AU3683878A - Penicillanic acid 1,1-dioxides as beta-lactamase inhibitors - Google Patents

Penicillanic acid 1,1-dioxides as beta-lactamase inhibitors

Info

Publication number: AU3683878A
Authority: AU; Australia
Prior art keywords: dioxides; beta; penicillanic acid; lactamase inhibitors; lactamase
Prior art date: 1977-06-07
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Granted

Application number

AU36838/78A

Other versions

AU513636B2 (en

Inventor

Wayne Ernest Barth

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Pfizer Inc

Original Assignee

Pfizer Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1977-06-07

Filing date

1978-06-02

Publication date

1979-12-06

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27122691&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AU3683878(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1978-06-02 Application filed by Pfizer Inc filed Critical Pfizer Inc

1979-12-06 Publication of AU3683878A publication Critical patent/AU3683878A/en

1980-12-11 Application granted granted Critical

1980-12-11 Publication of AU513636B2 publication Critical patent/AU513636B2/en

1994-06-03 Anticipated expiration legal-status Critical

Status Ceased legal-status Critical Current

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
- A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/429—Thiazoles condensed with heterocyclic ring systems
- A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Oncology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Communicable Diseases (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

AU36838/78A 1977-06-07 1978-06-02 Penicillanic acid 1,1-dioxides as beta-lactamase inhibitors Ceased AU513636B2 (en)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date
US80432077A	1977-06-07	1977-06-07
US804320		1977-06-07
US87938178A	1978-02-21	1978-02-21
US879381		1978-02-21

Related Child Applications (3)

Application Number	Title	Priority Date	Filing Date
AU48465/79A Addition AU514926B2 (en)	1977-06-07	1979-06-27	Combination of derivatives of pencillin and cephalosporan
AU64030/80A Division AU522487B2 (en)	1977-06-07	1980-10-31	Intermediate compounds to penicillanic and 11-dioxides
AU64031/80A Division AU522465B2 (en)	1977-06-07	1980-10-31	Intermediate compounds to penicillanic and 11-dioxides

Publications (2)

Publication Number	Publication Date
AU3683878A true AU3683878A (en)	1979-12-06
AU513636B2 AU513636B2 (en)	1980-12-11

Family

ID=27122691

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AU36838/78A Ceased AU513636B2 (en)	1977-06-07	1978-06-02	Penicillanic acid 1,1-dioxides as beta-lactamase inhibitors

Country Status (35)

