Nothing Special   »   [go: up one dir, main page]

ATE541580T1 - Selbst anordnende peptid-amphiphile und relevante verfahren für die abgabe von wachstumsfaktor - Google Patents

Selbst anordnende peptid-amphiphile und relevante verfahren für die abgabe von wachstumsfaktor

Info

Publication number
ATE541580T1
ATE541580T1 AT04817014T AT04817014T ATE541580T1 AT E541580 T1 ATE541580 T1 AT E541580T1 AT 04817014 T AT04817014 T AT 04817014T AT 04817014 T AT04817014 T AT 04817014T AT E541580 T1 ATE541580 T1 AT E541580T1
Authority
AT
Austria
Prior art keywords
self
growth factor
assembling peptide
peptide amphiphiles
relevant methods
Prior art date
Application number
AT04817014T
Other languages
English (en)
Inventor
Samuel Stupp
Jack Donners
Gabriel Silva
Heather Behanna
Shawn Anthony
Original Assignee
Univ Northwestern
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Northwestern filed Critical Univ Northwestern
Application granted granted Critical
Publication of ATE541580T1 publication Critical patent/ATE541580T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Toxicology (AREA)
  • Biomedical Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Surgery (AREA)
  • Neurology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Neurosurgery (AREA)
  • General Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
AT04817014T 2003-12-05 2004-12-06 Selbst anordnende peptid-amphiphile und relevante verfahren für die abgabe von wachstumsfaktor ATE541580T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US52750403P 2003-12-05 2003-12-05
PCT/US2004/040550 WO2005056039A1 (en) 2003-12-05 2004-12-06 Self-assembling peptide amphiphiles and related methods for growth factor delivery

Publications (1)

Publication Number Publication Date
ATE541580T1 true ATE541580T1 (de) 2012-02-15

Family

ID=34676751

Family Applications (1)

Application Number Title Priority Date Filing Date
AT04817014T ATE541580T1 (de) 2003-12-05 2004-12-06 Selbst anordnende peptid-amphiphile und relevante verfahren für die abgabe von wachstumsfaktor

Country Status (12)

Country Link
US (3) US7544661B2 (de)
EP (2) EP2314305A3 (de)
JP (2) JP4851939B2 (de)
KR (1) KR20070004560A (de)
CN (2) CN102225964A (de)
AT (1) ATE541580T1 (de)
AU (2) AU2004296181A1 (de)
CA (1) CA2549164A1 (de)
ES (1) ES2380340T3 (de)
MX (1) MXPA06006388A (de)
NZ (1) NZ547671A (de)
WO (1) WO2005056039A1 (de)

