BE2022C541I2 - - Google Patents
Download PDFInfo
- Publication number
- BE2022C541I2 BE2022C541I2 BE2022C541C BE2022C541C BE2022C541I2 BE 2022C541 I2 BE2022C541 I2 BE 2022C541I2 BE 2022C541 C BE2022C541 C BE 2022C541C BE 2022C541 C BE2022C541 C BE 2022C541C BE 2022C541 I2 BE2022C541 I2 BE 2022C541I2
- Authority
- BE
- Belgium
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/36—Blood coagulation or fibrinolysis factors
- A61K38/37—Factors VIII
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/38—Albumins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Diabetes (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US45057803P | 2003-02-26 | 2003-02-26 | |
| PCT/US2004/006034 WO2004075923A2 (en) | 2003-02-26 | 2004-02-26 | Polymer-factor viii moiety conjugates |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BE2022C541I2 true BE2022C541I2 (ja) | 2023-08-09 |
Family
ID=32927670
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BE2022C541C BE2022C541I2 (ja) | 2003-02-26 | 2022-09-05 |
Country Status (21)
| Country | Link |
|---|---|
| US (13) | US7199223B2 (ja) |
| EP (4) | EP2572733A1 (ja) |
| JP (2) | JP5539607B2 (ja) |
| KR (1) | KR101085375B1 (ja) |
| CN (2) | CN1767857A (ja) |
| AU (2) | AU2004215912B2 (ja) |
| BE (1) | BE2022C541I2 (ja) |
| BR (1) | BRPI0407882B1 (ja) |
| CA (2) | CA2517369C (ja) |
| CY (1) | CY1125235T1 (ja) |
| DK (1) | DK1596887T3 (ja) |
| ES (1) | ES2911435T3 (ja) |
| FR (1) | FR22C1043I2 (ja) |
| HU (1) | HUE058897T2 (ja) |
| IL (1) | IL170424A (ja) |
| LT (1) | LT1596887T (ja) |
| MX (1) | MXPA05009169A (ja) |
| NL (1) | NL301184I2 (ja) |
| PT (1) | PT1596887T (ja) |
| SI (1) | SI1596887T1 (ja) |
| WO (1) | WO2004075923A2 (ja) |
Families Citing this family (150)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7173003B2 (en) | 2001-10-10 | 2007-02-06 | Neose Technologies, Inc. | Granulocyte colony stimulating factor: remodeling and glycoconjugation of G-CSF |
| US7214660B2 (en) * | 2001-10-10 | 2007-05-08 | Neose Technologies, Inc. | Erythropoietin: remodeling and glycoconjugation of erythropoietin |
| US7157277B2 (en) | 2001-11-28 | 2007-01-02 | Neose Technologies, Inc. | Factor VIII remodeling and glycoconjugation of Factor VIII |
| US8008252B2 (en) * | 2001-10-10 | 2011-08-30 | Novo Nordisk A/S | Factor VII: remodeling and glycoconjugation of Factor VII |
| ES2291613T3 (es) * | 2002-01-16 | 2008-03-01 | Biocompatibles Uk Limited | Conjugados de polimeros. |
| DE60336555D1 (de) * | 2002-06-21 | 2011-05-12 | Novo Nordisk Healthcare Ag | Pegylierte glykoformen von faktor vii |
| GB0301014D0 (en) * | 2003-01-16 | 2003-02-19 | Biocompatibles Ltd | Conjugation reactions |
| CN1767857A (zh) * | 2003-02-26 | 2006-05-03 | 尼克塔治疗亚拉巴马公司 | 聚合物－因子ⅷ部分共轭物 |
| CA2522345A1 (en) | 2003-04-09 | 2004-11-18 | Neose Technologies, Inc. | Glycopegylation methods and proteins/peptides produced by the methods |
| WO2006127896A2 (en) | 2005-05-25 | 2006-11-30 | Neose Technologies, Inc. | Glycopegylated factor ix |
| US8791070B2 (en) | 2003-04-09 | 2014-07-29 | Novo Nordisk A/S | Glycopegylated factor IX |
| JP5048332B2 (ja) * | 2003-05-23 | 2012-10-17 | ネクター セラピューティクス | 特定の原子配置を有するポリマー誘導体 |
| US7947261B2 (en) | 2003-05-23 | 2011-05-24 | Nektar Therapeutics | Conjugates formed from polymer derivatives having particular atom arrangements |
| US9005625B2 (en) | 2003-07-25 | 2015-04-14 | Novo Nordisk A/S | Antibody toxin conjugates |
| WO2005039641A2 (en) * | 2003-10-15 | 2005-05-06 | The Regents Of The University Of California | Biomacromolecule polymer conjugates |
| US20080305992A1 (en) | 2003-11-24 | 2008-12-11 | Neose Technologies, Inc. | Glycopegylated erythropoietin |
| US20060040856A1 (en) | 2003-12-03 | 2006-02-23 | Neose Technologies, Inc. | Glycopegylated factor IX |
| US6887952B1 (en) * | 2004-02-12 | 2005-05-03 | Biosite, Inc. | N-aryl-carbamic acid ester-derived and valeric acid ester-derived cross-linkers and conjugates, and methods for their synthesis and use |
