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AU624972B2 - Substituted 2-imino-3-alkylbenzothiazolines and their preparation and use - Google Patents

Substituted 2-imino-3-alkylbenzothiazolines and their preparation and use

Info

Publication number
AU624972B2
AU624972B2 AU58847/90A AU5884790A AU624972B2 AU 624972 B2 AU624972 B2 AU 624972B2 AU 58847/90 A AU58847/90 A AU 58847/90A AU 5884790 A AU5884790 A AU 5884790A AU 624972 B2 AU624972 B2 AU 624972B2
Authority
AU
Australia
Prior art keywords
substituted
preparation
alkylbenzothiazolines
imino
denotes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU58847/90A
Other versions
AU5884790A (en
Inventor
Patrick Jimonet
Joseph Le Blevec
Conception Nemecek
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Rhone Poulenc Sante SA
Original Assignee
Rhone Poulenc Sante SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR8909483A external-priority patent/FR2649704B1/en
Priority claimed from FR9005889A external-priority patent/FR2661910B1/en
Application filed by Rhone Poulenc Sante SA filed Critical Rhone Poulenc Sante SA
Publication of AU5884790A publication Critical patent/AU5884790A/en
Application granted granted Critical
Publication of AU624972B2 publication Critical patent/AU624972B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D277/82—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Steroid Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Compounds of formula: <IMAGE> in which R1 denotes a substituted 1-piperazinyl, substituted 1,2,3,6-tetrahydro-1-pyridyl or substituted piperidino radical, R2 denotes a polyfluoroalkoxy radical and n is equal to 2 or 3, salts of these compounds with an acid, processes for their preparation and medications containing them.
AU58847/90A 1989-07-13 1990-07-10 Substituted 2-imino-3-alkylbenzothiazolines and their preparation and use Ceased AU624972B2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
FR8909483A FR2649704B1 (en) 1989-07-13 1989-07-13 IMINO-2 ETHYL-3 BENZOTHIAZOLINE DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND MEDICINAL PRODUCTS CONTAINING THEM
FR8909483 1989-07-13
FR9005889A FR2661910B1 (en) 1990-05-11 1990-05-11 IMINO-2 HETEROCYCLYLALKYL-3 BENZOTHIAZOLINE DERIVATIVES, THEIR PREPARATION AND THE MEDICINAL PRODUCTS CONTAINING THEM.
FR9005889 1990-05-11

Publications (2)

Publication Number Publication Date
AU5884790A AU5884790A (en) 1991-01-17
AU624972B2 true AU624972B2 (en) 1992-06-25

Family

ID=26227474

Family Applications (1)

Application Number Title Priority Date Filing Date
AU58847/90A Ceased AU624972B2 (en) 1989-07-13 1990-07-10 Substituted 2-imino-3-alkylbenzothiazolines and their preparation and use

Country Status (20)

Country Link
EP (1) EP0409692B1 (en)
JP (1) JPH0386871A (en)
AT (1) ATE102612T1 (en)
AU (1) AU624972B2 (en)
CA (1) CA2021031A1 (en)
CZ (1) CZ281164B6 (en)
DE (1) DE69007196T2 (en)
DK (1) DK0409692T3 (en)
ES (1) ES2062445T3 (en)
FI (1) FI93109C (en)
HU (1) HU210827B (en)
IE (1) IE63318B1 (en)
IL (1) IL95053A (en)
NO (1) NO175590C (en)
NZ (1) NZ234487A (en)
PL (2) PL164152B1 (en)
PT (1) PT94701B (en)
RU (1) RU1836368C (en)
SK (1) SK342590A3 (en)
YU (1) YU47723B (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2674853B1 (en) * 1991-04-03 1995-01-20 Synthelabo PIPERIDINYLGUANIDINE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION.
FR2678619B1 (en) * 1991-07-04 1993-09-17 Rhone Poulenc Rorer Sa DERIVATIVES OF 1,2,4-THIADIAZOLO [3,4-B] BENZOTHIAZOLE, THEIR PREPARATION AND THE MEDICINAL PRODUCTS CONTAINING THEM.
WO1993021170A1 (en) * 1992-04-15 1993-10-28 Rhone-Poulenc Rorer S.A. 3,4-dihydro-2h-1,2,4-benzothiadiazine-1,1-dioxide-3-carboxylic acid derivatives, preparation thereof and drugs containing same
FR2696457B1 (en) * 1992-10-02 1994-11-25 Rhone Poulenc Rorer Sa Derivatives of 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide, their preparation and the medicaments containing them.
US5889010A (en) * 1995-05-18 1999-03-30 Pfizer Inc. Benzimidazole derivatives having dopaminergic activity

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU4618989A (en) * 1988-12-15 1990-06-21 Rhone-Poulenc Sante 2-iminobenzothiazoline derivatives, their preparation and pharmaceutical compositions containing them
EP0375510A1 (en) * 1988-12-15 1990-06-27 Rhone-Poulenc Sante 2-Imino-6-polyfluoroalcoxy-benzothiazole derivatives, process for their preparation and medicaments containing them

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2631163B2 (en) * 1976-07-10 1978-06-29 Basf Ag, 6700 Ludwigshafen Process for the preparation of 2-iminobenzothiazoles
FR2492258A1 (en) * 1980-10-17 1982-04-23 Pharmindustrie NEW AMINO-2 TRIFLUOROMETHOXY-6 BENZOTHIAZOLE-BASED MEDICINAL PRODUCT

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU4618989A (en) * 1988-12-15 1990-06-21 Rhone-Poulenc Sante 2-iminobenzothiazoline derivatives, their preparation and pharmaceutical compositions containing them
EP0375510A1 (en) * 1988-12-15 1990-06-27 Rhone-Poulenc Sante 2-Imino-6-polyfluoroalcoxy-benzothiazole derivatives, process for their preparation and medicaments containing them

Also Published As

Publication number Publication date
NO175590C (en) 1994-11-02
HUT58732A (en) 1992-03-30
CZ342590A3 (en) 1996-01-17
DK0409692T3 (en) 1994-04-05
CA2021031A1 (en) 1991-01-14
HU904189D0 (en) 1990-12-28
SK278908B6 (en) 1998-04-08
YU133990A (en) 1992-07-20
PL164326B1 (en) 1994-07-29
YU47723B (en) 1996-01-08
AU5884790A (en) 1991-01-17
NO903113D0 (en) 1990-07-12
NZ234487A (en) 1992-04-28
NO903113L (en) 1991-01-14
PT94701B (en) 1997-03-31
EP0409692A2 (en) 1991-01-23
DE69007196T2 (en) 1994-06-30
IE63318B1 (en) 1995-04-05
ATE102612T1 (en) 1994-03-15
NO175590B (en) 1994-07-25
SK342590A3 (en) 1998-04-08
ES2062445T3 (en) 1994-12-16
EP0409692A3 (en) 1991-03-27
FI93109C (en) 1995-02-27
DE69007196D1 (en) 1994-04-14
PL164152B1 (en) 1994-06-30
CZ281164B6 (en) 1996-07-17
PT94701A (en) 1991-03-20
FI93109B (en) 1994-11-15
RU1836368C (en) 1993-08-23
IL95053A (en) 1994-05-30
HU210827B (en) 1995-08-28
JPH0386871A (en) 1991-04-11
FI903531A0 (en) 1990-07-12
IL95053A0 (en) 1991-06-10
EP0409692B1 (en) 1994-03-09
IE902551A1 (en) 1991-02-27

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Legal Events

Date Code Title Description
MK14 Patent ceased section 143(a) (annual fees not paid) or expired