ATE546543T1 - Screening-verfahren mit verwendung des neuen substrats epha4 für gamma-sekretase - Google Patents
Screening-verfahren mit verwendung des neuen substrats epha4 für gamma-sekretaseInfo
- Publication number
- ATE546543T1 ATE546543T1 AT08765357T AT08765357T ATE546543T1 AT E546543 T1 ATE546543 T1 AT E546543T1 AT 08765357 T AT08765357 T AT 08765357T AT 08765357 T AT08765357 T AT 08765357T AT E546543 T1 ATE546543 T1 AT E546543T1
- Authority
- AT
- Austria
- Prior art keywords
- epha4
- secretase
- screening method
- new substrate
- gamma secretase
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
- C12Q1/37—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
- G01N2500/02—Screening involving studying the effect of compounds C on the interaction between interacting molecules A and B (e.g. A = enzyme and B = substrate for A, or A = receptor and B = ligand for the receptor)
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/975—Kit
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- Analytical Chemistry (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Enzymes And Modification Thereof (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US94268707P | 2007-06-08 | 2007-06-08 | |
| PCT/JP2008/060567 WO2008150010A1 (ja) | 2007-06-08 | 2008-06-09 | γ-セクレターゼの新規基質EphA4を利用したスクリーニング方法 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE546543T1 true ATE546543T1 (de) | 2012-03-15 |
Family
ID=40093812
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT08765357T ATE546543T1 (de) | 2007-06-08 | 2008-06-09 | Screening-verfahren mit verwendung des neuen substrats epha4 für gamma-sekretase |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US7910324B2 (de) |
| EP (1) | EP2166110B1 (de) |
| JP (1) | JP5511377B2 (de) |
| AT (1) | ATE546543T1 (de) |
| WO (1) | WO2008150010A1 (de) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE546543T1 (de) | 2007-06-08 | 2012-03-15 | Eisai R&D Man Co Ltd | Screening-verfahren mit verwendung des neuen substrats epha4 für gamma-sekretase |
| EP2177623A4 (de) * | 2007-07-19 | 2010-12-29 | Eisai R&D Man Co Ltd | SCREENINGVERFAHREN MIT c-MET, EINEM NEUEN SUBSTRAT FÜR GAMMA-SEKRETASE |
| JPWO2009017234A1 (ja) * | 2007-08-01 | 2010-10-28 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | γ−セクレターゼの新規基質ｃ−Ｒｅｔを利用したスクリーニング方法 |
| JP5580598B2 (ja) | 2007-11-15 | 2014-08-27 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | γ−セクレターゼの新規基質ＥｐｈＡ７を利用したスクリーニング方法 |
| JP5508857B2 (ja) * | 2007-11-30 | 2014-06-04 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 新規活性を有するＥｐｈＡ４ポリペプチドおよびその用途 |
| WO2010141974A1 (en) * | 2009-06-10 | 2010-12-16 | The University Of Melbourne | Therapeutic applications |
| WO2012081502A1 (ja) | 2010-12-17 | 2012-06-21 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | ゼラチナーゼによるEphA4の切断反応を指標としたスクリーニング方法 |
| JP5961608B2 (ja) | 2011-04-25 | 2016-08-02 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | ＥｐｈＡ４細胞外ドメインの測定による認知機能障害を伴う神経系疾患の検出方法 |
| MX2018002164A (es) | 2015-09-08 | 2018-09-12 | Eisai R&D Man Co Ltd | Anticerpo anti-epha4. |
| CN108884135B (zh) * | 2015-10-27 | 2024-03-26 | 昆士兰大学 | 治疗方法以及可用于其中的药剂 |
| CN117398459A (zh) | 2019-07-01 | 2024-01-16 | 卫材R&D管理有限公司 | 抗EphA4抗体 |
| WO2022138707A1 (ja) * | 2020-12-24 | 2022-06-30 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 筋萎縮性側索硬化症の治療用医薬組成物 |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20020068361A1 (en) | 1997-04-08 | 2002-06-06 | Douglas Clary | Methods of evaluating specific cellular functions of receptor protein tyrosine kinases in a ligand independent manner |
