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BG95635A - Хидроксиапатит-антиген конюгати и метод за пораждане на поли-ig имунен отговор - Google Patents

Хидроксиапатит-антиген конюгати и метод за пораждане на поли-ig имунен отговор

Info

Publication number
BG95635A
BG95635A BG095635A BG9563591A BG95635A BG 95635 A BG95635 A BG 95635A BG 095635 A BG095635 A BG 095635A BG 9563591 A BG9563591 A BG 9563591A BG 95635 A BG95635 A BG 95635A
Authority
BG
Bulgaria
Prior art keywords
hydroxyapatite
gendering
poly
immune response
antigen
Prior art date
Application number
BG095635A
Other languages
English (en)
Other versions
BG60371B1 (bg
Inventor
Jean-Pierre Kraehenbuhl
Helen Amerongen
Marian Neutra
Original Assignee
Institut Suisse De Recherches Experimentales Sur Lecancer
President And Fellows Of Harvard College
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Institut Suisse De Recherches Experimentales Sur Lecancer, President And Fellows Of Harvard College filed Critical Institut Suisse De Recherches Experimentales Sur Lecancer
Publication of BG95635A publication Critical patent/BG95635A/bg
Publication of BG60371B1 publication Critical patent/BG60371B1/bg

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/52—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an inorganic compound, e.g. an inorganic ion that is complexed with the active ingredient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A61K2039/541—Mucosal route
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55505—Inorganic adjuvants

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Inorganic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Virology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Saccharide Compounds (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Изобретението се отнася до метод за пораждане на антигенчувствителни ig -а -продуциращи лимфобласти в бозайници, като се използва имуногенсъдържащ антиген или антигенна смес заедно с хидроксилиран калциев фосфат /хидроксиапатит/, който антиген се прилага върху повърхността на лигавица на бозайника. 13 претенции
BG95635A 1990-04-16 1991-12-16 ХИДРОКСИАПАТИТАНТИГЕН КОНЮГАТИ И МЕТОД ЗА ПОРАЖДАНЕ НА ПОЛИ-Ig ИМУНЕН ОТГОВОР BG60371B1 (bg)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/510,154 US5443832A (en) 1990-04-16 1990-04-16 Hydroxyapatite-antigen conjugates and methods for generating a poly-Ig immune response
PCT/US1991/002599 WO1991016072A1 (en) 1990-04-16 1991-04-16 Hydroxyapatite-antigen conjugates and methods for generating a poly-ig immune response

Publications (2)

Publication Number Publication Date
BG95635A true BG95635A (bg) 1993-12-24
BG60371B1 BG60371B1 (bg) 1994-11-15

Family

ID=24029591

Family Applications (1)

Application Number Title Priority Date Filing Date
BG95635A BG60371B1 (bg) 1990-04-16 1991-12-16 ХИДРОКСИАПАТИТАНТИГЕН КОНЮГАТИ И МЕТОД ЗА ПОРАЖДАНЕ НА ПОЛИ-Ig ИМУНЕН ОТГОВОР

Country Status (16)