Families Citing this family (78)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7491690B2 (en) 2001-11-14 2009-02-17 Northwestern University Self-assembly and mineralization of peptide-amphiphile nanofibers
WO2003070749A2 (en) 2002-02-15 2003-08-28 Northwestern University Self-assembly of peptide-amphiphile nanofibers under physiological conditions
WO2004018628A2 (en) * 2002-08-21 2004-03-04 Northwestern University Charged peptide-amphiphile solutions & self-assembled peptide nanofiber networks formed therefrom
WO2004106359A2 (en) * 2002-09-23 2004-12-09 Northwestern University Self-assembled peptide-amphiphiles & self-assembled peptide nanofiber networks presenting multiple signals
US7554021B2 (en) 2002-11-12 2009-06-30 Northwestern University Composition and method for self-assembly and mineralization of peptide amphiphiles
AU2003298647A1 (en) 2002-11-14 2004-06-15 Claussen, Randal, C. Synthesis and self-assembly of abc triblock bola peptide
WO2004072104A2 (en) * 2003-02-11 2004-08-26 Northwestern University Methods and materials for nanocrystalline surface coatings and attachment of peptide amphiphile nanofibers thereon
WO2005056576A2 (en) * 2003-12-05 2005-06-23 Northwestern University Branched peptide amphiphiles, related epitope compounds and self assembled structures thereof
AU2004296181A1 (en) 2003-12-05 2005-06-23 Northwestern University Self-assembling peptide amphiphiles and related methods for growth factor delivery
US7923109B2 (en) 2004-01-05 2011-04-12 Board Of Regents, The University Of Texas System Inorganic nanowires
US20060247165A1 (en) * 2005-01-21 2006-11-02 Stupp Samuel I Methods and compositions for encapsulation of cells
KR20070108555A (ko) * 2005-03-04 2007-11-12 노오쓰웨스턴 유니버시티 혈관신생 헤파린 결합 펩티드 양친매성 화합물
US9162005B2 (en) * 2005-04-25 2015-10-20 Arch Biosurgery, Inc. Compositions for prevention of adhesions and other barrier applications
US8299032B2 (en) * 2005-06-27 2012-10-30 Menicon Co., Ltd. Self-assembling peptide and gel produced from the same
CN100475836C (zh) * 2005-12-09 2009-04-08 中国人民解放军军事医学科学院野战输血研究所 间充质干细胞亲和肽的筛选与用途
US7807624B2 (en) * 2006-01-11 2010-10-05 Affinergy, Inc. Methods and compositions for promoting attachment of cells of endothelial cell lineage to medical devices
WO2007098541A1 (en) * 2006-02-28 2007-09-07 Regenertech Pty Limited Tissue regeneration ii
US8834840B1 (en) 2006-10-04 2014-09-16 Northwestern University Magnetic resonance imaging of self-assembled biomaterial scaffolds
US8076295B2 (en) 2007-04-17 2011-12-13 Nanotope, Inc. Peptide amphiphiles having improved solubility and methods of using same
FR2919188B1 (fr) * 2007-07-27 2010-02-26 Proteins & Peptides Man Complexes entre un polymere amphiphile et une proteine osteogenique appartenant a la famille des bmps
US20090098652A1 (en) * 2007-08-17 2009-04-16 Northwestern University Self assembling peptide systems and methods
US20090291113A1 (en) * 2008-04-14 2009-11-26 Adocia Osteogenic composition comprising a growth factor, a soluble cation salt and organic support
CA2720203A1 (fr) * 2008-04-14 2009-10-22 Adocia Composition osteogenique comprenant un complexe facteur de croissance/polymere amphiphile un sel soluble de cation et un support organique
KR101712560B1 (ko) * 2008-06-24 2017-03-06 바이오엑티브 써지컬, 아이엔씨. 줄기 세포 또는 기타 생활성 물질이 혼입된 수술용 봉합사
CA2769878A1 (en) 2008-08-07 2010-02-11 Bioactive Surgical, Inc. Stem cell capture and immobilization coatings for medical devices and implants
