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BR0010256A - Composto, processo para a preparação de um composto, formulação farmacêutica, uso de um composto, método de tratamento ou profilaxia de condições associadas com a inibição da carboxipeptidase u, kit de partes, e, método de tratamento de um paciente sofrendo de ou susceptìvel a uma condição em que a inibição da carboxipeptidase u e um mecanismo antitrombótico diferente são necessários - Google Patents

Composto, processo para a preparação de um composto, formulação farmacêutica, uso de um composto, método de tratamento ou profilaxia de condições associadas com a inibição da carboxipeptidase u, kit de partes, e, método de tratamento de um paciente sofrendo de ou susceptìvel a uma condição em que a inibição da carboxipeptidase u e um mecanismo antitrombótico diferente são necessários

Info

Publication number
BR0010256A
BR0010256A BR0010256-3A BR0010256A BR0010256A BR 0010256 A BR0010256 A BR 0010256A BR 0010256 A BR0010256 A BR 0010256A BR 0010256 A BR0010256 A BR 0010256A
Authority
BR
Brazil
Prior art keywords
compound
treatment
carboxypeptidase
inhibition
preparation
Prior art date
Application number
BR0010256-3A
Other languages
English (en)
Inventor
Marcel Linschoten
Magnus Polla
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of BR0010256A publication Critical patent/BR0010256A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/34—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55—Protease inhibitors
    • A61K38/57—Protease inhibitors from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/132—Amines having two or more amino groups, e.g. spermidine, putrescine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
    • C07C211/02—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C211/09—Diamines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/55—Acids; Esters

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyridine Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)

Abstract

"COMPOSTO, PROCESSO PARA A PREPARAçãO DE UM COMPOSTO, FORMULAçãO FARMACêUTICA, USO DE UM COMPOSTO, MéTODO DE TRATAMENTO OU PROFILAXIA DE CONDIçõES ASSOCIADAS COM A INIBIçãO DA CARBOXIPEPTIDASE U, KIT DE PARTES, E, MéTODO DE TRATAMENTO DE UM PACIENTE SOFRENDO DE OU SUSCEPTìVEL A UMA CONDIçãO EM QUE A INIBIçãO DA CARBOXIPEPTIDASE U E UM MECANISMO ANTITROMBóTICO DIFERENTE SãO NECESSáRIOS A presente invenção refere-se a compostos de Fórmula (I) e a seus sais ou solvatos farmaceuticamente aceitáveis, ou solvatos de tais sais, compostos estes inibindo a carboxipeptidase U e, assim, podendo ser usados na prevenção e tratamento de doenças associadas com a carboxipeptidase U. Em outros aspectos, a invenção refere-se a compostos da invenção para uso em terapia; a processos para preparação de tais novos compostos; a composições farmacêuticas contendo pelo menos um composto da invenção, ou um seu sal ou solvato farmaceuticamente aceitável, como ingrediente ativo; e ao uso dos compostos ativos na manufatura de medicamentos para o uso médico indicado acima.
BR0010256-3A 1999-05-03 2000-05-03 Composto, processo para a preparação de um composto, formulação farmacêutica, uso de um composto, método de tratamento ou profilaxia de condições associadas com a inibição da carboxipeptidase u, kit de partes, e, método de tratamento de um paciente sofrendo de ou susceptìvel a uma condição em que a inibição da carboxipeptidase u e um mecanismo antitrombótico diferente são necessários BR0010256A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE9901572A SE9901572D0 (sv) 1999-05-03 1999-05-03 New compounds
PCT/SE2000/000846 WO2000066550A1 (en) 1999-05-03 2000-05-03 New compounds

Publications (1)

Publication Number Publication Date
BR0010256A true BR0010256A (pt) 2002-02-13

Family

ID=20415425

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0010256-3A BR0010256A (pt) 1999-05-03 2000-05-03 Composto, processo para a preparação de um composto, formulação farmacêutica, uso de um composto, método de tratamento ou profilaxia de condições associadas com a inibição da carboxipeptidase u, kit de partes, e, método de tratamento de um paciente sofrendo de ou susceptìvel a uma condição em que a inibição da carboxipeptidase u e um mecanismo antitrombótico diferente são necessários

Country Status (23)

