BG105268A - Compounds, compositions and methods for stimulating neuronal growth and elongation - Google Patents

Compounds, compositions and methods for stimulating neuronal growth and elongation

Info

Publication number: BG105268A
Authority: BG; Bulgaria
Prior art keywords: compounds; compositions; methods; elongation; neuronal growth
Prior art date: 1998-07-17

Application number

BG105268A

Other languages

Bulgarian (bg)

English (en)

Inventor

Susumu Katoh

Hiroshi Kawakami

Hiroki Tada

Maria LINTON

Original Assignee

Agouron Pharmaceuticals, Inc.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-07-17

Filing date

2001-02-16

Publication date

2001-11-30

2001-02-16 Application filed by Agouron Pharmaceuticals, Inc. filed Critical Agouron Pharmaceuticals, Inc.

2001-11-30 Publication of BG105268A publication Critical patent/BG105268A/xx

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Psychology (AREA)
Hospice & Palliative Care (AREA)
Psychiatry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Peptides Or Proteins (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

BG105268A 1998-07-17 2001-02-16 Compounds, compositions and methods for stimulating neuronal growth and elongation BG105268A (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US9329998P	1998-07-17	1998-07-17
US13288499P	1999-05-06	1999-05-06
PCT/US1999/015965 WO2000004020A1 (en)	1998-07-17	1999-07-15	Compounds, compositions, and methods for stimulating neuronal growth and elongation

Publications (1)

Publication Number	Publication Date
BG105268A true BG105268A (en)	2001-11-30

Family

ID=26787372

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BG105268A BG105268A (en)	1998-07-17	2001-02-16	Compounds, compositions and methods for stimulating neuronal growth and elongation

Country Status (35)

Country	Link
US (1)	US6630472B1 (lt)
EP (1)	EP1098897B1 (lt)
JP (1)	JP2002520413A (lt)
KR (1)	KR20010071920A (lt)
CN (1)	CN1318067A (lt)
AP (1)	AP2001002052A0 (lt)
AT (1)	ATE268772T1 (lt)
AU (1)	AU756912B2 (lt)
BG (1)	BG105268A (lt)
BR (1)	BR9912423A (lt)
CA (1)	CA2337377A1 (lt)
DE (1)	DE69917907T2 (lt)
DK (1)	DK1098897T3 (lt)
EA (1)	EA200100149A1 (lt)
EE (1)	EE200100032A (lt)
ES (1)	ES2226409T3 (lt)
GE (1)	GEP20043368B (lt)
HR (1)	HRP20010118A2 (lt)
HU (1)	HUP0200637A3 (lt)
ID (1)	ID27428A (lt)
IL (1)	IL140676A0 (lt)
IS (1)	IS5805A (lt)
LT (1)	LT4850B (lt)
LV (1)	LV12665B (lt)
NO (1)	NO20010191L (lt)
NZ (1)	NZ509211A (lt)
OA (1)	OA11581A (lt)
PL (1)	PL345598A1 (lt)
PT (1)	PT1098897E (lt)
SI (1)	SI20638A (lt)
SK (1)	SK462001A3 (lt)
TR (1)	TR200100122T2 (lt)
WO (1)	WO2000004020A1 (lt)
YU (1)	YU2901A (lt)
ZA (1)	ZA200100320B (lt)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6818643B1 (en) *	1999-12-08	2004-11-16	Bristol-Myers Squibb Company	Neurotrophic bicyclic diamides
JP2004532854A (ja) *	2001-05-10	2004-10-28	アグロンファ−マシュ−テイカルズインコ−ポレイテッド	複素２環式ｆｋｂｐリガンド
EP2899192A1 (en) *	2014-01-24	2015-07-29	Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.	Diazabicyclo[4.3.1]decane derivatives for treatment of psychiatric disorders
EP3097103B1 (en) *	2014-01-24	2017-11-15	Max-Planck-Gesellschaft zur Förderung der Wissenschaften	Diazabicyclo[4.3.1]decane derivatives for treatment of psychiatric disorders

