AU2001282873A1 - Quinuclidine-substituted aryl compounds for treatment of disease - Google Patents
Quinuclidine-substituted aryl compounds for treatment of diseaseInfo
- Publication number
- AU2001282873A1 AU2001282873A1 AU2001282873A AU8287301A AU2001282873A1 AU 2001282873 A1 AU2001282873 A1 AU 2001282873A1 AU 2001282873 A AU2001282873 A AU 2001282873A AU 8287301 A AU8287301 A AU 8287301A AU 2001282873 A1 AU2001282873 A1 AU 2001282873A1
- Authority
- AU
- Australia
- Prior art keywords
- quinuclidine
- disease
- treatment
- substituted aryl
- aryl compounds
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US22616400P | 2000-08-18 | 2000-08-18 | |
| US60226164 | 2000-08-18 | ||
| US28496101P | 2001-04-19 | 2001-04-19 | |
| US60284961 | 2001-04-19 | ||
| PCT/US2001/021137 WO2002016357A2 (en) | 2000-08-18 | 2001-08-17 | Quinuclidine-substituted aryl moieties for treatment of disease (nicotinic acetylcholine receptor ligands) |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AU2001282873A1 true AU2001282873A1 (en) | 2002-03-04 |
Family
ID=26920267
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2001282873A Abandoned AU2001282873A1 (en) | 2000-08-18 | 2001-08-17 | Quinuclidine-substituted aryl compounds for treatment of disease |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US6486172B2 (en) |
| AU (1) | AU2001282873A1 (en) |
| PE (1) | PE20030091A1 (en) |
| WO (1) | WO2002016357A2 (en) |
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| US7214686B2 (en) | 1997-06-30 | 2007-05-08 | Targacept, Inc. | Pharmaceutical compositions and methods for effecting dopamine release |
| SE0000540D0 (en) | 2000-02-18 | 2000-02-18 | Astrazeneca Ab | New compounds |
| US8914114B2 (en) | 2000-05-23 | 2014-12-16 | The Feinstein Institute For Medical Research | Inhibition of inflammatory cytokine production by cholinergic agonists and vagus nerve stimulation |
| US6544908B1 (en) * | 2000-08-30 | 2003-04-08 | Micron Technology, Inc. | Ammonia gas passivation on nitride encapsulated devices |
| AU2002339810A1 (en) * | 2001-10-16 | 2003-04-28 | Astrazeneca Ab | Azabicyclic compounds for the treatment of fibromyalgia syndrome |
| DE10164139A1 (en) | 2001-12-27 | 2003-07-10 | Bayer Ag | 2-heteroaryl carboxamides |
| JP2005522457A (en) * | 2002-02-26 | 2005-07-28 | ノース ショア−ロング アイランド ジューイッシュ リサーチ インスティチュート | Inhibition of inflammatory cytokine production by stimulation of brain muscarinic receptors |
| EP1581223B2 (en) | 2002-12-06 | 2016-05-25 | The Feinstein Institute for Medical Research | Inhibition of inflamation using alpha 7 receptor-binding cholinergic agonists |
| US7238715B2 (en) * | 2002-12-06 | 2007-07-03 | The Feinstein Institute For Medical Research | Treatment of pancreatitis using alpha 7 receptor-binding cholinergic agonists |
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| IL155666A (en) * | 2003-04-29 | 2013-12-31 | Neurim Pharma 1991 | Composition for treating insomnia |
| JP2007533641A (en) | 2003-10-15 | 2007-11-22 | ターガセプト，インコーポレイテッド | Azabicyclo compounds for pain relief and treatment of central nervous system disorders |
| US10912712B2 (en) | 2004-03-25 | 2021-02-09 | The Feinstein Institutes For Medical Research | Treatment of bleeding by non-invasive stimulation |