| CA2558583C (en) * | 2004-03-15 | 2013-07-09 | Nektar Therapeutics Al, Corporation | Polymer-based compositions and conjugates of hiv entry inhibitors |
| WO2005115477A2 (en) | 2004-04-13 | 2005-12-08 | Quintessence Biosciences, Inc. | Non-natural ribonuclease conjugates as cytotoxic agents |
| WO2006010143A2 (en) | 2004-07-13 | 2006-01-26 | Neose Technologies, Inc. | Branched peg remodeling and glycosylation of glucagon-like peptide-1 [glp-1] |
| US20080176790A1 (en) | 2004-10-29 | 2008-07-24 | Defrees Shawn | Remodeling and Glycopegylation of Fibroblast Growth Factor (Fgf) |
| AU2012203813B2 (en) * | 2004-11-12 | 2013-10-24 | Bayer Healthcare Llc | Site-directed modification of FVIII |
| AU2016203693B2 (en) * | 2004-11-12 | 2018-08-23 | Bayer Healthcare Llc | Site-directed modification of FVIII |
| EP1824988B1 (en) | 2004-11-12 | 2017-04-19 | Bayer HealthCare LLC | Site-directed modification of fviii |
| AU2013203348B2 (en) * | 2004-11-12 | 2016-03-03 | Bayer Healthcare Llc | Site-directed modification of FVIII |
| MX2007007877A (es) * | 2004-12-27 | 2007-08-21 | Baxter Int | Conjugados de polimero-factor de von willebrand. |
| MX2007008229A (es) | 2005-01-10 | 2007-09-11 | Neose Technologies Inc | Factor estimulador de colonias de granulocitos glicopegilado. |
| EP1848461A2 (en) * | 2005-02-16 | 2007-10-31 | Nektar Therapeutics Al, Corporation | Conjugates of an epo moiety and a polymer |
| US20060233740A1 (en) * | 2005-03-23 | 2006-10-19 | Bossard Mary J | Conjugates of an hGH moiety and a polymer |
| US20080227691A1 (en) * | 2005-04-01 | 2008-09-18 | Novo Nordisk Health Care Ag | Blood Coagulation FVIII Analogues |
| EP2386571B1 (en) | 2005-04-08 | 2016-06-01 | ratiopharm GmbH | Compositions and methods for the preparation of protease resistant human growth hormone glycosylation mutants |
| EP1885403B1 (en) * | 2005-04-12 | 2013-05-08 | Nektar Therapeutics | Poly(ethyleneglycol) conjugates of Lysostaphin |
| ES2553160T3 (es) * | 2005-06-17 | 2015-12-04 | Novo Nordisk Health Care Ag | Reducción y derivatización selectivas de proteínas Factor VII transformadas por ingeniería que comprenden al menos una cisteína no nativa |
| AU2006278490A1 (en) * | 2005-08-04 | 2007-02-15 | Nektar Therapeutics | Conjugates of a G-CSF moiety and a polymer |
| US20070105755A1 (en) | 2005-10-26 | 2007-05-10 | Neose Technologies, Inc. | One pot desialylation and glycopegylation of therapeutic peptides |
| WO2007056191A2 (en) | 2005-11-03 | 2007-05-18 | Neose Technologies, Inc. | Nucleotide sugar purification using membranes |
| WO2007078820A2 (en) * | 2005-12-19 | 2007-07-12 | Sun Bio, Inc. | Methylmaleimidyl polymer derivatives |
| US8580746B2 (en) * | 2006-03-30 | 2013-11-12 | Palatin Technologies, Inc. | Amide linkage cyclic natriuretic peptide constructs |
| CA2647146A1 (en) * | 2006-03-30 | 2007-10-11 | Palatin Technologies, Inc. | Linear natriuretic peptide constructs |
| BRPI0709427A2 (pt) * | 2006-03-30 | 2011-07-12 | Palatin Technologies Inc | "construto cìclico, composição farmacêutica e uso de um composto |
| US7645860B2 (en) * | 2006-03-31 | 2010-01-12 | Baxter Healthcare S.A. | Factor VIII polymer conjugates |
| BRPI0708832A2 (pt) * | 2006-03-31 | 2011-06-14 | Baxter Int | construÇço proteinÁcea |
| US7985839B2 (en) | 2006-03-31 | 2011-07-26 | Baxter International Inc. | Factor VIII polymer conjugates |
| US7982010B2 (en) | 2006-03-31 | 2011-07-19 | Baxter International Inc. | Factor VIII polymer conjugates |
| JP2009537609A (ja) * | 2006-05-24 | 2009-10-29 | ノボ ノルディスク ヘルス ケア アーゲー | 延長されたｆｉｘアナログ及び誘導体 |
| JP2009541333A (ja) | 2006-06-23 | 2009-11-26 | クインテセンス バイオサイエンシーズ インコーポレーティッド | 修飾リボヌクレアーゼ |
| WO2008010991A2 (en) * | 2006-07-17 | 2008-01-24 | Quintessence Biosciences, Inc. | Methods and compositions for the treatment of cancer |
| US20080280818A1 (en) * | 2006-07-21 | 2008-11-13 | Neose Technologies, Inc. | Glycosylation of peptides via o-linked glycosylation sequences |