WO2010033726A2 (en) 2008-09-17 2010-03-25 The Brigham And Women's Hospital, Inc. Drug delivery composition comprising a self-assembled gelator
US8883967B2 (en) * 2009-03-27 2014-11-11 Kansas State University Research Foundation Branched amphipathic oligo-peptides that self-assemble into vesicles
US8450271B2 (en) 2009-04-13 2013-05-28 Northwestern University Peptide-based scaffolds for cartilage regeneration and methods for their use
US20100322979A1 (en) * 2009-06-22 2010-12-23 University Of South Carolina Peptidomimetic Resorbable Peptide-Polymer Hybrid Polyester Nanoparticles
WO2011002258A2 (ko) * 2009-07-02 2011-01-06 한양대학교 산학협력단 아르기닌 기제 양친성 펩티드 마이셀
KR101220162B1 (ko) * 2009-07-02 2013-01-14 한양대학교 산학협력단 아르기닌―기제 양친성 펩티드 마이셀
WO2011123061A1 (en) * 2010-03-31 2011-10-06 Agency For Science, Technology And Research Amphiphilic linear peptide/peptoid and hydrogel comprising the same
US8940858B2 (en) * 2010-05-17 2015-01-27 Northwestern University Fibrous microcapsules and methods of assembly and use thereof
GB201011602D0 (en) * 2010-07-09 2010-08-25 Univ London Pharmacy Delivery of hydrophilic peptides
WO2012031015A1 (en) * 2010-09-01 2012-03-08 The Regents Of The University Of California Cell culture screen for agents that control adipogenesis and myofibroblast differentiation
US20130280334A1 (en) 2010-09-24 2013-10-24 Massachusetts Institute Of Technology Nanostructured Gels Capable of Controlled Release of Encapsulated Agents
US8546338B2 (en) 2010-12-08 2013-10-01 Johnson & Johnson Consumer Companies, Inc. Self-assembling hydrogels based on dicephalic peptide amphiphiles
WO2012149515A2 (en) * 2011-04-29 2012-11-01 Northwestern University Novel vegf mimetic peptide-based scaffolds for therapeutic angiogenesis and methods for their use
US9241891B2 (en) 2012-10-30 2016-01-26 The Procter & Gamble Company Personal care compositions comprising self-assembling peptides
KR20150088841A (ko) 2012-11-25 2015-08-03 더 리전트 오브 더 유니버시티 오브 캘리포니아 피하 지방생성을 자극하는 펩타이드
US9169294B2 (en) * 2013-03-11 2015-10-27 Northwestern University Anti-angiogenic molecules, nanostructures and uses thereof
KR102427429B1 (ko) * 2013-03-15 2022-08-01 인3바이오 리미티드 자기조립형 합성 단백질
DK3035974T3 (da) 2013-08-22 2020-01-02 Arch Biosurgery Inc Implanterbare net til styring af bevægelsen af fluider
WO2015048747A1 (en) 2013-09-30 2015-04-02 Northwestern University Targeted therapy for the prevention of restenosis in the cardiovascular system
WO2015080670A1 (en) * 2013-11-30 2015-06-04 Agency For Science, Technology And Research Novel ultrashort hydrophobic peptides that self-assemble into nanofibrous hydrogels and their uses
WO2015184125A1 (en) 2014-05-28 2015-12-03 The Regents Of The University Of California Peptides, compositions, and methods for stimulating subcutaneous adipogenesis
US20160159869A1 (en) 2014-12-09 2016-06-09 Northwestern University Bmp-2-binding peptide amphiphile nanofibers
DE102015000363A1 (de) 2015-01-20 2016-07-21 Emc Microcollections Gmbh Neue modular funktionalisierbare Peptid-Hydrogele
WO2016168302A1 (en) * 2015-04-14 2016-10-20 Northwestern University Supramolecular glyconanostructures
US20170051016A1 (en) 2015-08-17 2017-02-23 Northwestern University Anti-inflammatory nanofibers
US11517648B2 (en) 2015-10-14 2022-12-06 Northwestern University Nanofiber paste for growth factor delivery and bone regeneration
