Nothing Special   »   [go: up one dir, main page]

AU1987088A - A process for preparing a protein or polypeptide, a dna sequence coding for the polypeptide, a microorganism containing the dna sequence as well as the polypeptide and its use as a pharmaceutical preparation - Google Patents

A process for preparing a protein or polypeptide, a dna sequence coding for the polypeptide, a microorganism containing the dna sequence as well as the polypeptide and its use as a pharmaceutical preparation

Info

Publication number
AU1987088A
AU1987088A AU19870/88A AU1987088A AU1987088A AU 1987088 A AU1987088 A AU 1987088A AU 19870/88 A AU19870/88 A AU 19870/88A AU 1987088 A AU1987088 A AU 1987088A AU 1987088 A AU1987088 A AU 1987088A
Authority
AU
Australia
Prior art keywords
polypeptide
dna sequence
protein
preparing
well
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU19870/88A
Inventor
Henrik Dalboge
Kim Ry Hejnaes
Jens Molvig
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novo Nordisk AS
Original Assignee
Nordisk Gentofte AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DK320987A external-priority patent/DK320987D0/en
Priority claimed from DK177488A external-priority patent/DK177488A/en
Application filed by Nordisk Gentofte AS filed Critical Nordisk Gentofte AS
Publication of AU1987088A publication Critical patent/AU1987088A/en
Assigned to NOVO NORDISK A/S reassignment NOVO NORDISK A/S Amend patent request/document other than specification (104) Assignors: NORDISK GENTOFTE A/S
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • C12N15/625—DNA sequences coding for fusion proteins containing a sequence coding for a signal sequence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/545—IL-1
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/61—Growth hormone [GH], i.e. somatotropin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/65—Insulin-like growth factors, i.e. somatomedins, e.g. IGF-1, IGF-2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/034—Fusion polypeptide containing a localisation/targetting motif containing a motif for targeting to the periplasmic space of Gram negative bacteria as a soluble protein, i.e. signal sequence should be cleaved
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
    • C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Endocrinology (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Diabetes (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Emergency Medicine (AREA)
  • Immunology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Obesity (AREA)
  • Physics & Mathematics (AREA)
  • Hematology (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AU19870/88A 1987-06-24 1988-06-23 A process for preparing a protein or polypeptide, a dna sequence coding for the polypeptide, a microorganism containing the dna sequence as well as the polypeptide and its use as a pharmaceutical preparation Abandoned AU1987088A (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DK320987A DK320987D0 (en) 1987-06-24 1987-06-24 PROCEDURE FOR PREPARING A MATURE POLYPEPTIDE WITH AN ADMINISTRATIVE AMINO-TERMINAL EXTENSION
DK3209/87 1987-06-24
DK177488A DK177488A (en) 1988-03-30 1988-03-30 POLYPEPTIDE AND PHARMACEUTICAL PREPARATION CONTAINING POLYPEPTIDE
DK1774/88 1988-03-30

Publications (1)

Publication Number Publication Date
AU1987088A true AU1987088A (en) 1989-01-19

Family

ID=26066106

Family Applications (1)

Application Number Title Priority Date Filing Date
AU19870/88A Abandoned AU1987088A (en) 1987-06-24 1988-06-23 A process for preparing a protein or polypeptide, a dna sequence coding for the polypeptide, a microorganism containing the dna sequence as well as the polypeptide and its use as a pharmaceutical preparation

Country Status (5)

Country Link
EP (1) EP0371041A1 (en)
JP (1) JPH03503596A (en)
AU (1) AU1987088A (en)
FI (1) FI896261A0 (en)
WO (1) WO1988010299A1 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU644105B2 (en) * 1989-08-25 1993-12-02 Amgen, Inc. Production of biologically active insulin-like growth factor I from high expression host cell systems

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6858409B1 (en) 1988-05-27 2005-02-22 Amgen Inc. Nucleic acids encoding interleukin-1 inhibitors and processes for preparing interleukin-1 inhibitors
US5075222A (en) 1988-05-27 1991-12-24 Synergen, Inc. Interleukin-1 inhibitors
DK470689A (en) * 1988-09-30 1990-03-31 Lilly Co Eli HIS UNKNOWN DNA SEQUENCES CODING FOR PROTEIN DERIVATIVES THAT ALLOW HIGH EXPRESSION OF RECOMBINANT PROTEINS WITH LOW MOLECULE WEIGHT
DK105489D0 (en) * 1989-03-03 1989-03-03 Novo Nordisk As POLYPEPTIDE
DK0527778T3 (en) * 1990-04-09 1996-10-21 Upjohn Co Improved method of purifying recombinant proteins and compounds useful in such a method
US5594115A (en) * 1990-04-09 1997-01-14 Pharmacia & Upjohn Company Process of purifying recombinant proteins and compounds useful in such process
DE69126434D1 (en) * 1990-08-20 1997-07-10 Novo Nordisk As Process for the production of biologically active IGF-1 by using amino-terminally extended IGF-1
DE4105480A1 (en) * 1991-02-21 1992-08-27 Boehringer Mannheim Gmbh IMPROVED ACTIVATION OF RECOMBINANT PROTEINS
US5378613A (en) * 1991-09-24 1995-01-03 Eli Lilly And Company Method for increased expression of low molecular weight recombinant polypeptides
US5496713A (en) * 1992-09-09 1996-03-05 Mitsui Toatsu Chemicals, Inc. Process for producing 20 kD human growth hormone
CZ76297A3 (en) * 1994-09-12 1998-01-14 Schering Aktiengesellschaft Process for preparing modified palladipine - inhibitor of blood platelet aggregation induced by collagen
GB9916630D0 (en) * 1999-07-16 1999-09-15 Univ Manchester Molecules derived from interleukins

