ATE507295T1 - COMPOSITIONS AND METHODS FOR DENDRITIC CELL-BASED IMMUNOTHERAPY - Google Patents
COMPOSITIONS AND METHODS FOR DENDRITIC CELL-BASED IMMUNOTHERAPYInfo
- Publication number
- ATE507295T1 ATE507295T1 AT01920913T AT01920913T ATE507295T1 AT E507295 T1 ATE507295 T1 AT E507295T1 AT 01920913 T AT01920913 T AT 01920913T AT 01920913 T AT01920913 T AT 01920913T AT E507295 T1 ATE507295 T1 AT E507295T1
- Authority
- AT
- Austria
- Prior art keywords
- compositions
- methods
- immunostimulatory
- dendritic cell
- based immunotherapy
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- 239000000203 mixture Substances 0.000 title abstract 3
- 238000009169 immunotherapy Methods 0.000 title abstract 2
- 230000003308 immunostimulating effect Effects 0.000 abstract 5
- 102000037865 fusion proteins Human genes 0.000 abstract 3
- 108020001507 fusion proteins Proteins 0.000 abstract 3
- 101001012157 Homo sapiens Receptor tyrosine-protein kinase erbB-2 Proteins 0.000 abstract 1
- 102100030086 Receptor tyrosine-protein kinase erbB-2 Human genes 0.000 abstract 1
- 210000001744 T-lymphocyte Anatomy 0.000 abstract 1
- 239000000427 antigen Substances 0.000 abstract 1
- 102000036639 antigens Human genes 0.000 abstract 1
- 108091007433 antigens Proteins 0.000 abstract 1
- 210000004443 dendritic cell Anatomy 0.000 abstract 1
- 238000000338 in vitro Methods 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 230000003834 intracellular effect Effects 0.000 abstract 1
- 230000021633 leukocyte mediated immunity Effects 0.000 abstract 1
- 229920001184 polypeptide Polymers 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 230000001681 protective effect Effects 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/385—Haptens or antigens, bound to carriers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/461—Cellular immunotherapy characterised by the cell type used
- A61K39/4615—Dendritic cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/462—Cellular immunotherapy characterized by the effect or the function of the cells
- A61K39/4622—Antigen presenting cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
- A61K39/4643—Vertebrate antigens
- A61K39/4644—Cancer antigens
- A61K39/464402—Receptors, cell surface antigens or cell surface determinants
- A61K39/464403—Receptors for growth factors
- A61K39/464406—Her-2/neu/ErbB2, Her-3/ErbB3 or Her 4/ ErbB4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/53—Colony-stimulating factor [CSF]
- C07K14/535—Granulocyte CSF; Granulocyte-macrophage CSF
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/515—Animal cells
- A61K2039/5154—Antigen presenting cells [APCs], e.g. dendritic cells or macrophages
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/515—Animal cells
- A61K2039/5158—Antigen-pulsed cells, e.g. T-cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55522—Cytokines; Lymphokines; Interferons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6031—Proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
- A61K2239/31—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterized by the route of administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
- A61K2239/38—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterised by the dose, timing or administration schedule
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Microbiology (AREA)
- Genetics & Genomics (AREA)
- Cell Biology (AREA)
- Zoology (AREA)
- General Chemical & Material Sciences (AREA)
- Mycology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
- Biophysics (AREA)
- Wood Science & Technology (AREA)
- Communicable Diseases (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Virology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
