ATE536419T1 - Transposon basiertes targeting- system - Google Patents
Transposon basiertes targeting- systemInfo
- Publication number
- ATE536419T1 ATE536419T1 AT04709610T AT04709610T ATE536419T1 AT E536419 T1 ATE536419 T1 AT E536419T1 AT 04709610 T AT04709610 T AT 04709610T AT 04709610 T AT04709610 T AT 04709610T AT E536419 T1 ATE536419 T1 AT E536419T1
- Authority
- AT
- Austria
- Prior art keywords
- transposase
- binding domain
- dna
- poly
- peptide
- Prior art date
Links
- 230000008685 targeting Effects 0.000 title abstract 4
- 102000008579 Transposases Human genes 0.000 abstract 5
- 108010020764 Transposases Proteins 0.000 abstract 5
- 108091033319 polynucleotide Proteins 0.000 abstract 4
- 102000040430 polynucleotide Human genes 0.000 abstract 4
- 239000002157 polynucleotide Substances 0.000 abstract 4
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 4
- 230000004568 DNA-binding Effects 0.000 abstract 3
- 230000027455 binding Effects 0.000 abstract 3
- 108020004414 DNA Proteins 0.000 abstract 2
- 239000012634 fragment Substances 0.000 abstract 2
- 108020001507 fusion proteins Proteins 0.000 abstract 2
- 102000037865 fusion proteins Human genes 0.000 abstract 2
- 108091028043 Nucleic acid sequence Proteins 0.000 abstract 1
- 230000001413 cellular effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/90—Stable introduction of foreign DNA into chromosome
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Diabetes (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Hematology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Oncology (AREA)
- Physical Education & Sports Medicine (AREA)
- Mycology (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Virology (AREA)
- Obesity (AREA)
- Plant Pathology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Communicable Diseases (AREA)
- AIDS & HIV (AREA)
- Neurology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Emergency Medicine (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP03002638 | 2003-02-10 | ||
| PCT/EP2004/001221 WO2004070042A1 (en) | 2003-02-10 | 2004-02-10 | Transposon-based targeting system |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE536419T1 true ATE536419T1 (de) | 2011-12-15 |
Family
ID=32842695
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT04709610T ATE536419T1 (de) | 2003-02-10 | 2004-02-10 | Transposon basiertes targeting- system |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US8420386B2 (de) |
| EP (1) | EP1594973B1 (de) |
| JP (1) | JP2006518204A (de) |
| AT (1) | ATE536419T1 (de) |
| DK (1) | DK1594973T3 (de) |
| WO (1) | WO2004070042A1 (de) |
Families Citing this family (48)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040172667A1 (en) | 2002-06-26 | 2004-09-02 | Cooper Richard K. | Administration of transposon-based vectors to reproductive organs |
| US7527966B2 (en) * | 2002-06-26 | 2009-05-05 | Transgenrx, Inc. | Gene regulation in transgenic animals using a transposon-based vector |
| US8071364B2 (en) | 2003-12-24 | 2011-12-06 | Transgenrx, Inc. | Gene therapy using transposon-based vectors |
| JP2008092911A (ja) * | 2006-10-16 | 2008-04-24 | Univ Of Tokyo | タンパク質結合検出方法 |
| EP2067402A1 (de) | 2007-12-07 | 2009-06-10 | Max Delbrück Centrum für Molekulare Medizin (MDC) Berlin-Buch; | Transposon-vermittelte Mutagenese in Spermatogoniestammzellen |
| WO2010036976A2 (en) | 2008-09-25 | 2010-04-01 | Transgenrx, Inc. | Novel vectors for production of antibodies |
| WO2010036978A2 (en) | 2008-09-25 | 2010-04-01 | Transgenrx, Inc. | Novel vectors for production of growth hormone |
| US8735156B2 (en) * | 2008-12-01 | 2014-05-27 | The Board Of Regents Of The University Of Texas System | Production and use of rat spermatogonial stem cell lines |
| EP2417263B1 (de) | 2009-04-09 | 2015-09-23 | ProteoVec Holding L.L.C. | Herstellung von proteinen unter verwendung von vektoren auf transposonbasis |
| US10221442B2 (en) | 2012-08-14 | 2019-03-05 | 10X Genomics, Inc. | Compositions and methods for sample processing |
| US9951386B2 (en) | 2014-06-26 | 2018-04-24 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
| US10752949B2 (en) | 2012-08-14 | 2020-08-25 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
