BR0011247A - Derivados (benzodioxano, benzofurano ou benzopirano) de pirrolidinila, piperidinila ou homopiperidinila substituìdos - Google Patents
Derivados (benzodioxano, benzofurano ou benzopirano) de pirrolidinila, piperidinila ou homopiperidinila substituìdosInfo
- Publication number
- BR0011247A BR0011247A BR0011247-0A BR0011247A BR0011247A BR 0011247 A BR0011247 A BR 0011247A BR 0011247 A BR0011247 A BR 0011247A BR 0011247 A BR0011247 A BR 0011247A
- Authority
- BR
- Brazil
- Prior art keywords
- alkyl
- substituted
- hydrogen
- cycloalkyl
- formula
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Nutrition Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Patente de Invenção: "DERIVADOS (BENZODIOXANO, BENZOFURANO OU BENZOPIRANO) DE PIRROLIDINILA, PIPERIDINILA OU HOMOPIPERIDINILA SUBSTITUìDOS". A presente invenção refere-se a compostos de fórmula (I), uma forma estereoquimicamente isomérica dos mesmos, uma forma N- óxido dos mesmos ou um sal de adição de ácido farmaceuticamente aceitável dos mesmos, em que -Z^ 1^-Z^ 2^- é um radical bivalente; R^ 1^, R^ 2^ e R^ 3^ são cada um independentemente selecionados dentre hidrogênio, C^ 1-6^ alquila, hidróxi, halo e outros; ou quando R^ 1^ e R^ 2^ estão em átomos de carbono adjacentes, R^ 1^ e R^ 2^ tomados juntos podem formar um radical bivalente de fórmula; Alk é C~ 1-6~ alcanodiila opcionalmente substituída; o radical bivalente (a) é uma piperidinila substituída, uma pirrolidinila opcionalmente substituída, homopiperidinila, piperazinila ou tropila; R^ 5^ é um radical de fórmula (c-1), (c-2), (c-3), (c-4), (c-5), em que n é 1 ou 2; p^ 1^ é 0, e P^ 2 é 1 ou 2; ou p^ 1^ é 1 ou 2, e P^ 2^ é 0; X é oxigênio, enxofre ou =NR^ 9^; Y é oxigênio ou enxofre; R^ 7^ é hidrogênio, C~ 1-6~ alquila, C~ 3-6~ cicloalquila, fenila ou fenilmetila; R^ 8^ é C~ 1-6~ alquila, C~ 3-6~ cicloalquil fenila ou fenilmetila; R^ 9^ é ciano, C~ 1-6~ alquila, C~ 3-6~ ciclo-alquila, C~ 1-6~ alquiloxicarbonila ou aminocarbonila; R^ 10^ é hidrogênio OU C~ 1-6~ alquila; e Q é um radical bivalente. Processos para preparar referidos produtos, formulações compreendendo referidos produtos e seu uso como medicamento são descritos, em particular para tratar condições que estão relacionadas a relaxamento fúndico prejudicado.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP99201746 | 1999-06-02 | ||
| PCT/EP2000/004747 WO2000075137A1 (en) | 1999-06-02 | 2000-05-23 | Pyrrolidinyl, piperidinyl or homopiperidinyl substituted (benzodioxan, benzofuran or benzopyran) derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR0011247A true BR0011247A (pt) | 2002-03-05 |
Family
ID=8240259
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR0011247-0A BR0011247A (pt) | 1999-06-02 | 2000-05-23 | Derivados (benzodioxano, benzofurano ou benzopirano) de pirrolidinila, piperidinila ou homopiperidinila substituìdos |
Country Status (30)
| Country | Link |
|---|---|
| US (2) | US6900222B1 (pt) |
| EP (1) | EP1187831B1 (pt) |
| JP (1) | JP2003501428A (pt) |
| KR (1) | KR100702526B1 (pt) |
| CN (1) | CN1131862C (pt) |
| AR (1) | AR033645A1 (pt) |
| AT (1) | ATE279409T1 (pt) |
| AU (1) | AU777601B2 (pt) |
| BG (1) | BG65278B1 (pt) |
| BR (1) | BR0011247A (pt) |
| CA (1) | CA2374905C (pt) |
| CZ (1) | CZ20014167A3 (pt) |
| DE (1) | DE60014896T2 (pt) |
| EA (1) | EA004648B1 (pt) |
| EE (1) | EE04720B1 (pt) |
| ES (1) | ES2231189T3 (pt) |
| HR (1) | HRP20010869A2 (pt) |
| HU (1) | HUP0201344A3 (pt) |
| IL (1) | IL146824A0 (pt) |
