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AU2002213100A1 - Indole compounds as minimally physiologial function monitioring agents - Google Patents

Indole compounds as minimally physiologial function monitioring agents

Info

Publication number
AU2002213100A1
AU2002213100A1 AU2002213100A AU1310002A AU2002213100A1 AU 2002213100 A1 AU2002213100 A1 AU 2002213100A1 AU 2002213100 A AU2002213100 A AU 2002213100A AU 1310002 A AU1310002 A AU 1310002A AU 2002213100 A1 AU2002213100 A1 AU 2002213100A1
Authority
AU
Australia
Prior art keywords
monitioring
physiologial
minimally
agents
function
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2002213100A
Inventor
Samuel Achilefu
Joseph E. Bugaj
Richard B. Dorshow
Raghavan Rajagopalan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mallinckrodt Inc
Original Assignee
Mallinckrodt Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mallinckrodt Inc filed Critical Mallinckrodt Inc
Publication of AU2002213100A1 publication Critical patent/AU2002213100A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C09DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09BORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B23/00Methine or polymethine dyes, e.g. cyanine dyes
    • C09B23/0008Methine or polymethine dyes, e.g. cyanine dyes substituted on the polymethine chain
    • C09B23/0025Methine or polymethine dyes, e.g. cyanine dyes substituted on the polymethine chain the substituent being bound through an oxygen atom
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404Indoles, e.g. pindolol
    • A61K31/405Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/10Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/10Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/24Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an alkyl or cycloalkyl radical attached to the ring nitrogen atom
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56Ring systems containing three or more rings
    • C07D209/58[b]- or [c]-condensed
    • C07D209/60Naphtho [b] pyrroles; Hydrogenated naphtho [b] pyrroles
    • CCHEMISTRY; METALLURGY
    • C09DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09BORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B23/00Methine or polymethine dyes, e.g. cyanine dyes
    • C09B23/0066Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain being part of a carbocyclic ring,(e.g. benzene, naphtalene, cyclohexene, cyclobutenene-quadratic acid)
    • CCHEMISTRY; METALLURGY
    • C09DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09BORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B23/00Methine or polymethine dyes, e.g. cyanine dyes
    • C09B23/0075Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain being part of an heterocyclic ring
    • CCHEMISTRY; METALLURGY
    • C09DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09BORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B23/00Methine or polymethine dyes, e.g. cyanine dyes
    • C09B23/02Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups
    • C09B23/08Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups more than three >CH- groups, e.g. polycarbocyanines

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Indole Compounds (AREA)
AU2002213100A 2000-10-16 2001-10-05 Indole compounds as minimally physiologial function monitioring agents Abandoned AU2002213100A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/688,946 2000-10-16
US09/688,946 US6733744B1 (en) 2000-10-16 2000-10-16 Indole compounds as minimally invasive physiological function monitoring agents
PCT/US2001/031719 WO2002032421A1 (en) 2000-10-16 2001-10-05 Indole compounds as minimally physiologial function monitioring agents

Publications (1)

Publication Number Publication Date
AU2002213100A1 true AU2002213100A1 (en) 2002-04-29

Family

ID=24766442

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2002213100A Abandoned AU2002213100A1 (en) 2000-10-16 2001-10-05 Indole compounds as minimally physiologial function monitioring agents

Country Status (6)