Family Cites Families (33)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4894366A (en)	1984-12-03	1990-01-16	Fujisawa Pharmaceutical Company, Ltd.	Tricyclo compounds, a process for their production and a pharmaceutical composition containing the same
US5196352A (en)	1989-01-19	1993-03-23	Merck & Co., Inc.	New FK-506 cytosolic binding protein
US5109112A (en)	1989-01-19	1992-04-28	Merck & Co., Inc.	FK-506 cytosolic binding protein
US5192773A (en)	1990-07-02	1993-03-09	Vertex Pharmaceuticals, Inc.	Immunosuppressive compounds
US5256656A (en) *	1990-07-31	1993-10-26	Nisshin Flour Milling Co., Ltd.	Azabicyclo derivatives
US5187166A (en) *	1990-07-31	1993-02-16	Nisshin Flour Milling Co., Ltd.	Azabicyclo derivatives and their use as antiemetics
CA2068062A1 (en)	1991-05-07	1992-11-08	Stephen A. Parent	Yeast mutants
US5362629A (en)	1991-08-05	1994-11-08	President And Fellows Of Harvard College	Detection of immunosuppressants
US5344831A (en) *	1992-01-31	1994-09-06	Nisshin Flour Milling Co., Ltd.	Diazabicyclo derivatives
DE4219973A1 (de)	1992-06-19	1993-12-23	Basf Ag	N-substituierte Azabicycloheptan-Derivate, ihre Herstellung und Verwendung
US5318895A (en)	1992-10-05	1994-06-07	Merck & Co., Inc.	Aspergillus niger mutants
US5798355A (en)	1995-06-07	1998-08-25	Gpi Nil Holdings, Inc.	Inhibitors of rotamase enzyme activity
JP3235913B2 (ja) *	1993-07-30	2001-12-04	エーザイ株式会社	アミノ安息香酸誘導体
US5612350A (en)	1993-11-30	1997-03-18	Abbott Laboratories	Macrocyclic immunomodulators with novel cyclohexyl ring replacements
DE4341402A1 (de)	1993-12-04	1995-06-08	Basf Ag	N-substituierte Azabicycloheptan-Derivate, ihre Herstellung und Verwendung
US5457182A (en)	1994-02-15	1995-10-10	Merck & Co., Inc.	FK-506 cytosolic binding protein, FKBP12.6
US5622866A (en)	1994-06-23	1997-04-22	Merck & Co., Inc.	Expression cassettes useful in construction of integrative and replicative expression vectors for Streptomyces
US5859031A (en) *	1995-06-07	1999-01-12	Gpi Nil Holdings, Inc.	Small molecule inhibitors of rotamase enzyme activity
US5614547A (en)	1995-06-07	1997-03-25	Guilford Pharmaceuticals Inc.	Small molecule inhibitors of rotamase enzyme
US5696135A (en)	1995-06-07	1997-12-09	Gpi Nil Holdings, Inc.	Inhibitors of rotamase enzyme activity effective at stimulating neuronal growth
US6037370A (en)	1995-06-08	2000-03-14	Vertex Pharmaceuticals Incorporated	Methods and compositions for stimulating neurite growth
US5801197A (en) *	1995-10-31	1998-09-01	Gpi Nil Holdings, Inc.	Rotamase enzyme activity inhibitors
US5786378A (en)	1996-09-25	1998-07-28	Gpi Nil Holdings, Inc.	Heterocyclic thioesters
US5801187A (en)	1996-09-25	1998-09-01	Gpi-Nil Holdings, Inc.	Heterocyclic esters and amides
US5780484A (en)	1996-11-13	1998-07-14	Vertex Pharmaceuticals Incorporated	Methods for stimulating neurite growth with piperidine compounds
US5840736A (en)	1996-11-13	1998-11-24	Vertex Pharmaceuticals Incorporated	Methods and compositions for stimulating neurite growth
US5811434A (en)	1996-11-13	1998-09-22	Vertex Pharmacueticals Incorporated	Methods and compositions for stimulating neurite growth
PA8442401A1 (es)	1996-12-09	2000-05-24	Guilford Pharm Inc	Inhibidores polipropilos de ciclofilina
US5935989A (en)	1996-12-31	1999-08-10	Gpi Nil Holdings Inc.	N-linked ureas and carbamates of heterocyclic thioesters
US5874449A (en)	1996-12-31	1999-02-23	Gpi Nil Holdings, Inc.	N-linked sulfonamides of heterocyclic thioesters
US5721256A (en)	1997-02-12	1998-02-24	Gpi Nil Holdings, Inc.	Method of using neurotrophic sulfonamide compounds
ZA98825B (en)	1997-02-27	1998-10-19	Guilford Pharm Inc	Method of using neurotrophic carbamates and ureas
US5846979A (en)	1997-02-28	1998-12-08	Gpi Nil Holdings, Inc.	N-oxides of heterocyclic esters, amides, thioesters, and ketones