AU2017360269B2 (en) * 2016-09-09 2021-04-22 Carnegie Mellon University Self-assembling peptide polymer
US10738294B2 (en) 2016-09-26 2020-08-11 Northwestern University Tissue factor (TF)—targeted nanotherapy
US10738338B2 (en) 2016-10-18 2020-08-11 The Research Foundation for the State University Method and composition for biocatalytic protein-oligonucleotide conjugation and protein-oligonucleotide conjugate
US10752656B2 (en) 2016-10-21 2020-08-25 Northwestern University Anti-microbial supramolecular structures
US10818377B2 (en) 2016-11-16 2020-10-27 University Of Washington Computational design of self-assembling cyclic protein homo-oligomers
CN106749522B (zh) * 2016-11-23 2023-11-14 华东理工大学 一种含有聚组氨酸的抗癌多肽及其制备与应用
WO2018101826A1 (en) 2016-11-30 2018-06-07 Universiteit Twente Functionalization of biopolymers with growth factor-binding peptides
US11174288B2 (en) 2016-12-06 2021-11-16 Northeastern University Heparin-binding cationic peptide self-assembling peptide amphiphiles useful against drug-resistant bacteria
US10584146B2 (en) 2016-12-07 2020-03-10 Uchicago Argonne, Llc Heme peptide materials for anti-inflammatory regenerative nanobiomedicine
WO2018144991A1 (en) 2017-02-03 2018-08-09 The Brigham And Women's Hospital, Inc. Self-assembled gels formed with anti-retroviral drugs, prodrugs thereof, and pharmaceutical uses thereof
EP3621594A1 (de) 2017-05-08 2020-03-18 Alivio Therapeutics, Inc. Formulierung von nanostrukturierten gelen für erhöhte wirkstoffladung und adhäsion
CN108070021B (zh) * 2017-12-27 2021-06-15 中南民族大学 可组装成高度有序纳米纤维的小分子肽及组装构建高度有序纳米纤维的方法
US12122811B2 (en) 2018-04-06 2024-10-22 Northwestern University BDNF mimetic peptide amphiphiles
WO2020076453A1 (en) 2018-10-11 2020-04-16 Alivio Therapeutics, Inc. Non-injectable hydrogel formulations for smart release
US12214076B2 (en) 2019-02-18 2025-02-04 Northwestern University Drug delivery vehicles for atherosclerosis nanomedicine
US20220088275A1 (en) * 2019-05-20 2022-03-24 Convalesce Inc. Hydrogels, methods of making, and methods of use
CN110283231B (zh) * 2019-06-03 2021-04-27 中南民族大学 一种基于两亲性寡肽自组装新型溶致液晶的制备和应用
US11964000B2 (en) 2020-04-10 2024-04-23 Northwestern University Cancer treatment methods using nanofiber stabilized growth factors
US12247063B2 (en) 2020-07-13 2025-03-11 Northwestern University Cell surface modification by coating with peptide amphiphiles (PAs)
US11998589B2 (en) 2020-07-13 2024-06-04 Northwestern University PEGylated peptide amphiphile nanofibers and methods of use
US12116461B2 (en) 2020-08-21 2024-10-15 Northwestern University Host-guest interactions for pa superstructure formation
US20240010683A1 (en) * 2020-11-06 2024-01-11 The Medical College Of Wisconsin, Inc. Peptide Inhibitors of Human Mitochondrial Fission Protein 1 and Methods of Use
WO2022182737A2 (en) * 2021-02-23 2022-09-01 Northwestern University Dynamic bioactive scaffolds and therapeutic uses thereof after cns injury
EP4377328A1 (de) * 2021-07-29 2024-06-05 Northwestern University Selbstanordnende peptidamphiphile mit einem mimetischen epitop des transformierenden wachstumsfaktors beta 1 (tgf-beta1)
EP4384532A4 (de) * 2021-08-09 2025-07-02 Gel4Med Inc Selbstanordnende amphiphile peptidhydrogele zur behandlung von nervenläsionen
WO2024064661A2 (en) * 2022-09-20 2024-03-28 The Curators Of The University Of Missouri Amino acid-modified lipids for rna delivery
CN117986325B (zh) * 2024-01-25 2024-12-13 中国人民解放军军事科学院军事医学研究院 一种多肽单体分子mbp、多肽共组装纳米粒及其应用