Country Link
US (1) US6733744B1 (en)
EP (1) EP1326602A4 (en)
JP (1) JP2004526669A (en)
AU (1) AU2002213100A1 (en)
CA (1) CA2425701A1 (en)
WO (1) WO2002032421A1 (en)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7790144B2 (en) * 2000-01-18 2010-09-07 Mallinckrodt Inc. Receptor-avid exogenous optical contrast and therapeutic agents
US6939532B2 (en) * 2000-01-18 2005-09-06 Mallinckrodt, Inc. Versatile hydrophilic dyes
US20080233050A1 (en) * 2000-01-18 2008-09-25 Mallinckrodt Inc. Diagnostic and therapeutic optical agents
US7556797B2 (en) * 2000-10-16 2009-07-07 Mallinckrodt Inc. Minimally invasive physiological function monitoring agents
US20030105300A1 (en) * 2001-10-17 2003-06-05 Mallinckrodt Inc. Tumor targeted photodiagnostic-phototherapeutic agents
US20030105299A1 (en) * 2001-10-17 2003-06-05 Mallinckrodt Inc. Carbocyanine dyes for tandem, photodiagnostic and therapeutic applications
BR0318028A (en) * 2003-01-24 2005-12-06 Schering Ag Thiol-reactive cyanine hydrophilic dyes and conjugates thereof with biomolecules for fluorescence diagnosis
US7172907B2 (en) * 2003-03-21 2007-02-06 Ge Healthcare Bio-Sciences Corp. Cyanine dye labelling reagents with meso-substitution
US7894880B2 (en) * 2003-10-23 2011-02-22 The Board Of Trustees Of The Leland Stanford Junior University Measurement of renal extraction fraction using contrast enhanced computed tomography
ES2375395T3 (en) * 2004-12-23 2012-02-29 Mallinckrodt Llc FLUORESCENT PIRAZINE DERIVATIVES AND METHOD OF USE OF THE SAME IN THE EVALUATION OF RENAL FUNCTION.
US20060280687A1 (en) * 2005-03-18 2006-12-14 Zhen Cheng Compounds for tissue imaging and methods of use thereof
US20100022449A1 (en) * 2006-03-09 2010-01-28 Mallinckrodt Inc. Receptor-avid exogenous optical contrast and therapeutic agents
DK2029554T3 (en) * 2006-06-22 2014-06-10 Medibeacon Llc Pyrazine derivatives and their applications for renal monitoring
US20090214436A1 (en) 2008-02-18 2009-08-27 Washington University Dichromic fluorescent compounds
US9433700B2 (en) 2009-04-27 2016-09-06 Medibeacon Inc. Tissue sealant compositions, vascular closure devices, and uses thereof
US10806804B2 (en) * 2015-05-06 2020-10-20 Washington University Compounds having RD targeting motifs and methods of use thereof
US9862682B2 (en) 2016-01-08 2018-01-09 BroadPharm Functionalized pegylated cyanine compounds, pharmaceutical compositions, and methods of use thereof
CN110476051B (en) 2017-01-30 2022-09-27 麦迪贝肯有限公司 Non-invasive monitoring method for fluorescent tracers with background separation correction
CN111205468B (en) * 2020-01-10 2021-06-25 浙江大学 Dye-loaded metal-organic framework material for multi-parameter fluorescence temperature sensing and preparation method thereof
CN112007170B (en) * 2020-08-14 2023-06-13 南方医科大学皮肤病医院(广东省皮肤病医院、广东省皮肤性病防治中心、中国麻风防治研究中心) Immune adjuvant functionalized metal organic framework material and preparation method and application thereof
CN113411501B (en) * 2021-06-29 2022-06-07 杭州晶耐科光电技术有限公司 Embedded and dual-spectrum imaging-based unmanned aerial vehicle-mounted electric power inspection method and system

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59192595A (en) * 1983-04-16 1984-10-31 Tdk Corp Optical recording medium
US5453505A (en) * 1994-06-30 1995-09-26 Biometric Imaging, Inc. N-heteroaromatic ion and iminium ion substituted cyanine dyes for use as fluorescence labels
EP0769145A1 (en) * 1994-06-30 1997-04-23 Biometric Imaging Inc. N-heteroaromatic ion and iminium ion substituted cyanine dyes for use as fluorescence labels
DE4445065A1 (en) * 1994-12-07 1996-06-13 Diagnostikforschung Inst Methods for in-vivo diagnostics using NIR radiation
US5928625A (en) * 1997-03-13 1999-07-27 Mallinckrodt Inc. Method of measuring physiological function
US6228344B1 (en) * 1997-03-13 2001-05-08 Mallinckrodt Inc. Method of measuring physiological function
WO1998048845A1 (en) * 1997-04-29 1998-11-05 Nycomed Imaging As Method of demarcating tissue
JP2000095758A (en) * 1998-09-18 2000-04-04 Schering Ag Near-infrared, fluorescent contrast medium, and its production
US6395257B1 (en) * 2000-01-18 2002-05-28 Mallinckrodt Inc. Dendrimer precursor dyes for imaging
EP1250091B1 (en) * 2000-01-18 2008-04-16 Mallinckrodt Inc. Hydrophilic cyanine dyes

Also Published As

Publication number Publication date
WO2002032421A1 (en) 2002-04-25
EP1326602A1 (en) 2003-07-16
WO2002032421A8 (en) 2002-09-06
US6733744B1 (en) 2004-05-11
CA2425701A1 (en) 2002-04-25
EP1326602A4 (en) 2007-03-21
JP2004526669A (en) 2004-09-02

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