ATE519739T1 - Neuartiges verfahren zur herstellung von sulphonylpyrrolen als hdac-hemmer - Google Patents

Neuartiges verfahren zur herstellung von sulphonylpyrrolen als hdac-hemmer

Info

Publication number: ATE519739T1
Authority: AT; Austria
Prior art keywords: sulphonylpyrroles; producing; novel process; hdac inhibitors; compound
Prior art date: 2008-03-12

Application number

AT09721108T

Other languages

English (en)

Inventor

Matthias Mueller

Bernd Mueller

Thomas Maier

Original Assignee

4Sc Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2008-03-12

Filing date

2009-03-11

Publication date

2011-08-15

2009-03-11 Application filed by 4Sc Ag filed Critical 4Sc Ag

2011-08-15 Application granted granted Critical

2011-08-15 Publication of ATE519739T1 publication Critical patent/ATE519739T1/de

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/46—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with hetero atoms directly attached to the ring nitrogen atom
- C07D207/48—Sulfur atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
General Health & Medical Sciences (AREA)
Pulmonology (AREA)
Immunology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Oncology (AREA)
Rheumatology (AREA)
Cardiology (AREA)
Physical Education & Sports Medicine (AREA)
Hospice & Palliative Care (AREA)
Urology & Nephrology (AREA)
Pain & Pain Management (AREA)
Heart & Thoracic Surgery (AREA)
Virology (AREA)
Psychology (AREA)
Endocrinology (AREA)
Communicable Diseases (AREA)
Molecular Biology (AREA)
Psychiatry (AREA)
Tropical Medicine & Parasitology (AREA)
Vascular Medicine (AREA)
Transplantation (AREA)
AIDS & HIV (AREA)
Otolaryngology (AREA)
Dermatology (AREA)

AT09721108T 2008-03-12 2009-03-11 Neuartiges verfahren zur herstellung von sulphonylpyrrolen als hdac-hemmer ATE519739T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP08004567A EP2100878A1 (de)	2008-03-12	2008-03-12	Neuartiges Verfahren zur Herstellung von Sulphonylpyrrole als HDAC-Hemmer
PCT/EP2009/052870 WO2009112529A1 (en)	2008-03-12	2009-03-11	Novel method for the production of sulphonylpyrroles as hdac inhibitors

Publications (1)

Publication Number	Publication Date
ATE519739T1 true ATE519739T1 (de)	2011-08-15

Family

ID=39639400

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT09721108T ATE519739T1 (de)	2008-03-12	2009-03-11	Neuartiges verfahren zur herstellung von sulphonylpyrrolen als hdac-hemmer

Country Status (23)

Country	Link
US (1)	US8785659B2 (de)
EP (2)	EP2100878A1 (de)
JP (1)	JP5530939B2 (de)
KR (1)	KR101571915B1 (de)
CN (1)	CN101970404B (de)
AT (1)	ATE519739T1 (de)
AU (1)	AU2009224623C1 (de)
BR (1)	BRPI0909752B8 (de)
CA (1)	CA2719074C (de)
CY (1)	CY1111994T1 (de)
DK (1)	DK2265580T3 (de)
EA (1)	EA017929B1 (de)
ES (1)	ES2370592T3 (de)
HK (1)	HK1150319A1 (de)
IL (1)	IL207995A (de)
MX (1)	MX2010010015A (de)
NZ (1)	NZ587824A (de)
PL (1)	PL2265580T3 (de)
PT (1)	PT2265580E (de)
SI (1)	SI2265580T1 (de)
UA (1)	UA102091C2 (de)
WO (1)	WO2009112529A1 (de)
ZA (1)	ZA201006422B (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP2100882A1 (de) *	2008-03-12	2009-09-16	4Sc Ag	(E) -N -(2-Aminophenyl) -3-{1-[4-(1-methyl-1H-pyrazol-4-yl)- benzolsulfonyl]-1H-pyrrol-3-yl} Acrylamid-Salze
JP2019511544A (ja)	2016-04-14	2019-04-25	４エスツェーアクチェンゲゼルシャフト	アジア人患者におけるレスミノスタットの医薬用途
TW201912183A (zh)	2017-08-31	2019-04-01	德商４Ｓｃ製藥公司	Hdac抑制劑與抗代謝藥劑組合用於癌症治療