| US8729129B2 (en) * | 2004-03-25 | 2014-05-20 | The Feinstein Institute For Medical Research | Neural tourniquet |
| GB0424284D0 (en) | 2004-11-02 | 2004-12-01 | Novartis Ag | Organic compounds |
| US11207518B2 (en) | 2004-12-27 | 2021-12-28 | The Feinstein Institutes For Medical Research | Treating inflammatory disorders by stimulation of the cholinergic anti-inflammatory pathway |
| WO2006073484A2 (en) | 2004-12-27 | 2006-07-13 | North Shore-Long Island Jewish Research Institute | Treating inflammatory disorders by electrical vagus nerve stimulation |
| JP2009506037A (en) | 2005-08-22 | 2009-02-12 | ターガセプト，インコーポレイテッド | Heteroaryl-substituted diazatricycloalkanes, methods for their preparation and methods for their use |
| US8316104B2 (en) | 2005-11-15 | 2012-11-20 | California Institute Of Technology | Method and apparatus for collaborative system |
| SA08290475B1 (en) * | 2007-08-02 | 2013-06-22 | Targacept Inc | (2S,3R)-N-(2-((3-Pyridinyl)Methyl)-1-Azabicyclo[2.2.2]Oct-3-yl)Benzofuran-2-Carboxamide, Novel Salt forms, and Methods of Use Thereof |
| WO2009029614A1 (en) | 2007-08-27 | 2009-03-05 | The Feinstein Institute For Medical Research | Devices and methods for inhibiting granulocyte activation by neural stimulation |
| ATE503754T1 (en) | 2007-10-01 | 2011-04-15 | Comentis Inc | 1H-INDOLE-3-CARBONIC ACID-QUINUCLIDINE-4-YLMETHYL ESTER DERIVATIVES AS LIGANDS FOR THE NICOTINIC ALPHA-7-ACETYLCHOLINE RECEPTOR FOR THE TREATMENT OF ALZHEIMER'S DISEASE |
| ES2430622T3 (en) | 2008-02-13 | 2013-11-21 | Targacept, Inc. | Combination of alpha 7 nicotinic and antipsychotic agonists |
| US9662490B2 (en) | 2008-03-31 | 2017-05-30 | The Feinstein Institute For Medical Research | Methods and systems for reducing inflammation by neuromodulation and administration of an anti-inflammatory drug |
| US9211409B2 (en) | 2008-03-31 | 2015-12-15 | The Feinstein Institute For Medical Research | Methods and systems for reducing inflammation by neuromodulation of T-cell activity |
| US20090275997A1 (en) * | 2008-05-01 | 2009-11-05 | Michael Allen Faltys | Vagus nerve stimulation electrodes and methods of use |
| CN102215909B (en) | 2008-11-18 | 2014-09-10 | 赛博恩特医疗器械公司 | Devices and methods for optimizing electrode placement for anti-inflamatory stimulation |
| TW201031664A (en) | 2009-01-26 | 2010-09-01 | Targacept Inc | Preparation and therapeutic applications of (2S,3R)-N-2-((3-pyridinyl)methyl)-1-azabicyclo[2.2.2]oct-3-yl)-3,5-difluorobenzamide |
| US9211410B2 (en) | 2009-05-01 | 2015-12-15 | Setpoint Medical Corporation | Extremely low duty-cycle activation of the cholinergic anti-inflammatory pathway to treat chronic inflammation |
| US8996116B2 (en) | 2009-10-30 | 2015-03-31 | Setpoint Medical Corporation | Modulation of the cholinergic anti-inflammatory pathway to treat pain or addiction |
| US8886339B2 (en) | 2009-06-09 | 2014-11-11 | Setpoint Medical Corporation | Nerve cuff with pocket for leadless stimulator |
| US8788034B2 (en) | 2011-05-09 | 2014-07-22 | Setpoint Medical Corporation | Single-pulse activation of the cholinergic anti-inflammatory pathway to treat chronic inflammation |
| US9833621B2 (en) | 2011-09-23 | 2017-12-05 | Setpoint Medical Corporation | Modulation of sirtuins by vagus nerve stimulation |