Family Cites Families (98)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4554101A (en) 1981-01-09 1985-11-19 New York Blood Center, Inc. Identification and preparation of epitopes on antigens and allergens on the basis of hydrophilicity
US5130123A (en) 1981-03-04 1992-07-14 The University Of Melbourne Dentifrice
US4930077A (en) 1987-04-06 1990-05-29 Fan David P Information processing expert system for text analysis and predicting public opinion based information available to the public
US5128319A (en) 1987-08-28 1992-07-07 Board Of Regents, The University Of Texas System Prophylaxis and therapy of acquired immunodeficiency syndrome
GB8812214D0 (en) * 1988-05-24 1988-06-29 Hoffmann La Roche Use of peptide from circumsporozoite protein of p falciparum as universally recognized t-cell epitope
US5110604A (en) 1988-06-30 1992-05-05 Collagen Corporation Processes for producing collagen matrixes and methods of using same
US5223409A (en) * 1988-09-02 1993-06-29 Protein Engineering Corp. Directed evolution of novel binding proteins
JPH0399096A (ja) 1989-09-11 1991-04-24 Agency Of Ind Science & Technol 短繊維型螺旋状分子会合体の長さ制御方法
DE4026978A1 (de) 1990-08-25 1992-02-27 Bayer Ag Auf traegern angebrachte ein- oder mehrlagige schichtelemente und ihre herstellung
CA2109085C (en) 1991-04-25 2003-03-11 Keith E. Dionne Implantable biocompatible immunoisolatory vehicle for delivery of selected therapeutic products
US5580563A (en) 1992-05-01 1996-12-03 Tam; James P. Multiple antigen peptide system having adjuvant properties, vaccines prepared therefrom and methods of use thereof
GB9215780D0 (en) 1992-07-24 1992-09-09 Univ London Pharmacy Peptide compounds
US5670483A (en) 1992-12-28 1997-09-23 Massachusetts Insititute Of Technology Stable macroscopic membranes formed by self-assembly of amphiphilic peptides and uses therefor
US5955343A (en) 1992-12-28 1999-09-21 Massachusetts Institute Of Technology Stable macroscopic membranes formed by self-assembly of amphiphilic peptides and uses therefor
SE9402531L (sv) 1994-07-19 1996-01-20 Medicarb Ab Sårläkningsmedel
US5843780A (en) 1995-01-20 1998-12-01 Wisconsin Alumni Research Foundation Primate embryonic stem cells
US6410690B1 (en) 1995-06-07 2002-06-25 Medarex, Inc. Therapeutic compounds comprised of anti-Fc receptor antibodies
DE69636626T2 (de) 1995-07-28 2007-08-30 Genzyme Corp., Cambridge Biologische abbaubare multiblokhydrogene und ihre verwendung wie trägerstoffe fur kontrollierte freisetzung pharmakologisch activen werstoffe und gewebekontaktmaterialen
US5622699A (en) * 1995-09-11 1997-04-22 La Jolla Cancer Research Foundation Method of identifying molecules that home to a selected organ in vivo
FR2739860B1 (fr) 1995-10-17 1998-01-02 Coletica Complexes amphiphiles, procede pour leur preparation et compositions en renfermant
SE9504347D0 (sv) 1995-12-01 1995-12-01 Boerje Sellergren Surface modification technique
US6051272A (en) 1996-03-15 2000-04-18 The Board Of Trustees Of The University Of Illinois Method for synthesizing organoapatites on to surgical metal alloys
US5733868A (en) 1996-04-16 1998-03-31 Depuy Orthopaedics, Inc. Poly(amino acid) adhesive tissue grafts
WO1997047695A1 (en) * 1996-06-12 1997-12-18 Hoechst Trespaphan Gmbh Transparent barrier coatings exhibiting reduced thin film interference
US6085206A (en) 1996-06-20 2000-07-04 Microsoft Corporation Method and system for verifying accuracy of spelling and grammatical composition of a document
US5993541A (en) 1996-07-31 1999-11-30 Geo Centers Inc Process for nucleation of ceramics and product thereof
US6096863A (en) 1996-08-23 2000-08-01 Regents Of The University Of Minnesota Self-assembling amphiphiles for construction of peptide secondary structures
US6458924B2 (en) 1996-08-30 2002-10-01 Novo Nordisk A/S Derivatives of GLP-1 analogs
ES2197458T3 (es) 1997-01-22 2004-01-01 Board Of Regents, The University Of Texas System Metodos de factor de tejido y composiciones para coagulacion y tratamientos de tumores.
US6331406B1 (en) 1997-03-31 2001-12-18 The John Hopkins University School Of Medicine Human enbryonic germ cell and methods of use
DE19882746T1 (de) 1997-04-03 2001-10-18 California Inst Of Techn Enzymvermittelte Modifikation von Fibrin für das Gewebs-Engineering
