AU2003238046A1 - Substituted 3- and 4- aminomethylpiperidines for use as beta-secretase in the treatment of alzheimer's disease - Google Patents
Substituted 3- and 4- aminomethylpiperidines for use as beta-secretase in the treatment of alzheimer's diseaseInfo
- Publication number
- AU2003238046A1 AU2003238046A1 AU2003238046A AU2003238046A AU2003238046A1 AU 2003238046 A1 AU2003238046 A1 AU 2003238046A1 AU 2003238046 A AU2003238046 A AU 2003238046A AU 2003238046 A AU2003238046 A AU 2003238046A AU 2003238046 A1 AU2003238046 A1 AU 2003238046A1
- Authority
- AU
- Australia
- Prior art keywords
- aminomethylpiperidines
- secretase
- alzheimer
- beta
- disease
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/26—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Neurosurgery (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP0207101 | 2002-06-27 | ||
| AU2002317852 | 2002-06-27 | ||
| PCT/EP2003/006674 WO2004002483A1 (en) | 2002-06-27 | 2003-06-25 | Substituted 3- and 4- aminomethylpiperidines for use as beta-secretase in the treatment of alzheimer’s disease |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AU2003238046A1 true AU2003238046A1 (en) | 2004-01-19 |
Family
ID=29797097
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2003238046A Abandoned AU2003238046A1 (en) | 2002-06-27 | 2003-06-25 | Substituted 3- and 4- aminomethylpiperidines for use as beta-secretase in the treatment of alzheimer's disease |
Country Status (2)
| Country | Link |
|---|---|
| AU (1) | AU2003238046A1 (en) |
| WO (1) | WO2004002483A1 (en) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0303683D0 (en) * | 2003-02-18 | 2003-03-19 | Prolysis Ltd | Antimicrobial agents |
| EP1604980A1 (en) * | 2004-06-08 | 2005-12-14 | Santhera Pharmaceuticals (Deutschland) Aktiengesellschaft | DPP-IV inhibitors |
| EP1807078A1 (en) | 2004-10-07 | 2007-07-18 | Vitae Pharmaceuticals, Inc. | Diaminoalkane aspartic protease inhibitors |
| TWI411607B (en) * | 2005-11-14 | 2013-10-11 | Vitae Pharmaceuticals Inc | Aspartic protease inhibitors |
| CL2007002689A1 (en) | 2006-09-18 | 2008-04-18 | Vitae Pharmaceuticals Inc | COMPOUNDS DERIVED FROM PIPERIDIN-1-CARBOXAMIDA, INHIBITORS OF THE RENINE; INTERMEDIARY COMPOUNDS; PHARMACEUTICAL COMPOSITION; AND USE IN THE TREATMENT OF DISEASES SUCH AS HYPERTENSION, CARDIAC INSUFFICIENCY, CARDIAC FIBROSIS, AMONG OTHERS. |
| EP2196453A1 (en) * | 2008-12-10 | 2010-06-16 | Cellvir | Novel substituted aryl derivatives, their process of preparation and their therapeutical uses as anti-HIV agents |
| AR077692A1 (en) | 2009-08-06 | 2011-09-14 | Vitae Pharmaceuticals Inc | SALTS OF 2 - ((R) - (3-CHLOROPHENYL) ((R) -1 - ((S) -2- (METHYLAMINE) -3 - ((R) -TETRAHYDRO-2H-PIRAN-3-IL) PROPILCARBAMOIL ) PIPERIDIN -3-IL) METOXI) METHYL ETILCARBAMATE |
| BR112015023560A8 (en) * | 2013-03-15 | 2017-12-26 | Actelion Pharmaceuticals Ltd | NEW ACRYLAMIDE DERIVATIVES AS ANTIMALARYAL AGENTS |
| EP3375778A1 (en) * | 2017-03-14 | 2018-09-19 | Artax Biopharma Inc. | Aryl-piperidine derivatives |
| CN112480066B (en) * | 2020-11-27 | 2021-08-31 | 太原理工大学 | Schiff base multifunctional fluorescent probe and preparation method and application thereof |
| CN113511998A (en) * | 2021-08-19 | 2021-10-19 | 南通华祥医药科技有限公司 | Synthesis method of 1-Boc-4-aminomethyl piperidine |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2658823B1 (en) * | 1990-02-27 | 1992-04-30 | Adir | NOVEL AMINOMETHYLPIPERIDINE DERIVATIVES, THEIR PREPARATION PROCESS AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM. |
| IE912760A1 (en) * | 1990-08-06 | 1992-02-12 | Smith Kline French Lab | Compounds |
