Nothing Special   »   [go: up one dir, main page]

ATE439452T1 - Verfahren zum nachweis von analyten mit hilfe von halbleiternanokrystallen - Google Patents

Verfahren zum nachweis von analyten mit hilfe von halbleiternanokrystallen

Info

Publication number
ATE439452T1
ATE439452T1 AT00928836T AT00928836T ATE439452T1 AT E439452 T1 ATE439452 T1 AT E439452T1 AT 00928836 T AT00928836 T AT 00928836T AT 00928836 T AT00928836 T AT 00928836T AT E439452 T1 ATE439452 T1 AT E439452T1
Authority
AT
Austria
Prior art keywords
semiconductor nanocrystals
detecting analytes
detecting
semiconductor
emits
Prior art date
Application number
AT00928836T
Other languages
English (en)
Inventor
Marcel Bruchez
R Daniels
Stephen Empedocles
Vince Phillips
Edith Wong
Donald Zehnder
Original Assignee
Life Technologies Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Life Technologies Corp filed Critical Life Technologies Corp
Application granted granted Critical
Publication of ATE439452T1 publication Critical patent/ATE439452T1/de

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G01N33/54346—Nanoparticles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y15/00—Nanotechnology for interacting, sensing or actuating, e.g. quantum dots as markers in protein assays or molecular motors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G01N33/532—Production of labelled immunochemicals
    • G01N33/533—Production of labelled immunochemicals with fluorescent label
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/588—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with semiconductor nanocrystal label, e.g. quantum dots
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2458/00—Labels used in chemical analysis of biological material
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/902—Specified use of nanostructure
    • Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
    • Y10S977/924—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis using nanostructure as support of dna analysis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Nanotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Pathology (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Materials Engineering (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analyzing Materials By The Use Of Magnetic Means (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
AT00928836T 1999-05-07 2000-05-05 Verfahren zum nachweis von analyten mit hilfe von halbleiternanokrystallen ATE439452T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US13308499P 1999-05-07 1999-05-07
PCT/US2000/012227 WO2000068692A1 (en) 1999-05-07 2000-05-05 A method of detecting an analyte using semiconductor nanocrystals

Publications (1)

Publication Number Publication Date
ATE439452T1 true ATE439452T1 (de) 2009-08-15

Family

ID=22456937

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00928836T ATE439452T1 (de) 1999-05-07 2000-05-05 Verfahren zum nachweis von analyten mit hilfe von halbleiternanokrystallen

Country Status (8)

Country Link
US (5) US6274323B1 (de)
EP (1) EP1179185B1 (de)
JP (1) JP2002544488A (de)
AT (1) ATE439452T1 (de)
AU (1) AU4701200A (de)
CA (1) CA2373146A1 (de)
DE (1) DE60042738D1 (de)
WO (1) WO2000068692A1 (de)

