BG20106A3 - Метод за получаване на несиметрични 1,4- дехидропиридини - Google Patents

Метод за получаване на несиметрични 1,4- дехидропиридини

Info

Publication number: BG20106A3
Authority: BG; Bulgaria
Prior art keywords: dehydropyridines; unsymmetrical; obtaining; obtaining unsymmetrical
Prior art date: 1971-04-10

Application number

BG023739A

Other languages

English (en)

Inventor

Horst Meyer

Fridrich Bossert

Wulf Valter

Kurt Stoepel

Original Assignee

Bayer Aktiengesellschaft

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1971-04-10

Filing date

1972-04-06

Publication date

1975-10-30

1972-04-06 Application filed by Bayer Aktiengesellschaft filed Critical Bayer Aktiengesellschaft

1975-10-30 Publication of BG20106A3 publication Critical patent/BG20106A3/bg

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/455—Nicotinic acids, e.g. niacin; Derivatives thereof, e.g. esters, amides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
- C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Public Health (AREA)
Epidemiology (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Hydrogenated Pyridines (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Pyridine Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Peptides Or Proteins (AREA)

BG023739A 1971-04-10 1972-04-06 Метод за получаване на несиметрични 1,4- дехидропиридини BG20106A3 (bg)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE2117572A DE2117572C3 (de)	1971-04-10	1971-04-10	Unsymmetrische 1,4-Dihydropyridin ^-dicarbonsäureester, Verfahren zu ihrer Herstellung sowie ihre Verwendung als Arzneimittel

Publications (1)

Publication Number	Publication Date
BG20106A3 true BG20106A3 (bg)	1975-10-30

Family

ID=5804434

Family Applications (4)

Application Number	Title	Priority Date	Filing Date
BG023740A BG19374A3 (bg)	1971-04-10	1972-04-06	Метод за получаване на несиметрични 1,4- дехидропиридини
BG020165A BG20353A3 (bg)	1971-04-10	1972-04-06	Метод за получаване на несиметрични 1,4-дихидропиридини
BG023739A BG20106A3 (bg)	1971-04-10	1972-04-06	Метод за получаване на несиметрични 1,4- дехидропиридини
BG23738A BG19595A3 (bg)	1971-04-10	1972-04-06

Family Applications Before (2)

Application Number	Title	Priority Date	Filing Date
BG023740A BG19374A3 (bg)	1971-04-10	1972-04-06	Метод за получаване на несиметрични 1,4- дехидропиридини
BG020165A BG20353A3 (bg)	1971-04-10	1972-04-06	Метод за получаване на несиметрични 1,4-дихидропиридини

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
BG23738A BG19595A3 (bg)	1971-04-10	1972-04-06

Country Status (27)

