Nothing Special   »   [go: up one dir, main page]

AU2003270693A1 - Substituted ketophosphonate compounds having bone anabolic activity - Google Patents

Substituted ketophosphonate compounds having bone anabolic activity

Info

Publication number
AU2003270693A1
AU2003270693A1 AU2003270693A AU2003270693A AU2003270693A1 AU 2003270693 A1 AU2003270693 A1 AU 2003270693A1 AU 2003270693 A AU2003270693 A AU 2003270693A AU 2003270693 A AU2003270693 A AU 2003270693A AU 2003270693 A1 AU2003270693 A1 AU 2003270693A1
Authority
AU
Australia
Prior art keywords
ketophosphonate
substituted
compounds
bone anabolic
anabolic activity
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2003270693A
Inventor
Raymond Azoulay
Craig Leigh Bentzen
Emanuele Buattini
Vinh Van Diep
Yves Guyon-Gellin
Daniele Masson
Lan Mong Nguyen
Eric Joseph Niesor
Hieu Trung Phan
Carlo Severi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ilex Oncology Research SARL
Original Assignee
Ilex Oncology Research SARL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ilex Oncology Research SARL filed Critical Ilex Oncology Research SARL
Publication of AU2003270693A1 publication Critical patent/AU2003270693A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6564Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
    • C07F9/6571Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms
    • C07F9/657163Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms the ring phosphorus atom being bound to at least one carbon atom
    • C07F9/657181Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms the ring phosphorus atom being bound to at least one carbon atom the ring phosphorus atom and, at least, one ring oxygen atom being part of a (thio)phosphonic acid derivative
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/12Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/18Drugs for disorders of the endocrine system of the parathyroid hormones
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/28Phosphorus compounds with one or more P—C bonds
    • C07F9/38Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40Esters thereof
    • C07F9/4003Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4006Esters of acyclic acids which can have further substituents on alkyl
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/28Phosphorus compounds with one or more P—C bonds
    • C07F9/38Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40Esters thereof
    • C07F9/4003Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4015Esters of acyclic unsaturated acids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/28Phosphorus compounds with one or more P—C bonds
    • C07F9/38Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40Esters thereof
    • C07F9/4003Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4018Esters of cycloaliphatic acids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/28Phosphorus compounds with one or more P—C bonds
    • C07F9/38Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40Esters thereof
    • C07F9/4003Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4056Esters of arylalkanephosphonic acids
    • C07F9/4059Compounds containing the structure (RY)2P(=X)-(CH2)n-C(=O)-(CH2)m-Ar, (X, Y = O, S, Se; n>=1, m>=0)

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Endocrinology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AU2003270693A 2002-09-19 2003-09-18 Substituted ketophosphonate compounds having bone anabolic activity Abandoned AU2003270693A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US41209102P 2002-09-19 2002-09-19
US60/412.091 2002-09-19
PCT/US2003/029080 WO2004026315A1 (en) 2002-09-19 2003-09-18 Substituted ketophosphonate compounds having bone anabolic activity

Publications (1)

Publication Number Publication Date
AU2003270693A1 true AU2003270693A1 (en) 2004-04-08

Family

ID=32030802

Family Applications (2)

Application Number Title Priority Date Filing Date
AU2003270693A Abandoned AU2003270693A1 (en) 2002-09-19 2003-09-18 Substituted ketophosphonate compounds having bone anabolic activity
AU2003299029A Abandoned AU2003299029A1 (en) 2002-09-19 2003-09-18 Substituted phosphonate compounds having bone anabolic activity

Family Applications After (1)

Application Number Title Priority Date Filing Date
AU2003299029A Abandoned AU2003299029A1 (en) 2002-09-19 2003-09-18 Substituted phosphonate compounds having bone anabolic activity

Country Status (4)