Country	Link
AR (1)	AR224111A1 (en)
AT (2)	AT360649B (en)
AU (1)	AU513636B2 (en)
BE (1)	BE867859A (en)
BG (2)	BG34615A3 (en)
CH (1)	CH634073A5 (en)
CS (1)	CS208472B2 (en)
DD (2)	DD148585A5 (en)
DE (2)	DE2857263C3 (en)
DK (1)	DK155740C (en)
EG (1)	EG13869A (en)
FI (1)	FI66003C (en)
FR (2)	FR2393804A1 (en)
GB (1)	GB2000138B (en)
GR (1)	GR72255B (en)
HK (1)	HK13184A (en)
HU (1)	HU180042B (en)
IE (1)	IE47079B1 (en)
IL (2)	IL54867A (en)
IN (1)	IN149747B (en)
IT (1)	IT1096381B (en)
KE (1)	KE3355A (en)
LU (1)	LU79774A1 (en)
MY (1)	MY8500092A (en)
NL (2)	NL180009C (en)
NO (2)	NO151746C (en)
NZ (1)	NZ187476A (en)
OA (1)	OA05964A (en)
PH (3)	PH26810A (en)
PL (1)	PL114501B1 (en)
PT (1)	PT68146A (en)
SE (2)	SE436206B (en)
SG (1)	SG65383G (en)
SU (1)	SU860706A1 (en)
YU (1)	YU41829B (en)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
LU77306A1 (en) *	1977-05-09	1979-01-18
DE2912511C2 (en) *	1977-06-07	1982-06-24	Pfizer Inc., 10017 New York, N.Y.	Pharmaceutical composition containing penicillanic acid
DK155942C (en) *	1977-12-23	1989-10-23	Pfizer	METHOD OF ANALOGUE FOR THE PREPARATION OF 6-AMINOPENICILLANIC ACID-1,1-DIOXIDE AND PHYSIOLOGICALLY ACCEPTABLE ACID ADDITION AND BASIS SALTS.
JPS54126735A (en) *	1978-03-24	1979-10-02	Toyama Chem Co Ltd	Bactericidal composition for medical use
US4241050A (en) *	1978-09-01	1980-12-23	Pfizer Inc.	Penam 1,1-dioxides as beta-lactamase inhibitors
CA1158639A (en) *	1978-12-11	1983-12-13	Eric M. Gordon	6-bromopenicillanic acid sulfone
IE49880B1 (en) *	1979-02-13	1986-01-08	Leo Pharm Prod Ltd	Penicillin derivatives
SE449103B (en) *	1979-03-05	1987-04-06	Pfizer	SET TO PENICILLANIC ACID-1,1-DIOXIDE AND ESSERS THEREOF
US4714761A (en) *	1979-03-05	1987-12-22	Pfizer Inc.	6,6-dihalopenicillanic acid 1,1-dioxides and process
US4420426A (en)	1979-03-05	1983-12-13	Pfizer Inc.	6-Alpha-halopenicillanic acid 1,1-dioxides
GB2045236A (en) *	1979-03-26	1980-10-29	Hoechst Uk Ltd	Oxapenem derivatives
US4309347A (en)	1979-05-16	1982-01-05	Pfizer Inc.	Penicillanoyloxymethyl penicillanate 1,1,1',1'-tetraoxide
US4244951A (en)	1979-05-16	1981-01-13	Pfizer Inc.	Bis-esters of methanediol with penicillins and penicillanic acid 1,1-dioxide
IL59948A0 (en) *	1979-05-21	1980-06-30	Rech Applications Therap	Penicillanic acid derivatives,their production and pharmaceutical compositions containing them
DE3051044C2 (en) *	1979-06-19	1989-03-30	Leo Pharmaceutical Products Ltd. A/S (Loevens Kemiske Fabrik Produktionsaktieselskab), Ballerup, Dk
US4256733A (en) *	1979-09-26	1981-03-17	Pfizer Inc.	Acetoxymethyl penam compounds as β-lactamase inhibitors
US4432970A (en) *	1979-11-23	1984-02-21	Pfizer Inc.	6-beta-Halopenicillanic acid 1,1-dioxides as beta-lactamase inhibitors
IL61880A (en) *	1980-01-21	1984-11-30	Bristol Myers Co	2beta-chloromethyl-2alpha-methylpenam-3alpha-carboxylic acid sulfone derivatives,their preparation and pharmaceutical compositions containing them
US4432903A (en) *	1980-09-08	1984-02-21	Pfizer Inc.	Bis-esters of methanediol with penicillins and penicillanic acid 1,1-dioxide
US4488994A (en) *	1980-09-08	1984-12-18	Pfizer Inc.	Bis-esters of methanediol with penicillins and penicillanic acid 1,1-dioxide
US4474698A (en) *	1980-12-11	1984-10-02	Pfizer Inc.	Process for preparing esters of penicillanic acid sulfone
US4419284A (en) *	1981-03-23	1983-12-06	Pfizer Inc.	Preparation of halomethyl esters (and related esters) of penicillanic acid 1,1-dioxide
EP0069962B1 (en) *	1981-07-15	1985-01-02	Kanebo, Ltd.	Novel ester of 1,1-dioxopenicillanic acid, process for production thereof, and use thereof as beta-lactamase inhibitor
PT76526B (en) *	1982-04-19	1986-01-21	Gist Brocades Nv	Preparation of 6-alpha-bromo- and/or 6,6-dibromopenicillanic acid 1,1-dioxides
US4502988A (en) *	1983-08-08	1985-03-05	Eli Lilly And Company	Oxidation process
EP0139047A1 (en) *	1983-10-18	1985-05-02	Gist-Brocades N.V.	Process for the preparation of 6,6-dibromopenicillanic acid 1,1-dioxide
US4647457A (en) *	1983-12-16	1987-03-03	Hoffmann-La Roche Inc.	Penicillanic acid derivatives
WO1987006230A1 (en) *	1986-04-10	1987-10-22	Leo Pharmaceutical Products Ltd. A/S	Method for preparing penicillanic acid derivatives
GB8808701D0 (en) *	1988-04-13	1988-05-18	Erba Carlo Spa	Beta-lactam derivatives
CN102977120B (en) *	2012-12-14	2015-05-27	江西富祥药业股份有限公司	Method for preparing and crystallizing sulbactam pivoxyl

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3197466A (en) *	1961-10-30	1965-07-27	Smith Kline French Lab	Penicillin sulfoxides and process
LU77306A1 (en) *	1977-05-09	1979-01-18
AU3796278A (en) *	1977-07-13	1980-01-17	Glaxo Group Ltd	Penams and azetidinones