| CN104769127A (zh) | 2012-08-14 | 2015-07-08 | 10X基因组学有限公司 | 微胶囊组合物及方法 |
| US10273541B2 (en) | 2012-08-14 | 2019-04-30 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
| US11591637B2 (en) | 2012-08-14 | 2023-02-28 | 10X Genomics, Inc. | Compositions and methods for sample processing |
| US10584381B2 (en) | 2012-08-14 | 2020-03-10 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
| US10323279B2 (en) | 2012-08-14 | 2019-06-18 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
| US9701998B2 (en) | 2012-12-14 | 2017-07-11 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
| EP2740353A1 (de) | 2012-12-06 | 2014-06-11 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Neuartige induzierbare Tiermodelle für Stressverhalten |
| US10533221B2 (en) | 2012-12-14 | 2020-01-14 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
| EP3567116A1 (de) | 2012-12-14 | 2019-11-13 | 10X Genomics, Inc. | Verfahren und systeme zur verarbeitung von polynukleotiden |
| KR20200140929A (ko) | 2013-02-08 | 2020-12-16 | 10엑스 제노믹스, 인크. | 폴리뉴클레오티드 바코드 생성 |
| WO2014143383A1 (en) * | 2013-03-13 | 2014-09-18 | Agilent Technologies, Inc. | Transposome tethered to a gene delivery vehicle |
| AU2014268710B2 (en) | 2013-05-23 | 2018-10-18 | The Board Of Trustees Of The Leland Stanford Junior University | Transposition into native chromatin for personal epigenomics |
| CN110548550B (zh) | 2014-04-10 | 2022-03-08 | 10X基因组学有限公司 | 用于封装和分割试剂的流体装置、系统和方法及其应用 |
| CA2953374A1 (en) | 2014-06-26 | 2015-12-30 | 10X Genomics, Inc. | Methods of analyzing nucleic acids from individual cells or cell populations |
| KR20170073667A (ko) | 2014-10-29 | 2017-06-28 | 10엑스 제노믹스, 인크. | 표적화 핵산 서열 분석을 위한 방법 및 조성물 |
| US9975122B2 (en) | 2014-11-05 | 2018-05-22 | 10X Genomics, Inc. | Instrument systems for integrated sample processing |
| US10221436B2 (en) | 2015-01-12 | 2019-03-05 | 10X Genomics, Inc. | Processes and systems for preparation of nucleic acid sequencing libraries and libraries prepared using same |
| US11274343B2 (en) | 2015-02-24 | 2022-03-15 | 10X Genomics, Inc. | Methods and compositions for targeted nucleic acid sequence coverage |
| WO2016137973A1 (en) | 2015-02-24 | 2016-09-01 | 10X Genomics Inc | Partition processing methods and systems |
| PT3882357T (pt) | 2015-12-04 | 2022-09-05 | 10X Genomics Inc | Métodos e composições para análise de ácidos nucleicos |
| WO2017197338A1 (en) | 2016-05-13 | 2017-11-16 | 10X Genomics, Inc. | Microfluidic systems and methods of use |
| JP6943376B2 (ja) * | 2016-08-30 | 2021-09-29 | 国立大学法人九州大学 | Ｄｎａ結合タンパク質の結合領域の近傍に所望のｄｎａ断片を挿入する方法 |
| EA201991431A1 (ru) | 2016-12-16 | 2020-01-17 | Б-Моген Биотехнолоджис, Инк. | УСИЛЕННЫЙ ОПОСРЕДОВАННЫЙ ТРАНСПОЗОНАМИ СЕМЕЙСТВА hAT ПЕРЕНОС ГЕНОВ И АССОЦИИРОВАННЫЕ КОМПОЗИЦИИ, СИСТЕМЫ И СПОСОБЫ |
| US11278570B2 (en) | 2016-12-16 | 2022-03-22 | B-Mogen Biotechnologies, Inc. | Enhanced hAT family transposon-mediated gene transfer and associated compositions, systems, and methods |
| US10815525B2 (en) | 2016-12-22 | 2020-10-27 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
| US10550429B2 (en) | 2016-12-22 | 2020-02-04 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
| US10011872B1 (en) | 2016-12-22 | 2018-07-03 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
| CN117512066A (zh) | 2017-01-30 | 2024-02-06 | 10X基因组学有限公司 | 用于基于微滴的单细胞条形编码的方法和系统 |
| US11913015B2 (en) | 2017-04-17 | 2024-02-27 | University Of Maryland, College Park | Embryonic cell cultures and methods of using the same |
| CN116064732A (zh) | 2017-05-26 | 2023-05-05 | 10X基因组学有限公司 | 转座酶可接近性染色质的单细胞分析 |
| US10400235B2 (en) | 2017-05-26 | 2019-09-03 | 10X Genomics, Inc. | Single cell analysis of transposase accessible chromatin |
| SG11201913654QA (en) | 2017-11-15 | 2020-01-30 | 10X Genomics Inc | Functionalized gel beads |
| US10829815B2 (en) | 2017-11-17 | 2020-11-10 | 10X Genomics, Inc. | Methods and systems for associating physical and genetic properties of biological particles |
| EP3775271A1 (de) | 2018-04-06 | 2021-02-17 | 10X Genomics, Inc. | Systeme und verfahren zur qualitätskontrolle in einer einzelzellenverarbeitung |
