ATE534632T1 - Thiazole, imidazole und pyrazole als proteinkinasehemmer - Google Patents

Thiazole, imidazole und pyrazole als proteinkinasehemmer

Info

Publication number: ATE534632T1
Authority: AT; Austria
Prior art keywords: protein kinase; thiazoles; pyrazoles; imidazoles; kinase inhibitors
Prior art date: 2006-04-11

Application number

AT07755181T

Other languages

English (en)

Inventor

Juan-Miguel Jimenez

Ronald Knegtel

Daniel Robinson

Philip Collier

Original Assignee

Vertex Pharma

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2006-04-11

Filing date

2007-04-11

Publication date

2011-12-15

2007-04-11 Application filed by Vertex Pharma filed Critical Vertex Pharma

2011-12-15 Application granted granted Critical

2011-12-15 Publication of ATE534632T1 publication Critical patent/ATE534632T1/de

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/587—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with aliphatic hydrocarbon radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms, said aliphatic radicals being substituted in the alpha-position to the ring by a hetero atom, e.g. with m >= 0, Z being a singly or a doubly bound hetero atom
- C07D277/593—Z being doubly bound oxygen or doubly bound nitrogen, which nitrogen is part of a possibly substituted oximino radical
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
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- A61P11/06—Antiasthmatics
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Immunology (AREA)
Diabetes (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Hematology (AREA)
Physical Education & Sports Medicine (AREA)
Pulmonology (AREA)
Virology (AREA)
Oncology (AREA)
Dermatology (AREA)
Heart & Thoracic Surgery (AREA)
Communicable Diseases (AREA)
Endocrinology (AREA)
Orthopedic Medicine & Surgery (AREA)
Obesity (AREA)
Rheumatology (AREA)
Cardiology (AREA)
Emergency Medicine (AREA)
Otolaryngology (AREA)
Molecular Biology (AREA)
Transplantation (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Tropical Medicine & Parasitology (AREA)

AT07755181T 2006-04-11 2007-04-11 Thiazole, imidazole und pyrazole als proteinkinasehemmer ATE534632T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US79108306P	2006-04-11	2006-04-11
PCT/US2007/008819 WO2007117692A2 (en)	2006-04-11	2007-04-11	Thiazoles, imidazoles, and pyrazoles useful as inhibitors of protein kinases

Publications (1)

Publication Number	Publication Date
ATE534632T1 true ATE534632T1 (de)	2011-12-15

Family

ID=38508761

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT07755181T ATE534632T1 (de)	2006-04-11	2007-04-11	Thiazole, imidazole und pyrazole als proteinkinasehemmer

Country Status (9)