| US20100075375A1 (en) * | 2006-10-03 | 2010-03-25 | Novo Nordisk A/S | Methods for the purification of polypeptide conjugates |
| WO2008074032A1 (en) * | 2006-12-15 | 2008-06-19 | Baxter International Inc. | Factor viia- (poly) sialic acid conjugate having prolonged in vivo half-life |
| KR101503085B1 (ko) * | 2006-12-27 | 2015-03-16 | 넥타르 테라퓨틱스 | 방출가능한 연결을 갖는 폰 빌레브란드 인자 및 인자 ⅷ폴리머 컨주게이트 |
| CN101588819B (zh) * | 2006-12-27 | 2012-11-21 | 尼克塔治疗公司 | 具有可释放的键合的ix因子部分-聚合物轭合物 |
| WO2008124406A2 (en) | 2007-04-03 | 2008-10-16 | Neose Technologies, Inc. | Methods of treatment using glycopegylated g-csf |
| CA2690611C (en) | 2007-06-12 | 2015-12-08 | Novo Nordisk A/S | Improved process for the production of nucleotide sugars |
| WO2009045539A2 (en) * | 2007-10-05 | 2009-04-09 | Nektar Therapeutics Al, Corporation | Oligomer-corticosteroid conjugates |
| US8697062B2 (en) | 2007-10-08 | 2014-04-15 | Quintessence Biosciences, Inc. | Compositions and methods for ribonuclease-based therapeutics |
| AU2008323768A1 (en) * | 2007-11-09 | 2009-05-14 | Baxter Healthcare S.A. | Modified recombinant Factor VIII and von Willebrand Factor and methods of use |
| JP5806816B2 (ja) * | 2007-12-27 | 2015-11-10 | バクスター・インターナショナル・インコーポレイテッドＢａｘｔｅｒ Ｉｎｔｅｒｎａｔｉｏｎａｌ Ｉｎｃｏｒｐ０Ｒａｔｅｄ | 生理学的に許容されるポリマー分子を特異的に検出するための方法および組成物 |
| AU2009219232B2 (en) | 2008-02-27 | 2014-02-27 | Novo Nordisk A/S | Conjugated Factor VIII molecules |
| TWI395593B (zh) | 2008-03-06 | 2013-05-11 | Halozyme Inc | 可活化的基質降解酵素之活體內暫時性控制 |
| CA2721229C (en) | 2008-04-14 | 2022-08-23 | Halozyme, Inc. | Modified hyaluronidases and uses in treating hyaluronan-associated diseases and conditions |
| TWI394580B (zh) | 2008-04-28 | 2013-05-01 | Halozyme Inc | 超快起作用胰島素組成物 |
| US20110286988A1 (en) * | 2008-06-04 | 2011-11-24 | Bayer Healthcare Llc | FVIII Muteins for Treatment of Von Willebrand Disease |
| RU2528855C2 (ru) | 2008-06-24 | 2014-09-20 | Цсл Беринг Гмбх | Модифицированный фактор виллебранда с удлиненным полупериодом существования in vivo, его применения и способы получения |
| US8575102B2 (en) | 2008-08-01 | 2013-11-05 | Nektar Therapeutics | Conjugates having a releasable linkage |
| KR101660059B1 (ko) * | 2008-08-22 | 2016-09-26 | 박스알타 인코퍼레이티드 | 중합체 벤질 카르보네이트-유도체 |
| WO2010039985A1 (en) | 2008-10-01 | 2010-04-08 | Quintessence Biosciences, Inc. | Therapeutic Ribonucleases |
| DK2349341T3 (da) | 2008-10-15 | 2014-01-06 | Baxter Int | Pegylering af rekombinante blodkoagulationsfaktorer i nærvær af bundne antistoffer |
| AU2009305612B2 (en) * | 2008-10-17 | 2015-05-21 | Takeda Pharmaceutical Company Limited | Modified blood factors comprising a low degree of water soluble polymer |
| JP5281358B2 (ja) * | 2008-10-27 | 2013-09-04 | 学校法人常翔学園 | 高分子、経上皮吸収促進剤、及び医薬用製剤 |
| US20120027743A1 (en) * | 2008-11-03 | 2012-02-02 | Bayer Healthcare Llc | Method for the Treatment of Hemophilia |
| MX2011006110A (es) | 2008-12-09 | 2011-06-24 | Halozyme Inc | Polipeptidos ph20 solubles extendidos y usos de los mismos. |
| US20120121613A1 (en) * | 2009-01-19 | 2012-05-17 | Bayer Healthcare Llc | Protein conjugate having an endopeptidase- cleavable bioprotective moiety |
| EP3178835B1 (en) | 2009-02-03 | 2019-04-10 | Amunix Pharmaceuticals, Inc. | Extended recombinant polypeptides and compositions comprising same |
| JP2012518029A (ja) * | 2009-02-19 | 2012-08-09 | ノヴォ・ノルディスク・アー／エス | 第ｖｉｉｉ因子の修飾 |
| EP2437786B1 (en) | 2009-06-01 | 2016-05-18 | Yeda Research and Development Co. Ltd. | Prodrugs containing albumin binding probe |
| US8642737B2 (en) | 2010-07-26 | 2014-02-04 | Baxter International Inc. | Nucleophilic catalysts for oxime linkage |
| KR101912335B1 (ko) * | 2009-07-27 | 2018-10-26 | 리폭센 테크놀로지즈 리미티드 | 비혈액 응고 단백질의 글리코폴리시알화 |
| US8809501B2 (en) | 2009-07-27 | 2014-08-19 | Baxter International Inc. | Nucleophilic catalysts for oxime linkage |
