|
US6429290B1
(en)
|
1994-08-17 |
2002-08-06 |
The Rockefeller University |
OB polypeptides, modified forms and derivatives
|
|
US6001968A
(en)
|
1994-08-17 |
1999-12-14 |
The Rockefeller University |
OB polypeptides, modified forms and compositions
|
|
GB9509164D0
(en)
*
|
1995-05-05 |
1995-06-28 |
Smithkline Beecham Plc |
Novel compounds
|
|
WO1997016550A1
(en)
*
|
1995-11-02 |
1997-05-09 |
Bristol-Myers Squibb Company |
Polypeptide fragments derived from the obese gene product
|
|
AU730501B2
(en)
*
|
1996-04-23 |
2001-03-08 |
Novozymes A/S |
Animal feed additives
|
|
TR199802534T2
(en)
*
|
1996-06-06 |
1999-03-22 |
Smithkline Beecham P.L.C. |
Leptin (OB Protein) fragmanlar�
|
|
WO1998016545A1
(en)
*
|
1996-10-11 |
1998-04-23 |
Eli Lilly And Company |
Therapeutic proteins
|
|
US6420339B1
(en)
|
1998-10-14 |
2002-07-16 |
Amgen Inc. |
Site-directed dual pegylation of proteins for improved bioactivity and biocompatibility
|
|
ATE475094T1
(en)
|
2001-10-22 |
2010-08-15 |
Amgen Inc |
USE OF LEPTIN FOR TREATING LIPOATROPHY IN HUMAN BEINGS AND METHOD FOR DETERMINING PREDIPOSITION TO TREATMENT
|
|
US7105526B2
(en)
|
2002-06-28 |
2006-09-12 |
Banyu Pharmaceuticals Co., Ltd. |
Benzimidazole derivatives
|
|
US7772188B2
(en)
|
2003-01-28 |
2010-08-10 |
Ironwood Pharmaceuticals, Inc. |
Methods and compositions for the treatment of gastrointestinal disorders
|
|
CA2551037A1
(en)
|
2003-09-22 |
2005-03-31 |
Banyu Pharmaceutical Co., Ltd. |
Novel piperidine derivative
|
|
EP1734963A4
(en)
|
2004-04-02 |
2008-06-18 |
Merck & Co Inc |
Method of treating men with metabolic and anthropometric disorders
|
|
US7737155B2
(en)
|
2005-05-17 |
2010-06-15 |
Schering Corporation |
Nitrogen-containing heterocyclic compounds and methods of use thereof
|
|
JP5154927B2
(en)
|
2005-05-30 |
2013-02-27 |
Ｍｓｄ株式会社 |
Novel piperidine derivatives
|
|
AU2006277253A1
(en)
|
2005-08-10 |
2007-02-15 |
Msd K.K. |
Pyridone compound
|
|
WO2007024004A1
(en)
|
2005-08-24 |
2007-03-01 |
Banyu Pharmaceutical Co., Ltd. |
Phenylpyridone derivative
|
|
US8716220B2
(en)
|
2005-09-07 |
2014-05-06 |
Nikolaos Tezapsidis |
Leptin compositions and methods for treating progressive cognitive function disorders resulting from accumulation of neurofibrillary tangles and amyloid beta
|
|
US8227408B2
(en)
|
2005-09-07 |
2012-07-24 |
Neurotez, Inc. |
Leptin as an anti-amyloidogenic biologic and methods for delaying the onset and reducing Alzheimer's disease-like pathology
|
|
EP1939194A4
(en)
|
2005-09-07 |
2010-12-08 |
Banyu Pharma Co Ltd |
Bicyclic aromatic substituted pyridone derivative
|
|
CN101277960A
(en)
|
2005-09-29 |
2008-10-01 |
默克公司 |
Acylated spiropiperidine derivatives as melanocortin-4 receptor modulators
|
|
US20080255084A1
(en)
|
2005-10-21 |
2008-10-16 |
Randy Lee Webb |
Combination of Organic Compounds
|
|
US8163770B2
(en)
|
2005-10-27 |
2012-04-24 |
Msd. K. K. |
Benzoxathiin derivative
|
|
EP1953165B1
(en)
|
2005-11-10 |
2012-02-01 |
Msd K.K. |
Aza-substituted spiro derivative
|
|
CA2664113C
(en)
|
2006-09-22 |
2013-05-28 |
Merck & Co., Inc. |
Use of platencin and platensimycin as fatty acid synthesis inhibitors to treat obesity, diabetes and cancer
|
|
WO2008047544A1
(en)
|
2006-09-28 |
2008-04-24 |
Banyu Pharmaceutical Co., Ltd. |
Diaryl ketimine derivative
|
|
EP2145884B1
(en)
|
2007-04-02 |
2014-08-06 |
Msd K.K. |
Indoledione derivative
|
|
US8969514B2
(en)
|
2007-06-04 |
2015-03-03 |
Synergy Pharmaceuticals, Inc. |
Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
|
|
EP2527360B1
(en)
|
2007-06-04 |
2015-10-28 |
Synergy Pharmaceuticals Inc. |
Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
|
|
AU2009220605A1
(en)
|
2008-03-06 |
2009-09-11 |
Msd K.K. |
Alkylaminopyridine derivative
|
|
EP2272841A1
(en)
|
2008-03-28 |
2011-01-12 |
Banyu Pharmaceutical Co., Ltd. |
Diarylmethylamide derivative having antagonistic activity on melanin-concentrating hormone receptor
|
|
KR20110028457A
(en)
|
2008-05-21 |
2011-03-18 |
뉴로테즈 인코포레이티드 |
Methods for treating progressive cognitive disorders related to neurofibrillary tangles
|
|
AU2009256157B2
(en)
|
2008-06-04 |
2014-12-18 |
Bausch Health Ireland Limited |
Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
|
|
CA2727914A1
(en)
|
2008-06-19 |
2009-12-23 |
Banyu Pharmaceutical Co., Ltd. |
Spirodiamine-diaryl ketoxime derivative technical field
|
|
CA2730603C
(en)
|
2008-07-16 |
2019-09-24 |
Synergy Pharmaceuticals Inc. |
Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
|
|
JPWO2010013595A1
(en)
|
2008-07-30 |
2012-01-12 |
Ｍｓｄ株式会社 |
5-membered or 5-membered or 6-membered condensed cycloalkylamine derivative
|
|
MX2011004258A
(en)
|
2008-10-22 |
2011-06-01 |
Merck Sharp & Dohme |
Novel cyclic benzimidazole derivatives useful anti-diabetic agents.