Families Citing this family (363)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6607829B1 (en) 1997-11-13 2003-08-19 Massachusetts Institute Of Technology Tellurium-containing nanocrystalline materials
US6207392B1 (en) 1997-11-25 2001-03-27 The Regents Of The University Of California Semiconductor nanocrystal probes for biological applications and process for making and using such probes
US6582962B1 (en) * 1998-02-27 2003-06-24 Ventana Medical Systems, Inc. Automated molecular pathology apparatus having independent slide heaters
DE69940430D1 (de) 1998-06-24 2009-04-02 Illumina Inc Dekodierung von matrixartig-angeordneten Sensoren durch Mikropartikel
US6617583B1 (en) * 1998-09-18 2003-09-09 Massachusetts Institute Of Technology Inventory control
US7079241B2 (en) * 2000-04-06 2006-07-18 Invitrogen Corp. Spatial positioning of spectrally labeled beads
EP1039291A1 (de) * 1999-03-26 2000-09-27 Sony International (Europe) GmbH Optochemischer Fühler and Herstellungsmethode
US20030129654A1 (en) * 1999-04-15 2003-07-10 Ilya Ravkin Coded particles for multiplexed analysis of biological samples
US20030166015A1 (en) * 1999-04-15 2003-09-04 Zarowitz Michael A. Multiplexed analysis of cell-substrate interactions
US7253435B2 (en) * 1999-04-15 2007-08-07 Millipore Corporation Particles with light-polarizing codes
US20030207249A1 (en) * 1999-04-15 2003-11-06 Beske Oren E. Connection of cells to substrates using association pairs
US20030134330A1 (en) * 1999-04-15 2003-07-17 Ilya Ravkin Chemical-library composition and method
US6908737B2 (en) * 1999-04-15 2005-06-21 Vitra Bioscience, Inc. Systems and methods of conducting multiplexed experiments
ATE439452T1 (de) * 1999-05-07 2009-08-15 Life Technologies Corp Verfahren zum nachweis von analyten mit hilfe von halbleiternanokrystallen
US6544732B1 (en) * 1999-05-20 2003-04-08 Illumina, Inc. Encoding and decoding of array sensors utilizing nanocrystals
US8481268B2 (en) 1999-05-21 2013-07-09 Illumina, Inc. Use of microfluidic systems in the detection of target analytes using microsphere arrays
US8080380B2 (en) 1999-05-21 2011-12-20 Illumina, Inc. Use of microfluidic systems in the detection of target analytes using microsphere arrays
US8497131B2 (en) * 1999-10-06 2013-07-30 Becton, Dickinson And Company Surface enhanced spectroscopy-active composite nanoparticles comprising Raman-active reporter molecules
US7192778B2 (en) * 1999-10-06 2007-03-20 Natan Michael J Surface enhanced spectroscopy-active composite nanoparticles
US7955794B2 (en) 2000-09-21 2011-06-07 Illumina, Inc. Multiplex nucleic acid reactions
US20020004246A1 (en) * 2000-02-07 2002-01-10 Daniels Robert H. Immunochromatographic methods for detecting an analyte in a sample which employ semiconductor nanocrystals as detectable labels
US8076063B2 (en) 2000-02-07 2011-12-13 Illumina, Inc. Multiplexed methylation detection methods
US7582420B2 (en) 2001-07-12 2009-09-01 Illumina, Inc. Multiplex nucleic acid reactions
DK1259643T3 (da) * 2000-02-07 2009-02-23 Illumina Inc Fremgangsmåde til detektion af nukleinsyre ved anvendelse af universel priming
US7361488B2 (en) * 2000-02-07 2008-04-22 Illumina, Inc. Nucleic acid detection methods using universal priming
EP1255865B1 (de) 2000-02-07 2007-04-18 Illumina, Inc. Nukleinsäure Nachweisverfahren mit universellem Priming
DE10006432A1 (de) * 2000-02-14 2001-08-16 Ganzimmun Inst Fuer Ganzheitli Verfahren zum Nachweis von Helicobacter pylori in Stuhl- und Speichelproben
DE60136335D1 (de) 2000-02-16 2008-12-11 Illumina Inc Parallele genotypisierung mehrerer patientenproben
CA2400379A1 (en) * 2000-02-16 2001-08-23 Quantum Dot Corporation Microarray methods utilizing semiconductor nanocrystals
WO2002079764A1 (en) * 2001-01-26 2002-10-10 Nanoplex Technologies, Inc. Surface-enhanced spectroscopy-active sandwich nanoparticles
US6571028B1 (en) 2000-03-21 2003-05-27 Evident Technologies Optical switch having a saturable absorber
US20020090650A1 (en) * 2000-04-06 2002-07-11 Quantum Dot Corporation Two-dimensional spectral imaging system
AU2001257454A1 (en) * 2000-04-28 2001-11-12 Quantum Dot Corporation Methods and compositions for polynucleotide analysis using generic capture sequences
US20050192430A1 (en) * 2000-05-24 2005-09-01 Rosenthal Sandra J. Linker arms for nanocrystals and compounds thereof
US20050013775A1 (en) * 2000-06-01 2005-01-20 Kotov Nicholas A. Bioconjugates of nanoparticles as radiopharmaceuticals
WO2001091808A2 (en) * 2000-06-01 2001-12-06 The Board Of Regents For Oklahoma State University Bioconjugates of nanoparticles as radiopharmaceuticals
US6611640B2 (en) 2000-10-03 2003-08-26 Evident Technologies Optical dispersion compensator