1999
- 1999-07-15 ES ES99934043T patent/ES2226409T3/es not_active Expired - Lifetime
- 1999-07-15 DK DK99934043T patent/DK1098897T3/da active
- 1999-07-15 EA EA200100149A patent/EA200100149A1/ru unknown
- 1999-07-15 ID IDW20010130A patent/ID27428A/id unknown
- 1999-07-15 SI SI9920067A patent/SI20638A/sl not_active IP Right Cessation
- 1999-07-15 IL IL14067699A patent/IL140676A0/xx unknown
- 1999-07-15 GE GE4273A patent/GEP20043368B/en unknown
- 1999-07-15 YU YU2901A patent/YU2901A/sh unknown
- 1999-07-15 JP JP2000560126A patent/JP2002520413A/ja not_active Withdrawn
- 1999-07-15 AU AU49963/99A patent/AU756912B2/en not_active Ceased
- 1999-07-15 EP EP99934043A patent/EP1098897B1/en not_active Expired - Lifetime
- 1999-07-15 WO PCT/US1999/015965 patent/WO2000004020A1/en not_active Application Discontinuation
- 1999-07-15 PT PT99934043T patent/PT1098897E/pt unknown
- 1999-07-15 BR BR9912423-8A patent/BR9912423A/pt not_active Application Discontinuation
- 1999-07-15 TR TR2001/00122T patent/TR200100122T2/xx unknown
- 1999-07-15 CN CN99810848A patent/CN1318067A/zh active Pending
- 1999-07-15 CA CA002337377A patent/CA2337377A1/en not_active Abandoned
- 1999-07-15 AP APAP/P/2001/002052A patent/AP2001002052A0/en unknown
- 1999-07-15 PL PL99345598A patent/PL345598A1/xx not_active Application Discontinuation
- 1999-07-15 SK SK46-2001A patent/SK462001A3/sk unknown
- 1999-07-15 NZ NZ509211A patent/NZ509211A/xx unknown
- 1999-07-15 HU HU0200637A patent/HUP0200637A3/hu unknown
- 1999-07-15 KR KR1020017000654A patent/KR20010071920A/ko not_active Application Discontinuation
- 1999-07-15 EE EEP200100032A patent/EE200100032A/xx unknown
- 1999-07-15 OA OA1200100015A patent/OA11581A/en unknown
- 1999-07-15 DE DE69917907T patent/DE69917907T2/de not_active Expired - Fee Related
- 1999-07-15 AT AT99934043T patent/ATE268772T1/de not_active IP Right Cessation
- 1999-07-16 US US09/356,240 patent/US6630472B1/en not_active Expired - Fee Related
2001
- 2001-01-11 ZA ZA200100320A patent/ZA200100320B/en unknown
- 2001-01-12 IS IS5805A patent/IS5805A/is unknown
- 2001-01-12 NO NO20010191A patent/NO20010191L/no not_active Application Discontinuation
- 2001-02-15 LT LT2001012A patent/LT4850B/lt not_active IP Right Cessation
- 2001-02-16 BG BG105268A patent/BG105268A/xx unknown
- 2001-02-16 HR HR20010118A patent/HRP20010118A2/hr not_active Application Discontinuation
- 2001-03-13 LV LV010023A patent/LV12665B/lv unknown