| US11051744B2 (en) | 2009-11-17 | 2021-07-06 | Setpoint Medical Corporation | Closed-loop vagus nerve stimulation |
| WO2011079309A2 (en) | 2009-12-23 | 2011-06-30 | Setpoint Medical Corporation | Neural stimulation devices and systems for treatment of chronic inflammation |
| KR101698250B1 (en) | 2010-05-17 | 2017-01-19 | 포럼 파마슈티칼즈 인크. | A crystalline form of (r)-7-chloro-n-(quinuclidin-3-yl)benzo[b]thiophene-2-carboxamide hydrochloride monohydrate |
| US9572983B2 (en) | 2012-03-26 | 2017-02-21 | Setpoint Medical Corporation | Devices and methods for modulation of bone erosion |
| MX358512B (en) | 2012-05-08 | 2018-08-24 | Forum Pharmaceuticals Inc | Methods of maintaining, treating or improving cognitive function. |
| WO2016007630A1 (en) | 2014-07-11 | 2016-01-14 | Alpharmagen, Llc | Quinuclidine compounds for modulating alpha7 -nicotinic acetylcholine receptor activity |
| US11311725B2 (en) | 2014-10-24 | 2022-04-26 | Setpoint Medical Corporation | Systems and methods for stimulating and/or monitoring loci in the brain to treat inflammation and to enhance vagus nerve stimulation |
| WO2016126807A1 (en) | 2015-02-03 | 2016-08-11 | Setpoint Medical Corporation | Apparatus and method for reminding, prompting, or alerting a patient with an implanted stimulator |
| US9724340B2 (en) | 2015-07-31 | 2017-08-08 | Attenua, Inc. | Antitussive compositions and methods |
| US10596367B2 (en) | 2016-01-13 | 2020-03-24 | Setpoint Medical Corporation | Systems and methods for establishing a nerve block |
| US10314501B2 (en) | 2016-01-20 | 2019-06-11 | Setpoint Medical Corporation | Implantable microstimulators and inductive charging systems |
| WO2017127756A1 (en) | 2016-01-20 | 2017-07-27 | Setpoint Medical Corporation | Control of vagal stimulation |
| US11471681B2 (en) | 2016-01-20 | 2022-10-18 | Setpoint Medical Corporation | Batteryless implantable microstimulators |
| US10583304B2 (en) | 2016-01-25 | 2020-03-10 | Setpoint Medical Corporation | Implantable neurostimulator having power control and thermal regulation and methods of use |
| EP3668402B1 (en) | 2017-08-14 | 2024-07-31 | Setpoint Medical Corporation | Vagus nerve stimulation pre-screening test |
| US11660443B2 (en) | 2018-04-20 | 2023-05-30 | The Feinstein Institutes For Medical Research | Methods and apparatuses for reducing bleeding via electrical trigeminal nerve stimulation |
| US11260229B2 (en) | 2018-09-25 | 2022-03-01 | The Feinstein Institutes For Medical Research | Methods and apparatuses for reducing bleeding via coordinated trigeminal and vagal nerve stimulation |
| EP4153053A4 (en) | 2020-05-21 | 2024-06-19 | The Feinstein Institutes for Medical Research | Systems and methods for vagus nerve stimulation |
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|---|---|---|---|---|
| US3702324A (en) | 1970-06-24 | 1972-11-07 | Stanford Research Inst | 3,4,5-trimethoxybenzamides of substituted anilines and of alkylpiperidines |
| NL7611713A (en) | 1975-11-03 | 1977-05-05 | Thomae Gmbh Dr K | PROCESS FOR THE PREPARATION OF COMPOUNDS AND PREPARATIONS WITH VALUABLE PHARMACOLOGICAL PROPERTIES. |
| FR2531083B1 (en) | 1982-06-29 | 1986-11-28 | Sandoz Sa | NOVEL PIPERIDINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS MEDICINES |