1978
- 1978-05-04 IN IN327/DEL/78A patent/IN149747B/en unknown
- 1978-05-09 PH PH21116A patent/PH26810A/en unknown
- 1978-05-16 YU YU1170/78A patent/YU41829B/en unknown
- 1978-05-18 OA OA56500A patent/OA05964A/en unknown
- 1978-05-20 EG EG322/78A patent/EG13869A/en active
- 1978-05-30 BG BG042176A patent/BG34615A3/en unknown
- 1978-05-30 BG BG039910A patent/BG34614A3/en unknown
- 1978-06-01 CS CS783579A patent/CS208472B2/en unknown
- 1978-06-02 GB GB7826308A patent/GB2000138B/en not_active Expired
- 1978-06-02 AU AU36838/78A patent/AU513636B2/en not_active Ceased
- 1978-06-05 DE DE2857263A patent/DE2857263C3/en not_active Expired
- 1978-06-05 GR GR56439A patent/GR72255B/el unknown
- 1978-06-05 DE DE2824535A patent/DE2824535C3/en not_active Expired
- 1978-06-06 PL PL1978207396A patent/PL114501B1/en unknown
- 1978-06-06 FI FI781800A patent/FI66003C/en not_active IP Right Cessation
- 1978-06-06 FR FR787816893A patent/FR2393804A1/en active Granted
- 1978-06-06 SU SU782624408A patent/SU860706A1/en active
- 1978-06-06 DK DK251478A patent/DK155740C/en not_active IP Right Cessation
- 1978-06-06 CH CH618078A patent/CH634073A5/en not_active IP Right Cessation
- 1978-06-06 IE IE1140/78A patent/IE47079B1/en not_active IP Right Cessation
- 1978-06-06 NL NLAANVRAGE7806126,A patent/NL180009C/en not_active IP Right Cessation
- 1978-06-06 NZ NZ187476A patent/NZ187476A/en unknown
- 1978-06-06 IL IL54867A patent/IL54867A/en unknown
- 1978-06-06 SE SE7806628A patent/SE436206B/en not_active IP Right Cessation
- 1978-06-06 BE BE188352A patent/BE867859A/en not_active IP Right Cessation
- 1978-06-06 AT AT411278A patent/AT360649B/en active Protection Beyond IP Right Term
- 1978-06-06 IT IT24270/78A patent/IT1096381B/en active Protection Beyond IP Right Term
- 1978-06-06 HU HU78PI630A patent/HU180042B/en unknown
- 1978-06-06 PT PT68146A patent/PT68146A/en unknown
- 1978-06-06 NO NO781970A patent/NO151746C/en unknown
- 1978-06-06 LU LU79774A patent/LU79774A1/en unknown
- 1978-06-07 DD DD78218400A patent/DD148585A5/en unknown
- 1978-06-07 DD DD78205839A patent/DD140888A5/en unknown
- 1978-08-18 AR AR272228A patent/AR224111A1/en active
- 1978-09-08 PH PH21587A patent/PH16465A/en unknown
- 1978-09-08 PH PH21586A patent/PH21116A/en unknown
- 1978-09-19 FR FR787826789A patent/FR2393805A1/en active Granted
1980
- 1980-03-07 AT AT0128580A patent/AT364084B/en not_active IP Right Cessation
1981
- 1981-02-19 IL IL62168A patent/IL62168A0/en unknown
1982
- 1982-09-15 NO NO823126A patent/NO152448C/en unknown
1983
- 1983-10-27 SE SE8305916A patent/SE447995B/en not_active IP Right Cessation
- 1983-11-02 SG SG653/83A patent/SG65383G/en unknown
- 1983-11-22 KE KE3355A patent/KE3355A/en unknown
1984
- 1984-02-16 HK HK131/84A patent/HK13184A/en not_active IP Right Cessation
1985
- 1985-12-30 MY MY92/85A patent/MY8500092A/en unknown
1993
- 1993-06-11 NL NL930064C patent/NL930064I2/en unknown