US6181909B1 (en) 1997-07-22 2001-01-30 Educational Testing Service System and method for computer-based automatic essay scoring
US6269368B1 (en) 1997-10-17 2001-07-31 Textwise Llc Information retrieval using dynamic evidence combination
JP4222726B2 (ja) 1997-12-02 2009-02-12 ゼン‐バイオ，インコーポレイテッド 骨芽細胞の発生および使用
GB9801061D0 (en) 1998-01-20 1998-03-18 Univ Nottingham Patterning technique
SE519827C2 (sv) * 1998-03-30 2003-04-15 Viranative Ab Näringsmedium innehållande metionin samt användning av detta
GB9809084D0 (en) 1998-04-28 1998-06-24 Nycomed Imaging As Improvements in or relating to diagnostic/therapeutic agents
US6548048B1 (en) 1998-04-28 2003-04-15 Amersham Health As Lipopeptide stabilized microbubbles as diagnostic/therapeutic agents
US7601685B2 (en) * 1998-08-27 2009-10-13 Eidgenossische Technische Hochschule Zurich Growth factor modified protein matrices for tissue engineering
EP1107791B8 (de) 1998-09-04 2007-11-07 Scios Inc. Hydrogelzusammensetzungen mit kontrollierter freigabe für die verabreichung von wachstumsfaktoren
JP2000093503A (ja) * 1998-09-15 2000-04-04 Isotis Bv 医療用インプラントをコ―トする方法
US6114038A (en) * 1998-11-10 2000-09-05 Biocrystal Ltd. Functionalized nanocrystals and their use in detection systems
US7744912B1 (en) 1999-02-01 2010-06-29 Eidgenossische Technische Hochschule Zurich Biomaterials formed by nucleophilic addition reaction to conjugated unsaturated groups
WO2000045831A1 (en) 1999-02-02 2000-08-10 Thomas Jefferson University Peptides modulating activities of heparin, other glycosaminoglycans or proteoglycans
CA2364415A1 (en) 1999-03-02 2000-09-08 University Of Massachusetts, A Public Institution Of Higher Education Of The Commonwealth Of Massachusetts, As Represented By Its Amherst Campus Embryonic or stem-like cell lines produced by cross species nuclear transplantation
US6473730B1 (en) 1999-04-12 2002-10-29 The Trustees Of Columbia University In The City Of New York Method and system for topical segmentation, segment significance and segment function
DE69929323T2 (de) 1999-04-22 2006-09-07 Eidgenössische Technische Hochschule (ETH) Kontrollierte abgabe der wachstumsfaktoren von heparin enthaltenden matrizen
US20090087878A9 (en) * 1999-05-06 2009-04-02 La Rosa Thomas J Nucleic acid molecules associated with plants
CN1362965A (zh) 1999-06-30 2002-08-07 先进细胞技术公司 细胞质转移使受体细胞去分化
US6444723B1 (en) 1999-11-10 2002-09-03 The United States Of America As Represented By The Secretary Of Commerce Crosslinked micellar gel composition
AU2466601A (en) * 1999-12-28 2001-07-09 Regents Of The University Of Michigan, The Process for ex vivo formation of mammalian bone and uses thereof
US20030044890A1 (en) * 2000-01-31 2003-03-06 Rosen Craig A. Nucleic acids, proteins, and antibodies
AU2001241410A1 (en) * 2000-01-31 2001-08-07 Human Genome Sciences, Inc. Nucleic acids, proteins, and antibodies
ES2206407T3 (es) 2000-02-04 2004-05-16 Chienna B.V. Revestimiento proteico.
US6689165B2 (en) 2000-03-31 2004-02-10 Board Of Supervisors Of Louisana State University And Agricultural And Mechanical College Surface modifications for enhanced epithelialization
BR0110679A (pt) 2000-04-28 2004-04-20 Univ Dublin Derivados anfìfilos macrocìclicos e seus análogos
JP2004501429A (ja) 2000-05-11 2004-01-15 ユニバーシティ・オブ・サザン・カリフォルニア 機械翻訳技法
JP2004515751A (ja) * 2000-09-08 2004-05-27 ボード・オブ・リージエンツ，ザ・ユニバーシテイ・オブ・テキサス・システム インビトロターゲティングのための方法および組成物
EP2363424B1 (de) 2000-10-19 2016-08-10 Ecole Polytechnique Federale de Lausanne (EPFL) Blockcopolymere für multifunktionale selbstanordnende Systeme
ATE354802T1 (de) * 2000-11-06 2007-03-15 Thrasos Inc Methoden zum screening knochenmorphogenetishemimetika
MXPA03006566A (es) 2001-01-23 2004-10-15 Educational Testing Service Metodo para el analisis automatico de examenes.
DE60230593D1 (de) 2001-02-06 2009-02-12 Massachusetts Inst Technology Peptidgerüstverkapselung von gewebszellen und verwendungen davon
US7449180B2 (en) * 2001-02-06 2008-11-11 John Kisiday Macroscopic scaffold containing amphiphilic peptides encapsulating cells
US7179784B2 (en) 2001-07-10 2007-02-20 Massachusetts Institute Of Technology Surfactant peptide nanostructures, and uses thereof