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4960787A (en)	1989-02-06	1990-10-02	Ciba-Geigy Corporation	Certain pyrrolyl-substituted hydroxamic acid derivatives
KR100236806B1 (ko)	1991-12-10	2000-01-15	시오노 요시히코	방향족 설폰아미드계 하이드록삼산 유도체
AU5886296A (en)	1995-06-02	1996-12-18	G.D. Searle & Co.	Heterocyclo substituted hydroxamic acid derivatives as cyclo oxygenase-2 and 5-lipoxygenase inhibitors
WO2005087724A2 (en)	2004-03-11	2005-09-22	Altana Pharma Ag	Sulphonylpyrroles as hdac inhibitors
EA015533B1 (ru) *	2005-03-15	2011-08-30	4Сц Аг	N-сульфонилпирролы и их применение в качестве ингибиторов гистондезацетилазы
US8188138B2 (en)	2005-09-21	2012-05-29	4Sc Ag	Sulphonylpyrrole hydrochloride salts as histone deacetylases inhibitors
PT1928872E (pt)	2005-09-21	2012-05-25	4Sc Ag	Utilização de novos sulfonilpirroles como inibidores de hdacs

2008
- 2008-03-12 EP EP08004567A patent/EP2100878A1/de not_active Ceased
2009
- 2009-03-11 PT PT09721108T patent/PT2265580E/pt unknown
- 2009-03-11 EP EP09721108A patent/EP2265580B1/de active Active
- 2009-03-11 EA EA201001270A patent/EA017929B1/ru not_active IP Right Cessation
- 2009-03-11 SI SI200930103T patent/SI2265580T1/sl unknown
- 2009-03-11 KR KR1020107020293A patent/KR101571915B1/ko active IP Right Grant
- 2009-03-11 JP JP2010550194A patent/JP5530939B2/ja active Active
- 2009-03-11 WO PCT/EP2009/052870 patent/WO2009112529A1/en active Application Filing
- 2009-03-11 AU AU2009224623A patent/AU2009224623C1/en active Active
- 2009-03-11 MX MX2010010015A patent/MX2010010015A/es active IP Right Grant
- 2009-03-11 BR BRPI0909752A patent/BRPI0909752B8/pt active IP Right Grant
- 2009-03-11 PL PL09721108T patent/PL2265580T3/pl unknown
- 2009-03-11 NZ NZ587824A patent/NZ587824A/en unknown
- 2009-03-11 CN CN2009801082773A patent/CN101970404B/zh active Active
- 2009-03-11 DK DK09721108.0T patent/DK2265580T3/da active
- 2009-03-11 UA UAA201011865A patent/UA102091C2/ru unknown
- 2009-03-11 AT AT09721108T patent/ATE519739T1/de active
- 2009-03-11 US US12/921,928 patent/US8785659B2/en active Active
- 2009-03-11 CA CA2719074A patent/CA2719074C/en active Active
- 2009-03-11 ES ES09721108T patent/ES2370592T3/es active Active
2010
- 2010-09-05 IL IL207995A patent/IL207995A/en active IP Right Grant
- 2010-09-07 ZA ZA2010/06422A patent/ZA201006422B/en unknown
2011
- 2011-06-08 HK HK11105798.0A patent/HK1150319A1/xx unknown
- 2011-11-03 CY CY20111101060T patent/CY1111994T1/el unknown

Also Published As

Publication number	Publication date
CY1111994T1 (el)	2015-11-04
ZA201006422B (en)	2011-10-26
KR20100121656A (ko)	2010-11-18
EP2265580B1 (de)	2011-08-10
AU2009224623B2 (en)	2013-07-18
CA2719074C (en)	2017-01-17
AU2009224623C1 (en)	2014-01-23
KR101571915B1 (ko)	2015-11-25
JP5530939B2 (ja)	2014-06-25
CA2719074A1 (en)	2009-09-17
EP2265580A1 (de)	2010-12-29
US20110105568A1 (en)	2011-05-05
EA017929B1 (ru)	2013-04-30
PT2265580E (pt)	2011-11-21
UA102091C2 (ru)	2013-06-10
BRPI0909752B1 (pt)	2020-11-24
AU2009224623A1 (en)	2009-09-17
ES2370592T3 (es)	2011-12-20
CN101970404A (zh)	2011-02-09
CN101970404B (zh)	2013-05-08
EP2100878A1 (de)	2009-09-16
BRPI0909752A2 (pt)	2015-10-06
MX2010010015A (es)	2011-04-05
NZ587824A (en)	2012-05-25
US8785659B2 (en)	2014-07-22
DK2265580T3 (da)	2011-10-31
EA201001270A1 (ru)	2011-04-29
JP2011513467A (ja)	2011-04-28
PL2265580T3 (pl)	2012-01-31
IL207995A0 (en)	2010-12-30
WO2009112529A1 (en)	2009-09-17
HK1150319A1 (en)	2011-11-25
SI2265580T1 (sl)	2011-12-30
IL207995A (en)	2013-04-30
BRPI0909752B8 (pt)	2021-05-25

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