| WO2000033788A2 (en) * | 1998-12-11 | 2000-06-15 | American Biogenetic Sciences Inc. | Substituted nitrogen heterocyclic compounds and therapeutic uses thereof |
| GB0007376D0 (en) * | 2000-03-28 | 2000-05-17 | Knoll Ag | Therapeutic agents |
| CA2406652A1 (en) * | 2000-04-20 | 2001-11-01 | Nps Allelix Corp. | Aminopiperidines for use as glyt-1 inhibitors |
-
2003
- 2003-06-25 WO PCT/EP2003/006674 patent/WO2004002483A1/en not_active Application Discontinuation
- 2003-06-25 AU AU2003238046A patent/AU2003238046A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| WO2004002483A1 (en) | 2004-01-08 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EP1940373B8 (en) | 1-fluoro-1-deoxy-scyllo-inositol for the treatment of alzheimer's disease | |
| EP1392287B8 (en) | Use of substituted azetidinone derivatives in the treatment of Alzheimer's disease | |
| AU2003206413A1 (en) | Substituted amino carboxamides for the treatment of alzheimer's disease | |
| TWI340640B (en) | Combination, kit and pharmaceutical composition for treatment of parkinson's disease | |
| EP1656359A4 (en) | Macrocyclic beta-secretase inhibitors for the treatment of alzheimer's disease | |
| HK1091815A1 (en) | [1,8]naphthyridin-2-ones and related compounds for the treatment of schizophrenia | |
| PT2527315E (en) | Compounds, compositions and methods for the treatment of amyloid diseases and synucleinopathies such as alzheimer's disease, type 2 diabetes and parkinson's disease | |
| EP1758854A4 (en) | Pyrrolidin-3-yl compounds useful as beta-secretase inhibitors for the treatment of alzheimer's disease | |
| EP1807396A4 (en) | 2-aminopyridine compounds useful as beta-secretase inhibitors for the treatment of alzheimer's disease | |
| IL177787A0 (en) | 1-aminovyclohexane derivatives for the treatment of agitation and other behavioral disorders, especially those associated with alzheimer's disease | |
| AU2005313582A8 (en) | Malonamide derivatives as inhibitors of gamma-secretase for the treatment of Alzheimer's disease | |
| AU2003217275A1 (en) | Azabicyclic compounds for the treatment of disease | |
| AU2002335794A1 (en) | Allylamides useful in the treatment of alzheimer's disease | |
| AU2002315131A1 (en) | Aminediols as agents for the treatment of alzheimer's disease | |
| AU2002212471A1 (en) | Peptides for use in the treatment of alzheimer's disease | |
| AU2003238046A1 (en) | Substituted 3- and 4- aminomethylpiperidines for use as beta-secretase in the treatment of alzheimer's disease | |
| AU2003303141A1 (en) | Hydroxypropyl amides for the treatment of alzheimer's disease | |
| AU2003254146A1 (en) | Methods for the treatment of parkinson's disease | |
| IL184849A0 (en) | Organic compounds useful for the treatment of alzheimer's disease, their use and method of preparation | |
| IL172213A0 (en) | Compounds useful in the therapy of alzheimer's disease and formulations containing them | |
| AU2003273310A1 (en) | Substituted aminoethers for the treatment of alzheimer's disease | |
| PL375564A1 (en) | Substituted 5-chroman-5-yl-ethylamine compounds and their use for the treatment of glaucoma | |
| AU2003284898A1 (en) | Combinative nicotinic/d1 agonism therapy for the treatment of alzheimer's disease | |
| AU2003303217A1 (en) | Use of substituted 2,5-diamidoindoles for the treatment of urological diseases | |
| AU2003222667A1 (en) | 1,3-thiazoles as lxr modulators in the treatment of cardiovascular diseases |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MK6 | Application lapsed section 142(2)(f)/reg. 8.3(3) - pct applic. not entering national phase |