AU2021466848A1 - Polyalkylene alkyl compound for defoaming fermentation broth - Google Patents
Polyalkylene alkyl compound for defoaming fermentation broth Download PDFInfo
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- AU2021466848A1 AU2021466848A1 AU2021466848A AU2021466848A AU2021466848A1 AU 2021466848 A1 AU2021466848 A1 AU 2021466848A1 AU 2021466848 A AU2021466848 A AU 2021466848A AU 2021466848 A AU2021466848 A AU 2021466848A AU 2021466848 A1 AU2021466848 A1 AU 2021466848A1
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- control agent
- foam
- foam control
- fermentation
- compound
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- 230000004151 fermentation Effects 0.000 title claims description 28
- 238000000855 fermentation Methods 0.000 title claims description 27
- -1 alkyl compound Chemical class 0.000 title description 3
- 229920001281 polyalkylene Polymers 0.000 title 1
- 239000006260 foam Substances 0.000 claims abstract description 57
- 238000000034 method Methods 0.000 claims abstract description 35
- 150000001875 compounds Chemical class 0.000 claims abstract description 16
- 239000000203 mixture Substances 0.000 claims abstract description 16
- 230000015572 biosynthetic process Effects 0.000 claims abstract description 8
- 230000002401 inhibitory effect Effects 0.000 claims abstract description 4
- 239000003795 chemical substances by application Substances 0.000 claims description 26
- 125000004432 carbon atom Chemical group C* 0.000 claims description 7
- 229930195733 hydrocarbon Natural products 0.000 claims description 7
- 239000004215 Carbon black (E152) Substances 0.000 claims description 6
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 claims description 6
- GOOHAUXETOMSMM-UHFFFAOYSA-N Propylene oxide Chemical compound CC1CO1 GOOHAUXETOMSMM-UHFFFAOYSA-N 0.000 claims description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 6
- 238000009472 formulation Methods 0.000 claims description 4
- 239000004094 surface-active agent Substances 0.000 claims description 4
- 108090000790 Enzymes Proteins 0.000 claims description 2
- 102000004190 Enzymes Human genes 0.000 claims description 2
- 108010015776 Glucose oxidase Proteins 0.000 claims description 2
- 239000004366 Glucose oxidase Substances 0.000 claims description 2
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims description 2
- 239000004472 Lysine Substances 0.000 claims description 2
- 150000001413 amino acids Chemical class 0.000 claims description 2
- 229940088598 enzyme Drugs 0.000 claims description 2
- 229940116332 glucose oxidase Drugs 0.000 claims description 2
- 235000019420 glucose oxidase Nutrition 0.000 claims description 2
- 239000002480 mineral oil Substances 0.000 claims description 2
- 229920001296 polysiloxane Polymers 0.000 claims description 2
- 235000015112 vegetable and seed oil Nutrition 0.000 claims description 2
- 239000001993 wax Substances 0.000 claims description 2
- 239000013530 defoamer Substances 0.000 claims 1
- 239000006137 Luria-Bertani broth Substances 0.000 description 10
- 235000010633 broth Nutrition 0.000 description 9
- 238000005187 foaming Methods 0.000 description 5
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 4
- 239000007789 gas Substances 0.000 description 4
- 238000004519 manufacturing process Methods 0.000 description 4
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 3
- 239000000654 additive Substances 0.000 description 3
- 150000001298 alcohols Chemical class 0.000 description 3
- 229910052799 carbon Inorganic materials 0.000 description 3
- 230000000052 comparative effect Effects 0.000 description 3
- 239000008367 deionised water Substances 0.000 description 3
- 229910021641 deionized water Inorganic materials 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 235000012054 meals Nutrition 0.000 description 3
- 244000005700 microbiome Species 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 2
- 241000233866 Fungi Species 0.000 description 2
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 238000013019 agitation Methods 0.000 description 2
- 239000003054 catalyst Substances 0.000 description 2
- 238000011156 evaluation Methods 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 229910052757 nitrogen Inorganic materials 0.000 description 2
- 235000015097 nutrients Nutrition 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 239000012138 yeast extract Substances 0.000 description 2
- 208000035143 Bacterial infection Diseases 0.000 description 1
- XFXPMWWXUTWYJX-UHFFFAOYSA-N Cyanide Chemical compound N#[C-] XFXPMWWXUTWYJX-UHFFFAOYSA-N 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 235000019733 Fish meal Nutrition 0.000 description 1