| AU2010281453C1 (en) | 2009-07-27 | 2019-08-15 | Takeda Pharmaceutical Company Limited | Blood coagulation protein conjugates |
| HUE028056T2 (en) | 2009-07-27 | 2016-11-28 | Baxalta GmbH | Blood coagulation protein conjugates |
| US9062299B2 (en) | 2009-08-24 | 2015-06-23 | Amunix Operating Inc. | Coagulation factor IX compositions and methods of making and using same |
| DK2477603T3 (en) | 2009-09-17 | 2016-06-13 | Baxalta Inc | STABLE CO-DEVELOPMENT OF hyaluronidase and Immunoglobulin, AND METHODS OF USE THEREOF |
| CA3078259A1 (en) * | 2010-04-20 | 2011-10-27 | Octapharma Ag | Melezitose for stabilizing human blood plasma proteins |
| GB201007356D0 (en) | 2010-04-30 | 2010-06-16 | Leverton Licence Holdings Ltd | Conjugated factor VIIa |
| GB201007357D0 (en) * | 2010-04-30 | 2010-06-16 | Leverton Licence Holdings Ltd | Conjugated factor VIII |
| EP2591101B1 (en) | 2010-07-09 | 2018-11-07 | Bioverativ Therapeutics Inc. | Systems for factor viii processing and methods thereof |
| DK2595624T3 (en) | 2010-07-20 | 2018-03-26 | Halozyme Inc | Methods of treating or preventing adverse side effects associated with administration of an anti-hyaluronan agent |
| TWI595004B (zh) | 2010-11-03 | 2017-08-11 | 介控生化科技公司 | 經修飾之第九因子多胜肽及其用途 |
| HUE049352T2 (hu) | 2010-12-22 | 2020-09-28 | Baxalta GmbH | Anyagok és módszerek egy vízoldható zsírsavszármazéknak egy fehérjéhez való konjugálására |
| EP2907504B1 (en) | 2011-02-08 | 2017-06-28 | Halozyme, Inc. | Composition and lipid formulation of a hyaluronan-degrading enzyme and the use thereof for treatment of benign prostatic hyperplasia |
| WO2012140647A2 (en) | 2011-04-11 | 2012-10-18 | Yeda Research And Development Co. Ltd | Albumin binding probes and drug conjugates thereof |
| WO2012140650A2 (en) * | 2011-04-12 | 2012-10-18 | Hepacore Ltd. | Conjugates of carboxy polysaccharides with fibroblast growth factors and variants thereof |
| US20130011378A1 (en) | 2011-06-17 | 2013-01-10 | Tzung-Horng Yang | Stable formulations of a hyaluronan-degrading enzyme |
| EA201400030A1 (ru) | 2011-06-17 | 2014-07-30 | Галозим, Инк. | Способ непрерывного подкожного введения инсулина с использованием фермента, разрушающего хиалуронан |
| ES2566549T3 (es) | 2011-06-17 | 2016-04-13 | Halozyme, Inc. | Formulaciones estables de enzima degradante de hialuronano |
| WO2013040501A1 (en) | 2011-09-16 | 2013-03-21 | Pharmathene, Inc. | Compositions and combinations of organophosphorus bioscavengers and hyaluronan-degrading enzymes, and uses thereof |
| AU2012328880B2 (en) | 2011-10-24 | 2017-02-23 | Halozyme, Inc. | Companion diagnostic for anti-hyaluronan agent therapy and methods of use thereof |
| BR112014016195A2 (pt) | 2011-12-30 | 2020-10-27 | Halozyme, Inc. | variantes de polipeptídio ph20, formulações e usos das mesmas |
| NZ626945A (en) | 2012-01-12 | 2016-10-28 | Biogen Ma Inc | Chimeric factor viii polypeptides and uses thereof |
| CA2864904C (en) | 2012-02-15 | 2023-04-25 | Amunix Operating Inc. | Factor viii compositions and methods of making and using same |
| HUE043537T2 (hu) * | 2012-02-15 | 2019-08-28 | Bioverativ Therapeutics Inc | Rekombináns VIII faktor fehérjék |
| WO2013120939A1 (en) | 2012-02-15 | 2013-08-22 | Csl Behring Gmbh | Von willebrand factor variants having improved factor viii binding affinity |
| NZ700073A (en) | 2012-04-04 | 2016-08-26 | Halozyme Inc | Combination therapy with an anti - hyaluronan agent and a tumor - targeted taxane |
| GB201910184D0 (en) * | 2012-04-16 | 2019-08-28 | Cantab Biopharmaceuticals Patents Ltd | Optimised subcutaneous therapeutic agents |
| JP2015521589A (ja) | 2012-06-08 | 2015-07-30 | バイオジェン・エムエイ・インコーポレイテッドＢｉｏｇｅｎ ＭＡ Ｉｎｃ． | プロコアグラント化合物 |
| JP2015525222A (ja) | 2012-06-08 | 2015-09-03 | バイオジェン・エムエイ・インコーポレイテッドＢｉｏｇｅｎ ＭＡ Ｉｎｃ． | キメラ性凝固因子 |
| US20140017265A1 (en) * | 2012-07-05 | 2014-01-16 | Mersana Therapeutics, Inc. | Terminally Modified Polymers and Conjugates Thereof |
