AU2007214652B2

AU2007214652B2 - Pesticidal composition

Info

Publication number: AU2007214652B2
Application number: AU2007214652A
Authority: AU
Inventors: Forbes Richard Emslie
Original assignee: Bayer Intellectual Property GmbH
Current assignee: Bayer Intellectual Property GmbH
Priority date: 2006-02-17
Filing date: 2007-02-14
Publication date: 2013-05-16
Anticipated expiration: 2027-02-14
Also published as: CN101621930A; ZA200807935B; NZ570512A; CN101621930B; AU2007214652A1; UY30168A1; AR059519A1; BRPI0707846B1; WO2007093393A3; MX2008010451A; WO2007093393A2; BRPI0707846A2

Abstract

This invention relates to a pesticidal composition against ticks, in particular on cattle, having flumethrin and fluazuron as its active ingredients. In addition to the above active ingredients the composition may include N-methylpyrrolidone, dipropylene glycol monomethyl ether and, optionally, a dye as a carrier and adjuvants.

Description

C:\NRPori1N\DCC~iJXI069162_1,DOC-16/04/2013 -1 PESTICIDAL COMPOSITION FIELD OF THE INVENTION This invention relates to a pesticidal composition. 5 BACKGROUND TO THE INVENTION Many compounds are available for pesticidal applications in animals. In many instances, especially for the control of ticks, it is desirable to have a pour on composition. It is desirable for such compositions to have good knockdown and extended persistency. At 10 present, however, most available compositions have one or the other of these qualities, seldom both. The present invention seeks to provide a pesticidal pour on composition which will alleviate the abovementioned problem. 15 SUMMARY OF THE INVENTION In accordance with this invention there is provided a pesticidal pour on composition characterised in that the active ingredients include flumethrin and fluazuron. 20 A first aspect of the invention provides a pesticidal pour on composition comprising flumethrin and fluazuron. A second aspect of the invention provides a use of a pesticidal pour on composition as defined in the first aspect for the control of ticks on an animal. 25 A third aspect of the invention provides a method for controlling ticks comprising applying to an animal in need thereof a pesticidal pour on composition as claimed defined in the first aspect. 30 Further features of the invention provide for the composition to contain 9 to 11 g/l flumethrin and 20 to 40 g/l fluazuron, preferably 10 g/I flumethrin and 25 g/I fluazuron. Still further features of the invention provide for the composition to include a carrier and adjuvants; for these to possibly include N-methylpyrrolidone, dipropylene glycol 35 monomethyl ether and optionally a dye; and for there to be 196 to 241 g/l, preferably 210 a to 230 g/l, particularly preferably 215 to 225, in particular about 218.8 g/l N methylpyrrolidone; 649 to 794 g/l, preferably 670 to 771 g/Il, particularly preferably 700 to 740 g/Il, in particular about 721 g/Il dipropylene glycol monomethyl ether and, optionally, 0.09 to 0,11 g/l, in particular 0,10 g/Il patent blue dye. 5 The following example illustrates one embodiment of a pesticidal pour on composition made in accordance with the invention WO 2007/093393 PCT/EP2007/001257 -2 EXAMPLE 1 A pesticidal pour on composition is prepared by admixing the following compounds: Flumethrin* 10,0 g/I Fluazuron* 25,0 g/I 5 N methylpyrrolidone 218,76 g/l Dipropylene glycol monomethyl ether 721,48 g/I Patent blue dye 0,1 g/I *quantities assuming 100% potency of Flumethrin and Fluazuron 10 Where potency adjustment is necessary the dipropylene glycol monomethyl ether is utilised to compensate for volumetric changes. The dipropylene glycol monomethyl ether used was that sold under the trade name "Dowanol DPM". A dye is optional and where it is not used the dipropylene glycol monomethyl ether is made up to volume. 15 The composition so obtained can be used as a pour on product against ticks on animals, in particular cattle. A preferred application dose, in particular for cattle, is 1 m/10 kg which equates to flumethrin 0.9 to 1.1 mg/kg, preferably 1 mg/kg; fluazuron 2 to 4 mg/kg, preferably 2.5 mg/kg. Other application doses may be suitable depending on the situation in the respective case. It has been found that the composition provides a comparable to improved 20 tick knockdown and persistency than flumethrin by itself and longer persistency than fluazuron by itself against Rhipicephalus (Boophilus) decoloratus blue ticks. The increased persistency was found to be at least 35 days against pyrethroid resistant Rhipicephalus (Boophilus) decoloratus blue ticks, and at least 60 days against susceptible Rhipicephalus (Boophilus) decoloratus blue ticks, which was longer than the 48 days demonstrated against 25 susceptible ticks for fluazuron when used alone. The composition is thus superior to either of these two known products used individually indicating an unexpected synergistic effect, as the dose rate of the invention represents a 16.7 % decrease in the application rate of fluazuron. This mechanism of this synergistic effect is not yet understood. 30 It will be appreciated that many other embodiments of a pesticidal composition exist which fall within the scope of the invention, particularly as regards the concentration of the active compounds and the excipients used. Any suitable carriers and adjuvants can be used in suitable concentrations.

