Nothing Special   »   [go: up one dir, main page]

BR0016304A - Formulação de solução aquosa de interferon estável, método de preparação e usos para a mesma - Google Patents

Formulação de solução aquosa de interferon estável, método de preparação e usos para a mesma

Info

Publication number
BR0016304A
BR0016304A BR0016304-0A BR0016304A BR0016304A BR 0016304 A BR0016304 A BR 0016304A BR 0016304 A BR0016304 A BR 0016304A BR 0016304 A BR0016304 A BR 0016304A
Authority
BR
Brazil
Prior art keywords
preparation
formulation
interferon solution
aqueous stable
stable interferon
Prior art date
Application number
BR0016304-0A
Other languages
English (en)
Inventor
Lei Zhang
Original Assignee
Tianjin Hualida Bioengineering
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tianjin Hualida Bioengineering filed Critical Tianjin Hualida Bioengineering
Publication of BR0016304A publication Critical patent/BR0016304A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/21—Interferons [IFN]
    • A61K38/212—IFN-alpha
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Dermatology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Inorganic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Virology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

"FORMULAçãO DE SOLUçãO AQUOSA DE INTERFERON ESTáVEL, MéTODO DE PREPARAçãO E USOS PARA A MESMA". A presente invenção relaciona-se com uma formulação de solução aquosa de alfa interferon que pode ser livre de conservantes ou de ingredientes extraídos de sangue humano, a qual compreende os seguintes componentes: a. alfa interferon; b. um sistema tamponador para manter pH 4,5-9,0; c. um agente estabilizante; d. um tensoativo não-iónico; e. um regulador de pressão osmótica; o método de preparação e os usos no tratamento de doenças virais, tumorais e imunes da mesma.
BR0016304-0A 1999-12-06 2000-12-05 Formulação de solução aquosa de interferon estável, método de preparação e usos para a mesma BR0016304A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CNB991255828A CN1175901C (zh) 1999-12-06 1999-12-06 一种稳定的干扰素水溶液
PCT/CN2000/000531 WO2001041793A1 (fr) 1999-12-06 2000-12-05 Formulation stable d'interferon en solution, son procede de preparation et ses applications

Publications (1)

Publication Number Publication Date
BR0016304A true BR0016304A (pt) 2002-11-05

Family

ID=5284022

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0016304-0A BR0016304A (pt) 1999-12-06 2000-12-05 Formulação de solução aquosa de interferon estável, método de preparação e usos para a mesma

Country Status (10)

Country Link
US (1) US20030170207A1 (pt)
EP (1) EP1250932B1 (pt)
CN (1) CN1175901C (pt)
AT (1) ATE460175T1 (pt)
AU (1) AU1848901A (pt)
BR (1) BR0016304A (pt)
DE (1) DE60043994D1 (pt)
MX (1) MXPA02005563A (pt)
RU (1) RU2242242C2 (pt)
WO (1) WO2001041793A1 (pt)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1245215C (zh) 2001-02-28 2006-03-15 四川省生物工程研究中心 重组高效复合干扰素用作乙型肝炎表面抗原和e抗原抑制剂
TWI272948B (en) * 2003-05-01 2007-02-11 Ares Trading Sa HSA-free stabilized interferon liquid formulations
US7585647B2 (en) 2003-08-28 2009-09-08 Guangwen Wei Nucleic acid encoding recombinant interferon
UA88300C2 (ru) 2004-05-17 2009-10-12 Эйрес Трейдинг С.А. Гидрогелевые композиции, которые содержат интерферон
JP4988562B2 (ja) * 2004-06-01 2012-08-01 アレス トレーディング ソシエテ アノニム 安定化したインターフェロン液体製剤
CN1724567B (zh) * 2004-07-22 2010-08-18 北京三元基因工程有限公司 一种稳定的重组人干扰素α1b水溶液
CU23432B6 (es) 2005-11-02 2009-10-16 Ct Ingenieria Genetica Biotech Formulaciones estabilizadas que contienen a los interferones gamma y alfa en proporciones potenciadoras
DK2234645T3 (da) 2007-12-20 2012-07-09 Merck Serono Sa Peg-interferon-beta-formuleringer
KR101303388B1 (ko) * 2010-10-26 2013-09-03 한미사이언스 주식회사 지속형 인터페론 알파 결합체의 액상 제제
CN102988984B (zh) * 2012-12-21 2015-05-20 嘉和生物药业有限公司 增强稳定性的抗TNF-α人单克隆抗体的含水药物制剂
RU2564951C1 (ru) * 2014-08-28 2015-10-10 Закрытое акционерное общество "Вектор-Медика" (ЗАО "Вектор-Медика") Композиция водного раствора рекомбинантного интерферона альфа-2 человека для ректального применения
CN106421755A (zh) * 2016-11-03 2017-02-22 广州凯耀资产管理有限公司 一种干扰素组合物及其制备方法
RU2768656C1 (ru) * 2021-09-10 2022-03-24 Илья Александрович Марков Противовирусное средство в жидкой форме и способ его приготовления
CN113797317B (zh) * 2021-10-26 2024-01-09 科兴生物制药股份有限公司 一种组合物及其制备方法和应用
CN113797318B (zh) * 2021-10-26 2023-06-30 深圳科兴药业有限公司 一种干扰素组合物及其制备方法和应用
CN115177719A (zh) * 2022-07-29 2022-10-14 广州源博医药科技有限公司 一种犬α干扰素水针剂型及其制备方法和应用

