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AU8598175A - 2-hydroxy-w-aminoalkyl-derivatives of aminoglycoside antibiotics - Google Patents

2-hydroxy-w-aminoalkyl-derivatives of aminoglycoside antibiotics

Info

Publication number
AU8598175A
AU8598175A AU85981/75A AU8598175A AU8598175A AU 8598175 A AU8598175 A AU 8598175A AU 85981/75 A AU85981/75 A AU 85981/75A AU 8598175 A AU8598175 A AU 8598175A AU 8598175 A AU8598175 A AU 8598175A
Authority
AU
Australia
Prior art keywords
aminoalkyl
hydroxy
derivatives
aminoglycoside antibiotics
aminoglycoside
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
AU85981/75A
Other versions
AU478659B2 (en
Inventor
William Moore James
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Corp
Original Assignee
Pfizer Corp
Pfizer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Corp, Pfizer Inc filed Critical Pfizer Corp
Application granted granted Critical
Publication of AU8598175A publication Critical patent/AU8598175A/en
Publication of AU478659B2 publication Critical patent/AU478659B2/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
    • C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
    • C07H15/226—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings
    • C07H15/228—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to adjacent ring-carbon atoms of the cyclohexane rings
    • C07H15/23—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to adjacent ring-carbon atoms of the cyclohexane rings with only two saccharide radicals in the molecule, e.g. ambutyrosin, butyrosin, xylostatin, ribostamycin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
    • C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
    • C07H15/226—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings
    • C07H15/234—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to non-adjacent ring carbon atoms of the cyclohexane rings, e.g. kanamycins, tobramycin, nebramycin, gentamicin A2

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AU85981/75A 1974-10-26 1975-10-23 2-hydroxy-w-aminoalkyl-derivatives of aminoglycoside antibiotics Expired AU478659B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB46412/74 1974-10-26
GB4641274A GB1464401A (en) 1974-10-26 1974-10-26 Aminoglycosides

Publications (2)

Publication Number Publication Date
AU8598175A true AU8598175A (en) 1976-12-09
AU478659B2 AU478659B2 (en) 1976-12-09

Family

ID=

Also Published As

Publication number Publication date
NL7512465A (en) 1976-04-28
DE2547738B2 (en) 1977-12-01
SU617017A3 (en) 1978-07-25
ZA756326B (en) 1976-09-29
ES442051A1 (en) 1977-04-01
JPS5519237B2 (en) 1980-05-24
DK147075C (en) 1984-11-05
DE2547738C3 (en) 1978-08-03
JPS5168543A (en) 1976-06-14
EG11975A (en) 1978-06-30
CA1039275A (en) 1978-09-26
BG24821A3 (en) 1978-05-12
IL48263A0 (en) 1975-12-31
SE7511945L (en) 1976-04-27
PH12782A (en) 1979-08-17
RO72878B (en) 1983-06-30
IE42452B1 (en) 1980-08-13
PL99933B1 (en) 1978-08-31
NL162081C (en) 1980-04-15
DK481175A (en) 1976-04-27
DD122522A5 (en) 1976-10-12
FI752951A (en) 1976-04-27
NZ179050A (en) 1978-03-06
CH601339A5 (en) 1978-07-14
NL162081B (en) 1979-11-15
DK147075B (en) 1984-04-02
CS195712B2 (en) 1980-02-29
GB1464401A (en) 1977-02-16
FR2289202B1 (en) 1978-11-10
RO72878A (en) 1983-07-07
FR2289202A1 (en) 1976-05-28
ATA809575A (en) 1977-03-15
IE42452L (en) 1976-04-26
DE2547738A1 (en) 1976-05-06
IL48263A (en) 1978-03-10
BE834864A (en) 1976-04-26
AT340051B (en) 1977-11-25
AR205593A1 (en) 1976-05-14
HU172060B (en) 1978-05-28
LU73644A1 (en) 1977-05-31

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