- 2a Throughout this specification and the claims which follow, unless the context requires otherwise, the word "comprise", and variations such as "comprises" or "comprising", will be understood to imply the inclusion of a stated integer or step or group of integers or steps but not the exclusion of any other integer or step or group of integers or steps. 5 The reference in this specification to any prior publication (or information derived from it), or to any matter which is known, is not, and should not be taken as, an acknowledgement or admission or any form of suggestion that that prior publication (or information derived from it) or known matter forms part of the common general knowledge in the field of 10 endeavour to which this specification relates.

Claims

3. A pesticidal pour on composition as claimed in claim 1 or claim 2, wherein the composition comprises 10 g/l flumethrin and 25 g/l fluazuron. 10
4. A pesticidal pour on composition as claimed in any one of claims 1 to 3, wherein the composition further comprises a carrier and/or at least one adjuvant.
5. A pesticidal pour on composition as claimed in claim 4, wherein the carrier and/or 15 the at least one adjuvant is selected from the group consisting of N-methylpyrrolidone, dipropylene glycol monomethyl ether and a dye.
6. A pesticidal pour on composition as claimed in claim 5, comprising 196 to 241 g/l N-methylpyrrolidone. 20
7. A pesticidal pour on composition as claimed in claim 5 or claim 6, comprising 649 to 794 gI dipropylene glycol monomethyl ether.
8. A pesticidal pour on composition as claimed in any one of claims 5 to 7, 25 comprising 0.09 to 0.11 g/l patent blue dye.
9. A pesticidal pour on composition as claimed in any one of claims 1 to 8, wherein the composition provides improved knockdown and/or improved persistency against Rhipicephalus (Boophilus) decoloratus blue ticks on cattle compared to flumethrin or 30 fluazuron alone.
10. Use of a pesticidal pour on composition as claimed in any one of claims 1 to 9 for the control of ticks on an animal. 35 11. Use as claimed in claim 10, wherein the animal is cattle. C:\NRPalrtbiOU 06916j .O C-1Q04/2013a -4
12. Use as claimed in claim 10 or claim 11, wherein the ticks are Rhipicephalus (Boophilus) decoloratus blue ticks.
13. A method for controlling ticks comprising applying to an animal in need thereof a 5 pesticidal pour on composition as claimed in any one of claims 1 to 9.
14. A method as claimed in claim 13, wherein the animal is cattle.
15. A method as claimed in claim 13 or claim 14, wherein the ticks are Rhipicephalus 10 (Boophilus) decoloratus blue ticks.
16. A pesticidal pour on composition as defined in claim 1, substantially as hereinbefore described with reference to the Example.