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0150067A3 (en) * 1984-01-23 1986-12-30 Takeda Chemical Industries, Ltd. Stable composition of gamma-interferon
US5997856A (en) * 1988-10-05 1999-12-07 Chiron Corporation Method and compositions for solubilization and stabilization of polypeptides, especially proteins
US6261800B1 (en) * 1989-05-05 2001-07-17 Genentech, Inc. Luteinizing hormone/choriogonadotropin (LH/CG) receptor
CA2024046A1 (en) * 1989-09-28 1991-03-29 Alberto Ferro Stabilized leukocyte-interferons
US5482931A (en) * 1993-06-29 1996-01-09 Ferring Ab Stabilized pharmaceutical peptide compositions
US5766582A (en) * 1994-10-11 1998-06-16 Schering Corporation Stable, aqueous alfa interferon solution formulations
JP2758154B2 (ja) * 1995-04-06 1998-05-28 エフ・ホフマン−ラ ロシユ アーゲー インターフェロンを含む液体製剤

Also Published As

Publication number Publication date
ATE460175T1 (de) 2010-03-15
CN1175901C (zh) 2004-11-17
RU2242242C2 (ru) 2004-12-20
MXPA02005563A (es) 2004-09-10
WO2001041793A1 (fr) 2001-06-14
EP1250932A4 (en) 2006-04-19
AU1848901A (en) 2001-06-18
EP1250932B1 (en) 2010-03-10
DE60043994D1 (de) 2010-04-22
EP1250932A1 (en) 2002-10-23
RU2002118115A (ru) 2004-02-20
US20030170207A1 (en) 2003-09-11
CN1256148A (zh) 2000-06-14

Similar Documents

Publication Publication Date Title
BR0016304A (pt) Formulação de solução aquosa de interferon estável, método de preparação e usos para a mesma
CO5150202A1 (es) Composicion de tisu facial y metodo para usarla para el secuestro de irritantes de la piel de la secrecion nasal
ATE173148T1 (de) Kombinationspräparat zur förderung des haarwachstums und ggf. des haut- und nagelwachstums sowie zur verhinderung bzw. zur beseitigung von haarausfall
BR9906372A (pt) Composição farmaceutica aquosa para aplicação na mucosa
BR0011116A (pt) Usos de uma nsaid que libera no como um sal farmaceuticamente aceitável ou um enanciÈmero do mesmo, e de uma nsaid que libera no e de um inibidor de bomba de próton suscetìvel a ácido ou um sal do mesmo ou um enanciÈmero ou de um sal do enanciÈmero, método para o tratamento de uma infecção bacteriana, e, formulação farmacêutica adequada para uso no tratamento de infecções bacterianas
GR1002451B (el) Αντιφλεγμονωδεις συνθεσεις που εχουν ως βαση ενεργα συστατικα ορισμενων βοτανων χρησιμοποιουμενες για σκοπους ιατρικους και κτηνιατρικους, και μεθοδοι παρασκευης φαρμακων και σκευασματων για τους παραπανω σκοπους.
UA42028C2 (uk) ПРЕПАРАТ <font face="Symbol">a</font>-ІНТЕРФЕРОНУ У ВИГЛЯДІ СТАБІЛЬНОГО ВОДНОГО РОЗЧИНУ
BRPI0013010B8 (pt) formulação aquosa de cloreto de sódio de moxifloxacina, processo para sua preparação e aplicação da referida formulação, bem como preparado de combinação e aplicação de uma solução aquosa de cloridrato de moxifloxacina
BR9708858A (pt) Formulaç o farmacêutica e processos para preparar a mesma e para tratar um disturbio em um paciente afetável por hormônio de crescimento
BR9815255A (pt) Toxina de botulismo modificada, vacina oralcontra o botulismo, vacina oral contra umantìgeno selecionado e método para ministraroralmente um agente terapêutico a um animal
AR029623A1 (es) Composiciones farmaceuticas de eritropoyetina
PT914110E (pt) Metodo de modulacao da micro-circulacao
DK0910399T3 (da) Stabilt farmaceutisk BDNF-præparat
DK1098643T3 (da) Phenylacetylglutamin, phenylacetylisoglutamin og/eller phenylacetat til behandling af neoplastiske sygdomme
BRPI0014878B8 (pt) composição farmacêutica contendo ciclosonida para aplicação à mucosa
BRPI0416376A (pt) composições para a redução da colonização bacteriana e da invasão do snc e métodos de uso destes
BR9916893A (pt) Tratamento
ATE515258T1 (de) Mukosales verabreichungssytem
ATE395064T1 (de) Kombinationspräparate von 3-n- formylhydroxylaminopropylphosphonsäurederivaten oder 3-n- acetylhydroxylaminopropylphosphonsäurederivaten mit speziellen pharmazeutischen wirkstoffen
ATE205399T1 (de) Eine lagerstabile wässrige lösung zur infusion die einen thrombininhibitor enthält
ES2128353T3 (es) Composicion topica que contiene penciclovir.
SE8200748L (sv) Terapeutiskt medel
DK93091D0 (da) Laegemidler til behandling af toxoplasmose
ES2178798T3 (es) Medicamento nefroprotector.
ATE203903T1 (de) Delta-aminolävulinsäure enthaltendes arzneimittel

Legal Events

Date Code Title Description
B25D Requested change of name of applicant approved

Owner name: TIANJIN HUALIDA BIOTECHNOLOGY CO. LTD (CN)

Free format text: ALTERADO DE: TIANJIN HUALIDA BIOENGINEERING CO. LTD

B25G Requested change of headquarter approved

Owner name: TIANJIN HUALIDA BIOTECHNOLOGY CO. LTD (CN)

Free format text: ALTERADA A SEDE DO TITULAR CONFORME SOLICITADO NA PETICAO NO 005440/SP DE 26/03/2004.

B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B11E Dismissal acc. art. 34 of ipl - requirements for examination incomplete
B11T Dismissal of application maintained [chapter 11.20 patent gazette]