Country	Link
US (1)	US3799936A (bg)
JP (1)	JPS5527054B1 (bg)
AT (1)	AT316552B (bg)
AU (1)	AU459338B2 (bg)
BE (1)	BE781879A (bg)
BG (4)	BG19374A3 (bg)
CA (1)	CA925513A (bg)
CH (2)	CH571493A5 (bg)
CS (2)	CS177821B2 (bg)
DD (1)	DD104519A5 (bg)
DE (1)	DE2117572C3 (bg)
DK (1)	DK132321C (bg)
ES (1)	ES401615A1 (bg)
FI (1)	FI55187C (bg)
FR (1)	FR2132831B1 (bg)
GB (1)	GB1331405A (bg)
HU (1)	HU165875B (bg)
IE (1)	IE36947B1 (bg)
IL (1)	IL39170A (bg)
LU (1)	LU65129A1 (bg)
NL (1)	NL170140C (bg)
NO (1)	NO133711C (bg)
PL (2)	PL84571B1 (bg)
RO (2)	RO59959A (bg)
SE (1)	SE371824B (bg)
SU (2)	SU475771A3 (bg)
ZA (1)	ZA722355B (bg)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3887558A (en) *	1972-03-06	1975-06-03	Bayer Ag	Process for producing 2,6-diamino -1,4- dihydro-3,5-pyridine-dicarboxylates and derivatives thereof
US3935223A (en) *	1972-03-06	1976-01-27	Bayer Aktiengesellschaft	2-Amino-1,4-dihydropyridine derivatives
US3939171A (en) *	1972-03-06	1976-02-17	Bayer Aktiengesellschaft	2-Amino-1,4-dihydropyridine derivatives
US3917619A (en) *	1972-03-06	1975-11-04	Bayer Ag	2-Amino-4,5-dihydropyridine derivatives
US3988458A (en) *	1972-03-06	1976-10-26	Bayer Aktiengesellschaft	Bicyclic derivatives of 1,4-dihydropyridine 3,5-carboxylic acid esters
US3920823A (en) *	1972-03-06	1975-11-18	Bayer Ag	Use of unsymmetrical esters of n-substituted 1,4-dihydropyridine 3,5-dicarboxylic acid as cardio-vascular agents
DD106832A5 (bg) *	1972-03-06	1974-07-05
US3857849A (en) *	1973-02-28	1974-12-31	Bayer Ag	2-amino-1,4-dihydropyridine derivatives
DE2210674C3 (de) *	1972-03-06	1981-09-24	Bayer Ag, 5090 Leverkusen	2-Amino-6-methyl-1,4-dihydropyridine, Verfahren zu ihrer Herstellung und sie enthaltende Arzneimittel
US4001258A (en) *	1972-03-06	1977-01-04	Bayer Aktiengesellschaft	2-amino-1,4-dihydropyridine derivatives
DE2210672C3 (de) *	1972-03-06	1980-03-20	Bayer Ag, 5090 Leverkusen	N-substituierte unsymmetrische 1 ^-Dihydropyridin-S^-dicarbonsäureester, Verfahren zu ihrer Herstellung sowie ihre Verwendung als Arzneimittel
US3917622A (en) *	1972-03-06	1975-11-04	Bayer Ag	2-Amino-1,4-dihydropyridine derivatives
US3917620A (en) *	1972-03-06	1975-11-04	Bayer Ag	2-Amino-4,5-dihydropyridine derivatives
US3989708A (en) *	1972-08-31	1976-11-02	Bayer Aktiengesellschaft	2-Amino-1,4-dihydropyridine derivatives
DE2242786A1 (de) *	1972-08-31	1974-03-14	Bayer Ag	Verfahren zur herstellung von neuen 2-amino-1,4-dihydropyridinen mit einer carbonylfunktion sowie ihre verwendung als arzneimittel
DE2248150A1 (de) *	1972-09-30	1974-04-04	Bayer Ag	Dihydropyridinpolyester, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
GB1409865A (en) *	1973-02-13	1975-10-15	Science Union & Cie	Dihydropyridines derivatives their preparation and pharmaceu tical compositions containing them
DK152285C (da) *	1975-07-02	1988-10-10	Fujisawa Pharmaceutical Co	Analogifremgangsmaade til fremstilling af 1,4-dihydropyridinderivater
FR2405937A1 (fr) *	1977-10-14	1979-05-11	Labaz	Nouveaux derives de dihydropyridine, leur procede de preparation et leur application
SE429652B (sv) *	1978-06-30	1983-09-19	Haessle Ab	2.6-dimetyl-4-(2.3-diklorfenyl)-1.4-dihydropyridin-3.5-dikarboxylsyra-3-metylester-5-etylester
SE7910521L (sv) *	1979-12-20	1981-06-21	Haessle Ab	Nya 2-metyl-6-substituerade-4-(2,3-disubstituerad fenyl)-1,4-dihydropyridin-3,5-diestrar med hypotesiva egenskaper, samt forfarande for deras framstellning, och farmaceutiska beredningar innehallande desamma
JPS60120861A (ja) *	1983-12-02	1985-06-28	Otsuka Pharmaceut Co Ltd	ジヒドロピリジン誘導体
IE57810B1 (en) *	1984-03-27	1993-04-21	Delagrange Lab	1,4-dihydropyridine derivatives,their preparation and their use
JPS6143165A (ja) *	1984-08-07	1986-03-01	Otsuka Pharmaceut Co Ltd	ジヒドロピリジン誘導体の製造法
US5571827A (en) *	1990-03-13	1996-11-05	Sepracor Inc.	Methods and compositions for treating hypertension, angina and other disorders using optically pure s(-) nitrendipine
WO1993009774A1 (en) *	1991-11-18	1993-05-27	G.D. Searle & Co.	2-(4-substituted)phenylmethylene derivatives and methods of use
EE03192B1 (et) *	1993-12-10	1999-06-15	Bayer Aktiengesellschaft	Isopropüül-(2-metoksüetüül)-4-(2-kloro-3-tsüanofenüül)-1,4-dihüdro-2,6-dimetüülpüri diin-3,5-dikarboksülaat, selle enantiomeerid ja vaheühend, meetodid nimetatud ühendite valmistamiseks ja kasutamine
ATE234286T1 (de) *	1993-12-10	2003-03-15	Bayer Ag	Phenyl-substituierte 1,4-dihydropyridine mit cerebraler aktivität
DE19727350C1 (de) *	1997-06-27	1999-01-21	Bayer Ag	Verfahren zur Herstellung von Nifedipin

