ATE533747T1 - Verfahren zur herstellung von tetrahydrochinolinderivaten - Google Patents
Verfahren zur herstellung von tetrahydrochinolinderivatenInfo
- Publication number
- ATE533747T1 ATE533747T1 AT07741046T AT07741046T ATE533747T1 AT E533747 T1 ATE533747 T1 AT E533747T1 AT 07741046 T AT07741046 T AT 07741046T AT 07741046 T AT07741046 T AT 07741046T AT E533747 T1 ATE533747 T1 AT E533747T1
- Authority
- AT
- Austria
- Prior art keywords
- tetrahydrocinoline
- derivatives
- producing
- tetrahydrocinoline derivatives
- producing tetrahydrocinoline
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
- C07D215/42—Nitrogen atoms attached in position 4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/22—Oxygen atoms attached in position 2 or 4
- C07D215/233—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 4
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Quinoline Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2006092783 | 2006-03-30 | ||
| JP2006322845 | 2006-11-30 | ||
| PCT/JP2007/057610 WO2007116922A1 (en) | 2006-03-30 | 2007-03-29 | A process for preparing tetrahydroquinoline derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE533747T1 true ATE533747T1 (de) | 2011-12-15 |
Family
ID=38123770
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT07741046T ATE533747T1 (de) | 2006-03-30 | 2007-03-29 | Verfahren zur herstellung von tetrahydrochinolinderivaten |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US8084611B2 (de) |
| EP (2) | EP2007728B1 (de) |
| JP (1) | JP5275971B2 (de) |
| AR (1) | AR060174A1 (de) |
| AT (1) | ATE533747T1 (de) |
| ES (1) | ES2374315T3 (de) |
| PE (1) | PE20071150A1 (de) |
| TW (1) | TW200808731A (de) |
| UY (1) | UY30244A1 (de) |
| WO (1) | WO2007116922A1 (de) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE550333T1 (de) | 2007-11-05 | 2012-04-15 | Novartis Ag | 4-benzylamino-1-carboxyacyl-piperidinderivate als cetp-hemmer zur behandlung von krankheiten wie hyperlipidämie oder arteriosklerose |
| ES2425776T3 (es) * | 2007-12-03 | 2013-10-17 | Novartis Ag | Derivados 1,2-disustituidos de 4-bencilamino-pirrolidina como inhibidores CETP útiles para el tratamiento de enfermedades tales como hiperlipidemia o arteriosclerosis |
| CN102020608B (zh) * | 2010-09-17 | 2012-09-05 | 清华大学 | 喹啉化合物的制备方法 |
| DK3180314T3 (da) | 2014-08-12 | 2022-08-29 | Newamsterdam Pharma B V | Fremgangsmåde til fremstilling af syntetiske mellemprodukter til fremstilling af tetrahydroquinolin-derivater |
| WO2017023165A1 (en) * | 2015-08-04 | 2017-02-09 | Dezima Pharma B.V. | Pharmaceutical composition and therapeutic combination comprising a cholesteryl ester transfer protein inhibitor and an atp citrate lyase inhibitor – ampk activator |
| US10085999B1 (en) | 2017-05-10 | 2018-10-02 | Arixa Pharmaceuticals, Inc. | Beta-lactamase inhibitors and uses thereof |
| EP3676247B8 (de) | 2017-10-02 | 2023-04-12 | Arixa Pharmaceuticals, Inc. | Aztreonamderivate und verwendungen davon |
| EP3590927A1 (de) | 2018-07-05 | 2020-01-08 | Bayer Animal Health GmbH | Neuartige verbindungen zur bekämpfung von arthropoden |
| WO2020072442A1 (en) | 2018-10-01 | 2020-04-09 | Arixa Pharmaceuticals, Inc. | Derivatives of relebactam and uses thereof |