| EP3810764A2 (de) | 2018-06-21 | 2021-04-28 | B-Mogen Biotechnologies, Inc. | Durch transposon der hat-familie vermittelter verbesserter gentransfer und zugehörige zusammensetzungen, systeme und verfahren |
| CN113423834A (zh) * | 2018-11-08 | 2021-09-21 | 加总生物公司 | 微核小体核心蛋白及其在核酸递送中的用途 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US1334350A (en) * | 1916-08-11 | 1920-03-23 | Jr Edward T Condon | Automatic stop mechanism for talking-machines |
| AU7097494A (en) * | 1993-06-01 | 1994-12-20 | Targeted Genetics Corporation | Envelope fusion vectors for use in gene delivery |
| DE69841648D1 (de) | 1997-03-11 | 2010-06-17 | Univ Minnesota | Dns-basiertes transposon-system für die einführung von nucleinsäure in die dns einer zelle |
| WO1999005295A1 (en) * | 1997-07-25 | 1999-02-04 | Thomas Jefferson University | Composition and method for targeted integration into cells |
| AU1100201A (en) | 1999-10-28 | 2001-05-08 | Board Of Trustees Of The Leland Stanford Junior University | Methods of in vivo gene transfer using a sleeping beauty transposon system |
| AU2001278496A1 (en) | 2000-07-21 | 2002-02-05 | Syngenta Participations Ag | Zinc finger domain recognition code and uses thereof |
| US7431922B2 (en) * | 2002-03-29 | 2008-10-07 | Tissuegene, Inc. | Bioadhesive directed somatic cell therapy |
| AU2003268022B2 (en) * | 2002-07-24 | 2009-02-05 | Manoa Biosciences Inc. | Transposon-based vectors and methods of nucleic acid integration |
| US20060236413A1 (en) * | 2003-02-10 | 2006-10-19 | Zoltan Ivics | Transposon-based targeting system |
-
2004
- 2004-02-10 WO PCT/EP2004/001221 patent/WO2004070042A1/en active Application Filing
- 2004-02-10 US US10/544,971 patent/US8420386B2/en active Active
- 2004-02-10 AT AT04709610T patent/ATE536419T1/de active
- 2004-02-10 EP EP04709610A patent/EP1594973B1/de not_active Expired - Lifetime
- 2004-02-10 DK DK04709610.2T patent/DK1594973T3/da active
- 2004-02-10 JP JP2006501791A patent/JP2006518204A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| JP2006518204A (ja) | 2006-08-10 |
| DK1594973T3 (da) | 2012-02-13 |
| US8420386B2 (en) | 2013-04-16 |
| WO2004070042A1 (en) | 2004-08-19 |
| US20060258603A1 (en) | 2006-11-16 |
| EP1594973B1 (de) | 2011-12-07 |
| EP1594973A1 (de) | 2005-11-16 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE536419T1 (de) | Transposon basiertes targeting- system | |
| DK1594971T3 (da) | Transposonbaseret målretningssystem | |
| MX348154B (es) | Anticuerpos de enlace a il-1-beta y fragmentos de los mismos. | |
| WO2005056759A3 (en) | Methods of generating variant proteins with increased host string content and compositions thereof | |
| PH12015501848A1 (en) | Binding agents | |
| EA200700917A1 (ru) | Способ рефолдинга рекомбинантных антител | |
| WO2006033859A3 (en) | Compositions and methods for protein production | |
| MX348432B (es) | Epitopes. | |
| DE602004025101D1 (de) | Humane anti-humane cd3-bindungsmoleküle | |
| DK1594972T3 (da) | Transposon-baseret målretningssystem | |
| EA200701192A1 (ru) | Антагонисты toll-подобного рецептора 3, способы их получения и применение | |
| EA200700404A1 (ru) | Белки слияния на основе rage и способы их использования | |
| WO2007115571A8 (en) | Erbb receptor-derived peptide fragments | |
| NZ598770A (en) | Monoclonal antibodies | |
| ATE408624T1 (de) | Verfahren zur reinigung von fsh | |
| TW200745159A (en) | IL-6 binding proteins | |
| WO2010142551A8 (en) | Amino acid sequences directed against receptors to cytokines belonging to the il-17 family | |
| DK1519944T3 (da) | Fremgangsmåder til fremstilling af fibrinogen | |
| WO2002024912A3 (en) | Isolated nucleic acid molecules which encode a soluble il-tif/il-22 receptor or binding protein which binds to il-tif/il-22, and uses thereof | |
| WO2006132739A3 (en) | Novel chemical compounds | |
| IL175646A0 (en) | Antibodies and/or conjugates thereof which bind to the amino terminal fragment of urokinase, compositions and uses thereof | |
| WO2006127458A3 (en) | Novel chemical compounds | |
| DK1470154T3 (da) | Peptider og nukleinsyrer af cathelicidin-familien afledt fra fisk og anvendelser deraf | |
| WO2006097336A3 (en) | A novel component of the wg/wnt signaling pathway | |
| ATE521626T1 (de) | Fusionsprotein zur inhibierung von gebärmutterhalskrebs |