis-(1H-indol-3-YL)-maleinimide derivatives, processes for the preparation thereof and pharmaceutical compositions containing them
JPH07504673A (ja) 1992-03-20 1995-05-25 ザ・ウエルカム・ファウンデーション・リミテッド 抗ウイルス活性を有するインドール誘導体
DE69323183T2 (de) * 1992-03-20 1999-05-27 The Wellcome Foundation Ltd., Greenford Weitere indolderivate mit antiviraler wirkung
DE4217964A1 (de) * 1992-05-30 1993-12-02 Goedecke Ag Indolocarbazol-Imide und deren Verwendung
PE91598A1 (es) 1996-07-29 1998-12-24 Hoffmann La Roche Pirroles sustituidos
PE91698A1 (es) 1996-07-29 1998-12-24 Hoffmann La Roche Pirroles sustituidos
PE91498A1 (es) 1996-07-29 1998-12-22 Hoffmann La Roche Pirroles sustituidos
PL195323B1 (pl) * 1998-03-17 2007-09-28 Hoffmann La Roche Podstawione bisindolilomaleimidy do hamowania proliferacji komórek

Also Published As

Publication number Publication date
HRP20020536A2 (en) 2004-08-31
NO20022927L (no) 2002-06-18
NO20022927D0 (no) 2002-06-18
ZA200204313B (en) 2003-08-29
WO2001046178A3 (en) 2001-12-06
PL357603A1 (en) 2004-07-26
IL150200A0 (en) 2002-12-01
RU2261862C2 (ru) 2005-10-10
WO2001046178A2 (en) 2001-06-28
US6281356B1 (en) 2001-08-28
KR100508741B1 (ko) 2005-08-17
YU46302A (sh) 2005-06-10
CN1193027C (zh) 2005-03-16
MXPA02006162A (es) 2002-12-05
UY26498A1 (es) 2001-06-29
AU3726701A (en) 2001-07-03
JP2003518112A (ja) 2003-06-03
EP1242409A2 (en) 2002-09-25
HUP0204572A3 (en) 2004-07-28
CZ20022492A3 (cs) 2003-02-12
KR20020062365A (ko) 2002-07-25
NZ519359A (en) 2004-04-30
AU782920B2 (en) 2005-09-08
CA2394852A1 (en) 2001-06-28
RU2002119557A (ru) 2004-01-10
MA26860A1 (fr) 2004-12-20
PE20011098A1 (es) 2001-10-26
CO5090902A1 (es) 2001-10-30
AR027035A1 (es) 2003-03-12
HK1054382A1 (en) 2003-11-28
JO2199B1 (en) 2003-12-23
CN1411457A (zh) 2003-04-16
MY133682A (en) 2007-11-30
HUP0204572A2 (en) 2003-05-28

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 7A E 8A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 DA RPI 2008 DE 30/06/2009.