AU2003238157A1 - Fused-ring pyrimidin-4(3h)-one derivatives, processes for the preparation and uses thereof - Google Patents

Fused-ring pyrimidin-4(3h)-one derivatives, processes for the preparation and uses thereof

Info

Publication number: AU2003238157A1
Authority: AU; Australia
Prior art keywords: pyrimidin; fused; derivatives; processes; preparation
Prior art date: 2002-06-18
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Abandoned

Application number

AU2003238157A

Other versions

AU2003238157A8 (en

Inventor

Satoru Kaneko

Richard Martin

Raju Mohan

Kozo Oda

Edwin J. Schweiger

Tsuyoshi Watanabe

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Sankyo Co Ltd

X Ceptor Therapeutics Inc

Original Assignee

Sankyo Co Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-06-18

Filing date

2003-06-17

Publication date

2003-12-31

2003-06-17 Application filed by Sankyo Co Ltd filed Critical Sankyo Co Ltd

2003-12-31 Publication of AU2003238157A8 publication Critical patent/AU2003238157A8/en

2003-12-31 Publication of AU2003238157A1 publication Critical patent/AU2003238157A1/en

Status Abandoned legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
- C07D239/88—Oxygen atoms
- C07D239/91—Oxygen atoms with aryl or aralkyl radicals attached in position 2 or 3
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Diabetes (AREA)
Hematology (AREA)
Obesity (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

AU2003238157A 2002-06-18 2003-06-17 Fused-ring pyrimidin-4(3h)-one derivatives, processes for the preparation and uses thereof Abandoned AU2003238157A1 (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US38966202P	2002-06-18	2002-06-18
US60/389,662		2002-06-18
PCT/JP2003/007677 WO2003106435A1 (en)	2002-06-18	2003-06-17	Fused-ring pyrimidin-4(3h)-one derivatives, processes for the preparation and uses thereof

Publications (2)

Publication Number	Publication Date
AU2003238157A8 AU2003238157A8 (en)	2003-12-31
AU2003238157A1 true AU2003238157A1 (en)	2003-12-31

Family

ID=29736669

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AU2003238157A Abandoned AU2003238157A1 (en)	2002-06-18	2003-06-17	Fused-ring pyrimidin-4(3h)-one derivatives, processes for the preparation and uses thereof

Country Status (3)

Country	Link
AU (1)	AU2003238157A1 (en)
TW (1)	TW200401770A (en)
WO (1)	WO2003106435A1 (en)