- 244000046052 Phaseolus vulgaris Species 0.000 description 1
- 235000010627 Phaseolus vulgaris Nutrition 0.000 description 1
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 1
- 229910021529 ammonia Inorganic materials 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 208000022362 bacterial infectious disease Diseases 0.000 description 1
- 229920001400 block copolymer Polymers 0.000 description 1
- 230000005587 bubbling Effects 0.000 description 1
- 229940041514 candida albicans extract Drugs 0.000 description 1
- 239000004202 carbamide Substances 0.000 description 1
- 150000001735 carboxylic acids Chemical class 0.000 description 1
- 150000002016 disaccharides Chemical class 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 239000003925 fat Substances 0.000 description 1
- 150000002191 fatty alcohols Chemical class 0.000 description 1
- 239000004467 fishmeal Substances 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 150000002430 hydrocarbons Chemical class 0.000 description 1
- 238000010191 image analysis Methods 0.000 description 1
- 238000009655 industrial fermentation Methods 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 239000002609 medium Substances 0.000 description 1
- 230000002503 metabolic effect Effects 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 230000000116 mitigating effect Effects 0.000 description 1
- 150000002772 monosaccharides Chemical class 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 238000004886 process control Methods 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 230000029058 respiratory gaseous exchange Effects 0.000 description 1
- 229920002545 silicone oil Polymers 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 230000008685 targeting Effects 0.000 description 1
- 239000012137 tryptone Substances 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D19/00—Degasification of liquids
- B01D19/02—Foam dispersion or prevention
- B01D19/04—Foam dispersion or prevention by addition of chemical substances
- B01D19/0404—Foam dispersion or prevention by addition of chemical substances characterised by the nature of the chemical substance
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Toxicology (AREA)
- Dispersion Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Degasification And Air Bubble Elimination (AREA)
Abstract
The present invention relates to a method for inhibiting the formation of foam in a process comprising the step of adding an effective amount of a foam control agent to a process mixture. The foam control agent comprises a compound that can be represented by the formula, RO (EO)
Description
This invention relates to a method of inhibiting the formation of foam in industrial processes such as in fermentation broths.
INTRODUCTION
Foam is generated in almost any industrial process where a liquid, gas, foam-stabilizing surfactants and agitation are present. In most cases, foam is undesirable, especially in fermentation industry. Foaming is a nuisance during fermentation process because it causes process control issues and reduces the mechanical efficiency. For example, the existence of foam in fermentation tank may result in a prolonged fermentation cycle, reduce production capacity, waste raw materials, affect bacterial respiration, cause bacterial infection and may affect the quality of the finished products.
Current methods to control foam include mechanical means such as the use of baffles and mixing control systems. In conjunction, chemical defoamers or antifoamers are often used. There are different classes of additives used in prevention, removal and mitigation of foam formation that work via differing mechanisms and are effective for different foam types (e.g. macro vs micro foams) . While in principle these classes differ, the terms used to define them are often used interchangeably. In addition, many, if not most additives, do not solely perform only one function.
Antifoamers are additives that prevent or inhibit foam formation from the outset, and are typically added to a potentially foaming solution prior to foam formation. Defoamers are compounds that are added to mixtures in order to destroy foam that has already been generated, targeting surface foam (macro foam) and aiming to bring about rapid foam collapse. Deaerators function in a manner similar to defoamers, also aiming to destroy foam that has already been generated, but they target sub-surface foam (micro foam) . Well known defoamers, antifoamers and deaerators include amongst others, silicone oils as well as block copolymers of lower alkylene glycols.
