ATE517893T1 - Arylvinylazacycloalkan-verbindungen sowie herstellungsverfahren dafür und verwendung davon - Google Patents

Arylvinylazacycloalkan-verbindungen sowie herstellungsverfahren dafür und verwendung davon

Info

Publication number: ATE517893T1
Authority: AT; Austria
Prior art keywords: arylvinylazacycloalkan; compounds; production process; production; arylvinylazacycloalkan compounds
Prior art date: 2003-03-05

Application number

AT08075106T

Other languages

English (en)

Inventor

Jeffrey Daniel Schmitt

Gary Maurice Dull

Arielle Genevois-Borella

Marc Capet

Michel Cheve

Craig Harrison Miller

Original Assignee

Targacept Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-03-05

Filing date

2004-03-04

Publication date

2011-08-15

2004-03-04 Application filed by Targacept Inc filed Critical Targacept Inc

2011-08-15 Application granted granted Critical

2011-08-15 Publication of ATE517893T1 publication Critical patent/ATE517893T1/de

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
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- A61P1/12—Antidiarrhoeals
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A—HUMAN NECESSITIES
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- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Addiction (AREA)
Epidemiology (AREA)
Physical Education & Sports Medicine (AREA)
Psychology (AREA)
Orthopedic Medicine & Surgery (AREA)
Immunology (AREA)
Virology (AREA)
AIDS & HIV (AREA)
Anesthesiology (AREA)
Cardiology (AREA)
Vascular Medicine (AREA)
Urology & Nephrology (AREA)
Rheumatology (AREA)
Tropical Medicine & Parasitology (AREA)
Heart & Thoracic Surgery (AREA)
Hospice & Palliative Care (AREA)
Molecular Biology (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

AT08075106T 2003-03-05 2004-03-04 Arylvinylazacycloalkan-verbindungen sowie herstellungsverfahren dafür und verwendung davon ATE517893T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US10/379,868 US7098331B2 (en)	2003-03-05	2003-03-05	Arylvinylazacycloalkane compounds and methods of preparation and use thereof

Publications (1)

Publication Number	Publication Date
ATE517893T1 true ATE517893T1 (de)	2011-08-15

Family

ID=32926772

Family Applications (3)

Application Number	Title	Priority Date	Filing Date
AT08075106T ATE517893T1 (de)	2003-03-05	2004-03-04	Arylvinylazacycloalkan-verbindungen sowie herstellungsverfahren dafür und verwendung davon
AT04717398T ATE394394T1 (de)	2003-03-05	2004-03-04	Arylvinylazacycloalkane verbindungen und methoden zu ihrer herstellung und deren verwendung
AT09075124T ATE496046T1 (de)	2003-03-05	2004-03-04	Arylvinylazacycloalkan-verbindungen und verfahren zu deren herstellung und verwendung

Family Applications After (2)

Application Number	Title	Priority Date	Filing Date
AT04717398T ATE394394T1 (de)	2003-03-05	2004-03-04	Arylvinylazacycloalkane verbindungen und methoden zu ihrer herstellung und deren verwendung
AT09075124T ATE496046T1 (de)	2003-03-05	2004-03-04	Arylvinylazacycloalkan-verbindungen und verfahren zu deren herstellung und verwendung

Country Status (32)

Country	Link
US (8)	US7098331B2 (de)
EP (3)	EP1601670B1 (de)
JP (3)	JP4663627B2 (de)
KR (4)	KR100953150B1 (de)
CN (3)	CN101550132B (de)
AR (3)	AR043469A1 (de)
AT (3)	ATE517893T1 (de)
AU (3)	AU2004217903B2 (de)
BR (1)	BRPI0409576A (de)
CA (1)	CA2516514C (de)
CL (1)	CL2004000452A1 (de)
CY (2)	CY1110391T1 (de)
DE (2)	DE602004031165D1 (de)
DK (2)	DK1601670T3 (de)
EA (3)	EA019240B1 (de)
ES (3)	ES2389106T3 (de)
GT (1)	GT200400033A (de)
HK (3)	HK1084949A1 (de)
IL (3)	IL170155A (de)
JO (1)	JO2488B1 (de)
MX (1)	MXPA05009386A (de)
NO (3)	NO331920B1 (de)
NZ (1)	NZ541795A (de)
PA (1)	PA8597201A1 (de)
PE (1)	PE20040930A1 (de)
PL (5)	PL216979B1 (de)
PT (2)	PT1601670E (de)
SI (2)	SI1601670T1 (de)
TW (3)	TW200927746A (de)
UY (1)	UY28218A1 (de)
WO (1)	WO2004078752A1 (de)
ZA (1)	ZA200506790B (de)