Disclosed are immunostimulatory fusion proteins and methods for generating protective DC-induced, T cell-mediated immune responses in vitro and in vivo. The immunostimulatory fusion proteins comprise a polypeptide antigen component and an immunostimulatory component derived from the intracellular domain of the HER-2 protein. Also disclosed are immunostimulatory compositions comprising dendritic cells pulsed with such an immunostimulatory fusion protein and methods for immunotherapy using the compositions.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US19350400P | 2000-03-30 | 2000-03-30 | |
PCT/US2001/010515 WO2001074855A2 (en) | 2000-03-30 | 2001-03-30 | Compositions and methods for dendritic cell-based immunotherapy |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE507295T1 true ATE507295T1 (en) | 2011-05-15 |
Family
ID=22713907
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT01920913T ATE507295T1 (en) | 2000-03-30 | 2001-03-30 | COMPOSITIONS AND METHODS FOR DENDRITIC CELL-BASED IMMUNOTHERAPY |
Country Status (13)
Country | Link |
---|---|
US (2) | US7060279B2 (en) |
EP (1) | EP1272633B1 (en) |
JP (1) | JP5110674B2 (en) |
AT (1) | ATE507295T1 (en) |
AU (2) | AU4791901A (en) |
CA (1) | CA2403964C (en) |
CY (1) | CY1111718T1 (en) |
DE (1) | DE60144516D1 (en) |
DK (1) | DK1272633T3 (en) |
ES (1) | ES2362715T3 (en) |
NZ (1) | NZ522066A (en) |
PT (1) | PT1272633E (en) |
WO (1) | WO2001074855A2 (en) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7198920B1 (en) | 1999-01-29 | 2007-04-03 | Corika Corporation | HER-2/neu fusion proteins |
US7229623B1 (en) | 2000-08-03 | 2007-06-12 | Corixa Corporation | Her-2/neu fusion proteins |
US7413869B2 (en) * | 2002-04-05 | 2008-08-19 | Dendreon Corporation | Method for determining potency of antigenic presenting cell based vaccines |
WO2003087338A2 (en) * | 2002-04-11 | 2003-10-23 | Amgen, Inc. | Her-2 receptor tyrosine kinase molecules and uses thereof |
ES2527946T3 (en) | 2003-03-05 | 2015-02-02 | Dendreon Corporation | Compositions and methods employing alternative reading frame polypeptides for the treatment of cancer and infectious diseases |
WO2007147165A2 (en) * | 2006-06-16 | 2007-12-21 | Bresagen, Inc. | Human cancer stem cell culture compositions comprising erbb2 variants and methods of use thereof |
US7972602B2 (en) * | 2006-08-11 | 2011-07-05 | Dendreon Corporation | Promiscuous HER-2/Neu CD4 T cell epitopes |
US20090181078A1 (en) | 2006-09-26 | 2009-07-16 | Infectious Disease Research Institute | Vaccine composition containing synthetic adjuvant |
PT2118128E (en) * | 2007-01-15 | 2013-01-29 | Glaxosmithkline Biolog Sa | Fusion proteins comprising the tumor rejection antigens ny-eso-1 and lage-1 |
US8309096B2 (en) | 2007-01-15 | 2012-11-13 | Glaxosmithkline Biologicals S.A. | Fusion protein |
EP2118128B1 (en) * | 2007-01-15 | 2012-11-07 | GlaxoSmithKline Biologicals SA | Fusion proteins comprising the tumor rejection antigens ny-eso-1 and lage-1 |
US8153120B2 (en) * | 2007-03-22 | 2012-04-10 | Dendreon Corporation | Methods for inducing a natural killer (NK) cell-mediated immune response and for increasing NK cell activity |
EP2780363B1 (en) | 2011-11-17 | 2019-07-03 | Glia SP Z.O.O. | Compositions and methods for treating glioma |
EP2777711A1 (en) * | 2013-03-11 | 2014-09-17 | Icon Genetics GmbH | Her2/Neu cancer vaccine |
WO2017096247A1 (en) | 2015-12-04 | 2017-06-08 | Mayo Foundation For Medical Education And Research | Methods and vaccines for inducing immune responses to multiple different mhc molecules |
TW202216776A (en) | 2020-07-07 | 2022-05-01 | 美商康愈有限責任公司 | Mic antibodies and binding agents and methods of using the same |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2048981B (en) * | 1979-05-23 | 1982-11-17 | Coal Ind | Equipment for laying a layer of elongate material adjacent to an exposed rock or mineral surface in an underground mine |