There is however an ongoing need for improved stable, simple, low cost, aqueous defoamers, antifoamers and /or deaerators in concentrated form for effective application in the chemical, household and industrial process industries.
SUMMARY
The present invention relates to a method for inhibiting the formation of foam in a process comprising the step of adding an effective amount of a foam control agent to a process mixture. The foam control agent comprises a compound that can be represented by the formula, RO (EO)
n (PO)
mH, where R is a linear hydrocarbon radical having from 12 to 18 carbon atoms; EO is ethylene oxide; PO is propylene oxide; n can be any integer from 2 to 9; and m can be any integer from 8 to 19. Furthermore, the compounds can be characterized in that the molecular weight of R is from 10 to 29 percent by weight of the compound. These compositions have been found to be superior in controlling foam formation versus conventional antifoamers in fermentation, preferably in amino acids fermentation and enzyme fermentation, more preferably in lysine, MSG and glucose oxidase fermentation.
The present invention has utility in any process where a liquid and a gas are present and agitation or other means of surface interaction between the liquid and gas is present, as under such conditions foam has a tendency to be generated. In particular, the present invention has been found to have utility in controlling foaming in a fermentation broth. For purposes of this invention, "fermentation broth" means an aqueous dispersion of nutrients usually with microorganisms, from which a metabolic product is ultimately extracted. The microorganisms are preferably bacteria or fungi or yeast. Typical nutrients seen in fermentation comprise a source of carbon, nitrogen, salts, and organism-specific requirements. Typical carbon sources include monosaccharides, disaccharides, polysaccharides, alcohols, carboxylic acids, fats, and hydrocarbons. Nitrogen sources often also include carbon, and are exemplified by ammonia, urea, bean meal, grain meal, seed meal, fish meal, cornsteep liquor, and yeast extracts. Salts can be specifically added to the fermentation broth as well.
The method of the present invention comprises the step of adding an effective amount of a foam control agent to a process mixture. The foam control agent comprises a compound that can be represented by the formula, RO (EO)
n (PO)
mH, where R is a linear hydrocarbon radical having from 12 to 18 carbon atoms; EO is ethylene oxide; PO is propylene oxide; n can be any integer from 2 to 9 inclusive; and m can be any integer from 8 to 19 inclusive. Furthermore, the compounds can be characterized in that the molecular weight of R is from 8 to 29 percent by weight of the compound.
While R is a linear hydrocarbon radical having from 12 to 18 carbon atoms for many applications it may be preferred that R be from 16 to 18 carbons. Similarly, while m can be an integer from 8 to 19, for some applications it may be preferred that m at least 10, or even 12 up to 17 or even 15. Likewise, while n can be any integer from 2 to 9, or some applications it may be preferred that n be at least 3, or even 4 up to 8 or even 7.
For many applications it may be desirable to choose R, m and n such that the molecule as a molecular weight of from 600 to 3000 grams per mole, preferably 710 to 1800 grams per mole, more preferably 900 to 1200 grams per mole.
The number of carbons in the R group should be selected so that the molecular weight of R represents from 8 to 29 percent by weight of the compound, more preferably from 12, 15 or even 18 to 27, 25 of even 23 percent by weight of the compound.
The preferred foam control agents for use in the present invention can also be characterized by their cloud point, which can be determined according to ASTM D2024. Preferably the cloud point will be from 10℃ to 30℃, more preferably from 10℃ to 25℃.
As will be readily understood from the formula, the foam control agents for use in the present invention are fatty alcohol initiated alkoxylates. Such materials can be prepared according to methods well known in the art, such as were propoxylating and ethoxylating alcohols of the formula ROH (where R is a linear hydrocarbon radical having from 12 to 18 carbon atoms, as for the foam control agent formula) utilizing well-known alkoxylation catalysts such as double metal cyanide (DMC) or KOH catalysts. Each alcohol product was targeted to consist of between 8 to 19 moles of propylene oxide and 2 to 9 mole of ethylene oxide. The alcohols can be advantageously ethoxylated using purified ethylene oxide at 150-160 ℃ and 40-60 psig in a single, continuous run and then propoxylated using purified propylene oxide at 130-150 ℃ and 40-60 psig in a single, continuous run.