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE1923990C3 (de) *	1969-05-10	1978-11-23	Bayer Ag	Verfahren zur Herstellung von N-substituierten M-Dihydropyridin-S.S-dicarbonsäureestern

1971
- 1971-04-10 DE DE2117572A patent/DE2117572C3/de not_active Expired
1972
- 1972-03-09 CH CH1159775A patent/CH571493A5/xx not_active IP Right Cessation
- 1972-03-09 CH CH345972A patent/CH571491A5/xx not_active IP Right Cessation
- 1972-03-27 AU AU40454/72A patent/AU459338B2/en not_active Expired
- 1972-04-05 SU SU1932086A patent/SU475771A3/ru active
- 1972-04-05 SU SU1768162A patent/SU431671A3/ru active
- 1972-04-06 FI FI947/72A patent/FI55187C/fi active
- 1972-04-06 BG BG023740A patent/BG19374A3/bg unknown
- 1972-04-06 BG BG020165A patent/BG20353A3/bg unknown
- 1972-04-06 BG BG023739A patent/BG20106A3/bg unknown
- 1972-04-06 BG BG23738A patent/BG19595A3/xx unknown
- 1972-04-07 DK DK172272A patent/DK132321C/da not_active IP Right Cessation
- 1972-04-07 US US00242238A patent/US3799936A/en not_active Expired - Lifetime
- 1972-04-07 DD DD162141A patent/DD104519A5/xx unknown
- 1972-04-07 JP JP3450672A patent/JPS5527054B1/ja active Pending
- 1972-04-07 NL NLAANVRAGE7204694,A patent/NL170140C/xx not_active IP Right Cessation
- 1972-04-07 IE IE455/72A patent/IE36947B1/xx unknown
- 1972-04-07 NO NO1191/72A patent/NO133711C/no unknown
- 1972-04-07 ZA ZA722355A patent/ZA722355B/xx unknown
- 1972-04-07 AT AT301772A patent/AT316552B/de not_active IP Right Cessation
- 1972-04-07 LU LU65129D patent/LU65129A1/xx unknown
- 1972-04-08 PL PL1972154621A patent/PL84571B1/pl unknown
- 1972-04-08 PL PL1972175387A patent/PL92407B1/pl unknown
- 1972-04-08 ES ES401615A patent/ES401615A1/es not_active Expired
- 1972-04-10 CS CS2378A patent/CS177821B2/cs unknown
- 1972-04-10 CS CS3558A patent/CS177846B2/cs unknown
- 1972-04-10 BE BE781879A patent/BE781879A/xx not_active IP Right Cessation
- 1972-04-10 FR FR7212513A patent/FR2132831B1/fr not_active Expired
- 1972-04-10 RO RO197270489A patent/RO59959A/ro unknown
- 1972-04-10 RO RO197279438A patent/RO63113A/ro unknown
- 1972-04-10 CA CA139294A patent/CA925513A/en not_active Expired
- 1972-04-10 SE SE7204607A patent/SE371824B/xx unknown
- 1972-04-10 GB GB1646372A patent/GB1331405A/en not_active Expired
- 1972-04-10 IL IL7239170A patent/IL39170A/xx unknown
- 1972-04-10 HU HUBA2728A patent/HU165875B/hu unknown