Country Link
EP (1) EP1551418A4 (en)
JP (1) JP2006504697A (en)
AU (2) AU2003270693A1 (en)
WO (2) WO2004026315A1 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8466096B2 (en) 2007-04-26 2013-06-18 Afton Chemical Corporation 1,3,2-dioxaphosphorinane, 2-sulfide derivatives for use as anti-wear additives in lubricant compositions
EP2324041A4 (en) 2008-08-13 2012-06-13 Targanta Therapeutics Corp Phosphonated rifamycins and uses thereof for the prevention and treatment of bone and joint infections
KR101550085B1 (en) 2008-11-13 2015-09-03 바스프 에스이 Benzylidene compounds comprising phosphono-groups
EP2270021A1 (en) 2009-06-18 2011-01-05 Centre National de la Recherche Scientifique Phosphonates synthons for the synthesis of phosphonates derivatives showing better bioavailability
ES2683883T3 (en) * 2013-06-20 2018-09-28 Ivoclar Vivadent Ag Β-ketophosphonic acids and dental materials based on them

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE786251A (en) * 1971-07-14 1973-01-15 Ici Ltd NEW DERIVATIVES OF CYCLOPENTANE
US3982016A (en) * 1975-08-06 1976-09-21 Pfizer Inc. Bone deposition by 16-aryl-13,14-dihydro-PGE2 p-biphenyl esters
EP0466197A1 (en) * 1984-05-23 1992-01-15 Green Cross Corporation A lipoxygenase inhibitor
JPH0377894A (en) * 1989-08-18 1991-04-03 Toray Ind Inc Methylene diphosphonic acid compound
DE69108733T2 (en) * 1990-08-21 1995-09-14 Upjohn Co BISPHOSPHONIC ACID DERIVATIVES AS AN ANTIARTHRITIC AGENT.
ZA941088B (en) * 1993-02-19 1995-09-27 Symphar Sa Substituted ketophosphonates the processes for their preparation and pharmaceutical compositions containing them
US5508273A (en) * 1993-12-30 1996-04-16 Ortho Pharmaceutical Corporation Substituted phosphonic acids and derivatives useful in treating bone wasting diseases

Also Published As

Publication number Publication date
EP1551418A4 (en) 2006-05-03
AU2003299029A1 (en) 2004-04-08
AU2003299029A8 (en) 2004-04-08
WO2004026245A8 (en) 2004-07-22
WO2004026315A1 (en) 2004-04-01
WO2004026245A2 (en) 2004-04-01
WO2004026245A3 (en) 2004-06-10
EP1551418A1 (en) 2005-07-13
JP2006504697A (en) 2006-02-09

Similar Documents

Publication Publication Date Title
AU2003243150A1 (en) Resorption-controllable medical implants
EP2295053B8 (en) Novel 2H-chromen-2-one-3-carboxamides for medical uses
AU2003266949A1 (en) Compounds
PT1583763E (en) Benzoazolylpiperazine derivatives having vr1-antagonist activity
AU2003221098A1 (en) Oligofluorenylene compounds
AU2003254553A1 (en) Medical implant
AU2003253106A1 (en) Medical implant
AU2003232258A1 (en) Medical implant
AU2003238812A1 (en) Dental implant
AU2003253241A1 (en) Implant system
AU2003247151A1 (en) Elastomeric covers for orthopedic implants
AU2002229459A1 (en) Bone plate
AU2003258298A1 (en) Medical implants
AU2003215209A1 (en) Syringe
AU2003245800A1 (en) Flavourant compounds
GB0215775D0 (en) Pharmaceutical compounds
AU2003216053A1 (en) Guanidino compounds
AU2003210515A1 (en) Methods for sterilizing tissue
AU2003299100A1 (en) Pyrimidine compounds as therapeutic agents
AU2003215150A1 (en) Therapeutic compounds
AU2003216859A1 (en) Amidoacetonitrile compounds
AU2003270693A1 (en) Substituted ketophosphonate compounds having bone anabolic activity
AU2003288248A1 (en) Dihalo-allyloxy-phenol derivatives having pesticidal activity
AU2003291642A1 (en) Pyrazoloazepine compounds as pharmaceutical agents
AU2003247578A1 (en) Compound for flex sole

Legal Events

Date Code Title Description
MK6 Application lapsed section 142(2)(f)/reg. 8.3(3) - pct applic. not entering national phase