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AU2001294565A1 - In vitro assay for measuring the immunogenicity of a vaccine - Google Patents

In vitro assay for measuring the immunogenicity of a vaccine

Info

Publication number
AU2001294565A1
AU2001294565A1 AU2001294565A AU9456501A AU2001294565A1 AU 2001294565 A1 AU2001294565 A1 AU 2001294565A1 AU 2001294565 A AU2001294565 A AU 2001294565A AU 9456501 A AU9456501 A AU 9456501A AU 2001294565 A1 AU2001294565 A1 AU 2001294565A1
Authority
AU
Australia
Prior art keywords
vaccine
measuring
immunogenicity
vitro assay
immunogenically
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001294565A
Inventor
Mark A. Schenerman
Robert J. Strouse
Joann Suzich
Sheau-Chiann Wang
Wendy I. White
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
MedImmune LLC
Original Assignee
MedImmune LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by MedImmune LLC filed Critical MedImmune LLC
Publication of AU2001294565A1 publication Critical patent/AU2001294565A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/081—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from DNA viruses
    • C07K16/084—Papovaviridae, e.g. papillomavirus, polyomavirus, SV40, BK virus, JC virus

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Virology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)

Abstract

The present invention provides an assay for measuring the immunogenicity of a vaccine, wherein the vaccine contains an epitope having a conformation associated with an immunogenically active form of the vaccine and a fragment having a conformation associated with an immunogenically inactive form of the vaccine, wherein the method includes exposing a sample of the vaccine to a first ligand capable of binding to the epitope in the conformation associated with the immunogenically active form of the vaccine and a second ligand capable of binding to the fragment in the conformation associated with the immunogenically inactive form of the vaccine and measuring the amount of first ligand bound to the vaccine sample and the amount of the second ligand bound to the vaccine sample.
AU2001294565A 2000-09-18 2001-09-17 In vitro assay for measuring the immunogenicity of a vaccine Abandoned AU2001294565A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US23343900P 2000-09-18 2000-09-18
US60233439 2000-09-18
PCT/US2001/028877 WO2002024961A1 (en) 2000-09-18 2001-09-17 In vitro assay for measuring the immunogenicity of a vaccine

Publications (1)

Publication Number Publication Date
AU2001294565A1 true AU2001294565A1 (en) 2002-04-02

Family

ID=22877259

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001294565A Abandoned AU2001294565A1 (en) 2000-09-18 2001-09-17 In vitro assay for measuring the immunogenicity of a vaccine

Country Status (9)

Country Link
US (1) US20020160358A1 (en)
EP (1) EP1319089B1 (en)
JP (1) JP4746819B2 (en)
AT (1) ATE490346T1 (en)
AU (1) AU2001294565A1 (en)
CA (1) CA2422635C (en)
DE (1) DE60143583D1 (en)
ES (1) ES2357381T3 (en)
WO (1) WO2002024961A1 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7833724B2 (en) * 2006-03-20 2010-11-16 Teva Women's Health, Inc. Methods for comparing the immunogenicity of products and uses thereof
GB0607462D0 (en) * 2006-04-13 2006-05-24 Avecia Ltd Assay
WO2008150276A2 (en) * 2006-09-26 2008-12-11 The Board Of Regents Of The University Of Texas System Virus coated nanoparticles and uses thereof
EP3152347A4 (en) * 2014-06-04 2018-04-11 Indevr, Inc. Universal capture array for multiplexed subtype-specific quantification and stability determination of influenza proteins
US20200158729A1 (en) * 2017-06-06 2020-05-21 Indevr, Inc. Simultaneous in vitro analysis of vaccine potency and toxin concentration

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0422981A1 (en) * 1989-10-10 1991-04-17 Institut National De La Recherche Agronomique (Inra) Reagents and method for the immunochemical determination of the degree of denaturation of proteinaceous substances
DE122011100018I1 (en) * 1993-03-09 2011-11-17 Univ Rochester Preparation of human papilloma virus capsid protein and virus-like particles.
US5654419A (en) * 1994-02-01 1997-08-05 The Regents Of The University Of California Fluorescent labels and their use in separations
AU742409B2 (en) * 1997-09-05 2002-01-03 Medimmune, Llc In vitro method for disassembly/reassembly of papillomavirus virus-like particles (VLPs)

Also Published As

Publication number Publication date
EP1319089A1 (en) 2003-06-18
JP2004510144A (en) 2004-04-02
JP4746819B2 (en) 2011-08-10
DE60143583D1 (en) 2011-01-13
ATE490346T1 (en) 2010-12-15
ES2357381T3 (en) 2011-04-25
WO2002024961A1 (en) 2002-03-28
EP1319089A4 (en) 2004-07-14
US20020160358A1 (en) 2002-10-31
CA2422635A1 (en) 2002-03-28
CA2422635C (en) 2011-11-15
EP1319089B1 (en) 2010-12-01

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