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US7098331B2 (en) *	2003-03-05	2006-08-29	Targacept, Inc.	Arylvinylazacycloalkane compounds and methods of preparation and use thereof
FR2896800B1 (fr) *	2006-01-30	2008-04-11	Servier Lab	Nouveaux composes pyridinylaminoalkylene-et pyridinyloxyalkylene-cyclopropanamines polysubstitues, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
WO2008157365A2 (en) *	2007-06-15	2008-12-24	Targacept, Inc.	Vinylazacycloalkanes for treating neuropathic pain
EP2296640A1 (de) *	2008-05-12	2011-03-23	Targacept Inc.	Verfahren zur prävention der entwicklung von retinopathie durch orale verabreichung von nnr-liganden
US9145396B2 (en)	2008-12-01	2015-09-29	Targacept, Inc.	Synthesis and novel salt forms of (R)-5-((E)-2-pyrrolidin-3ylvinyl)pyrimidine
TW201024283A (en) *	2008-12-01	2010-07-01	Targacept Inc	Synthesis and novel salt forms of (R)-3-((E)-2-(pyrrolidin-3-yl)vinyl)-5-(tetrahydropyran-4-yloxy)pyridine
EP2364307B1 (de)	2008-12-01	2017-07-05	Oyster Point Pharma, Inc.	Synthese und neue salzformen von (r)-5-((e)-2-(pyrrolidin-3-ylvinyl)pyrimidin
WO2010080757A2 (en)	2009-01-07	2010-07-15	Astrazeneca Ab	Combinations with an alpha-4beta-2 nicotinic agonist
WO2010147938A2 (en) *	2009-06-17	2010-12-23	Targacept, Inc.	Reversal of l-dopa-induced dyskinesia by neuronal nicotinic receptor ligands
EP2509982A1 (de)	2009-12-07	2012-10-17	Targacept, Inc.	3,6-diazabicyclo[3.1.1]heptane als neuronale nikotinische acetylcholinreceptorliganden
JP2013522201A (ja) *	2010-03-11	2013-06-13	ターガセプト，インコーポレイテッド	便秘のためのアリールビニルアザシクロアルカン化合物
US20110274628A1 (en) *	2010-05-07	2011-11-10	Borschke August J	Nicotine-containing pharmaceutical compositions
US20140081714A1 (en) *	2012-09-19	2014-03-20	Salesforce.Com, Inc.	Systems and methods of rewarding users in an on-demand system
US20140278929A1 (en) *	2013-03-15	2014-09-18	Yahoo! Inc.	System and method identifying opportunities for advertising entities based on user goal achievement
NZ746468A (en)	2016-04-07	2023-06-30	Oyster Point Pharma Inc	Methods of treating ocular conditions
KR101848601B1 (ko) *	2016-07-27	2018-04-12	송기봉	일회용 위생 티슈
EP3820443A1 (de)	2018-07-10	2021-05-19	Oyster Point Pharma, Inc.	Kombinationen von positiven allosterischen modulatoren und nikotinischen acetylcholinrezeptoragonisten zur behandlung von augenleiden
WO2020014217A1 (en)	2018-07-10	2020-01-16	Oyster Point Pharma, Inc.	Methods of treating ocular conditions
WO2021222230A1 (en)	2020-04-28	2021-11-04	Oyster Point Pharma, Inc.	Local administration of nicotinic acetylcholine receptor agonists for the inhibition of coronavirus infections

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US7098331B2 (en) *	2003-03-05	2006-08-29	Targacept, Inc.	Arylvinylazacycloalkane compounds and methods of preparation and use thereof

2003
- 2003-03-05 US US10/379,868 patent/US7098331B2/en not_active Expired - Lifetime
2004
- 2004-02-10 TW TW098105932A patent/TW200927746A/zh unknown
- 2004-02-10 TW TW093103017A patent/TWI339662B/zh not_active IP Right Cessation
- 2004-02-10 TW TW098105931A patent/TWI377204B/zh not_active IP Right Cessation
- 2004-03-02 PE PE2004000228A patent/PE20040930A1/es not_active Application Discontinuation
- 2004-03-04 EA EA200900706A patent/EA019240B1/ru not_active IP Right Cessation
- 2004-03-04 CA CA2516514A patent/CA2516514C/en not_active Expired - Lifetime
- 2004-03-04 GT GT200400033A patent/GT200400033A/es unknown
- 2004-03-04 JP JP2006509059A patent/JP4663627B2/ja not_active Expired - Fee Related
- 2004-03-04 ES ES08075106T patent/ES2389106T3/es not_active Expired - Lifetime
- 2004-03-04 EP EP04717398A patent/EP1601670B1/de not_active Expired - Lifetime
- 2004-03-04 DK DK04717398T patent/DK1601670T3/da active
- 2004-03-04 MX MXPA05009386A patent/MXPA05009386A/es active IP Right Grant
- 2004-03-04 PL PL378415A patent/PL216979B1/pl unknown
- 2004-03-04 UY UY28218A patent/UY28218A1/es not_active Application Discontinuation
- 2004-03-04 PA PA20048597201A patent/PA8597201A1/es unknown
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Also Published As