| FR2529548A1 (en) | 1982-07-02 | 1984-01-06 | Delalande Sa | NOVEL DERIVATIVES OF AMINO-3 QUINUCLIDINE, THEIR PROCESS AND THEIR THERAPEUTIC APPLICATION |
| US5175173A (en) | 1983-12-22 | 1992-12-29 | Sun Jung Hui | Carboxamides useful as antiemetic or antipsychotic agents |
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| DE201165T1 (en) | 1985-03-14 | 1989-04-20 | Beecham Group P.L.C., Brentford | MEDICINES FOR TREATING EMESIS, ANXIETAS AND "IRRITABLE BOWEL SYNDROME". |
| GB8520616D0 (en) | 1985-08-16 | 1985-09-25 | Beecham Group Plc | Compounds |
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| HU895334D0 (en) | 1986-07-30 | 1990-01-28 | Sandoz Ag | Process for the preparation of nasal pharmaceutical compositions |
| PH23937A (en) | 1986-12-16 | 1990-01-23 | Robins Co Inc A H | Anxiolytic-n-(1-azabicyclo(2.2.2.)oct-3-yl)benzamides and thiobenzamides |
| US5237066A (en) * | 1987-02-04 | 1993-08-17 | Delande S.A. | Enantiomers of absolute configuration S of amide derivatives of 3-aminoquinuclidine, the process for preparing them and their application in therapy |
| US4835162A (en) | 1987-02-12 | 1989-05-30 | Abood Leo G | Agonists and antagonists to nicotine as smoking deterents |
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| GB8718345D0 (en) | 1987-08-03 | 1987-09-09 | Fordonal Sa | N-substituted benzamides |
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| EP0436245A1 (en) | 1989-12-27 | 1991-07-10 | Duphar International Research B.V | Substituted 3,4-annelated benzimidazol-2(1H)-ones |
| US5057519A (en) | 1990-06-11 | 1991-10-15 | Bristol-Myers Squibb Company | 5-HT3 antagonists: use in reducing opiate tolerance |
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| US5977144A (en) | 1992-08-31 | 1999-11-02 | University Of Florida | Methods of use and compositions for benzylidene- and cinnamylidene-anabaseines |
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| US5723103A (en) | 1994-12-09 | 1998-03-03 | Vanderbilt University | Substituted benzamides and radioligand analogs and methods of use |
| US5741819A (en) * | 1995-06-07 | 1998-04-21 | 3-Dimensional Pharmaceuticals, Inc. | Arylsulfonylaminobenzene derivatives and the use thereof as factor Xa inhibitors |
| SE9600683D0 (en) | 1996-02-23 | 1996-02-23 | Astra Ab | Azabicyclic esters of carbamic acids useful in therapy |
| AU4980200A (en) | 1999-05-27 | 2000-12-18 | Pharmacia & Upjohn Company | Methods and compositions for measuring ion channel conductance |
| SE9903760D0 (en) * | 1999-10-18 | 1999-10-18 | Astra Ab | New compounds |
| SE9904176D0 (en) | 1999-11-18 | 1999-11-18 | Astra Ab | New use |
| SE0000540D0 (en) * | 2000-02-18 | 2000-02-18 | Astrazeneca Ab | New compounds |
-
2001
- 2001-08-17 US US09/932,597 patent/US6486172B2/en not_active Expired - Fee Related
- 2001-08-17 WO PCT/US2001/021137 patent/WO2002016357A2/en active Search and Examination
- 2001-08-17 AU AU2001282873A patent/AU2001282873A1/en not_active Abandoned
- 2001-08-21 PE PE2001000839A patent/PE20030091A1/en not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| PE20030091A1 (en) | 2003-02-13 |
| US20020040035A1 (en) | 2002-04-04 |
| WO2002016357A2 (en) | 2002-02-28 |
| WO2002016357A3 (en) | 2002-05-30 |
| US6486172B2 (en) | 2002-11-26 |
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