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AU2001246510A1 - Glycosaminoglycans derived from the k5 polysaccharide having high anticoagulant and antithrombotic activity and process for their preparation - Google Patents

Glycosaminoglycans derived from the k5 polysaccharide having high anticoagulant and antithrombotic activity and process for their preparation

Info

Publication number
AU2001246510A1
AU2001246510A1 AU2001246510A AU4651001A AU2001246510A1 AU 2001246510 A1 AU2001246510 A1 AU 2001246510A1 AU 2001246510 A AU2001246510 A AU 2001246510A AU 4651001 A AU4651001 A AU 4651001A AU 2001246510 A1 AU2001246510 A1 AU 2001246510A1
Authority
AU
Australia
Prior art keywords
polysaccharide
preparation
antithrombotic activity
high anticoagulant
glycosaminoglycans derived
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001246510A
Inventor
Giovanni Cipolletti
Pasqua Oreste
Giorgio Zoppetti
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Inalco SpA
Original Assignee
Inalco SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Inalco SpA filed Critical Inalco SpA
Publication of AU2001246510A1 publication Critical patent/AU2001246510A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
    • A61K31/727—Heparin; Heparan
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Polymers & Plastics (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Biochemistry (AREA)
  • Materials Engineering (AREA)
  • Oncology (AREA)
  • Obesity (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
AU2001246510A 2000-03-30 2001-03-27 Glycosaminoglycans derived from the k5 polysaccharide having high anticoagulant and antithrombotic activity and process for their preparation Abandoned AU2001246510A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
ITMI200A000665 2000-03-30
IT2000MI000665A IT1318432B1 (en) 2000-03-30 2000-03-30 GLYCOSAMINOGLICANS DERIVED FROM THE K5 POLYSACCHARIDE HAVING HIGH ANTI-AGULATING AND ANTI-THROMBOTIC ACTIVITY AND PROCESS FOR THEM
PCT/EP2001/003461 WO2001072848A1 (en) 2000-03-30 2001-03-27 Glycosaminoglycans derived from the k5 polysaccharide having high anticoagulant and antithrombotic activity and process for their preparation

Publications (1)

Publication Number Publication Date
AU2001246510A1 true AU2001246510A1 (en) 2001-10-08

Family

ID=11444676

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001246510A Abandoned AU2001246510A1 (en) 2000-03-30 2001-03-27 Glycosaminoglycans derived from the k5 polysaccharide having high anticoagulant and antithrombotic activity and process for their preparation

Country Status (9)