Country Link
US (2) US5443832A (bg)
EP (1) EP0477339B1 (bg)
JP (1) JPH04507106A (bg)
KR (1) KR100188836B1 (bg)
AT (1) ATE144428T1 (bg)
AU (1) AU643011B2 (bg)
BG (1) BG60371B1 (bg)
BR (1) BR9105718A (bg)
CA (1) CA2060318A1 (bg)
DE (1) DE69122828T2 (bg)
HU (1) HU216103B (bg)
OA (1) OA09525A (bg)
RO (1) RO109817B1 (bg)
RU (1) RU2126270C1 (bg)
WO (1) WO1991016072A1 (bg)
ZA (1) ZA912838B (bg)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5443832A (en) * 1990-04-16 1995-08-22 Institut Swisse De Recherches Experimentales Sur Le Cancer Hydroxyapatite-antigen conjugates and methods for generating a poly-Ig immune response
GB2245559A (en) * 1990-06-25 1992-01-08 Farmos Oy Bioceramic system for delivery of a bioactive compound.
US5972336A (en) * 1992-11-03 1999-10-26 Oravax Merieux Co. Urease-based vaccine against helicobacter infection
US6290962B1 (en) 1992-11-03 2001-09-18 Oravax, Inc. Urease-based vaccine and treatment for helicobacter infection
US6440425B1 (en) 1995-05-01 2002-08-27 Aventis Pasteur Limited High molecular weight major outer membrane protein of moraxella
US8333996B2 (en) * 1995-05-19 2012-12-18 Etex Corporation Calcium phosphate delivery vehicle and adjuvant
US6290970B1 (en) * 1995-10-11 2001-09-18 Aventis Pasteur Limited Transferrin receptor protein of Moraxella
JPH107575A (ja) * 1996-06-21 1998-01-13 Synsorb Biotec Inc 細菌性赤痢の処置
AU733712B2 (en) * 1996-06-21 2001-05-24 Synsorb Biotech Inc. Use of oligosaccharides for neutralising E. coli toxins
US8728536B2 (en) * 1996-10-16 2014-05-20 Etex Corporation Chemotherapeutic composition using nanocrystalline calcium phosphate paste
AU771552B2 (en) * 1999-02-05 2004-03-25 Alk-Abello A/S Novel mucosal delivery system
US20020051794A1 (en) * 2000-08-09 2002-05-02 Alk-Abello A/S Novel parenteral vaccine formulations and uses thereof
AU2006204620B2 (en) * 2000-09-14 2008-05-29 Px Biosolutions Pty Ltd Composition comprising immunogenic nanoparticles
AUPR011700A0 (en) 2000-09-14 2000-10-05 Austin Research Institute, The Composition comprising immunogenic virus sized particles (VSP)
WO2002065981A2 (en) * 2000-10-20 2002-08-29 Etex Corporation Chemotherapeutic composition using calcium phosphate paste
EP3254710B1 (en) * 2003-04-11 2019-05-22 Etex Corporation Osteoinductive bone material
WO2005074991A1 (ja) * 2004-02-09 2005-08-18 Kabushiki Kaisha Sangi 抗腫瘍剤
JPWO2005100398A1 (ja) * 2004-04-14 2008-03-06 株式会社 バイオマトリックス研究所 抗体ライブラリー作製方法
CA2562675A1 (en) * 2004-04-15 2005-12-15 Etex Corporation Delayed-setting calcium phosphate pastes
US20060115499A1 (en) * 2004-09-27 2006-06-01 Alk-Abello A/S Liquid allergy vaccine formulation for oromucosal administration
JPWO2006038315A1 (ja) * 2004-10-07 2008-07-31 株式会社サンギ 経皮・経粘膜吸収製剤
JP5097540B2 (ja) * 2005-04-06 2012-12-12 株式会社サンギ 腸管吸収用抗腫瘍剤
FR2885525B1 (fr) * 2005-05-13 2009-09-18 Urodelia Sa Medicament notamment anti-cancereux, destine a des traitements par immunotherapie, en particulier autologue
WO2007053781A2 (en) * 2005-11-01 2007-05-10 Novartis Ag Compositions with antigens adsorbed to calcium phosphate
DK1951299T3 (da) 2005-11-04 2012-04-02 Novartis Vaccines & Diagnostic Influenzavacciner indeholdende kombinationer af partikelformige adjuvanser og immunforstærkere
US8147860B2 (en) 2005-12-06 2012-04-03 Etex Corporation Porous calcium phosphate bone material
US8685654B2 (en) * 2007-12-24 2014-04-01 Novartis Ag Assays for adsorbed influenza vaccines
GB201319548D0 (en) * 2013-11-05 2013-12-18 Medical Res Council Amorphous magnesium-substituted calcium phosphate compositions and their uses
TWI654993B (zh) * 2016-11-04 2019-04-01 National Health Research Institutes 陽離子型生物可降解性陶瓷聚合物微粒子用以遞送疫苗之用途

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US4016252A (en) * 1972-04-06 1977-04-05 Institut Pasteur Calcium phosphate gel for adsorbing vaccines
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JPS62248487A (ja) * 1986-04-22 1987-10-29 Dentaru Kagaku Kk グルカナーゼを固定化したアパタイトおよびその製造法
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US5443832A (en) * 1990-04-16 1995-08-22 Institut Swisse De Recherches Experimentales Sur Le Cancer Hydroxyapatite-antigen conjugates and methods for generating a poly-Ig immune response

Also Published As

Publication number Publication date
OA09525A (en) 1992-11-15
EP0477339A1 (en) 1992-04-01
BR9105718A (pt) 1992-07-21
BG60371B1 (bg) 1994-11-15
EP0477339B1 (en) 1996-10-23
AU7684991A (en) 1991-11-11
WO1991016072A1 (en) 1991-10-31
EP0477339A4 (en) 1993-04-21
KR920702628A (ko) 1992-10-06
CA2060318A1 (en) 1991-10-17
KR100188836B1 (ko) 1999-06-01
DE69122828T2 (de) 1997-05-28
RO109817B1 (ro) 1995-06-30
DE69122828D1 (de) 1996-11-28
HUT63337A (en) 1993-08-30
US6541000B1 (en) 2003-04-01
JPH04507106A (ja) 1992-12-10
US5443832A (en) 1995-08-22
HU216103B (hu) 1999-04-28
RU2126270C1 (ru) 1999-02-20
ATE144428T1 (de) 1996-11-15
HU9200135D0 (en) 1992-04-28
AU643011B2 (en) 1993-11-04
ZA912838B (en) 1992-03-25

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