US4399216A (en) | 1980-02-25 | 1983-08-16 | The Trustees Of Columbia University | Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials |
CA2158281A1 (en) * | 1993-03-15 | 1994-09-29 | Jay A. Berzofsky | Peptide coated dendritic cells as immunogens |
US5801005A (en) * | 1993-03-17 | 1998-09-01 | University Of Washington | Immune reactivity to HER-2/neu protein for diagnosis of malignancies in which the HER-2/neu oncogene is associated |
US5586538A (en) * | 1995-11-13 | 1996-12-24 | Caterpillar Inc. | Method of correcting engine maps based on engine temperature |
US6080409A (en) | 1995-12-28 | 2000-06-27 | Dendreon Corporation | Immunostimulatory method |
WO1998046769A1 (en) * | 1997-04-11 | 1998-10-22 | Dendreon Corporation | Composition and method for inducing an immune response against tumour-related antigens |
US6194152B1 (en) * | 1997-08-20 | 2001-02-27 | Dendreon Corporation | Prostate tumor polynucleotide compositions and methods of detection thereof |
NZ512807A (en) * | 1998-12-14 | 2003-10-31 | Dendreon Corp | Compositions and methods for enhancement of major histocompatibility complex class 1 restricted antigen presentation by attaching the antigen to a specific peptide |
CZ20012587A3 (en) * | 1999-01-29 | 2002-05-15 | Corixa Corporation | Isolated protein, nucleic acid, virus vector, pharmaceutical preparation, isolated population of T cells, method of reinforcing immune response, method of removing tumor cells, method of stimulating and/or propagating T cells and process for preparing a fusion protein |
IL145982A0 (en) * | 1999-04-19 | 2002-07-25 | Smithkline Beecham Biolog | Vaccines |
US6406681B1 (en) * | 2000-08-21 | 2002-06-18 | Aeropharm Technology, Inc. | Method of treating a systemic disease |
-
2001
- 2001-03-30 EP EP01920913A patent/EP1272633B1/en not_active Expired - Lifetime
- 2001-03-30 PT PT01920913T patent/PT1272633E/en unknown
- 2001-03-30 US US09/821,883 patent/US7060279B2/en not_active Expired - Fee Related
- 2001-03-30 DK DK01920913.9T patent/DK1272633T3/en active
- 2001-03-30 DE DE60144516T patent/DE60144516D1/en not_active Expired - Lifetime
- 2001-03-30 AU AU4791901A patent/AU4791901A/en active Pending
- 2001-03-30 AU AU2001247919A patent/AU2001247919B2/en not_active Ceased
- 2001-03-30 AT AT01920913T patent/ATE507295T1/en active
- 2001-03-30 CA CA2403964A patent/CA2403964C/en not_active Expired - Fee Related
- 2001-03-30 WO PCT/US2001/010515 patent/WO2001074855A2/en active IP Right Grant
- 2001-03-30 NZ NZ522066A patent/NZ522066A/en not_active IP Right Cessation
- 2001-03-30 JP JP2001572544A patent/JP5110674B2/en not_active Expired - Fee Related
- 2001-03-30 ES ES01920913T patent/ES2362715T3/en not_active Expired - Lifetime
-
2005
- 2005-06-03 US US11/144,912 patent/US7659117B2/en not_active Expired - Fee Related
-
2011
- 2011-07-20 CY CY20111100718T patent/CY1111718T1/en unknown
Also Published As
Publication number | Publication date |
---|---|
EP1272633A2 (en) | 2003-01-08 |
DK1272633T3 (en) | 2011-05-23 |
US20050232932A1 (en) | 2005-10-20 |
AU4791901A (en) | 2001-10-15 |
WO2001074855A3 (en) | 2002-03-07 |
EP1272633B1 (en) | 2011-04-27 |
ES2362715T3 (en) | 2011-07-12 |
NZ522066A (en) | 2004-08-27 |
WO2001074855A2 (en) | 2001-10-11 |
US7659117B2 (en) | 2010-02-09 |
JP5110674B2 (en) | 2012-12-26 |
CA2403964A1 (en) | 2001-10-11 |
AU2001247919B2 (en) | 2006-02-09 |
CA2403964C (en) | 2013-04-30 |
CY1111718T1 (en) | 2015-10-07 |
DE60144516D1 (en) | 2011-06-09 |
US20020061310A1 (en) | 2002-05-23 |
US7060279B2 (en) | 2006-06-13 |
PT1272633E (en) | 2011-06-27 |
JP2003529608A (en) | 2003-10-07 |
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