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AU2003282380A1 - A method for the separation of the letrozole precursor 4-1-(1,2,4-triazolyl) methyl benzonitrile from its 1,3,4-triazolyl isomer - Google Patents

A method for the separation of the letrozole precursor 4-1-(1,2,4-triazolyl) methyl benzonitrile from its 1,3,4-triazolyl isomer

Info

Publication number
AU2003282380A1
AU2003282380A1 AU2003282380A AU2003282380A AU2003282380A1 AU 2003282380 A1 AU2003282380 A1 AU 2003282380A1 AU 2003282380 A AU2003282380 A AU 2003282380A AU 2003282380 A AU2003282380 A AU 2003282380A AU 2003282380 A1 AU2003282380 A1 AU 2003282380A1
Authority
AU
Australia
Prior art keywords
triazolyl
letrozole
isomer
precursor
separation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2003282380A
Other versions
AU2003282380A8 (en
Inventor
Kalisatya Bhujangarao Adibhatla
Kompella Amala
Sreenivas Rachakonda
Nannapaneni Venkaiah Chowdary
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Adibhatla Kali satya Bhujanga rao
Natco Pharma Ltd
Original Assignee
Natco Pharma Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Natco Pharma Ltd filed Critical Natco Pharma Ltd
Publication of AU2003282380A1 publication Critical patent/AU2003282380A1/en
Publication of AU2003282380A8 publication Critical patent/AU2003282380A8/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AU2003282380A 2003-11-14 2003-11-14 A method for the separation of the letrozole precursor 4-1-(1,2,4-triazolyl) methyl benzonitrile from its 1,3,4-triazolyl isomer Abandoned AU2003282380A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/IN2003/000357 WO2005047269A1 (en) 2003-11-14 2003-11-14 A method for the separation of the letrozole precursor 4-‘1-(1,2,4-triazolyl) methyl!benzonitrile from its 1,3,4-triazolyl isomer

Publications (2)

Publication Number Publication Date
AU2003282380A1 true AU2003282380A1 (en) 2004-06-06
AU2003282380A8 AU2003282380A8 (en) 2005-06-06

Family

ID=34586952

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2003282380A Abandoned AU2003282380A1 (en) 2003-11-14 2003-11-14 A method for the separation of the letrozole precursor 4-1-(1,2,4-triazolyl) methyl benzonitrile from its 1,3,4-triazolyl isomer

Country Status (2)

Country Link
AU (1) AU2003282380A1 (en)
WO (1) WO2005047269A1 (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7705159B2 (en) 2005-07-06 2010-04-27 Sicor, Inc. Process for the preparation of letrozole
WO2007054964A2 (en) * 2005-10-20 2007-05-18 Cadila Healthcare Limited Process for the preparation of letrozole
US7538230B2 (en) 2005-11-14 2009-05-26 Chemagis Ltd. Letrozole production process
US7465749B2 (en) 2005-11-14 2008-12-16 Chemagis, Ltd. Letrozole purification process
WO2009069140A1 (en) 2007-11-28 2009-06-04 Dabur Pharma Limited An improved process for preparation of letrozole and its intermediates
WO2010146391A1 (en) 2009-06-15 2010-12-23 Generics [Uk] Limited Regioselective synthesis of letrozole
CN103298795A (en) * 2010-08-27 2013-09-11 基因里克斯(英国)有限公司 Pure intermediate for preparing letrozole
CN103242251B (en) * 2013-05-22 2015-07-15 哈药集团制药总厂 Preparation method of letrozole
WO2015029519A1 (en) * 2013-09-02 2015-03-05 株式会社クレハ Method for producing triazole compound
CN103601691A (en) * 2013-10-17 2014-02-26 连云港杰瑞药业有限公司 Preparation method of high purity 4-[1-(1,2,4-triazole)methyl]-cyanophenyl

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4749713A (en) * 1986-03-07 1988-06-07 Ciba-Geigy Corporation Alpha-heterocycle substituted tolunitriles

Also Published As

Publication number Publication date
AU2003282380A8 (en) 2005-06-06
WO2005047269A1 (en) 2005-05-26

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Legal Events

Date Code Title Description
TH Corrigenda

Free format text: IN VOL 19, NO 28, PAGE(S) 1848 UNDER THE HEADING APPLICATIONS OPI - NAME INDEX UNDER THE NAME AMALA, KOMPELLA; RACHAKONDA, SREENIVAS; ADIBHATLA,KALI,SATYA, BHUJANGA,RAO; VENKAIAH CHOWDARY, NANNAPANENI; NATCO PHARMA LIMITED, APPLICATION NO. 2003282380, UNDER INID (43) CORRECT THE DATE TO READ 06.06.2005

MK6 Application lapsed section 142(2)(f)/reg. 8.3(3) - pct applic. not entering national phase