Country Link
US (4) US20030023079A1 (en)
EP (1) EP1268559A1 (en)
JP (1) JP2003528945A (en)
CN (1) CN1177865C (en)
AU (1) AU2001246510A1 (en)
CA (1) CA2404478A1 (en)
IT (1) IT1318432B1 (en)
RU (1) RU2283319C2 (en)
WO (1) WO2001072848A1 (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020062019A1 (en) * 2000-03-30 2002-05-23 Pasqua Oreste Glycosaminoglycans derived from K5 polysaccharide having high anticoagulant and antithrombotic activities and process for their preparation
US8227449B2 (en) 2000-03-30 2012-07-24 Glycores 2000 S.R.L. Glycosaminoglycans derived from K5 polysaccharide having high anticoagulant and antithrombotic activities and process for their preparation
ITMI20032498A1 (en) 2003-12-17 2005-06-18 Pasqua Anna Oreste ANTITROMBOTIC POLYSACCHARIDES AT LOW MOLECULAR WEIGHT E
ITMI20010397A1 (en) * 2001-02-27 2002-08-27 Giorgio Zoppetti HIGHLY N, O-SULPHATED DERIVATIVES OF POLYSACCHARIDE K5 AND THEIR PREPARATION
AU2003240191A1 (en) * 2002-06-18 2003-12-31 Glycores 2000 S.R.L. Process for the manufacture of n-acyl-(epi)k5-amine-o-sulfate-derivatives and products thus obtained
US8513407B2 (en) * 2002-06-18 2013-08-20 Glycores 2000 S.R.L. Process for the preparation of N-acyl-(epi)K5-amine-O-sulfate-derivatives and products thus obtained
US20120253029A1 (en) 2002-06-18 2012-10-04 Pasqua Anna Oreste Process for the preparation of highly o-sulfated epimerized derivatives of k5 polysaccharide and intermediates therein
ITMI20031618A1 (en) * 2003-08-06 2005-02-07 Inalco Spa POLYSACCHARIDE DERIVATIVES EQUIPPED WITH HIGH ACTIVITY
WO2006023487A2 (en) * 2004-08-16 2006-03-02 Massachusetts Institute Of Technology Rapid two-step synthesis of anti-coagulants
WO2007058592A1 (en) * 2005-11-21 2007-05-24 Ge Healthcare Bio-Sciences Ab A method of chromatography using semi-synthetic heparin ligands
ITMI20091445A1 (en) * 2009-08-07 2011-02-08 Inalco S P A A Socio Unico SEMI-SYNTHETIC DERIVATIVES OF K5 POLISACCARIDE FOR THE PREVENTION AND TREATMENT OF TISSUE DAMAGE ASSOCIATED WITH ISCHEMIA AND / OR REPERFUSION
CN111670038B (en) * 2018-02-02 2024-01-26 深圳市海普瑞药业集团股份有限公司 Glycosaminoglycan derivative, preparation method and application thereof

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5262403A (en) * 1986-03-10 1993-11-16 Board Of Regents, The University Of Texas System Glycosaminoglycan derivatives and their use as inhibitors of tumor invasiveness of metastatic profusion-II
FR2669932B1 (en) * 1990-12-03 1994-07-01 Sanofi Sa NOVEL HEPAROSANE-N, O-SULFATE, ITS PREPARATION PROCESS AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING IT.
FR2704861B1 (en) * 1993-05-07 1995-07-28 Sanofi Elf Purified heparin fractions, process for obtaining them and pharmaceutical compositions containing them.
IT1271057B (en) * 1994-11-04 1997-05-26 Inalco Spa POLYSACCHARIDES HAVING A HIGH CONTENT OF HYDURONIC ACID
US5728554A (en) * 1995-04-11 1998-03-17 Cytel Corporation Enzymatic synthesis of glycosidic linkages
IT1282994B1 (en) * 1996-05-10 1998-04-03 Inalco Spa DERIVATIVES OF THE POLYSACCHARIDE K5 HAVING HIGH ANTI-COAGULANT ACTIVITY
IT1290814B1 (en) * 1997-03-24 1998-12-11 Istituto Scient Di Chimica E B GLYCOSAMINOGLICANS WITH HIGH ANTI-THROMBOTIC ACTIVITY
US6329351B1 (en) * 1997-08-28 2001-12-11 Istituto Scientifico Di Chimica E Biochimica “G. Ronzoni” Semi-synthetic sulphaminoheparosansulphates having high anti-metastatic activity and reduced haemorrhagic risk

Also Published As

Publication number Publication date
JP2003528945A (en) 2003-09-30
US20030023079A1 (en) 2003-01-30
EP1268559A1 (en) 2003-01-02
ITMI20000665A1 (en) 2001-09-30
IT1318432B1 (en) 2003-08-25
RU2283319C2 (en) 2006-09-10
US20040146994A1 (en) 2004-07-29
CA2404478A1 (en) 2001-10-04
CN1422283A (en) 2003-06-04
ITMI20000665A0 (en) 2000-03-30
US20090105192A1 (en) 2009-04-23
WO2001072848A1 (en) 2001-10-04
RU2002129018A (en) 2004-02-27
CN1177865C (en) 2004-12-01
US20060281152A1 (en) 2006-12-14

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