Country Link
US (2) US7354895B1 (pt)
EP (1) EP1180099A1 (pt)
JP (1) JP4270759B2 (pt)
KR (1) KR20020010631A (pt)
CN (1) CN1358187A (pt)
AR (1) AR028826A1 (pt)
AU (1) AU4447100A (pt)
BR (1) BR0010256A (pt)
CA (1) CA2371215A1 (pt)
CZ (1) CZ20013931A3 (pt)
EE (1) EE200100573A (pt)
HK (1) HK1042493A1 (pt)
HU (1) HUP0202379A3 (pt)
IL (1) IL145953A0 (pt)
IS (1) IS6141A (pt)
MX (1) MXPA01011043A (pt)
NO (1) NO20015374L (pt)
PL (1) PL356140A1 (pt)
SE (1) SE9901572D0 (pt)
SK (1) SK15662001A3 (pt)
TR (1) TR200103144T2 (pt)
WO (1) WO2000066550A1 (pt)
ZA (2) ZA200108967B (pt)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100681632B1 (ko) * 1999-09-14 2007-02-09 메이지 세이카 가이샤 리미티드 카르복시펩티다아제 ｂ 저해활성을 갖는 포스폰산 유도체
EE200300070A (et) * 2000-08-17 2005-02-15 Pfizer Inc. Asendatud imidasoolid kui TAFIa inhibiitorid
SE0103272D0 (sv) 2001-09-28 2001-09-28 Astrazeneca Ab Chemical compounds
MXPA04006573A (es) * 2002-01-22 2004-10-04 Pfizer Acidos 3-(imidazolil)-2-alcoxipropanoicos.
WO2003061653A1 (en) 2002-01-22 2003-07-31 Pfizer Limited 3-(imidazolyl)-2-aminopropanoic acids for use as tafi-a inhibitors for the treatment of thrombotic diseases
US6713496B2 (en) 2002-01-22 2004-03-30 Pfizer Inc 3-(imidazolyl)-2-alkoxypropanoic acids
CN1332964C (zh) 2002-03-21 2007-08-22 舍林股份公司 血浆羧肽酶b抑制剂
AU2009310841A1 (en) 2008-10-29 2010-05-06 Taisho Pharmaceutical Co., Ltd. Compounds having TAFIa inhibitory activity
ES2960034T3 (es) * 2019-02-08 2024-02-29 Astrazeneca Ab Inhibidores de la arginasa y métodos de uso de los mismos
CN111110837B (zh) * 2020-01-06 2022-11-25 中国人民解放军陆军军医大学 一种羧肽酶抑制剂在制备预防重症致死性轮状病毒感染药物中的应用

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US4849414A (en) * 1986-06-11 1989-07-18 E. R. Squibb & Sons, Inc. Substituted aminoalkanoylaminoalkyl phosphonate angiotensin converting enzyme inhibitors
FR2610951B1 (fr) * 1987-02-17 1989-05-05 Aerospatiale Armature tissee pour materiau composite
IL86951A (en) * 1987-07-06 1996-07-23 Procter & Gamble Pharma Methylene phosphonoalkylphosphinates and pharmaceutical preparations containing them
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UA58543C2 (uk) 1997-02-27 2003-08-15 Амерікан Ціанамід Компані N-гідрокси-2-(алкіл-, арил-, або гетероарилсульфаніл, -сульфініл або -сульфоніл)-3-заміщені алкіл-, арил- або гетероариламіди як інгібітори матричних металопротеїназ
AR023819A1 (es) * 1999-05-03 2002-09-04 Astrazeneca Ab FORMULACIoN FARMACEUTICA, KIT DE PARTES Y UTILIZACION DE DICHA FORMULACION
SE9901573D0 (sv) * 1999-05-03 1999-05-03 Astra Ab New compounds
KR100681632B1 (ko) * 1999-09-14 2007-02-09 메이지 세이카 가이샤 리미티드 카르복시펩티다아제 ｂ 저해활성을 갖는 포스폰산 유도체

Also Published As

Publication number Publication date
NO20015374D0 (no) 2001-11-02
EP1180099A1 (en) 2002-02-20
HUP0202379A3 (en) 2003-04-28
AU4447100A (en) 2000-11-17
TR200103144T2 (tr) 2004-11-22
HK1042493A1 (zh) 2002-08-16
MXPA01011043A (es) 2002-06-04
EE200100573A (et) 2003-02-17
US20060079484A1 (en) 2006-04-13
ZA200108966B (en) 2003-01-30
US7354895B1 (en) 2008-04-08
WO2000066550A8 (en) 2001-01-25
JP2002543179A (ja) 2002-12-17
IL145953A0 (en) 2002-11-10
IS6141A (is) 2001-11-01
US7423012B2 (en) 2008-09-09
WO2000066550A1 (en) 2000-11-09
JP4270759B2 (ja) 2009-06-03
CA2371215A1 (en) 2000-11-09
PL356140A1 (en) 2004-06-14
AR028826A1 (es) 2003-05-28
SE9901572D0 (sv) 1999-05-03
CN1358187A (zh) 2002-07-10
HUP0202379A2 (hu) 2002-12-28
KR20020010631A (ko) 2002-02-04
SK15662001A3 (sk) 2002-09-10
CZ20013931A3 (cs) 2002-04-17
NO20015374L (no) 2001-11-02
ZA200108967B (en) 2003-01-30

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