.
The foam control agents of the present can be added to the target process mixture (such as fermentation broth) in any amount which is effective to prevent and or break down foam occurring in the mixture. Typically, this may be in an amount from 1 to 5000 ppm, preferably from 5 to 3000 ppm, even more preferably from 10 to 2500 ppm, or even 100 to 2000 ppm by weight of the process mixture.
It has been found that foam control agents for use in the present invention are particularly effective with the process mixture is at a temperature of from about 25℃ to about 45℃.
In another aspect of the present invention, the foam control agent is added to the process mixture as part of a formulation which may comprise, (in addition to the foam control agent described above) one or more of the following components: water, additional foam control agents (including other control agents which fall within the formula described above) , seed oils, mineral oils, wax, surfactants and silicones. Other surfactants which may be added include other materials sold under the Dowfax
TM-trademark including Dowfax
TM 146, Dowfax
TM-144, Dowfax
TM-142, Dowfax
TM-122, Dowfax
TM-123, Dowfax
TM-114, Dowfax
TM-111, Dowfax
TM-117, Dowfax
TM-163, Dowfax
TM-105, and Dowfax
TM-107.
EXAMPLES
To demonstrate the effectiveness of the present invention, a commercial Luria Broth ( “LB broth” ) is used as a standard foaming medium to evaluate foam control agent performance. The fermentation broth solution is prepared by simply dissolving LB Broth Miller in deionized water. LB Broth Miller is supplied by BD Co., Ltd. The LB Broth Miller is reported to contain Tryptone, Yeast extract and Sodium Chloride. The fermentation broth solution is prepared by simply dissolving LB Broth Miller into deionized water in the concentration reported in the tables. No additional microorganism, such as bacteria or fungi or yeast, is added and no sterilization process is applied since the formulation is not intentionally inoculated. Two suppliers of LB broth were utilized for the study. Examples 1-13 and the blanks (unless otherwise noted) were using LB broth from Thermo Fisher Scientific Inc. (lot 200806082408) . Examples 3-2 and Comparative Examples 1-11 and one blank as noted were tested on LB broth from BD Co., Ltd. (lot 5114604) .
The evaluation of foam control agent performance is determined by using Foamscan instrument, which mimics a fermentation tank in an industrial fermentation process by providing a settled airflow speed and temperature. The foaming properties and foam stability are observed and evaluated by optical characteristic (by image analysis) . The volume of foam vs time can be read out by default.
The foam control performance is evaluated by the following procedures:
First 5g (or 2.5 g) of the LB Broth Miller is added into 100 mL deionized water to get the 50 g/L (or 25g/L) fermentation broth solution reported in Table 1.
Then the indicated amount of foam control agent is added into 100 g of the fermentation broth solution to get the formulation for foam testing.
Next the temperature of the Foamscan water bath is set to the indicated temperature (30℃ or 35℃ or 40℃) .
Then 60 mL of the testing solution is injected into a 260 ml sample tube.
When the solution is heated to the target temperature, the test begins by starting the gas (compressed air) bubbling through the solution at a flow rate of 450mL/s.
The foam volume is measured at every 15 seconds up until 300 seconds in total. As the sample tube is 260 ml, foam measurements in excess of 200 ml could not be made.
Table 1 . Innovative examples and comparative examples
The results of this evaluation are presented in Table 2:
Table 2
From the results in Table 2, it can be seen that the innovative examples have comparable or better foam control performance than all comparative examples in LB broth.
Claims (14)
- A method for inhibiting the formation of foam in a process comprising the step of adding an effective amount of a foam control agent to a process mixture, which foam control agent comprises a compound that can be represented by the formulaRO (EO) n (PO) mHwhere R is a linear hydrocarbon radical having from 12 to 18 carbon atoms; EO is ethylene oxide; PO is propylene oxide; n can be any integer from 2 to 9; and m can be any integer from 8 to 19;wherein the compound is further characterized in that the molecular weight of R is from 8 to 29 percent by weight of the compound.