| US10138291B2 (en) | 2012-07-11 | 2018-11-27 | Bioverativ Therapeutics Inc. | Factor VIII complex with XTEN and von Willebrand Factor protein, and uses thereof |
| JP2015527350A (ja) * | 2012-08-13 | 2015-09-17 | ノヴォ ノルディスク アー／エス | 第ｖｉｉｉ因子の液体製剤 |
| WO2014062856A1 (en) | 2012-10-16 | 2014-04-24 | Halozyme, Inc. | Hypoxia and hyaluronan and markers thereof for diagnosis and monitoring of diseases and conditions and related methods |
| CA2888806A1 (en) | 2012-10-18 | 2014-04-24 | Biogen Idec Ma Inc. | Methods of using a fixed dose of a clotting factor |
| TWI647240B (zh) * | 2013-03-05 | 2019-01-11 | 韓美藥品股份有限公司 | 生理活性多肽複合物高產率製備之改良製程 |
| EP2970431A4 (en) * | 2013-03-13 | 2016-08-24 | Univ Emory | TARGETED REMOVAL OF FACTOR VIII IMMUNOCELLS |
| WO2014144549A1 (en) | 2013-03-15 | 2014-09-18 | Biogen Idec Ma Inc. | Factor ix polypeptide formulations |
| US20200157159A1 (en) | 2013-04-16 | 2020-05-21 | The Board Of Regents Of The University Of Oklahoma | Peptide compounds and compositions thereof |
| DK2796145T3 (da) | 2013-04-22 | 2018-01-29 | Csl Ltd | Et kovalent kompleks af von Willebrand-faktor og faktor VIII linket af en disulfidbro |
| MX2015016567A (es) | 2013-06-28 | 2016-03-31 | Biogen Ma Inc | Enlazador escindible por trombina con xten y usos del mismo. |
| TW201534726A (zh) | 2013-07-03 | 2015-09-16 | Halozyme Inc | 熱穩定ｐｈ２０玻尿酸酶變異體及其用途 |
| EP3033097B1 (en) | 2013-08-14 | 2021-03-10 | Bioverativ Therapeutics Inc. | Factor viii-xten fusions and uses thereof |
| WO2015023894A1 (en) | 2013-08-14 | 2015-02-19 | Biogen Idec Ma Inc. | Recombinant factor viii proteins |
| CN106456718A (zh) | 2014-01-10 | 2017-02-22 | 比奥根Ma公司 | 因子viii嵌合蛋白及其用途 |
| EP3114138B1 (en) | 2014-03-05 | 2021-11-17 | Pfizer Inc. | Improved muteins of clotting factor viii |
| KR20170026580A (ko) | 2014-07-02 | 2017-03-08 | 씨에스엘 리미티드 | 변형된 폰 빌레브란트 인자 |
| DK3186281T3 (da) | 2014-08-28 | 2019-06-11 | Halozyme Inc | Kombinationsterapi med et hyaluronan-nedbrydende enzym og en immun-checkpoint-inhibitor |
| WO2016061286A2 (en) | 2014-10-14 | 2016-04-21 | Halozyme, Inc. | Compositions of adenosine deaminase-2 (ada2), variants thereof and methods of using same |
| MA40835A (fr) | 2014-10-23 | 2017-08-29 | Biogen Ma Inc | Anticorps anti-gpiib/iiia et leurs utilisations |
| MA40861A (fr) | 2014-10-31 | 2017-09-05 | Biogen Ma Inc | Anticorps anti-glycoprotéines iib/iiia |
| US11155601B2 (en) | 2015-03-06 | 2021-10-26 | CSL Behring Lengnau AG | Modified von Willebrand factor having improved half-life |
| AU2016266627A1 (en) | 2015-05-22 | 2018-01-18 | CSL Behring Lengnau AG | Truncated von Willebrand Factor polypeptides for treating hemophilia |
| EP4089109A3 (en) | 2015-05-22 | 2023-03-01 | CSL Behring Lengnau AG | Methods for preparing modified von willebrand factor |
| WO2017024060A1 (en) | 2015-08-03 | 2017-02-09 | Biogen Ma Inc. | Factor ix fusion proteins and methods of making and using same |
| MX2018008293A (es) | 2016-01-07 | 2018-09-21 | CSL Behring Lengnau AG | Factor de von willebrand mutado. |
| JP6851381B6 (ja) | 2016-01-07 | 2021-04-21 | ツェー・エス・エル・ベーリング・レングナウ・アクチエンゲゼルシャフト | 変異切断型フォンウィルブランド因子 |
| EP3476860A4 (en) * | 2016-06-24 | 2020-01-22 | Mogam Institute for Biomedical Research | RECOMBINANT SINGLE CHAIN FVIII AND CHEMICAL CONJUGATE THEREOF |
| CN109475639A (zh) | 2016-07-22 | 2019-03-15 | 尼克塔治疗公司 | 具有含肟键联的因子viii部分的轭合物 |
| AU2017358861B2 (en) | 2016-11-11 | 2022-02-17 | CSL Behring Lengnau AG | Truncated von Willebrand Factor polypeptides for treating hemophilia |
| CA3043397A1 (en) | 2016-11-11 | 2018-05-17 | CSL Behring Lengnau AG | Truncated von willebrand factor polypeptides for extravascular administration in the treatment or prophylaxis of a blood coagulation disorder |
| AU2017368328A1 (en) | 2016-12-02 | 2019-07-18 | Bioverativ Therapeutics Inc. | Methods of inducing immune tolerance to clotting factors |
| KR20240069834A (ko) | 2016-12-02 | 2024-05-20 | 바이오버라티브 테라퓨틱스 인크. | 키메라 응고 인자를 사용해 혈우병성 관절증을 치료하는 방법 |