| WO2020185729A1 (en) | 2019-03-12 | 2020-09-17 | Arixa Pharmaceuticals, Inc. | Crystalline form of an avibactam derivative |
| WO2020219258A1 (en) | 2019-04-25 | 2020-10-29 | Arixa Pharmaceuticals, Inc. | Methods of synthesizing aztreonam derivatives |
| TWI843678B (zh) * | 2019-06-18 | 2024-05-21 | 美商美國禮來大藥廠 | 用於製備2-(2,6-二氯苯基)-1-[(1s,3r)-3-(羥甲基)-5-(3-羥基-3-甲基丁基)-1-甲基-3,4-二氫異喹啉-2(1h)-基]乙烯酮之方法及中間物 |
| CN117098541A (zh) | 2020-11-25 | 2023-11-21 | 阿卡格拉医药公司 | 用于递送核酸的脂质纳米粒及相关使用方法 |
| BR112023017999A2 (pt) | 2021-03-05 | 2023-11-14 | Newamsterdam Pharma B V | Obicetrapibe para tratamento de demências |
| IL310115A (en) | 2021-07-26 | 2024-03-01 | Newamsterdam Pharma B V | Treatment of sub-responders to high-dose statins |
| IL314031A (en) | 2021-12-30 | 2024-09-01 | Newamsterdam Pharma B V | Materials and methods for improved phosphotransferases |
| CN114516865B (zh) * | 2022-03-09 | 2023-06-23 | 成都师范学院 | 一类D-π-A型有机共轭分子及其制备方法和应用 |
| WO2023230587A2 (en) | 2022-05-25 | 2023-11-30 | Akagera Medicines, Inc. | Lipid nanoparticles for delivery of nucleic acids and methods of use thereof |
| US12006305B2 (en) | 2022-07-05 | 2024-06-11 | Newamsterdam Pharma B.V. | Salts of obicetrapib and processes for their manufacture and intermediates thereof |
| WO2024042061A1 (en) | 2022-08-22 | 2024-02-29 | Newamsterdam Pharma B.V. | Obicetrapib and ezetimibe combination treatment and fixed dose pharmaceutical compositions |
| WO2024165395A1 (en) | 2023-02-07 | 2024-08-15 | Newamsterdam Pharma B.V. | Obicetrapib and ezetimibe combination treatment and fixed dose pharmaceutical compositions |
Family Cites Families (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FI82094C (fi) | 1989-02-16 | 1997-09-09 | Valmet Corp | Anvaendning av en legering av ett metallpulver och en karbid eller nitrid innefattande belaeggningskomposition foer en i en pappersmaskin anvaendbar yankeecylinder |
| EP0386839B1 (de) | 1989-03-08 | 1997-01-15 | Merck Sharp & Dohme Ltd. | Tetrahydroquinolin-Derivate, verwendbar bei neurodegenerativen Krankheiten |
| NZ234854A (en) | 1989-08-11 | 1993-02-25 | Ici Plc | Quinoline derivatives, preparation, intermediates and pharmaceutical compositions thereof |
| JPH03161360A (ja) | 1989-11-21 | 1991-07-11 | Tdk Corp | サーマルヘッド |
| JPH03216566A (ja) | 1990-01-22 | 1991-09-24 | Mitsubishi Electric Corp | Ｃｃｄリニアイメージセンサのテスト装置 |
| GB9010394D0 (en) | 1990-05-09 | 1990-06-27 | Ici Plc | Heterocyclic compounds |
| IE914573A1 (en) | 1991-01-17 | 1992-07-29 | Ici Plc | Boron compounds |
| JPH05213884A (ja) | 1991-06-14 | 1993-08-24 | Upjohn Co:The | 新規な４−アミノキノリン類およびこれを有効成分とする高血圧・鬱血性心不全の予防・治療剤 |
| US5576460A (en) | 1994-07-27 | 1996-11-19 | Massachusetts Institute Of Technology | Preparation of arylamines |
| US5929281A (en) | 1996-04-19 | 1999-07-27 | Tosoh Corporation | Process for producing heterocyclic aromatic amine or arylamine |
| GT199900147A (es) | 1998-09-17 | 1999-09-06 | 1, 2, 3, 4- tetrahidroquinolinas 2-sustituidas 4-amino sustituidas. | |
| US6197786B1 (en) | 1998-09-17 | 2001-03-06 | Pfizer Inc | 4-Carboxyamino-2-substituted-1,2,3,4-tetrahydroquinolines |