Also Published As

Publication number	Publication date
BG19595A3 (bg)	1975-06-25
AT316552B (de)	1974-07-25
HU165875B (bg)	1974-12-28
SE371824B (bg)	1974-12-02
SU475771A3 (ru)	1975-06-30
IL39170A0 (en)	1972-06-28
FR2132831A1 (bg)	1972-11-24
FR2132831B1 (bg)	1975-12-26
DE2117572C3 (de)	1980-03-20
BG19374A3 (bg)	1975-06-15
GB1331405A (en)	1973-09-26
AU4045472A (en)	1973-10-04
CH571491A5 (bg)	1976-01-15
ES401615A1 (es)	1975-11-01
NO133711B (bg)	1976-03-08
IL39170A (en)	1975-04-25
RO59959A (bg)	1976-06-15
IE36947B1 (en)	1977-03-30
PL84571B1 (bg)	1976-04-30
US3799936A (en)	1974-03-26
CA925513A (en)	1973-05-01
BG20353A3 (bg)	1975-11-05
FI55187C (fi)	1979-06-11
AU459338B2 (en)	1975-03-05
CS177821B2 (bg)	1977-08-31
NL7204694A (bg)	1972-10-12
CH571493A5 (bg)	1976-01-15
LU65129A1 (bg)	1972-07-12
ZA722355B (en)	1972-12-27
FI55187B (fi)	1979-02-28
JPS5527054B1 (bg)	1980-07-17
DE2117572A1 (de)	1972-10-19
NL170140B (nl)	1982-05-03
SU431671A3 (bg)	1974-06-05
CS177846B2 (bg)	1977-08-31
NO133711C (bg)	1976-06-16
DE2117572B2 (bg)	1979-06-28
IE36947L (en)	1972-10-10
BE781879A (fr)	1972-10-10
DD104519A5 (bg)	1974-03-12
PL92407B1 (bg)	1977-04-30
RO63113A (fr)	1978-06-15
NL170140C (nl)	1982-10-01
DK132321B (da)	1975-11-24
DK132321C (da)	1976-04-26

Publication	Publication Date	Title
BG22827A3 (bg)	1977-04-20	Метод за получаване на 1,2,4-триазол-нуклеозиди
BG19374A3 (bg)	1975-06-15	Метод за получаване на несиметрични 1,4- дехидропиридини
BG21609A3 (bg)	1976-07-20	Метод за получаване на заместени бензинпеницилини
BG21599A3 (bg)	1976-07-20	Метод за получаване на 1,2,3-трихлорпропен
BG21027A3 (bg)	1976-01-20	Метод за получаване на изотиоцианобензазоли
BG19806A3 (bg)	1975-10-10	Метод за получаване на пиразоло-(1,5а)- пиримидини
BG19376A3 (bg)	1975-06-15	Метод за получаване на заместени бензилпеницилин
BG18872A3 (bg)	1975-03-20	Метод за получаване на 4-амино-1,2,4-триазин-5-они
BG20792A3 (bg)	1975-12-20	Метод за получаване на /2/ фурил - метил/ 6,7 бензоморфани
SU474150A3 (ru)	1975-06-14	Способ получени производных окса-1-диаза-3,8-спиро-(4,5)-декана
BG20336A3 (bg)	1975-11-05	Метод за получаване на 3-карбомоил-2.4.6- трийдефинил-алкилетери
BG26666A3 (bg)	1979-05-15	Метод за получаване на капролактам
BG19594A3 (bg)	1975-06-25	Метод за получаване на 1- ацетил-3- индолин- етаноли
BG20777A3 (bg)	1975-12-20	Метод за получаване на 4- /-4 -бифенилил/-1-бутанол
BG20410A3 (bg)	1975-11-05	Метод за получаване на 3,4-дихидро-2н- изохинолин-1-они
BG20562A3 (bg)	1975-12-05	Метод за получаване на халогенацетанилиди
BE789811A (fr)	1973-04-06	1,4-bis-acylpiperazines
FI56176B (fi)	1979-08-31	Foerfarande foer framstaellning av 2,4-diamino-5-bensylpyrimidiner
BG20605A3 (bg)	1975-12-05	Метод за получаване на заместени <2,3 д > пиримидини
SU430556A3 (ru)	1974-05-30	Способ получения полиарилен-1, 3, 4- -оксадиазолов
SU447884A3 (ru)	1974-10-25	Способ получения 3-циклопентилокси-7 -метил-3,16 ,17-триоксиэстратриенов
SE7601317L (sv)	1976-02-06	1,4-bensodiazepin-2-onderivat
SU444357A3 (ru)	1974-09-25	Способ получения 1,1-дигалоид3-арилпропена-1
SU474147A3 (ru)	1975-06-14	Способ получени 1,2-дигидро-2оксо-4-диалкиламино-пиримидо(4,5- )-хиноксалин-5,10-двуокисей
BG20776A3 (bg)	1975-12-20	Метод за получаване на 1,2,3-трихлорпропен