| MX (1) | MXPA01012323A (pt) |
| MY (1) | MY120617A (pt) |
| NO (1) | NO319950B1 (pt) |
| NZ (1) | NZ515478A (pt) |
| PL (1) | PL198532B1 (pt) |
| SK (1) | SK286159B6 (pt) |
| TR (1) | TR200103433T2 (pt) |
| TW (1) | TW575571B (pt) |
| UA (1) | UA73123C2 (pt) |
| WO (1) | WO2000075137A1 (pt) |
| ZA (1) | ZA200109863B (pt) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MXPA01012330A (es) | 1999-06-02 | 2002-07-30 | Janssen Pharmaceutica Nv | Derivados (benzodioxano, benzofurano o benzopirano) aminoalquil sustituidos. |
| JO2352B1 (en) * | 2000-06-22 | 2006-12-12 | جانسين فارماسيوتيكا ان. في | Compounds for the treatment of non-adaptation of the bottom of the uterus |
| JO2654B1 (en) | 2000-09-04 | 2012-06-17 | شركة جانسين فارماسوتيكا ان. في | Multiple aryl caroxa amides are useful as lipid - lowering agents |
| JO2409B1 (en) | 2000-11-21 | 2007-06-17 | شركة جانسين فارماسوتيكا ان. في | Second-phenyl carboxy amides are useful as lipid-lowering agents |
| CA2452596C (en) * | 2001-07-05 | 2010-12-21 | Takeda Chemical Industries, Ltd. | Benzo-fused 5-membered heterocyclic compounds, their production and use |
| EA009296B1 (ru) | 2003-04-24 | 2007-12-28 | Инсайт Корпорейшн | Производные азаспироалканов в качестве ингибиторов металлопротеаз |
| CN1696115B (zh) * | 2004-05-11 | 2010-06-09 | 中国科学院上海药物研究所 | 合成砌块4-取代基-4-氨基-哌啶衍生物、其制备方法和用途 |
| GB201612938D0 (en) * | 2016-07-26 | 2016-09-07 | Almac Discovery Ltd | Pharmaceutical compounds |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US19051A (en) * | 1858-01-05 | sloan | ||
| US3910930A (en) | 1973-01-04 | 1975-10-07 | Janssen Pharmaceutica Nv | 1-{55 1-{8 2-(1,4-Benzodioxan-2-yl)-2-hydroxyethyl{9 -4-piperidyl{56 -2-benzimidazolinones |
| US3929801A (en) | 1973-11-20 | 1975-12-30 | Janssen Pharmaceutica Nv | 2-Benzimidazolinones |
| GR71865B (pt) | 1978-03-20 | 1983-07-07 | Ciba Geigy | |
| ES469096A1 (es) | 1978-04-24 | 1978-11-16 | Antibioticos Sa | Un procedimiento para la preparacion dos sustancialmente insolubles en agua. |
| DE2852945A1 (de) | 1978-12-07 | 1980-06-26 | Boehringer Sohn Ingelheim | Benzodioxanyl-hydroxyaethylpiperidyl- imidazolidinone, verfahren zu ihrer herstellung und diese enthaltende arzneimittel |
| US4329348A (en) | 1979-02-26 | 1982-05-11 | Ciba-Geigy Corporation | N-Oxacyclic-alkylpiperidines as psychostimulants |
| DE3124366A1 (de) | 1981-06-20 | 1982-12-30 | Hoechst Ag, 6000 Frankfurt | N-oxacyclyl-alkylpiperidin-derivate, verfahren zu ihrer herstellung, sie enthaltende pharmazeutische praeparate und deren verwendung |
| FR2533584B1 (fr) | 1982-09-28 | 1986-03-21 | Pasteur Institut | Procede de detection du pouvoir mutagene de substances, susceptibles d'induire la deterioration d'adn cellulaires, mettant en jeu la production d'une reponse sos |
| DE3901814A1 (de) | 1988-07-28 | 1990-02-01 | Bayer Ag | Substituierte aminomethylzetraline sowie ihre heterocyclischen analoga |
| DE4140540A1 (de) | 1991-12-09 | 1993-06-17 | Bayer Ag | Neue azaheterocyclylmethyl-chromane |
| SI9300097B (en) | 1992-02-27 | 2001-12-31 | Janssen Pharmaceutica Nv | (benzodioxan, benzofuran or benzopyran) alkylamino) alkyl substituted guanidines |
| DE4319038A1 (de) | 1993-06-08 | 1994-12-15 | Bayer Ag | Verwendung von teilweise bekannten substituierten Chromanen als Arzneimittel, neue Wirkstoffe und Verfahren zu ihrer Herstellung |
| SK282402B6 (sk) | 1993-08-19 | 2002-01-07 | Janssen Pharmaceutica N. V. | Deriváty dihydrobenzopyránu, spôsob a medziprodukty na ich výrobu, ich použitie a farmaceutický prostriedok na ich báze |