WO2003040336A2 (en) 2001-11-06 2003-05-15 The General Hospital Corportation Stem and progenitor cell capture for tissue regeneration
US7491690B2 (en) 2001-11-14 2009-02-17 Northwestern University Self-assembly and mineralization of peptide-amphiphile nanofibers
WO2003070749A2 (en) * 2002-02-15 2003-08-28 Northwestern University Self-assembly of peptide-amphiphile nanofibers under physiological conditions
AU2003222167A1 (en) * 2002-04-02 2003-10-20 Northwestern University Peptide amphiphile solutions and self assembled peptide nanofiber networks
US6890654B2 (en) 2002-04-18 2005-05-10 Northwestern University Encapsulation of nanotubes via self-assembled nanostructures
JP2005185101A (ja) * 2002-05-30 2005-07-14 National Institute Of Agrobiological Sciences 植物の全長ｃＤＮＡおよびその利用
AU2003279912A1 (en) 2002-06-27 2004-01-19 Northwestern University Peptide rod amphiphiles and self-assembly of same
AU2003285853A1 (en) 2002-07-23 2004-04-30 Northwestern University Self-assembled hybrid compositions and method of making, using and ordering same
WO2004018628A2 (en) 2002-08-21 2004-03-04 Northwestern University Charged peptide-amphiphile solutions & self-assembled peptide nanofiber networks formed therefrom
WO2004106359A2 (en) 2002-09-23 2004-12-09 Northwestern University Self-assembled peptide-amphiphiles & self-assembled peptide nanofiber networks presenting multiple signals
US7135027B2 (en) * 2002-10-04 2006-11-14 Baxter International, Inc. Devices and methods for mixing and extruding medically useful compositions
AU2003304280A1 (en) 2002-11-12 2005-01-21 Northwestern University Composition and method for self-assembly and mineralization of peptide amphiphiles
US7554021B2 (en) 2002-11-12 2009-06-30 Northwestern University Composition and method for self-assembly and mineralization of peptide amphiphiles
AU2003298647A1 (en) 2002-11-14 2004-06-15 Claussen, Randal, C. Synthesis and self-assembly of abc triblock bola peptide
CN100364672C (zh) 2003-02-11 2008-01-30 西北大学 纳米晶体表面涂层和肽亲水脂分子纳米纤维向其上附着的方法和材料
WO2004072104A2 (en) 2003-02-11 2004-08-26 Northwestern University Methods and materials for nanocrystalline surface coatings and attachment of peptide amphiphile nanofibers thereon
GB0303362D0 (en) 2003-02-13 2003-03-19 Enact Pharma Plc Tissue regeneration
WO2005014619A2 (en) 2003-03-28 2005-02-17 Thomas Jefferson University Heparin-binding peptides and uses thereof
US20070141101A1 (en) 2003-04-10 2007-06-21 The Trustees Of Boston University Method for stimulating angiogenesis and wound healing
AU2004296181A1 (en) 2003-12-05 2005-06-23 Northwestern University Self-assembling peptide amphiphiles and related methods for growth factor delivery
WO2005056576A2 (en) 2003-12-05 2005-06-23 Northwestern University Branched peptide amphiphiles, related epitope compounds and self assembled structures thereof
US20050214257A1 (en) 2003-12-23 2005-09-29 Northwestern University Compositions and methods for controlling stem cell and tumor cell differentiation, growth, and formation
CN1956726B (zh) * 2004-03-23 2011-04-13 生命线营养健康公司 用于缓解哺乳动物炎症及氧化应激的组合物和方法
JP2008528509A (ja) * 2005-01-21 2008-07-31 アルザ コーポレイション 少なくとも１つの対イオンを含む、向上した安定性でマイクロニードルをコーティングするための治療用ペプチド製剤
US20060247165A1 (en) 2005-01-21 2006-11-02 Stupp Samuel I Methods and compositions for encapsulation of cells
KR20070108555A (ko) 2005-03-04 2007-11-12 노오쓰웨스턴 유니버시티 혈관신생 헤파린 결합 펩티드 양친매성 화합물
WO2007022287A2 (en) 2005-08-15 2007-02-22 Vegenics Limited Modified vegf and pdgf with improved angiogenic properties
CN1915438A (zh) 2006-07-27 2007-02-21 华中科技大学同济医学院附属协和医院 新型多肽神经组织工程支架材料及其制备方法和应用
US8114835B2 (en) * 2006-11-09 2012-02-14 Northwestern University Self-assembling peptide amphiphiles for tissue engineering
US8114834B2 (en) * 2006-11-09 2012-02-14 Northwestern University Self-assembling peptide amphiphiles
US8772228B2 (en) * 2007-02-14 2014-07-08 Northwestern University Aligned nanofibers and related methods of use
US8076295B2 (en) 2007-04-17 2011-12-13 Nanotope, Inc. Peptide amphiphiles having improved solubility and methods of using same
US20090098652A1 (en) * 2007-08-17 2009-04-16 Northwestern University Self assembling peptide systems and methods
US8450271B2 (en) 2009-04-13 2013-05-28 Northwestern University Peptide-based scaffolds for cartilage regeneration and methods for their use

