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AU2000260808A1 - Clinical method for the genetic screening of newborns using tandem mass spectrometry - Google Patents

Clinical method for the genetic screening of newborns using tandem mass spectrometry

Info

Publication number
AU2000260808A1
AU2000260808A1 AU2000260808A AU6080800A AU2000260808A1 AU 2000260808 A1 AU2000260808 A1 AU 2000260808A1 AU 2000260808 A AU2000260808 A AU 2000260808A AU 6080800 A AU6080800 A AU 6080800A AU 2000260808 A1 AU2000260808 A1 AU 2000260808A1
Authority
AU
Australia
Prior art keywords
mass spectrometry
newborns
tandem mass
quality assurance
results
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2000260808A
Inventor
Donald H. Chace
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Revvity Omics Inc
Original Assignee
Neo Gen Screening Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neo Gen Screening Inc filed Critical Neo Gen Screening Inc
Publication of AU2000260808A1 publication Critical patent/AU2000260808A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6848—Methods of protein analysis involving mass spectrometry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5091—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing the pathological state of an organism
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6806—Determination of free amino acids
    • G01N33/6812—Assays for specific amino acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/96—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood or serum control standard
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/50—Determining the risk of developing a disease
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/60—Complex ways of combining multiple protein biomarkers for diagnosis
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/24—Nuclear magnetic resonance, electron spin resonance or other spin effects or mass spectrometry

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Physiology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Steroid Compounds (AREA)

Abstract

A high-throughput method for screening newborns using electrospray tandem mass spectrometry (12). The method improves the current protocols using tandem mass spectrometry to provide accurate and consistent results at the clinical level through enhanced quality assurance and quality control (18) protocols for scan profiling and sample preparation (10) of blood from newborns. Precise concentrations of specific internal standards are used to distinguish twenty metabolites. Spectra of the samples are scanned and vigorously compared to known spectra as part of a diagnostic interpretation system (16). Quality assurance flags step compare peaks, metabolite concentration and scan intensities to a range of thresholds to determine whether or not the sample is contaminated, drug-ridden, diagnosable or unacceptable. All results and quality assurance flags are organized for post-acquisition data processing and data reduction (14) where values are compiled and stored for daily output results and trend analysis.
AU2000260808A 1999-03-26 2000-07-07 Clinical method for the genetic screening of newborns using tandem mass spectrometry Abandoned AU2000260808A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/277,119 US6258605B1 (en) 1999-03-26 1999-03-26 Clinical method for the genetic screening of newborns using tandem mass spectrometry
PCT/US2000/018716 WO2002004945A1 (en) 1999-03-26 2000-07-07 Clinical method for the genetic screening of newborns using tandem mass spectrometry

Publications (1)

Publication Number Publication Date
AU2000260808A1 true AU2000260808A1 (en) 2002-01-21

Family

ID=21741569

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2000260808A Abandoned AU2000260808A1 (en) 1999-03-26 2000-07-07 Clinical method for the genetic screening of newborns using tandem mass spectrometry

Country Status (8)