| US10781435B2 (en) | 2017-06-22 | 2020-09-22 | Catalyst Biosciences, Inc. | Modified membrane type serine protease 1 (MTSP-1) polypeptides and methods of use |
| US11491212B1 (en) | 2017-09-27 | 2022-11-08 | Catalyst Biosciences, Inc. | Subcutaneous administration of modified factor IX polypeptides and treatment of hemophilia B |
| US20190351031A1 (en) | 2018-05-16 | 2019-11-21 | Halozyme, Inc. | Methods of selecting subjects for combination cancer therapy with a polymer-conjugated soluble ph20 |
| JP2021523878A (ja) | 2018-05-18 | 2021-09-09 | バイオベラティブ セラピューティクス インコーポレイテッド | 血友病ａを処置する方法 |
| US20210261814A1 (en) * | 2018-07-20 | 2021-08-26 | Hercules Llc | Water soluble or dispersible composition |
| US11613744B2 (en) | 2018-12-28 | 2023-03-28 | Vertex Pharmaceuticals Incorporated | Modified urokinase-type plasminogen activator polypeptides and methods of use |
| CN113661239A (zh) | 2018-12-28 | 2021-11-16 | 催化剂生物科学公司 | 经修饰的尿激酶型纤溶酶原激活物多肽和使用方法 |
| WO2021154414A2 (en) | 2020-01-29 | 2021-08-05 | Catalyst Biosciences, Inc. | Gene therapy for hemophilia b with a chimeric aav capsid vector encoding modified factor ix polypeptides |
| US20220394450A1 (en) * | 2021-06-03 | 2022-12-08 | Apple Inc. | Systems and methods for emergency service access by reduced capability radio frequency devices |
Family Cites Families (56)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4179337A (en) | 1973-07-20 | 1979-12-18 | Davis Frank F | Non-immunogenic polypeptides |
| JPS59172425A (ja) | 1983-03-18 | 1984-09-29 | Nippon Chemiphar Co Ltd | 新規な血液凝固因子誘導体およびその製造法ならびにそれを含有する血液凝固促進剤 |
| WO1984003628A1 (en) | 1983-05-09 | 1984-09-27 | Nordisk Insulinlab | A concentrate of the antihemophilic factor viii and a process for producing it |
| US4757006A (en) | 1983-10-28 | 1988-07-12 | Genetics Institute, Inc. | Human factor VIII:C gene and recombinant methods for production |
| US4965199A (en) | 1984-04-20 | 1990-10-23 | Genentech, Inc. | Preparation of functional human factor VIII in mammalian cells using methotrexate based selection |
| DK525384D0 (da) | 1984-11-05 | 1984-11-05 | Nordisk Insulinlab | Praeparat paa basis af faktor viii til behandling af haemofili a inhibitorpatienter samt fremgangsmaade til fremstilling af et saadan praeparat |
| US4970300A (en) | 1985-02-01 | 1990-11-13 | New York University | Modified factor VIII |
| EP0218712B1 (en) | 1985-04-12 | 1992-02-26 | Genetics Institute, Inc. | Novel procoagulant proteins |
| AT387234B (de) | 1987-03-05 | 1988-12-27 | Vogelbusch Gmbh | Vorrichtung zur zuechtung von dauerformen insbesondere filamentoeser mikroorganismen |
| US4994439A (en) * | 1989-01-19 | 1991-02-19 | California Biotechnology Inc. | Transmembrane formulations for drug administration |
| SE465222C5 (sv) * | 1989-12-15 | 1998-02-10 | Pharmacia & Upjohn Ab | Ett rekombinant, humant faktor VIII-derivat och förfarande för dess framställning |
| US5397771A (en) | 1990-05-10 | 1995-03-14 | Bechgaard International Research And Development A/S | Pharmaceutical preparation |
| IT1248723B (it) | 1990-06-12 | 1995-01-26 | Scalvo S P A | Processo per la purificazione del fattore viii e fattore viii ottenuto con tale processo |
| US5766897A (en) | 1990-06-21 | 1998-06-16 | Incyte Pharmaceuticals, Inc. | Cysteine-pegylated proteins |
| CA2101918A1 (en) * | 1991-03-18 | 1992-09-19 | Samuel Zalipsky | Hydrazine containing conjugates of polypeptides and glycopolypeptides with polymers |
| DE4111393A1 (de) | 1991-04-09 | 1992-10-15 | Behringwerke Ag | Stabilisierte faktor viii-praeparationen |
| US6376463B1 (en) | 1992-04-07 | 2002-04-23 | Emory University | Modified factor VIII |
| US6037452A (en) * | 1992-04-10 | 2000-03-14 | Alpha Therapeutic Corporation | Poly(alkylene oxide)-Factor VIII or Factor IX conjugate |
| WO1994004193A1 (en) | 1992-08-21 | 1994-03-03 | Enzon, Inc. | Novel attachment of polyalkylene oxides to bio-effecting substances |