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US7671200B2 (en)	1999-10-27	2010-03-02	Cytokinetics, Inc.	Quinazolinone KSP inhibitors
US7230000B1 (en)	1999-10-27	2007-06-12	Cytokinetics, Incorporated	Methods and compositions utilizing quinazolinones
JP2006193426A (en) *	2003-09-05	2006-07-27	Sankyo Co Ltd	Substituted condensed-ring pyrimidin-4(3h)-one compound
WO2005108376A1 (en) *	2004-05-06	2005-11-17	Smithkline Beecham Corporation	Calcilytic compounds
AU2012200214B2 (en) *	2004-05-14	2013-10-24	Emisphere Technologies, Inc.	Compounds and compositions for delivering active agents
GB0412769D0 (en) *	2004-06-08	2004-07-07	Novartis Ag	Organic compounds
CA2572872C (en) *	2004-07-02	2013-10-22	Sankyo Company Limited	Tissue factor production inhibitor
WO2006045096A2 (en)	2004-10-20	2006-04-27	Resverlogix Corp.	Flavanoids and isoflavanoids for the prevention and treatment of cardiovascular diseases
DE602005010469D1 (en) *	2004-10-20	2008-11-27	Central Glass Co Ltd	POLYMERIZABLE FLUOR CONTAINING MONOMER AND POLYMER COMPOUND USING THIS
WO2006077012A2 (en) *	2005-01-18	2006-07-27	Genfit S.A.	USE OF LXR LIGANDS FOR THE MODULATION OF DENDRITIC CELLS (DCs)
WO2006109633A1 (en) *	2005-04-07	2006-10-19	Daiichi Sankyo Company, Limited	Substituted indole compound
EP1907564B1 (en)	2005-06-28	2013-10-23	Daiichi Sankyo Company, Limited	Lxr ligand testing method
CA2628441A1 (en)	2005-11-04	2007-05-18	Hydra Biosciences, Inc.	Compounds for modulating trpv3 function
EP1999116A2 (en) *	2005-12-22	2008-12-10	Prolexys Pharmaceuticals, Inc.	3-aryl-substituted quinazolones, and uses thereof
KR20090043583A (en)	2006-08-23	2009-05-06	뉴로젠 코포레이션	2-phenoxy pyrimidinone analogues
ES2380499T3 (en) *	2006-11-30	2012-05-14	Kowa Company. Ltd.	Carbinol compound substituted
JP5114938B2 (en) *	2006-12-19	2013-01-09	セントラル硝子株式会社	Fluorine-containing diamine and polymer compound using the same
US8053440B2 (en)	2007-02-01	2011-11-08	Resverlogix Corporation	Compounds for the prevention and treatment of cardiovascular diseases
WO2008124532A1 (en) *	2007-04-05	2008-10-16	Cv Therapeutics, Inc.	Quinazolinone derivatives as aldh-2 inhibitors
US20080255161A1 (en) *	2007-04-11	2008-10-16	Dmitry Koltun	3-HYDROQUINAZOLIN-4-ONE DERIVATIVES FOR USE AS STEAROYL CoA DESATURASE INHIBITORS
WO2008140750A1 (en)	2007-05-10	2008-11-20	Hydra Biosciences Inc.	Compounds for modulating trpv3 function
ES2532402T3 (en)	2008-06-26	2015-03-26	Resverlogix Corporation	Methods of preparing quinazolinone derivatives
CA2747417C (en) *	2009-01-08	2017-01-03	Resverlogix Corp.	Compounds for the prevention and treatment of cardiovascular disease
NZ708314A (en)	2009-03-18	2017-08-25	Resverlogix Corp	Quinazolinones for use as anticancer agents
PL2421533T3 (en)	2009-04-22	2019-05-31	Resverlogix Corp	Novel anti-inflammatory agents
BR112013001634A2 (en)	2010-07-23	2016-05-24	Takeda Pharmaceutical	compound or salt, medicament, methods for the prophylaxis or treatment of atherosclerosis, diabetes or obesity in a mammal, and use of the compound or salt
CN103517908A (en)	2010-09-07	2014-01-15	Seoul大学校产学协力财团	Sesterterpene compounds and use thereof
TR201909777T4 (en)	2011-11-01	2019-07-22	Resverlogix Corp	ORAL RELEASE RELEASE FORMULATIONS FOR SUBSTITUTED QINAZOLINONES
WO2014080291A2 (en)	2012-11-21	2014-05-30	Rvx Therapeutics Inc.	Biaryl derivatives as bromodomain inhibitors
US9073878B2 (en)	2012-11-21	2015-07-07	Zenith Epigenetics Corp.	Cyclic amines as bromodomain inhibitors
EP2935253B1 (en)	2012-12-21	2018-08-01	Zenith Epigenetics Ltd.	Novel heterocyclic compounds as bromodomain inhibitors
AU2015204572B2 (en)	2014-01-10	2020-07-30	Inspirna, Inc.	LXR agonists and uses thereof
JO3789B1 (en)	2015-03-13	2021-01-31	Resverlogix Corp	Compositions and therapeutic methods for the treatment of complement -associated diseases
BR112018012914B1 (en)	2015-12-22	2023-04-18	SHY Therapeutics LLC	COMPOUND, USE OF A COMPOUND AND PHARMACEUTICAL COMPOSITION
AU2017207291B2 (en)	2016-01-11	2023-06-15	The Rockefeller University	Methods for the treatment of myeloid derived suppressor cells related disorders
SG11201911929XA (en)	2017-06-21	2020-01-30	SHY Therapeutics LLC	Compounds that interact with the ras superfamily for the treatment of cancers, inflammatory diseases, rasopathies, and fibrotic disease
WO2019104062A1 (en)	2017-11-21	2019-05-31	Rgenix, Inc.	Polymorphs and uses thereof
CN118161500A (en)	2019-11-25	2024-06-11	安进公司	Heterocyclic compounds as delta-5 desaturase inhibitors and methods of use
US11174220B2 (en)	2019-12-13	2021-11-16	Inspirna, Inc.	Metal salts and uses thereof
CA3168103A1 (en)	2020-01-29	2021-08-05	Kamari Pharma Ltd.	Compounds and compositions for use in treating skin disorders

Family Cites Families (2)