|
|
CN102271509A
(en)
|
2008-10-31 |
2011-12-07 |
默沙东公司 |
Novel cyclic benzimidazole derivatives useful anti-diabetic agents
|
|
EP2379562A1
(en)
|
2008-12-16 |
2011-10-26 |
Schering Corporation |
Bicyclic pyranone derivatives as nicotinic acid receptor agonists
|
|
WO2010075068A1
(en)
|
2008-12-16 |
2010-07-01 |
Schering Corporation |
Pyridopyrimidine derivatives and methods of use thereof
|
|
EP2416797A4
(en)
|
2009-04-10 |
2013-04-24 |
Amylin Pharmaceuticals Llc |
Amylin agonist compounds for estrogen-deficient mammals
|
|
US8895596B2
(en)
|
2010-02-25 |
2014-11-25 |
Merck Sharp & Dohme Corp |
Cyclic benzimidazole derivatives useful as anti-diabetic agents
|
|
US9616097B2
(en)
|
2010-09-15 |
2017-04-11 |
Synergy Pharmaceuticals, Inc. |
Formulations of guanylate cyclase C agonists and methods of use
|
|
CA2813038C
(en)
|
2010-09-28 |
2021-12-28 |
Amylin Pharmaceuticals, Llc |
Highly soluble leptins
|
|
MY159058A
(en)
|
2011-02-25 |
2016-12-15 |
Merck Sharp & Dohme |
Novel cyclic azabenzimidazole derivatives useful as anti-diabetic agent
|
|
CA2880901A1
(en)
|
2012-08-02 |
2014-02-06 |
Merck Sharp & Dohme Corp. |
Antidiabetic tricyclic compounds
|
|
US9840512B2
(en)
|
2013-02-22 |
2017-12-12 |
Merck Sharp & Dohme Corp. |
Antidiabetic bicyclic compounds
|
|
US9650375B2
(en)
|
2013-03-14 |
2017-05-16 |
Merck Sharp & Dohme Corp. |
Indole derivatives useful as anti-diabetic agents
|
|
JP2016514671A
(en)
|
2013-03-15 |
2016-05-23 |
シナジー ファーマシューティカルズ インコーポレイテッド |
Guanylate cyclase agonists and uses thereof
|
|
WO2014151200A2
(en)
|
2013-03-15 |
2014-09-25 |
Synergy Pharmaceuticals Inc. |
Compositions useful for the treatment of gastrointestinal disorders
|
|
KR102272746B1
(en)
|
2013-06-05 |
2021-07-08 |
보슈 헬스 아일랜드 리미티드 |
Ultra-pure agonists of guanylate cyclase c, method of making and using same
|
|
WO2015051496A1
(en)
|
2013-10-08 |
2015-04-16 |
Merck Sharp & Dohme Corp. |
Antidiabetic tricyclic compounds
|
|
AU2015308350B2
(en)
|
2014-08-29 |
2020-03-05 |
Tes Pharma S.R.L. |
Inhibitors of alpha-amino-beta-carboxymuconic acid semialdehyde decarboxylase
|
|
AR109950A1
(en)
|
2016-10-14 |
2019-02-06 |
Tes Pharma S R L |
A-AMINO-b-CARBOXIMUCONIC SEMIAL DEHYDE DECARBOXYLASE ACID INHIBITORS
|
|
WO2018106518A1
(en)
|
2016-12-06 |
2018-06-14 |
Merck Sharp & Dohme Corp. |
Antidiabetic heterocyclic compounds
|
|
WO2018118670A1
(en)
|
2016-12-20 |
2018-06-28 |
Merck Sharp & Dohme Corp. |
Antidiabetic spirochroman compounds
|
|
TW202033516A
(en)
|
2018-11-20 |
2020-09-16 |
義大利商Ｔｅｓ製藥（股份）責任有限公司 |
Inhibitors of α-amino-β-carboxymuconic acid semialdehyde decarboxylase
|