Also Published As

Publication number Publication date
EP2314305A2 (de) 2011-04-27
US8138140B2 (en) 2012-03-20
WO2005056039A1 (en) 2005-06-23
ES2380340T3 (es) 2012-05-10
EP2314305A3 (de) 2011-08-10
NZ547671A (en) 2009-10-30
AU2004296181A1 (en) 2005-06-23
EP1696945B1 (de) 2012-01-18
CN102225964A (zh) 2011-10-26
EP1696945A4 (de) 2007-03-21
CA2549164A1 (en) 2005-06-23
KR20070004560A (ko) 2007-01-09
AU2011201593A1 (en) 2011-04-28
EP1696945A1 (de) 2006-09-06
JP2012006951A (ja) 2012-01-12
CN1905892A (zh) 2007-01-31
US8580923B2 (en) 2013-11-12
US20120264912A1 (en) 2012-10-18
US20090269847A1 (en) 2009-10-29
US20050209145A1 (en) 2005-09-22
JP2007513174A (ja) 2007-05-24
US7544661B2 (en) 2009-06-09
MXPA06006388A (es) 2006-09-04
JP4851939B2 (ja) 2012-01-11

Similar Documents

Publication Publication Date Title
ATE541580T1 (de) Selbst anordnende peptid-amphiphile und relevante verfahren für die abgabe von wachstumsfaktor
TW200607816A (en) Metastin derivatives and use thereof
EA200601313A1 (ru) Варианты участка f
CY1111225T1 (el) Νεα πεπτιδια ως αναστολεις πρωτεασης νs3-σερινης ιου ηπατiτιδας c
DE60230456D1 (de) Faktor-viii-polypeptide auf hohem expressionsnivea und verwendungsverfahren
EP1990059A3 (de) Verfahren zur Behandlung von Krebs
YU9404A (sh) Multimerna, usmerena kontrastna sredstva na bazi peptida
ATE368688T1 (de) Peptide, deren herstellung und verwendung zur bindung von immunglobulinen
ATE543833T1 (de) Bmp-7-varianten-zusammensetzungen, verfahren und verwendungen
NO20073914L (no) Biologisk aktive peptider
ATE506370T1 (de) Reagenzien und verfahren zur bildung von disulfid-bindungen und glykosylierung von proteinen
DE60325194D1 (de) Methoden zur verwendung von lamellaren körpern für therapeutische zwecke
HUP0402327A2 (hu) Inzulinszerű növekedési faktort kötő 5-ös fehérje expressziójának antiszensz módosítása
DE602004028239D1 (de) Protease, für die protease codierende dna und verfahren zur herstellung der protease
ATE370964T1 (de) Isoliertes fluoreszierendes protein aus clytia gregaria cgfp, sowie dessen verwendung
DE602004001047D1 (de) Phospholipidester von Clofarabin
WO2003093300A3 (en) Anti-microbial peptides and compositions
ATE505538T1 (de) Dna-vektoren
EP1392340A4 (de) Zytotoxische peptide und darauf basierende peptidomimetika und verfahren zur verwendung davon
ATE529437T1 (de) Verfahren zur sauerstoff-regulierten produktion von recombinanter staphylokinase