| US6147090A (en) * | 1998-09-17 | 2000-11-14 | Pfizer Inc. | 4-carboxyamino-2-methyl-1,2,3,4,-tetrahydroquinolines |
| HN2000000203A (es) | 1999-11-30 | 2001-06-13 | Pfizer Prod Inc | Procedimiento para la obtencion de 1,2,3,4-tetrahidroquinolinas 4-carboxiamino-2- sustituidas. |
| EP1167521A1 (de) | 2000-06-30 | 2002-01-02 | Aventis Animal Nutrition S.A. | Beschichtete enzymenthaltende Katalysator |
| AU2001279274A1 (en) | 2000-07-25 | 2002-02-05 | Digeo, Inc. | Allowance account for interactive television system |
| JP2002053557A (ja) * | 2000-08-14 | 2002-02-19 | Japan Tobacco Inc | アポリポ蛋白ａ−ｉ産生促進薬 |
| SK287781B6 (sk) * | 2000-08-18 | 2011-09-05 | Ajinomoto Co., Inc. | Fenylalanínové deriváty, farmaceutický prípravok s ich obsahom a ich použitie |
| SE0101161D0 (sv) * | 2001-03-30 | 2001-03-30 | Astrazeneca Ab | New compounds |
| JP3924250B2 (ja) | 2001-04-30 | 2007-06-06 | ファイザー・プロダクツ・インク | ４−アミノキノリン誘導体の中間体として有用な化合物 |
| EP1318139A3 (de) | 2001-12-07 | 2003-07-30 | Solvias AG | Verfahren zur Herstellung von 3-Aminokarbonsäuren und deren Estern |
| US6903233B2 (en) | 2002-03-11 | 2005-06-07 | Takasago International Corporation | Process for producing optically active 3-halogenocarboxylic acid ester and 3-azidocarboxylic acid ester |
| WO2004020393A1 (ja) | 2002-08-30 | 2004-03-11 | Japan Tobacco Inc. | ジベンジルアミン化合物及びその医薬用途 |
| KR20050055747A (ko) | 2002-10-04 | 2005-06-13 | 밀레니엄 파머슈티컬스 인코퍼레이티드 | 염증 질환 치료용의 ｐｇｄ2 수용체 길항제 |
| JP2004238322A (ja) | 2003-02-05 | 2004-08-26 | Sumika Fine Chemicals Co Ltd | （ｒ）−３−アミノペンタンニトリルメタンスルホン酸塩の製造方法 |
| WO2004072041A1 (en) | 2003-02-12 | 2004-08-26 | Care X S.A. | Tetrahydroquinolines as agonists of liver- x receptors |
| WO2004074255A2 (en) | 2003-02-18 | 2004-09-02 | Takasago International Corporation | Method for producing an optically active tetrahydroquinoline |
| MXPA05010456A (es) | 2003-03-28 | 2006-03-21 | Pfizer Prod Inc | Compuestos de quinolina y quinoxalina. |
| JP2004339205A (ja) | 2003-04-24 | 2004-12-02 | Ajinomoto Co Inc | 光学活性Ｎ−アリール−β−アミノ酸化合物の製造方法 |
| US7145030B2 (en) | 2003-04-24 | 2006-12-05 | Ajinomoto Co., Inc. | Production method for optically active N-aryl-β-amino acid compounds |
| ES2337061T3 (es) | 2003-09-18 | 2010-04-20 | Takasago International Corporation | Aminacion reductiva asimetrica de derivados de cetoacidos para producir derivados de aminoacidos. |
| EP1734961A2 (de) * | 2004-03-09 | 2006-12-27 | Elan Pharmaceuticals, Inc. | Verfahren zur behandlung von amyloidose mit bicyclischen aspartyl-proteasehemmern |
| DE602005014955D1 (de) | 2004-03-26 | 2009-07-30 | Lilly Co Eli | Verbindungen und verfahren zur behandlung von dyslipidämie |
| UA90269C2 (ru) | 2004-04-02 | 2010-04-26 | Мицубиси Танабе Фарма Корпорейшн | Тетрагидрохинолиновые производные и способ их получения |
| JP2005336083A (ja) | 2004-05-26 | 2005-12-08 | Sumitomo Chemical Co Ltd | 芳香族アミノ化合物の製造方法 |
| BRPI0512523A (pt) | 2004-06-24 | 2008-03-11 | Lilly Co Eli | composto ou um sal, enanciÈmero, racemato, diastereÈmero ou mistura de diastereÈmeros farmaceuticamente aceitável do mesmo, composição farmacêutica, e, uso de um composto |
-
2007
- 2007-03-26 TW TW096110313A patent/TW200808731A/zh unknown