| US5541199A (en) | 1995-06-02 | 1996-07-30 | American Home Products Corporation | Chroman-2-ylmethylamino derivatives |
| FR2744451B1 (fr) * | 1996-02-01 | 1998-04-24 | Pf Medicament | Nouvelles imidazolidinones, pyrimidinones, et 1,3-diazepin-2 -ones, leur preparation et leurs applications en therapeutique |
| US6133277A (en) | 1997-12-05 | 2000-10-17 | Janssen Pharmaceutica N.V. | (Benzodioxan, benzofuran or benzopyran) derivatives having fundic relaxation properties |
| MXPA01012330A (es) | 1999-06-02 | 2002-07-30 | Janssen Pharmaceutica Nv | Derivados (benzodioxano, benzofurano o benzopirano) aminoalquil sustituidos. |
| JO2352B1 (en) | 2000-06-22 | 2006-12-12 | جانسين فارماسيوتيكا ان. في | Compounds for the treatment of non-adaptation of the bottom of the uterus |
-
2000
- 2000-05-23 BR BR0011247-0A patent/BR0011247A/pt not_active Application Discontinuation
- 2000-05-23 IL IL14682400A patent/IL146824A0/xx not_active IP Right Cessation
- 2000-05-23 AU AU45685/00A patent/AU777601B2/en not_active Ceased
- 2000-05-23 HU HU0201344A patent/HUP0201344A3/hu unknown
- 2000-05-23 MX MXPA01012323A patent/MXPA01012323A/es active IP Right Grant
- 2000-05-23 US US09/980,451 patent/US6900222B1/en not_active Expired - Lifetime
- 2000-05-23 ES ES00927243T patent/ES2231189T3/es not_active Expired - Lifetime
- 2000-05-23 EE EEP200100640A patent/EE04720B1/xx not_active IP Right Cessation
- 2000-05-23 CN CN008083177A patent/CN1131862C/zh not_active Expired - Fee Related
- 2000-05-23 DE DE60014896T patent/DE60014896T2/de not_active Expired - Lifetime
- 2000-05-23 EP EP00927243A patent/EP1187831B1/en not_active Expired - Lifetime
- 2000-05-23 SK SK1692-2001A patent/SK286159B6/sk not_active IP Right Cessation
- 2000-05-23 UA UA2001128826A patent/UA73123C2/uk unknown
- 2000-05-23 CA CA2374905A patent/CA2374905C/en not_active Expired - Lifetime
- 2000-05-23 EA EA200101237A patent/EA004648B1/ru not_active IP Right Cessation
- 2000-05-23 WO PCT/EP2000/004747 patent/WO2000075137A1/en active IP Right Grant
- 2000-05-23 JP JP2001502420A patent/JP2003501428A/ja not_active Withdrawn
- 2000-05-23 TR TR2001/03433T patent/TR200103433T2/xx unknown
- 2000-05-23 AT AT00927243T patent/ATE279409T1/de not_active IP Right Cessation
- 2000-05-23 CZ CZ20014167A patent/CZ20014167A3/cs unknown
- 2000-05-23 KR KR1020017014585A patent/KR100702526B1/ko not_active IP Right Cessation
- 2000-05-23 PL PL352063A patent/PL198532B1/pl not_active IP Right Cessation
- 2000-05-23 NZ NZ515478A patent/NZ515478A/xx unknown
- 2000-05-24 TW TW89109976A patent/TW575571B/zh not_active IP Right Cessation
- 2000-05-30 MY MYPI20002410A patent/MY120617A/en unknown
- 2000-06-01 AR ARP000102715A patent/AR033645A1/es active IP Right Grant
-
2001
- 2001-11-22 HR HR20010869A patent/HRP20010869A2/hr not_active Application Discontinuation
- 2001-11-28 BG BG106157A patent/BG65278B1/bg unknown
- 2001-11-29 ZA ZA200109863A patent/ZA200109863B/xx unknown
- 2001-11-30 NO NO20015865A patent/NO319950B1/no not_active IP Right Cessation
-
2005
- 2005-03-14 US US11/079,606 patent/US7358239B2/en not_active Expired - Fee Related
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
| B15K | Others concerning applications: alteration of classification |
Free format text: ALTERADA DE INT.CL: C07D 405/14, C07D 405/12, A61K 31/505, A61P 9/00 Ipc: A61K 31/513 (2009.01), A61P 1/06 (2009.01), A61P 1 |
|
| B11B | Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements |