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AU4186493A - Novel phospholipid derivatives - Google Patents

Novel phospholipid derivatives

Info

Publication number
AU4186493A
AU4186493A AU41864/93A AU4186493A AU4186493A AU 4186493 A AU4186493 A AU 4186493A AU 41864/93 A AU41864/93 A AU 41864/93A AU 4186493 A AU4186493 A AU 4186493A AU 4186493 A AU4186493 A AU 4186493A
Authority
AU
Australia
Prior art keywords
phospholipid derivatives
novel phospholipid
novel
derivatives
medicaments
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
AU41864/93A
Other versions
AU664101B2 (en
Inventor
Jurgen Engel
Peter Hilgard
Bernhard Kutscher
Gerhard Nossner
Wolfgang Schumacher
Jurij Stekar
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aeterna Zentaris GmbH
Original Assignee
Aeterna Zentaris GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aeterna Zentaris GmbH filed Critical Aeterna Zentaris GmbH
Publication of AU4186493A publication Critical patent/AU4186493A/en
Application granted granted Critical
Publication of AU664101B2 publication Critical patent/AU664101B2/en
Assigned to ZENTARIS AKTIENGESELLSCHAFT reassignment ZENTARIS AKTIENGESELLSCHAFT Alteration of Name(s) in Register under S187 Assignors: ASTA MEDICA AKTIENGESELLSCHAFT
Assigned to ZENTARIS GMBH reassignment ZENTARIS GMBH Alteration of Name(s) in Register under S187 Assignors: ZENTARIS AKTIENGESELLSCHAFT
Assigned to AETERNA ZENTARIS GMBH reassignment AETERNA ZENTARIS GMBH Request to Amend Deed and Register Assignors: ZENTARIS GMBH
Anticipated expiration legal-status Critical
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/10—Phosphatides, e.g. lecithin
    • C07F9/106—Adducts, complexes, salts of phosphatides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/5532—Seven-(or more) membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/572—Five-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/576—Six-membered rings
    • C07F9/59—Hydrogenated pyridine rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Dermatology (AREA)
  • AIDS & HIV (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Saccharide Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Inorganic Compounds Of Heavy Metals (AREA)

Abstract

Novel phospholipid derivatives, preparation processes therefor and their use as medicaments are described.
AU41864/93A 1992-07-11 1993-07-09 Novel phospholipid derivatives Expired AU664101B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4222910A DE4222910A1 (en) 1992-07-11 1992-07-11 New phospholipid derivatives
DE4222910 1992-07-11

Publications (2)

Publication Number Publication Date
AU4186493A true AU4186493A (en) 1994-01-13
AU664101B2 AU664101B2 (en) 1995-11-02

Family

ID=6463031

Family Applications (1)

Application Number Title Priority Date Filing Date
AU41864/93A Expired AU664101B2 (en) 1992-07-11 1993-07-09 Novel phospholipid derivatives

Country Status (31)

Country Link
EP (1) EP0579939B1 (en)
JP (1) JP3311431B2 (en)
KR (1) KR100297180B1 (en)
CN (1) CN1039012C (en)
AT (1) ATE176477T1 (en)
AU (1) AU664101B2 (en)
BR (1) BR9302809A (en)
CA (2) CA2511753C (en)
CZ (1) CZ290863B6 (en)
DE (2) DE4222910A1 (en)
DK (1) DK0579939T3 (en)
EE (1) EE03140B1 (en)
ES (1) ES2129053T3 (en)
FI (1) FI111262B (en)
GR (1) GR3029602T3 (en)
HR (1) HRP931046B1 (en)
HU (1) HU218783B (en)
IL (1) IL106289A (en)
LT (1) LT3113B (en)
LV (1) LV10870B (en)
MX (1) MX9304133A (en)
NO (1) NO306468B1 (en)
PL (3) PL177811B1 (en)
RU (1) RU2108336C1 (en)
SG (1) SG46249A1 (en)
SI (1) SI9300365B (en)
SK (1) SK283827B6 (en)
TW (1) TW304956B (en)
UA (1) UA40567C2 (en)
YU (1) YU49079B (en)
ZA (1) ZA934971B (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0606480A (en) 2005-01-21 2008-03-11 Astex Therapeutics Ltd pharmaceutical compounds
PL1962862T3 (en) 2005-12-19 2014-01-31 Aeterna Zentaris Gmbh Alkyl phospholipid derivatives with reduced cytotoxicity and uses therof
EP1800684A1 (en) * 2005-12-20 2007-06-27 Zentaris GmbH Novel alkyl phospholipid derivatives and uses thereof
EP1869981A1 (en) * 2006-06-21 2007-12-26 Staatliches Weinbauinstitut Freiburg Alkylphospholipids and lysophospholipids for controlling plant pathogens
WO2008044045A1 (en) 2006-10-12 2008-04-17 Astex Therapeutics Limited Pharmaceutical combinations
US8916552B2 (en) 2006-10-12 2014-12-23 Astex Therapeutics Limited Pharmaceutical combinations