Country Link
US (1) US6258605B1 (en)
EP (2) EP1299720B1 (en)
AT (2) ATE408826T1 (en)
AU (1) AU2000260808A1 (en)
DE (2) DE60045783D1 (en)
DK (1) DK1299720T3 (en)
ES (1) ES2316373T3 (en)
WO (1) WO2002004945A1 (en)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7238531B2 (en) * 1999-01-30 2007-07-03 Pediatrix Screening, Inc. Method for interpreting tandem mass spectrometry data for clinical diagnosis
US7011977B2 (en) * 1999-01-30 2006-03-14 Sigma-Tau Pharmaceuticals, Inc. Quantification of carnitine levels in dialysis patients
US7297545B2 (en) * 1999-01-30 2007-11-20 Pediatrix Screening, Inc. Clinical method for the genetic screening of newborns using tandem mass spectrometry and internal standards therefor
IL144657A0 (en) * 1999-02-11 2002-06-30 Maxygen Inc High throughput mass spectrometry
US7013707B2 (en) * 1999-11-19 2006-03-21 Perkinelmer Las, Inc Method and apparatus for enhanced detection of a specie using a gas chromatograph
EP1113269B1 (en) * 1999-12-29 2006-10-18 PerkinElmer Life Sciences, Inc. Test tray, kit and methods for screening body fluids of newborns by tandem mass spectrometry
US20020009740A1 (en) * 2000-04-14 2002-01-24 Rima Kaddurah-Daouk Methods for drug discovery, disease treatment, and diagnosis using metabolomics
US7329489B2 (en) * 2000-04-14 2008-02-12 Matabolon, Inc. Methods for drug discovery, disease treatment, and diagnosis using metabolomics
KR20030079968A (en) * 2001-01-29 2003-10-10 메타라 인코포레이티드 Automated in-process isotope and mass spectrometry
GB0128498D0 (en) * 2001-11-28 2002-01-23 Inst Of Child Health International standards for sphingolipids
US6800489B2 (en) 2002-06-05 2004-10-05 Izaak Walton Killam Health Center Electrospray tandem mass spectrometry of transition metal diimine complexes of amino acids, α-hydroxyketones and hexose phosphates for newborn screening
US20040121421A1 (en) * 2002-09-03 2004-06-24 Qinghong Han Homocysteine assay adaptable to screening
US7298876B1 (en) * 2002-11-04 2007-11-20 R2 Technology, Inc. Method and apparatus for quality assurance and quality control in radiological equipment using automatic analysis tools
DE112004000338B4 (en) * 2003-02-24 2012-09-27 Waters Technologies Corp. (N.D.Ges.D. Staates Delaware) System and method for processing identified metabolites
US20050014279A1 (en) * 2003-07-14 2005-01-20 Nguyen Hoa Duc Method of analysis of amine by mass spectrometry
US7485435B2 (en) * 2004-08-30 2009-02-03 Perkinelmer Las, Inc. Simultaneous detection of metabolic enzyme activity and metabolite levels
US20050048499A1 (en) 2003-08-29 2005-03-03 Perkin Elmer Life Sciences, Inc. Tandem mass spectrometry method for the genetic screening of inborn errors of metabolism in newborns
WO2006025863A2 (en) * 2004-08-30 2006-03-09 Perkinelmer Las, Inc. Simultaneous detection of metabolic enzyme activity and metabolite levels
GB0415046D0 (en) 2004-07-05 2004-08-04 Micromass Ltd Mass spectrometer
JPWO2006098192A1 (en) * 2005-03-16 2008-08-21 味の素株式会社 Biological condition evaluation apparatus, biological condition evaluation method, biological condition evaluation system, biological condition evaluation program, evaluation function creation apparatus, evaluation function creation method, evaluation function creation program, and recording medium
WO2007003343A1 (en) * 2005-06-30 2007-01-11 Biocrates Life Sciences Ag Apparatus and method for analyzing a metabolite profile
WO2008033575A2 (en) * 2006-09-15 2008-03-20 Metabolon, Inc. Methods of identifying biochemical pathways
EP2330402B1 (en) 2009-12-01 2017-02-15 Spark Holland B.V. Method and apparatus for desorption of a blood sample from a medical test sheet
EP3129909B1 (en) 2014-04-08 2020-09-16 Metabolon, Inc. Small molecule biochemical profiling of individual subjects for disease diagnosis and health assessment
CN108645924B (en) * 2017-06-22 2021-07-20 南方医科大学 Detection method of metabolite of newborn based on ultra-high performance liquid chromatography tandem mass spectrometry technology
AU2018371784B2 (en) 2017-11-22 2024-10-17 Sun Pharmaceutical Industries, Inc. Deuterated analogs of D-serine and uses thereof
CN108982569A (en) * 2018-07-20 2018-12-11 中国科学院昆明植物研究所 A kind of two dimensional NMR method of the inside and outside source property glucose of simultaneous quantitative blood plasma

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2250632B (en) 1990-10-18 1994-11-23 Unisearch Ltd Tandem mass spectrometry systems based on time-of-flight analyser
US5352891A (en) 1993-07-16 1994-10-04 The Regents Of The University Of California Method and apparatus for estimating molecular mass from electrospray spectra
US5538897A (en) 1994-03-14 1996-07-23 University Of Washington Use of mass spectrometry fragmentation patterns of peptides to identify amino acid sequences in databases
US5629210A (en) * 1995-06-02 1997-05-13 University Of Pittsburgh Of The Commonwealth System Of Higher Education Rapid screening test for smith-lemli-opitz syndrome

Also Published As

Publication number Publication date
US6258605B1 (en) 2001-07-10
DK1299720T3 (en) 2009-01-26
EP2000800B1 (en) 2011-03-23
ATE503182T1 (en) 2011-04-15
DE60040303D1 (en) 2008-10-30
DE60045783D1 (en) 2011-05-05
ES2316373T3 (en) 2009-04-16
EP1299720A1 (en) 2003-04-09
EP2000800A2 (en) 2008-12-10
EP2000800A3 (en) 2008-12-17
ATE408826T1 (en) 2008-10-15
EP1299720A4 (en) 2006-07-26
EP1299720B1 (en) 2008-09-17
WO2002004945A1 (en) 2002-01-17

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