Also Published As

Publication number	Publication date
IE47079B1 (en)	1983-12-14
EG13869A (en)	1983-03-31
SU860706A1 (en)	1981-08-30
NO151746C (en)	1985-06-05
DD148585A5 (en)	1981-06-03
IT1096381B (en)	1985-08-26
CS208472B2 (en)	1981-09-15
IT7824270A0 (en)	1978-06-06
PH26810A (en)	1992-11-05
PL207396A1 (en)	1979-06-04
NL180009C (en)	1986-12-16
PL114501B1 (en)	1981-02-28
DE2824535C3 (en)	1981-01-22
DE2824535B2 (en)	1980-05-14
IL62168A0 (en)	1981-03-31
PH16465A (en)	1983-10-20
DE2857263C3 (en)	1981-12-17
AU513636B2 (en)	1980-12-11
AT360649B (en)	1981-01-26
AT364084B (en)	1981-09-25
ATA128580A (en)	1981-02-15
AR224111A1 (en)	1981-10-30
BE867859A (en)	1978-12-06
ATA411278A (en)	1980-06-15
DK155740C (en)	1989-10-23
NL930064I2 (en)	1994-04-18
DK251478A (en)	1978-12-08
DK155740B (en)	1989-05-08
FR2393804A1 (en)	1979-01-05
KE3355A (en)	1983-12-16
PH21116A (en)	1987-07-16
YU117078A (en)	1983-01-21
SE8305916L (en)	1983-10-27
NO152448B (en)	1985-06-24
DD140888A5 (en)	1980-04-02
SE436206B (en)	1984-11-19
BG34615A3 (en)	1983-10-15
IL54867A (en)	1981-11-30
IL54867A0 (en)	1978-08-31
NO781970L (en)	1978-12-08
FI781800A (en)	1978-12-08
YU41829B (en)	1988-02-29
FR2393805A1 (en)	1979-01-05
MY8500092A (en)	1985-12-31
SG65383G (en)	1985-03-29
HU180042B (en)	1983-01-28
IE781140L (en)	1978-12-07
FI66003C (en)	1984-08-10
DE2824535A1 (en)	1978-12-14
NO151746B (en)	1985-02-18
BG34614A3 (en)	1983-10-15
NL7806126A (en)	1978-12-11
PT68146A (en)	1978-07-01
NL930064I1 (en)	1993-09-01
FR2393805B1 (en)	1984-02-24
GR72255B (en)	1983-10-06
NO152448C (en)	1985-10-02
HK13184A (en)	1984-02-24
GB2000138A (en)	1979-01-04
FR2393804B1 (en)	1980-11-07
NO823126L (en)	1978-12-08
DE2857263B2 (en)	1981-04-23
NZ187476A (en)	1982-08-17
SE8305916D0 (en)	1983-10-27
IN149747B (en)	1982-04-03
SE7806628L (en)	1978-12-08
OA05964A (en)	1981-06-30
GB2000138B (en)	1982-03-03
CH634073A5 (en)	1983-01-14
SE447995B (en)	1987-01-12
FI66003B (en)	1984-04-30
LU79774A1 (en)	1980-01-22

Publication	Publication Date	Title
AU513636B2 (en)	1980-12-11	Penicillanic acid 1,1-dioxides as beta-lactamase inhibitors
GB2081269B (en)	1983-01-19	Penicillanic acid derivatives
AU6306180A (en)	1981-04-16	Syn-7-(2-amino-4-thiazolyl) methoxyimino-acetamido -3- acetoxymethyl-3-cephem-4-carboxylic acid
AU523346B2 (en)	1982-07-22	Cephalosporanic acid derivatives
AU534754B2 (en)	1984-02-16	Penicillanic acid derivatives
AU517074B2 (en)	1981-07-09	3 acetoxymethy-6-unsubstituted-penam compounds as beta- lactamase inhibitors
AU518781B2 (en)	1981-10-22	7-OXO-l-AZABICYCLO 3. 2. 0 HEPT-2-ENE-2-CARBOXYLIC ACID DERIVATIVES
DK166353C (en)	1993-09-06	Penicillanic acid 1,1-dioxide DERIVATIVES
AU525132B2 (en)	1982-10-21	Beta-lactam compounds
AU3615678A (en)	1979-11-22	6-azaoligocycloakyl-methylene amino-penicillanic acid derivatives
AU3553078A (en)	1979-11-01	O-aminodeoxyclayulanic acid derivatives
PH16933A (en)	1984-04-17	6-amidino penicillanic acid derivatives including the radical of a beta-lactamase inhibitors
AU518620B2 (en)	1981-10-08	7d-methoxy-7b-(1,3-dithietane-2-carboxamido)cephalosporanic acid derivatives
GB2051046B (en)	1984-03-28	Penicillanic acid derivatives
AU4689879A (en)	1979-11-29	Penicillanic acid derivative
AU3540678A (en)	1979-11-01	2-trichloromethyl-4-nitrobenzenesulfenic acid derivatives
AU524795B2 (en)	1982-10-07	Beta-lactam series compound
AU511232B2 (en)	1980-08-07	Penicillins
AU533598B2 (en)	1983-12-01	Antibacterial penicillin derivatives
KE3489A (en)	1985-01-11	7alpha-methoxy-7beta-(1,3-dithietane-2-carboxamido)cephalosporanic acid derivatives
GB2052981B (en)	1984-01-11	Penicillanic acid derivatives as -lactamose inhibitors
ZA782140B (en)	1979-03-28	Penicillanic acid 1,1-dioxides as b-lactamase inhibitors
ZA80880B (en)	1981-02-25	6-beta-substituted penicillanic acids as beta-lactamase inhibitors
AU512826B2 (en)	1980-10-30	6-ketenimine penicillin derivatives
SG55984G (en)	1985-03-08	Penicillanic acid derivatives