- The method of claim 1 wherein R has from 12 to 18 carbon atoms.
- The method of claim 1 wherein the foam control agent has a molecular weight in the range of from 600 to 3000.
- The method of claim 3 where the foam control agent has a molecular weight of from 712 to 1800.
- The method of claim 1 where the foam control agent has cloud point of from 10 to 30℃.
- The method of claim 1 where the process involves fermentation.
- The method of claim 6 where the temperature of fermentation process ranges from 25℃ to 45℃
- The method of claim 6 where fermentation process is an amino acid fermentation or an enzyme fermentation.
- The method of claim 8 where the fermentation products comprises one or more of lysine, MSG and glucose oxidase.
- The method of claim 1, wherein the foam control agent is added in an amount from 1 to 5000 ppm by weight of the process mixture.
- The method of claim 1 where n is from 4 to 7
- The method of claim 1 where m is from 12 to 15
- The method of claim 1 wherein the molecular weight of R is from 18 to 23 percent by weight of the foam control agent.
- A defoamer formulation comprising a foam control agent, water, and one or more of seed oils, mineral oils, wax, surfactants and silicones, wherein the foam control agent comprises a compound that can be represented by the formulaRO (EO) n (PO) mHwhere R is a linear hydrocarbon radical having from 12 to 18 carbon atoms; EO is ethylene oxide; PO is propylene oxide; n can be any integer from 2 to 9; and m can be any integer from 8 to 19;wherein the compound is further characterized in that the molecular weight of R is from 8 to 29 percent by weight of the compound.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/CN2021/121610 WO2023050125A1 (en) | 2021-09-29 | 2021-09-29 | Polyalkylene alkyl compound for defoaming fermentation broth |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AU2021466848A1 true AU2021466848A1 (en) | 2024-05-09 |
Family
ID=78401976
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2021466848A Pending AU2021466848A1 (en) | 2021-09-29 | 2021-09-29 | Polyalkylene alkyl compound for defoaming fermentation broth |
Country Status (7)
| Country | Link |
|---|---|
| EP (1) | EP4408563A1 (en) |
| JP (1) | JP2024535199A (en) |
| KR (1) | KR20240070614A (en) |
| CN (1) | CN117897212A (en) |
| AU (1) | AU2021466848A1 (en) |
| CA (1) | CA3233001A1 (en) |
| WO (1) | WO2023050125A1 (en) |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0404317A3 (en) * | 1989-06-22 | 1991-10-02 | Petrolite Corporation | Use of ethoxylated propoxylated alcohols to prevent or reduce foam in fermentation broths |
| US9150886B2 (en) * | 2011-03-14 | 2015-10-06 | Dow Brasil Sudeste Industrial Ltda. | Foam control of alcoholic fermentation processes |
-
2021
- 2021-09-29 EP EP21798547.2A patent/EP4408563A1/en active Pending
- 2021-09-29 AU AU2021466848A patent/AU2021466848A1/en active Pending
- 2021-09-29 CA CA3233001A patent/CA3233001A1/en active Pending
- 2021-09-29 CN CN202180101946.5A patent/CN117897212A/en active Pending
- 2021-09-29 WO PCT/CN2021/121610 patent/WO2023050125A1/en active Application Filing
- 2021-09-29 JP JP2024513492A patent/JP2024535199A/en active Pending
- 2021-09-29 KR KR1020247013524A patent/KR20240070614A/en active Search and Examination
Also Published As
| Publication number | Publication date |
|---|---|
| CA3233001A1 (en) | 2023-04-06 |
| WO2023050125A1 (en) | 2023-04-06 |
| JP2024535199A (en) | 2024-09-30 |
| CN117897212A (en) | 2024-04-16 |
| KR20240070614A (en) | 2024-05-21 |
| EP4408563A1 (en) | 2024-08-07 |
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