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Publication number	Priority date	Publication date	Assignee	Title
US6316503B1 (en) *	1999-03-15	2001-11-13	Tularik Inc.	LXR modulators
KR20020047186A (en) *	1999-09-28	2002-06-21	플레믹 크리스티안	Quinazolinones

2003
- 2003-06-17 AU AU2003238157A patent/AU2003238157A1/en not_active Abandoned
- 2003-06-17 WO PCT/JP2003/007677 patent/WO2003106435A1/en not_active Application Discontinuation
- 2003-06-17 TW TW092116370A patent/TW200401770A/en unknown

Also Published As

Publication number	Publication date
AU2003238157A8 (en)	2003-12-31
TW200401770A (en)	2004-02-01
WO2003106435A1 (en)	2003-12-24

Publication	Publication Date	Title
AU2003238157A1 (en)	2003-12-31	Fused-ring pyrimidin-4(3h)-one derivatives, processes for the preparation and uses thereof
AU2003242252A1 (en)	2003-12-22	Bicyclic pyrimidine derivatives
AU2002361992A1 (en)	2003-07-09	1,4-dihydro-1,4-diphenylpyridine derivatives
EP1416935B8 (en)	2008-08-27	4-amino-6-phenyl-pyrrolo[2,3-d]pyrimidine derivatives
AU2003260342A1 (en)	2004-02-23	Spirobifluorene derivatives, their preparation and uses thereof
AU2002349477A1 (en)	2003-06-10	Bicyclic derivative, process for producing the same, and use
AU2002341195A1 (en)	2003-05-01	Substituted 2-pyridine-cyclohexane-1,4-diamine derivatives
IL166100A0 (en)	2006-01-15	7,8,9-10-tetrahydro-6h-azepino,6,7,8,9-tetrahydro-pyrido and 2,3-dihydro-2h-pyrroloÄ2,1-bÜ quinazolinone derivatives
AUPR975601A0 (en)	2002-01-31	Quinazolinone derivatives
AU2003292007A1 (en)	2004-06-03	4-AMINO-5-PHENYL-7-CYCLOHEXYL-PYRROLO(2,3-d)PYRIMIDINE DERIVATIVES
AU2002352444A1 (en)	2003-07-09	Quinazolinedione derivatives
AU2003300522A1 (en)	2004-07-22	4-phenyl-pyrimido (4,5-b) indole derivatives
AU2003273989A1 (en)	2004-05-04	Quinazolinone derivatives useful as anti-hyperalgesic agents
AU2003211993A1 (en)	2003-09-04	(1,2,4)TRIAZOLO(1,5-c)PYRIMIDINE DERIVATIVES
AU2002362806A1 (en)	2003-07-03	Pyrimidine derivatives
AU2003213185A1 (en)	2003-09-09	Arylsulfone derivatives
EP1490358A4 (en)	2006-04-12	6-(4-substituted-anilino)pyrimidine derivatives, method for the preparation thereof and antiviral pharmaceutical composition comprising the same
AU2003260983A1 (en)	2004-04-30	Processes for the preparation of s-(-)-amlodipine
AU2003235951A1 (en)	2003-11-17	Process for the preparation of 2-aminopyrazine derivatives
AU2003281698A1 (en)	2004-02-16	1-phenylpiperidin-3-one derivatives and processes for the preparation thereof
AU2003300262A1 (en)	2004-07-14	Phthalimidylazo dyes, processes for the preparation thereof and the use thereof
AU2003263323A1 (en)	2004-03-29	Quinazolinone derivatives
AU2002368112A1 (en)	2004-02-16	Pyrimidine derivatives
AU2003255803A1 (en)	2004-03-11	Quinazolinone derivatives
AU2003299336A1 (en)	2004-07-14	Diphosphines, preparation and uses thereof

Legal Events

Date	Code	Title	Description
2005-03-10	MK6	Application lapsed section 142(2)(f)/reg. 8.3(3) - pct applic. not entering national phase
2005-08-18	TH	Corrigenda	Free format text: IN VOL 18, NO 8, PAGE(S) 2138 UNDER THE HEADING APPLICATIONS OPI - NAME INDEX UNDER THE NAME SANKYOCOMPANY, LIMITED, APPLICATION NO. 2003238157, UNDER INID (71) CORRECT THE NAME TO READ SANKYO COMPANY, LIMITED; X-CEPTOR THERAPEUTICS, INC.