Publication number	Publication date
AU2008258187A1 (en)	2009-01-15
DE602004031165D1 (de)	2011-03-03
CN101550132B (zh)	2012-03-28
CY1110391T1 (el)	2015-04-29
IL197890A (en)	2013-11-28
DK1601670T3 (da)	2008-08-25
CN1756754A (zh)	2006-04-05
US8067443B2 (en)	2011-11-29
HK1130254A1 (en)	2009-12-24
IL197889A (en)	2013-03-24
JP5537085B2 (ja)	2014-07-02
ATE394394T1 (de)	2008-05-15
CN100526308C (zh)	2009-08-12
TWI377204B (en)	2012-11-21
EA200801764A1 (ru)	2008-12-30
TW200927746A (en)	2009-07-01
NO20091888L (no)	2005-10-03
CL2004000452A1 (es)	2005-05-20
AR070570A2 (es)	2010-04-21
BRPI0409576A (pt)	2006-04-18
TWI339662B (en)	2011-04-01
PL1601670T3 (pl)	2008-10-31
JP2009292825A (ja)	2009-12-17
PL215059B1 (pl)	2013-10-31
HK1116800A1 (en)	2009-01-02
US8633222B2 (en)	2014-01-21
TW200505909A (en)	2005-02-16
ES2309507T3 (es)	2008-12-16
JP5537084B2 (ja)	2014-07-02
EP1947100A1 (de)	2008-07-23
PT2085395E (pt)	2011-04-20
AU2004217903B2 (en)	2010-03-04
PL2085395T3 (pl)	2011-05-31
AU2004217903A1 (en)	2004-09-16
CY1111615T1 (el)	2015-10-07
PA8597201A1 (es)	2004-09-28
ZA200506790B (en)	2006-05-31
DK2085395T3 (da)	2011-04-18
JP2006519868A (ja)	2006-08-31
PL394600A1 (pl)	2011-07-18
SI2085395T1 (sl)	2011-05-31
KR20090021227A (ko)	2009-02-27
US20140107164A1 (en)	2014-04-17
SI1601670T1 (sl)	2008-10-31
PE20040930A1 (es)	2005-02-18
EA200900706A1 (ru)	2009-10-30
EA014714B1 (ru)	2011-02-28
CA2516514C (en)	2012-02-07
EA019240B1 (ru)	2014-02-28
KR20120014236A (ko)	2012-02-16
PT1601670E (pt)	2008-07-11
US8063068B2 (en)	2011-11-22
PL216979B1 (pl)	2014-06-30
KR101185541B1 (ko)	2012-09-24
AU2008258188A1 (en)	2009-01-15
AR070569A2 (es)	2010-04-21
US20040176348A1 (en)	2004-09-09
GT200400033A (es)	2005-05-29
AU2008258187B2 (en)	2010-08-05
US20060094732A1 (en)	2006-05-04
TW200927745A (en)	2009-07-01
US20150164894A1 (en)	2015-06-18
EP2085395A1 (de)	2009-08-05
CN101550132A (zh)	2009-10-07
AR043469A1 (es)	2005-07-27
US7714001B2 (en)	2010-05-11
KR20090021228A (ko)	2009-02-27
DE602004013553D1 (de)	2008-06-19
NO331920B1 (no)	2012-04-30
EA200501425A1 (ru)	2006-02-24
JO2488B1 (en)	2009-10-05
AU2008258188B2 (en)	2011-02-24
UY28218A1 (es)	2005-06-30
IL170155A (en)	2013-08-29
EP1601670B1 (de)	2008-05-07
US20100010042A1 (en)	2010-01-14
EP2085395B1 (de)	2011-01-19
EA010870B1 (ru)	2008-12-30
US20080293778A1 (en)	2008-11-27
ES2389106T3 (es)	2012-10-23
JP2010001296A (ja)	2010-01-07
CN101255155A (zh)	2008-09-03
NO20054120L (no)	2005-10-03
EP1601670A1 (de)	2005-12-07
NO20054120D0 (no)	2005-09-05
JP4663627B2 (ja)	2011-04-06
ES2385941T3 (es)	2012-08-03
EP1947100B1 (de)	2011-07-27
NZ541795A (en)	2008-03-28
MXPA05009386A (es)	2005-11-04
CA2516514A1 (en)	2004-09-16
US7098331B2 (en)	2006-08-29
HK1084949A1 (en)	2006-08-11
PL394604A1 (pl)	2011-07-18
KR20060006006A (ko)	2006-01-18
NO332293B1 (no)	2012-08-20
PL378415A1 (pl)	2006-04-03
KR100953150B1 (ko)	2010-04-19
ATE496046T1 (de)	2011-02-15
NO20092231L (no)	2005-10-03
US20100267776A1 (en)	2010-10-21
WO2004078752A1 (en)	2004-09-16
US20110152293A1 (en)	2011-06-23
KR101018083B1 (ko)	2011-03-02

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