| US5298643A (en) | 1992-12-22 | 1994-03-29 | Enzon, Inc. | Aryl imidate activated polyalkylene oxides |
| AU6029594A (en) | 1993-01-15 | 1994-08-15 | Enzon, Inc. | Factor viii - polymeric conjugates |
| US5321095A (en) | 1993-02-02 | 1994-06-14 | Enzon, Inc. | Azlactone activated polyalkylene oxides |
| US5621039A (en) | 1993-06-08 | 1997-04-15 | Hallahan; Terrence W. | Factor IX- polymeric conjugates |
| SE504074C2 (sv) | 1993-07-05 | 1996-11-04 | Pharmacia Ab | Proteinberedning för subkutan, intramuskulär eller intradermal administrering |
| US5446090A (en) | 1993-11-12 | 1995-08-29 | Shearwater Polymers, Inc. | Isolatable, water soluble, and hydrolytically stable active sulfones of poly(ethylene glycol) and related polymers for modification of surfaces and molecules |
| US5612039A (en) * | 1994-03-14 | 1997-03-18 | Nini E. Policappelli | Dietary supplement |
| WO1996041813A2 (en) * | 1994-11-09 | 1996-12-27 | Offord Robin E | Functionalized polymers for site-specific attachment |
| US5569596A (en) * | 1995-01-04 | 1996-10-29 | The Board Of Regents Of The University Of Oklahoma | Method for bacterial reduction of chromium (VI) |
| US5932462A (en) | 1995-01-10 | 1999-08-03 | Shearwater Polymers, Inc. | Multiarmed, monofunctional, polymer for coupling to molecules and surfaces |
| SE9503380D0 (sv) * | 1995-09-29 | 1995-09-29 | Pharmacia Ab | Protein derivatives |
| US6158888A (en) | 1996-09-05 | 2000-12-12 | University Of Florida | Materials and methods for improved radiography |
| US5804420A (en) | 1997-04-18 | 1998-09-08 | Bayer Corporation | Preparation of recombinant Factor VIII in a protein free medium |
| WO1998051341A1 (en) | 1997-05-14 | 1998-11-19 | The University Of Manitoba | ANTIGEN-mPEG CONJUGATES SUPPRESS HUMORAL AND CELL MEDIATED IMMUNE RESPONSES |
| DE69811200T2 (de) | 1997-07-22 | 2003-10-09 | Nippon Steel Corp., Tokio/Tokyo | Einsatzstahl mit hervorragender verhinderung der sekundärrekristallisation während der aufkohlung, verfahren zu dessen herstellung, halbzeug für aufzukohlende teile |
| US5985263A (en) | 1997-12-19 | 1999-11-16 | Enzon, Inc. | Substantially pure histidine-linked protein polymer conjugates |
| US6358703B1 (en) | 1998-12-10 | 2002-03-19 | Bayer Corporation | Expression system for factor VIII |
| ATE526401T1 (de) | 1999-01-14 | 2011-10-15 | Bolder Biotechnology Inc | Verfahren zur herstellung von proteinen mit freien cysteinresten |
| US6309633B1 (en) | 1999-06-19 | 2001-10-30 | Nobex Corporation | Amphiphilic drug-oligomer conjugates with hydroyzable lipophile components and methods for making and using the same |
| AU2001238595A1 (en) | 2000-02-22 | 2001-09-03 | Shearwater Corporation | N-maleimidyl polymer derivatives |
| DE60129432T2 (de) | 2000-05-16 | 2008-04-17 | Bolder Biotechnology, Inc., Louisville | Verfahren zur rückfaltung von proteinen mit freien cysteinresten |
| KR100396983B1 (ko) | 2000-07-29 | 2003-09-02 | 이강춘 | 고반응성의 가지 달린 고분자 유도체 및 고분자와 단백질또는 펩타이드의 접합체 |
| TW593427B (en) * | 2000-12-18 | 2004-06-21 | Nektar Therapeutics Al Corp | Synthesis of high molecular weight non-peptidic polymer derivatives |
| AP1763A (en) * | 2001-05-21 | 2007-08-02 | Nektar Therapeutics | Pulmonary administration of chemically modified insulin |
| US6546159B1 (en) | 2001-08-22 | 2003-04-08 | Avanex Corporation | Method and apparatus for compensating differential group delay |
| ATE359829T1 (de) * | 2001-10-30 | 2007-05-15 | Nektar Therapeutics Al Corp | Wasserlösliche polymerkonjugate von retinoesäure |
| KR20050093856A (ko) | 2002-09-09 | 2005-09-23 | 넥타르 테라퓨틱스 에이엘, 코포레이션 | 수용성 중합체 알카날 |
| AU2003270555B2 (en) | 2002-09-09 | 2009-01-29 | Nektar Therapeutics | Method for preparing water-soluble polymer derivatives bearing a terminal carboxylic acid |
| AU2003303519C1 (en) | 2002-12-31 | 2010-08-12 | Nektar Therapeutics | Polymeric reagents comprising a ketone or a related functional group |