Also Published As

Publication number	Publication date
AU4996399A (en)	2000-02-07
CA2337377A1 (en)	2000-01-27
DK1098897T3 (da)	2004-10-18
DE69917907T2 (de)	2005-06-30
EE200100032A (et)	2002-06-17
EA200100149A1 (ru)	2001-08-27
EP1098897B1 (en)	2004-06-09
IS5805A (is)	2001-01-12
ZA200100320B (en)	2002-07-11
HUP0200637A3 (en)	2003-05-28
CN1318067A (zh)	2001-10-17
LT4850B (lt)	2001-10-25
HRP20010118A2 (en)	2002-02-28
SI20638A (sl)	2002-02-28
AU756912B2 (en)	2003-01-23
NZ509211A (en)	2002-10-25
NO20010191D0 (no)	2001-01-12
DE69917907D1 (de)	2004-07-15
EP1098897A1 (en)	2001-05-16
ID27428A (id)	2001-04-05
BR9912423A (pt)	2001-06-05
LT2001012A (lt)	2001-07-25
PT1098897E (pt)	2004-10-29
WO2000004020A1 (en)	2000-01-27
SK462001A3 (en)	2002-02-05
AP2001002052A0 (en)	2001-03-31
NO20010191L (no)	2001-03-16
KR20010071920A (ko)	2001-07-31
LV12665A (en)	2001-05-20
IL140676A0 (en)	2002-02-10
GEP20043368B (en)	2004-04-13
ATE268772T1 (de)	2004-06-15
LV12665B (lv)	2001-11-20
ES2226409T3 (es)	2005-03-16
HUP0200637A2 (en)	2002-08-28
YU2901A (sh)	2004-05-12
TR200100122T2 (tr)	2001-08-21
OA11581A (en)	2004-07-23
US6630472B1 (en)	2003-10-07
JP2002520413A (ja)	2002-07-09
PL345598A1 (en)	2001-12-17

Publication	Publication Date	Title
NZ310339A (en)	2000-03-27	Compositions for stimulating neurite growth comprising a neurotrophic amount of a compound with affinity for FKBP12 and a neurotrophic agent
MXPA02005510A (es)	2004-09-10	Compuestos, composiciones y metodos para estimular el crecimiento y alargamiento neuronal.
CA2206824A1 (en)	1996-12-19	Inhibitors of rotamase enzyme activity
AP9901518A0 (en)	1999-06-30	Methods and compositions for stimulating neurite growth using compounds with affinity for FKBP12 in combination with neurotrophic factors.
WO2001036589A3 (en)	2002-02-14	Human ex vivo immune system
WO1998025598A3 (en)	1998-07-30	Methods and pharmaceutical compositions for inhibiting tumour cell growth
AU1505788A (en)	1988-10-27	A method and a composition for treating neurological diseases such as migraine, by influencing the nerve cells
BRPI9611271A2 (pt)	2019-04-30	inibidores de atividade de enzima rotamase
WO2000018801A3 (en)	2000-07-13	Ncam binding compounds
BG105268A (en)	2001-11-30	Compounds, compositions and methods for stimulating neuronal growth and elongation
WO2001042784A3 (en)	2001-12-13	Methods for screening compounds active on neurons
CA2380943A1 (en)	2001-02-22	Mechanically elongated neuronal cells and methods for producing and using these cells
EP0354323A3 (en)	1990-06-13	Antidiabetic phosphates
WO2001028574A3 (en)	2001-11-08	Methods for inducing in vivo proliferation and migration of transplanted progenitor cells in the brain
WO1997014966B1 (en)	1997-06-05	Method of activating a novel ligand regulatory pathway
BR0210060A (pt)	2004-08-17	Ligandos de fkbp de heterobiciclos
MX9709829A (es)	1998-03-29	Metodos y composiciones para estimular el crecimiento de neurita.
EP1772517A3 (en)	2007-04-18	DSP-3 dual specificity phosphatase
WO2003044169A3 (en)	2004-10-28	Compositions and methods for reversibly inducing continual growth in normal cells
WO2000061180A3 (en)	2001-06-28	Products and methods for treating ptp lar related diseases
AR004113A1 (es)	1998-09-30	Inhibidores de actividad de enzima rotamasa.
ECSP003800A (es)	2001-04-23	Compuestos, composiciones y metodos para estimular el crecimiento y elongacion de neuronas