| AU6887698A (en) | 1997-04-08 | 1998-10-30 | Sugen, Inc. | Study and treatment of diseases related to specific cellular functions of receptor protein tyrosine kinases |
| US20060241074A1 (en) | 2001-08-14 | 2006-10-26 | The General Hospital Corporation | Methods for treatment of pain |
| US20070026409A1 (en) | 2001-08-14 | 2007-02-01 | The General Hospital Corporation | Nucleic acid and amino acid sequences involved in pain |
| EP1478772A2 (de) | 2001-08-14 | 2004-11-24 | The General Hospital Corporation | Nukleinsäure- und aminosäuresequenzen im zusammenhang mit schmerzen |
| JP2003169699A (ja) * | 2001-12-10 | 2003-06-17 | Japan Science & Technology Corp | 特異的γプロテアーゼ阻害剤のスクリーニング方法 |
| JP2004000060A (ja) | 2002-05-31 | 2004-01-08 | Otsuka Pharmaceut Co Ltd | アミロイドβ産生に影響を与える化合物のスクリーニング方法 |
| DE60316718T2 (de) | 2002-11-26 | 2008-01-24 | Pharmacia & Upjohn Co. Llc, Kalamazoo | Lösliche notch basierte substrate für gamma secretase, methoden, zusammensetzungen und verwendungen davon |
| WO2005045028A1 (ja) | 2003-11-10 | 2005-05-19 | Osaka Industrial Promotion Organization | セル・フリー・Ｎｏｔｃｈ切断分析方法及び薬剤スクリーニング方法 |
| EP1730279A2 (de) * | 2004-02-27 | 2006-12-13 | Oncotherapy Science, Inc. | Epha4 als therapeutisches ziel von prc und pdaca |
| EP1662259A1 (de) | 2004-11-25 | 2006-05-31 | Cellzome Ag | Verwendung von Eph Rezeptor-Inhibitoren zur Behandlung von neurodegenerativen Erkrankungen |
| GB0427023D0 (en) * | 2004-12-09 | 2005-01-12 | Merck Sharp & Dohme | Assay method |
| US20070051145A1 (en) * | 2005-09-02 | 2007-03-08 | Ez Trend Technology Co.,Ltd | Electric lock |
| EP1947193A1 (de) | 2007-01-17 | 2008-07-23 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Screening-Verfahren für antidiabetische Zusammensetzungen |
| ATE546543T1 (de) | 2007-06-08 | 2012-03-15 | Eisai R&D Man Co Ltd | Screening-verfahren mit verwendung des neuen substrats epha4 für gamma-sekretase |
| EP2183598A1 (de) * | 2007-07-13 | 2010-05-12 | Elan Pharmaceuticals Inc. | Zusammensetzungen und verfahren zur identifizierung der substratspezifität von gammasekretasehemmern |
| EP2177623A4 (de) * | 2007-07-19 | 2010-12-29 | Eisai R&D Man Co Ltd | SCREENINGVERFAHREN MIT c-MET, EINEM NEUEN SUBSTRAT FÜR GAMMA-SEKRETASE |
| US20090163594A1 (en) * | 2007-10-31 | 2009-06-25 | Elan Pharmaceuticals, Inc. | Triple Assay System for Identifying Substrate Selectivity of Gamma Secretase Inhibitors |
| JP5508857B2 (ja) * | 2007-11-30 | 2014-06-04 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 新規活性を有するＥｐｈＡ４ポリペプチドおよびその用途 |
| US20100113415A1 (en) * | 2008-05-29 | 2010-05-06 | Rajapakse Hemaka A | Epha4 rtk inhibitors for treatment of neurological and neurodegenerative disorders and cancer |
-
2008
- 2008-06-09 AT AT08765357T patent/ATE546543T1/de active
- 2008-06-09 US US12/135,307 patent/US7910324B2/en active Active
- 2008-06-09 EP EP08765357A patent/EP2166110B1/de active Active
- 2008-06-09 JP JP2009517923A patent/JP5511377B2/ja active Active
- 2008-06-09 WO PCT/JP2008/060567 patent/WO2008150010A1/ja active Application Filing
-
2011
- 2011-01-19 US US13/009,127 patent/US8137926B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| JPWO2008150010A1 (ja) | 2010-08-26 |
| EP2166110A1 (de) | 2010-03-24 |
| US20110111444A1 (en) | 2011-05-12 |
| EP2166110A4 (de) | 2010-07-28 |
| US8137926B2 (en) | 2012-03-20 |
| WO2008150010A1 (ja) | 2008-12-11 |
| JP5511377B2 (ja) | 2014-06-04 |
| US7910324B2 (en) | 2011-03-22 |
| EP2166110B1 (de) | 2012-02-22 |
| US20090142788A1 (en) | 2009-06-04 |
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