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE8204811L (en) * 1982-08-23 1984-02-24 Sven Lofdahl DNA FRAGMENT INCLUDING A SIGNAL SEQUENCE
JPS61264000A (en) * 1985-03-21 1986-11-21 イミユネツクス　コ−ポレイシヨン Synthesis of protein by labelled peptide
FR2593518B1 (en) * 1985-05-02 1989-09-08 Transgene Sa VECTORS FOR THE EXPRESSION AND SECRETION OF HIRUDIN BY TRANSFORMED YEASTS
JPS6236183A (en) * 1985-06-20 1987-02-17 ザ・サルク・インステイチユ−ト・バイオテクノロジ−／インダストリアル・アソシエイツ・インコ−ポレ−テツド Ugenoyobibunpi
DE3526995A1 (en) * 1985-07-27 1987-02-05 Hoechst Ag FUSION PROTEINS, METHOD FOR THEIR PRODUCTION AND THEIR USE

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU644105B2 (en) * 1989-08-25 1993-12-02 Amgen, Inc. Production of biologically active insulin-like growth factor I from high expression host cell systems

Also Published As

Publication number Publication date
JPH03503596A (en) 1991-08-15
FI896261A0 (en) 1989-12-22
WO1988010299A1 (en) 1988-12-29
EP0371041A1 (en) 1990-06-06

Similar Documents

Publication Publication Date Title
LTIP1467A (en) Tertiary hydroxyalkylxantines, process for the preparation thereof and pharmaceutical composition containing them
AU4607185A (en) Alpha-omega-dicarboxylic acids,process for their preparation and medicines composed thereof
AU7149587A (en) Linear polymer polypeptides, process for their preparation, and vaccines containing them
HU903974D0 (en) Process for the preparation of products with elongated effect, containing water-soluble peptides
AU3707889A (en) Arylcarboxamide substituted by alkylphosphonates, process for preparing the same and a pharmaceutical composition containing the same
AU5233686A (en) Dna sequence encoding a hirudin-like protein and process for preparing such protein
IL90209A0 (en) Dna coding for a hiv-1 protein,the protein produced and its use
AU1987088A (en) A process for preparing a protein or polypeptide, a dna sequence coding for the polypeptide, a microorganism containing the dna sequence as well as the polypeptide and its use as a pharmaceutical preparation
IL83357A (en) Renin-inhibiting peptides, process for their preparation, pharmaceutical compositions containing them, and their use
HUT58107A (en) Process for producing heparing-binding proteins, dna encoding them and pharmaceutical compositions comprising the proteins
IL80562A0 (en) Recombinant human lysozyme,its preparation by recombinant dna technology and pharmaceutical compositions containing it
AU1665088A (en) New compounds, processes for their preparation and uses thereof
AU6245790A (en) Regulatory dna sequence
GB2203740B (en) Novel peptides, their preparation and use
AU2197688A (en) New compounds, processes for their preparation and use thereof
AU7492187A (en) Improved stabilizers for live vaccines, process for their preparation and vaccines containing them
AU2820992A (en) Polypeptide, dna fragment encoding the same, drug composition containing the same and process for producing the same
AU7285087A (en) Matrix material, a process for the preparation thereof, and its use
EP0292808A3 (en) Substituted vinyl cephalosporins, process for their preparation and their use as medicines
AU5627090A (en) A novel alpha-amylase-pullulanase enzyme, a dna sequence coding the same, a recombinant dna molecule and a recombinant clone expressing the enzyme
AU2295988A (en) Renin-inhibiting dipeptides, a process for the preparation thereof, agents containing them, and their use
AU8306987A (en) Novel carbamoyloxylabdanes, intermediates and a process for the preparation thereof and their use as medicaments
IL89391A0 (en) Structural gene coding for an insecticidal endotoxin protein,said protein,its production and use of said gene and protein
AU588017B2 (en) Process for preparing 4,4-dialkyl-2-axetidinones
AU2990492A (en) Novel polypeptides having growth factor activity and nucleic acid sequences encoding the polypeptides