Country	Link
US (3)	US7589214B2 (de)
EP (1)	EP2007732B1 (de)
JP (1)	JP2009536617A (de)
CN (1)	CN101460466B (de)
AT (1)	ATE534632T1 (de)
AU (1)	AU2007235237B2 (de)
CA (1)	CA2648923A1 (de)
ES (1)	ES2376765T3 (de)
WO (1)	WO2007117692A2 (de)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU2007235237B2 (en) *	2006-04-11	2011-08-18	Vertex Pharmaceuticals Incorporated	Thiazoles, imidazoles, and pyrazoles useful as inhibitors of protein kinases
MX2011011136A (es) *	2009-04-24	2011-11-18	Tibotec Pharm Ltd	Eteres diarilicos.
EP2512246B1 (de)	2009-12-17	2015-09-30	Merck Sharp & Dohme Corp.	Aminopyrimidine als syk-hemmer
EP2513098B1 (de)	2009-12-17	2016-11-09	Merck Sharp & Dohme Corp.	Aminopyrimidine als syk-hemmer
EP2707357B1 (de)	2011-05-10	2017-01-18	Merck Sharp & Dohme Corp.	Pyridylaminopyrimidine als syk-hemmer
CN103619172A (zh)	2011-05-10	2014-03-05	默沙东公司	作为syk抑制剂的氨基嘧啶
US9145391B2 (en)	2011-05-10	2015-09-29	Merck Sharp & Dohme Corp.	Bipyridylaminopyridines as Syk inhibitors
JP6170944B2 (ja)	2011-12-28	2017-07-26	ヤンセン・サイエンシズ・アイルランド・ユーシー	Ｈｃｖ阻害剤としてのヘテロ−二環式誘導体
IN2015DN00524A (de)	2012-08-10	2015-06-26	Boehringer Ingelheim Int
GEP201606597B (en)	2012-11-02	2017-01-10	Pfizer	Bruton's tyrosine kinase inhibitors
CN103848810A (zh) *	2012-11-30	2014-06-11	北京赛林泰医药技术有限公司	鲁顿酪氨酸激酶抑制剂
JP6403751B2 (ja)	2013-03-14	2018-10-10	ベーリンガーインゲルハイムインターナショナルゲゼルシャフトミットベシュレンクテルハフツング	５−チアゾールカルボキサミン誘導体及びｂｔｋ阻害剤としてのその使用
US8940893B2 (en)	2013-03-15	2015-01-27	Boehringer Ingelheim International Gmbh	Heteroaromatic compounds as BTK inhibitors
SG11201602070TA (en)	2013-09-30	2016-04-28	Beijing Synercare Pharma Tech Co Ltd	Substituted nicotinimide inhibitors of btk and their preparation and use in the treatment of cancer, inflammation and autoimmune disease
RU2653504C2 (ru)	2013-12-13	2018-05-10	Ф. Хоффманн-Ля Рош Аг	Ингибиторы тирозинкиназы брутона
US9828364B2 (en)	2014-01-29	2017-11-28	Boehringer Ingelheim International Gmbh	Pyrazole compounds as BTK inhibitors
CN105085474B (zh) *	2014-05-07	2018-05-18	北京赛林泰医药技术有限公司	鲁顿酪氨酸激酶抑制剂
TW201607930A (zh) *	2014-07-18	2016-03-01	百濟神州有限公司	作為ｔ７９０ｍ／ｗｔ－ｅｇｆｒ的選擇性和不可逆的激酶抑制劑的５－氨基－４－氨甲醯基－吡唑化合物及其用途
RS62525B1 (sr)	2015-12-16	2021-11-30	Boehringer Ingelheim Int	Bipirazolil derivati korisni za lečenje autoimunih oboljenja
WO2017123695A1 (en)	2016-01-13	2017-07-20	Boehringer Ingelheim International Gmbh	Isoquinolones as btk inhibitors
BR112021016787A2 (pt) *	2019-02-25	2021-11-16	Beijing Innocare Pharma Tech Co Ltd	Método para preparar 6-(1-acriloilpiperidin-4-il)-2-(4-fenoxifenil)nicotinamida
WO2022012550A1 (en) *	2020-07-13	2022-01-20	Henan Normal University	Substituted 1h-imidazo [1, 2-b] pyrazole-3-carboxamide as bruton's tyrosine kinase inhibitors

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9608435D0 (en) *	1996-04-24	1996-06-26	Celltech Therapeutics Ltd	Chemical compounds
US6288061B1 (en) *	1997-12-26	2001-09-11	Welfide Corporation	Imidazole derivatives
WO2002022606A1 (en) *	2000-09-15	2002-03-21	Vertex Pharmaceuticals Incorporated	Pyrazole compounds useful as protein kinase inhibitors
ATE341539T1 (de) *	2001-01-26	2006-10-15	Chugai Pharmaceutical Co Ltd	Malonyl coa-decarboxylase inhibitoren als stoffwechselmodulatoren
EP2256106B1 (de) *	2003-07-22	2015-05-06	Astex Therapeutics Limited	3,4-disubstituierte 1H-Pyrazol-Verbindungen und deren Verwendung als Cyclin-abhängige Kinase (CDK) und Glycogen Synthase Kinase-3 (GSK-3) Modulatoren
WO2005123671A1 (ja) *	2004-06-22	2005-12-29	Taisho Pharmaceutical Co., Ltd.	ピロール誘導体
FR2881426B1 (fr) *	2005-02-03	2007-03-30	Aventis Pharma Sa	Pyrolles et imidazoles substitues, compositions les contenant, procede de frabrication et utilisation
AU2007235237B2 (en) *	2006-04-11	2011-08-18	Vertex Pharmaceuticals Incorporated	Thiazoles, imidazoles, and pyrazoles useful as inhibitors of protein kinases