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0050327B1 (en) * 1980-10-21 1984-06-20 Roche Diagnostics GmbH Phospholipids that contain sulphur, process for their preparation and medicines containing these compounds
JPS5984824A (en) * 1982-11-08 1984-05-16 Takeda Chem Ind Ltd Antitumor agent
DE3530767A1 (en) * 1985-08-28 1987-03-12 Max Planck Gesellschaft AGENT AGAINST MULTIPLE Sclerosis
IE59778B1 (en) * 1985-12-04 1994-04-06 Max Planck Gesellschaft Medicament with anti-tumour action containing hexadecylphosphocholine
DE3765502D1 (en) * 1986-07-14 1990-11-15 Nippon Chemiphar Co GLYCEROL DERIVATIVE AND ANTI-HYPERTENSIVE AGENT.
DE3881925T2 (en) * 1987-03-24 1994-01-27 Nippon Chemiphar Co Glycerol derivatives and anti-hypertensive agent.
DE3906952A1 (en) * 1989-03-04 1990-09-06 Boehringer Mannheim Gmbh (3- (C (DOWN ARROW)) (DOWN ARROW) (DOWN ARROW) 6 (DOWN ARROW) -C (DOWN ARROW) 1 (DOWN ARROW) (DOWN ARROW) 8 (DOWN ARROW)) ALKANSULFINYL AND 2 SULPHONE -METHOXYMETHYL-PROPYL) - (2-TRIMETHYLAMMONIO-ETHYL) PHOSPHATES, METHOD FOR PRODUCING THE MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS
DE3942933A1 (en) * 1989-12-23 1991-06-27 Boehringer Mannheim Gmbh USE OF ALKYLPHOSPHOLIPIDES AS ANTIVIRAL MEDICINAL PRODUCTS AND NEW PHOSPHOLIPID DERIVATIVES
DE4114586A1 (en) * 1991-05-04 1992-11-05 Boehringer Mannheim Gmbh MEDICINAL PRODUCTS CONTAINING AZACYCLODIPHOSPHONIC ACID DERIVATIVES, NEW AZACYCLODIPHOSPHONIC ACID DERIVATIVES AND METHOD FOR THE PRODUCTION THEREOF

Also Published As

Publication number Publication date
RU2108336C1 (en) 1998-04-10
UA40567C2 (en) 2001-08-15
CA2100228A1 (en) 1994-01-12
KR100297180B1 (en) 2001-11-30
HUT64548A (en) 1994-01-28
PL177811B1 (en) 2000-01-31
YU49079B (en) 2003-08-29
TW304956B (en) 1997-05-11
EE03140B1 (en) 1998-12-15
CA2511753C (en) 2007-09-25
DK0579939T3 (en) 1999-09-20
IL106289A (en) 2000-06-01
SG46249A1 (en) 1998-02-20
CA2511753A1 (en) 1994-01-12
ZA934971B (en) 1994-02-01
LTIP620A (en) 1994-07-15
MX9304133A (en) 1994-04-29
EP0579939A1 (en) 1994-01-26
SK283827B6 (en) 2004-02-03
CZ290863B6 (en) 2002-11-13
HU9301992D0 (en) 1993-09-28
KR940002265A (en) 1994-02-17
CN1039012C (en) 1998-07-08
JP3311431B2 (en) 2002-08-05
IL106289A0 (en) 1994-04-12
PL173388B1 (en) 1998-02-27
SI9300365A (en) 1994-03-31
CA2100228C (en) 2006-01-24
PL299624A1 (en) 1994-02-21
NO306468B1 (en) 1999-11-08
GR3029602T3 (en) 1999-06-30
PL175607B1 (en) 1999-01-29
FI111262B (en) 2003-06-30
ES2129053T3 (en) 1999-06-01
EP0579939B1 (en) 1999-02-03
FI933165A0 (en) 1993-07-09
SI9300365B (en) 2002-02-28
ATE176477T1 (en) 1999-02-15
DE59309355D1 (en) 1999-03-18
BR9302809A (en) 1994-03-15
HU218783B (en) 2000-12-28
CZ124993A3 (en) 1995-03-15
HRP931046B1 (en) 2000-06-30
YU47393A (en) 1997-08-22
AU664101B2 (en) 1995-11-02
LV10870A (en) 1995-10-20
HRP931046A2 (en) 1997-04-30
NO932502D0 (en) 1993-07-08
CN1084175A (en) 1994-03-23
DE4222910A1 (en) 1994-01-13
FI933165A (en) 1994-01-12
LV10870B (en) 1996-06-20
LT3113B (en) 1994-12-27
NO932502L (en) 1994-01-12
JPH0733791A (en) 1995-02-03
SK67093A3 (en) 1995-03-08

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Legal Events

Date Code Title Description
PC Assignment registered

Owner name: ZENTARIS AKTIENGESELLSCHAFT

Free format text: FORMER OWNER WAS: ASTA MEDICA AKTIENGESELLSCHAFT

PC Assignment registered

Owner name: ZENTARIS GMBH

Free format text: FORMER OWNER WAS: ZENTARIS AKTIENGESELLSCHAFT