- 2007-03-26 UY UY30244A patent/UY30244A1/es not_active Application Discontinuation
- 2007-03-28 AR ARP070101288A patent/AR060174A1/es not_active Application Discontinuation
- 2007-03-29 ES ES07741046T patent/ES2374315T3/es active Active
- 2007-03-29 US US12/295,618 patent/US8084611B2/en active Active
- 2007-03-29 EP EP07741046A patent/EP2007728B1/de active Active
- 2007-03-29 JP JP2009502420A patent/JP5275971B2/ja active Active
- 2007-03-29 PE PE2007000358A patent/PE20071150A1/es not_active Application Discontinuation
- 2007-03-29 AT AT07741046T patent/ATE533747T1/de active
- 2007-03-29 EP EP09174862A patent/EP2154132A1/de not_active Withdrawn
- 2007-03-29 WO PCT/JP2007/057610 patent/WO2007116922A1/en active Application Filing
Also Published As
| Publication number | Publication date |
|---|---|
| AR060174A1 (es) | 2008-05-28 |
| TW200808731A (en) | 2008-02-16 |
| EP2154132A1 (de) | 2010-02-17 |
| ES2374315T3 (es) | 2012-02-15 |
| JP2009532345A (ja) | 2009-09-10 |
| UY30244A1 (es) | 2007-11-30 |
| US20090292125A1 (en) | 2009-11-26 |
| US8084611B2 (en) | 2011-12-27 |
| PE20071150A1 (es) | 2007-12-03 |
| EP2007728A1 (de) | 2008-12-31 |
| JP5275971B2 (ja) | 2013-08-28 |
| EP2007728B1 (de) | 2011-11-16 |
| WO2007116922A1 (en) | 2007-10-18 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE533747T1 (de) | Verfahren zur herstellung von tetrahydrochinolinderivaten | |
| ATE455105T1 (de) | Verfahren zur herstellung von difluormethylpyrazolylcarboxylaten | |
| ATE408604T1 (de) | Verfahren zur herstellung von 1-alkyl-3- phenyluracilen | |
| ATE480531T1 (de) | Verfahren zur herstellung von benzopyran-2- olderivaten | |
| ATE535568T1 (de) | Verfahren zur herstellung von polyethylenzusammensetzungen | |
| ATE516816T1 (de) | Verfahren zur herstellung von impfstoffen | |
| DE602006015090D1 (de) | Verfahren zur herstellung von gezielt durchlässigen laminaten | |
| ATE529527T1 (de) | Verfahren zur herstellung von alkoholen | |
| ATE408609T1 (de) | Verfahren zur herstellung von n-phenylpyrazol-1- carboxamiden | |
| ATE430480T1 (de) | Verfahren zur herstellung von nährmittelzusammensetzungen | |
| ATE516362T1 (de) | Verfahren zur herstellung von biodiesel | |
| ATE489015T1 (de) | Verfahren zur herstellung von verschlüssen | |
| DE602007001585D1 (de) | Verfahren zur herstellung von kunstlatex | |
| DE502006001281D1 (de) | Verfahren zur herstellung substituierter biphenyle | |
| ATE546436T1 (de) | Verfahren zur herstellung von 2-amino-5- cyanobenzoesäurederivaten | |
| ATE518847T1 (de) | Verfahren zur herstellung von betamimetika | |
| ATE548345T1 (de) | Verfahren zur herstellung von agomelatin | |
| ATE444303T1 (de) | Verfahren zur herstellung von ferrisuccinylcasein | |
| ATE523483T1 (de) | Verfahren zur herstellung von betainen | |
| ATE540585T1 (de) | Verfahren zur herstellung von tomatenpaste | |
| ATE554088T1 (de) | Verfahren zur herstellung von pyridoä2,1- aüisochinolinderivaten | |
| DE602008006766D1 (de) | Verfahren zur herstellung von würzwürfeln | |
| ATE399157T1 (de) | Verfahren zur herstellung von telmisartan | |
| ATE510816T1 (de) | Verfahren zur herstellung von agomelatin | |
| ATE518829T1 (de) | Verfahren zur herstellung von escitalopram |