2007
- 2007-04-11 AU AU2007235237A patent/AU2007235237B2/en not_active Ceased
- 2007-04-11 CN CN2007800208154A patent/CN101460466B/zh not_active Expired - Fee Related
- 2007-04-11 JP JP2009505430A patent/JP2009536617A/ja active Pending
- 2007-04-11 CA CA002648923A patent/CA2648923A1/en not_active Abandoned
- 2007-04-11 EP EP07755181A patent/EP2007732B1/de not_active Not-in-force
- 2007-04-11 US US11/786,464 patent/US7589214B2/en not_active Expired - Fee Related
- 2007-04-11 AT AT07755181T patent/ATE534632T1/de active
- 2007-04-11 WO PCT/US2007/008819 patent/WO2007117692A2/en active Application Filing
- 2007-04-11 ES ES07755181T patent/ES2376765T3/es active Active
2009
- 2009-08-10 US US12/538,396 patent/US8236832B2/en not_active Expired - Fee Related
2012
- 2012-07-03 US US13/540,651 patent/US8865751B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
WO2007117692A2 (en)	2007-10-18
CN101460466A (zh)	2009-06-17
WO2007117692A3 (en)	2008-01-10
US20070298065A1 (en)	2007-12-27
US8865751B2 (en)	2014-10-21
JP2009536617A (ja)	2009-10-15
US20130090479A1 (en)	2013-04-11
ES2376765T3 (es)	2012-03-16
AU2007235237A1 (en)	2007-10-18
CN101460466B (zh)	2012-06-13
AU2007235237B2 (en)	2011-08-18
US20090306155A1 (en)	2009-12-10
EP2007732B1 (de)	2011-11-23
US7589214B2 (en)	2009-09-15
CA2648923A1 (en)	2007-10-18
EP2007732A2 (de)	2008-12-31
US8236832B2 (en)	2012-08-07

Publication	Publication Date	Title
ATE534632T1 (de)	2011-12-15	Thiazole, imidazole und pyrazole als proteinkinasehemmer
MX2009011810A (es)	2010-01-14	Tiazoles y pirazoles utiles como inhibidores de cinasa.
MX2009012719A (es)	2010-02-04	Tiazoles y pirazoles utiles como inhibidores de cinasa.
ATE497961T1 (de)	2011-02-15	Als proteinkinaseinhibitoren geeignete verbindungen
MX2009008253A (es)	2009-10-12	Derivados de 2-aminopiridina utiles como inhibidores de cinasa.
DE602007007985D1 (de)	2010-09-02	Als inhibitoren von proteinkinasen geeignete aminopyrimidine
MX2009009592A (es)	2009-11-10	Aminopiridinas utiles como inhibidores de proteinas cinasas.
ZA200906264B (en)	2010-11-24	Aminopyrimidines useful as inhibitors of protein kinases
NO20083918L (no)	2008-11-12	Dihydridiazepiner anvendelige som inhibitorer av proteinkinaser
MX2009009590A (es)	2009-11-10	Aminopirimidinas utiles como inhibidores de proteinas cinasas.
NO20084747L (no)	2008-11-25	Tetrahydropteridiner anvendbare som inhibitorer av protein kinaser
SG166828A1 (en)	2010-12-29	Aminopyrimidines useful as kinase inhibitors
DE602006021776D1 (de)	2011-06-16	Als kinaseinhibitoren geeignete aminopyrimidine
NO20072795L (no)	2007-06-01	Pyrazol [1,5-a]pyrimidiner som er nyttige som inhibitorer av proteinkinaser
MX2009010037A (es)	2009-11-05	Aminopirimidinas utiles como inhibidores de cinasas.
WO2007087283A3 (en)	2007-09-13	Thiophene-carboxamides useful as inhibitors of protein kinases
ATE542814T1 (de)	2012-02-15	Pyrazinkinaseinhibitoren
MX2009011811A (es)	2010-01-14	Aminopirimidinas utiles como inhibidores de cinasa.
WO2007139816A3 (en)	2008-01-17	Thiophene-carboxamides useful as inhibitors of protein kinases
WO2007120760A3 (en)	2007-11-29	Thiophene-carboxamides useful as inhibitors of protein kinases
MX2009007337A (es)	2009-07-15	Indazoles sustituidos con 5-piridinona.
NO20092130L (no)	2009-06-17	Tricykliske heteroarylforbindelser anvendelige som inhibitorer of januskinase
MX2009010127A (es)	2009-11-05	Compuestos utiles como inhibidores de janus cinasas.
ATE484501T1 (de)	2010-10-15	Als protein-kinase-inhibitoren nutzbare benzimidazole
MA32183B1 (fr)	2011-04-01	Pyrimidylcyclopentanes hydroxylés utilisés comme inhibiteurs de protéine kinase akt