| ATE400602T1 (de) * | 2002-12-31 | 2008-07-15 | Nektar Therapeutics Al Corp | Verfahren zur herstellung von hydrogelen aus thiosulfonat-zusammensetzungen und ihre verwendungen |
| MXPA05007348A (es) | 2003-01-06 | 2005-10-05 | Nektar Therapeutics Al Corp | Derivados de polimeros solubles en agua tiol-selectivos. |
| CN1767857A (zh) | 2003-02-26 | 2006-05-03 | 尼克塔治疗亚拉巴马公司 | 聚合物－因子ⅷ部分共轭物 |
| JP2006521372A (ja) | 2003-03-28 | 2006-09-21 | バイオポリメド インコーポレーテッド | 生物学的活性物質と生体適合性高分子の１：１接合体、この製造方法とこれを含む薬学組成物 |
| WO2004091499A2 (en) | 2003-04-09 | 2004-10-28 | Neose Technologies, Inc. | Intracellular formation of peptide conjugates |
| CA2522345A1 (en) | 2003-04-09 | 2004-11-18 | Neose Technologies, Inc. | Glycopegylation methods and proteins/peptides produced by the methods |
| JP5048332B2 (ja) | 2003-05-23 | 2012-10-17 | ネクター セラピューティクス | 特定の原子配置を有するポリマー誘導体 |
| KR102612902B1 (ko) | 2016-04-22 | 2023-12-18 | 삼성디스플레이 주식회사 | 투명 전도막 및 이를 포함하는 전자 소자 |
-
2004
- 2004-02-26 CN CNA2004800084228A patent/CN1767857A/zh active Pending
- 2004-02-26 EP EP12160605A patent/EP2572733A1/en not_active Withdrawn
- 2004-02-26 AU AU2004215912A patent/AU2004215912B2/en not_active Expired
- 2004-02-26 CN CN2010105418684A patent/CN102139114A/zh active Pending
- 2004-02-26 EP EP11152599.4A patent/EP2338523B1/en not_active Expired - Lifetime
- 2004-02-26 EP EP04715165.9A patent/EP1596887B1/en not_active Expired - Lifetime
- 2004-02-26 LT LTEPPCT/US2004/006034T patent/LT1596887T/lt unknown
- 2004-02-26 EP EP12160604A patent/EP2572732A1/en not_active Withdrawn
- 2004-02-26 PT PT47151659T patent/PT1596887T/pt unknown
- 2004-02-26 HU HUE04715165A patent/HUE058897T2/hu unknown
- 2004-02-26 US US10/789,956 patent/US7199223B2/en active Active
- 2004-02-26 KR KR1020057015960A patent/KR101085375B1/ko active IP Right Grant
- 2004-02-26 WO PCT/US2004/006034 patent/WO2004075923A2/en active Application Filing
- 2004-02-26 CA CA2517369A patent/CA2517369C/en not_active Expired - Lifetime
- 2004-02-26 CA CA2788505A patent/CA2788505C/en not_active Expired - Lifetime
- 2004-02-26 BR BRPI0407882-9A patent/BRPI0407882B1/pt active IP Right Grant
- 2004-02-26 DK DK04715165.9T patent/DK1596887T3/da active
- 2004-02-26 SI SI200432519T patent/SI1596887T1/sl unknown
- 2004-02-26 JP JP2006503916A patent/JP5539607B2/ja not_active Expired - Lifetime
- 2004-02-26 ES ES04715165T patent/ES2911435T3/es not_active Expired - Lifetime
- 2004-02-26 MX MXPA05009169A patent/MXPA05009169A/es active IP Right Grant
-
2005
- 2005-08-22 IL IL170424A patent/IL170424A/en active IP Right Grant
-
2007
- 2007-02-05 US US11/702,302 patent/US7858749B2/en active Active
-
2008
- 2008-06-06 US US12/157,072 patent/US7863421B2/en not_active Expired - Lifetime
-
2009
- 2009-04-03 AU AU2009201308A patent/AU2009201308B2/en not_active Expired
- 2009-12-11 US US12/636,469 patent/US8133977B2/en not_active Expired - Lifetime
- 2009-12-11 US US12/636,594 patent/US8247536B2/en not_active Expired - Lifetime
- 2009-12-11 US US12/636,635 patent/US8143378B2/en not_active Expired - Lifetime
-
2011
- 2011-07-15 JP JP2011156978A patent/JP2012025747A/ja not_active Withdrawn
-
2012
- 2012-03-27 US US13/431,872 patent/US8519102B2/en not_active Expired - Lifetime
- 2012-03-27 US US13/431,862 patent/US8618259B2/en not_active Expired - Lifetime
- 2012-03-27 US US13/431,844 patent/US8889831B2/en not_active Expired - Lifetime
-
2014
- 2014-10-17 US US14/517,679 patent/US20150038422A1/en not_active Abandoned
-
2015
- 2015-12-09 US US14/964,416 patent/US9999657B2/en not_active Expired - Lifetime
-
2018
- 2018-05-17 US US15/982,932 patent/US11141465B2/en not_active Expired - Lifetime
-
2021
- 2021-09-09 US US17/470,811 patent/US20210401948A1/en not_active Abandoned
-
2022
- 2022-06-09 CY CY20221100405T patent/CY1125235T1/el unknown
- 2022-07-01 NL NL301184C patent/NL301184I2/nl unknown
- 2022-08-11 FR FR22C1043C patent/FR22C1043I2/fr active Active
- 2022-09-05 BE BE2022C541C patent/BE2022C541I2/fr unknown