US20020155507A1 (en) * 2000-10-06 2002-10-24 Bruchez Marcel P. Cells having a spectral signature, and methods of preparation and use thereof
US20050059031A1 (en) * 2000-10-06 2005-03-17 Quantum Dot Corporation Method for enhancing transport of semiconductor nanocrystals across biological membranes
JP2004537712A (ja) 2000-10-18 2004-12-16 バーチャル・アレイズ・インコーポレーテッド 多重細胞分析システム
US6939604B1 (en) * 2000-10-19 2005-09-06 Arch Development Corporation Doped semiconductor nanocrystals
FI20002623A (fi) * 2000-11-30 2002-05-31 Inno Trac Diagnostics Oy Bioanalyyttinen määritysmenetelmä
US7171030B2 (en) * 2000-11-30 2007-01-30 University Of Medicine & Denistry Of New Jersey Systems for analyzing microtissue arrays
US6697548B2 (en) 2000-12-18 2004-02-24 Evident Technologies Fabry-perot opitcal switch having a saturable absorber
US20020110180A1 (en) * 2001-02-09 2002-08-15 Barney Alfred A. Temperature-sensing composition
US6710911B2 (en) 2001-03-02 2004-03-23 Evident Technologies Optical wavelength converter
EP1366347B8 (de) * 2001-03-09 2010-02-03 Univ Reims Champagne Ardenne L Hochempfindliche nicht-isotopische wasserlöslische nanokristalle
US6694158B2 (en) 2001-04-11 2004-02-17 Motorola, Inc. System using a portable detection device for detection of an analyte through body tissue
US7521019B2 (en) * 2001-04-11 2009-04-21 Lifescan, Inc. Sensor device and methods for manufacture
US6379622B1 (en) * 2001-04-11 2002-04-30 Motorola, Inc. Sensor incorporating a quantum dot as a reference
WO2002084271A2 (en) * 2001-04-16 2002-10-24 The Regents Of The University Of California Methods and sensors for luminescent and optoelectronic detection and analysis of polynucleotides
US7572642B2 (en) * 2001-04-18 2009-08-11 Ambrigen, Llc Assay based on particles, which specifically bind with targets in spatially distributed characteristic patterns
US20020164271A1 (en) * 2001-05-02 2002-11-07 Ho Winston Z. Wavelength-coded bead for bioassay and signature recogniton
DE10122836A1 (de) * 2001-05-11 2002-11-28 November Ag Molekulare Medizin Faser, Faden und Verfahren zur Markierung und Identifizierung
GB0113772D0 (en) * 2001-06-06 2001-07-25 Dynal Biotech Asa Process
RU2341513C2 (ru) * 2001-06-12 2008-12-20 Веллстат Терапьютикс Корпорейшн Соединения для лечения метаболических заболеваний
US7095959B2 (en) 2001-06-20 2006-08-22 Evident Technologies Optical time division multiplexing/demultiplexing system
US20030013109A1 (en) * 2001-06-21 2003-01-16 Ballinger Clinton T. Hairpin sensors using quenchable fluorescing agents
EP1410031A2 (de) * 2001-06-28 2004-04-21 ADVANCED RESEARCH AND TECHNOLOGY INSTITUTE, Inc. Verfahren zur herstellung mehrfarbiger kügelchen mit quantum-dot-tags und deren konjugate
US7473767B2 (en) 2001-07-03 2009-01-06 The Institute For Systems Biology Methods for detection and quantification of analytes in complex mixtures
CN100386627C (zh) * 2001-07-03 2008-05-07 包刚 过滤型蛋白芯片
JP2003028797A (ja) * 2001-07-11 2003-01-29 Hitachi Software Eng Co Ltd 蛍光読み取り装置
US7110640B2 (en) 2001-07-19 2006-09-19 Evident Technologies Reconfigurable optical add/drop filter
WO2003018846A1 (en) * 2001-08-31 2003-03-06 Minerva Biotechnologies Corporation Affinity tag modified particles
US6542229B1 (en) 2001-09-12 2003-04-01 Peter J. Kalal Sensors, methods of manufacture and sensing methods
US20030219800A1 (en) * 2001-10-18 2003-11-27 Beske Oren E. Multiplexed cell transfection using coded carriers
US6838289B2 (en) * 2001-11-14 2005-01-04 Beckman Coulter, Inc. Analyte detection system
DE10156612A1 (de) * 2001-11-20 2003-05-28 Markus Klotz Verfahren zum Bestimmen von Substanzen in einer flüssigen oder gasförmigen Probe
US20050118589A1 (en) * 2001-11-21 2005-06-02 Vann Charles S. Digital array
US20030143604A1 (en) * 2001-11-30 2003-07-31 Storhoff James J. Real-time monitoring of PCR amplification using nanoparticle probes
US20030162209A1 (en) * 2001-12-19 2003-08-28 George Martin PCR based high throughput polypeptide screening
US7241629B2 (en) * 2001-12-20 2007-07-10 Corning Incorporated Detectable labels, methods of manufacture and use
US20040171076A1 (en) * 2001-12-20 2004-09-02 Dejneka Matthew J. Detectable micro to nano sized structures, methods of manufacture and use
DE10200499A1 (de) * 2002-01-03 2003-07-10 Zeiss Carl Jena Gmbh Verfahren und/oder Anordnung zur Identifikation von fluoreszierenden, lumineszierenden und/oder absorbierenden Substanzen auf und/oder in Probenträgern
US20040026684A1 (en) * 2002-04-02 2004-02-12 Nanosys, Inc. Nanowire heterostructures for encoding information
CA2523626A1 (en) * 2002-04-26 2003-11-06 Board Of Regents, The University Of Texas System Method and system for the detection of cardiac risk factors
US8211657B2 (en) * 2002-04-29 2012-07-03 The Board Of Trustees Of The University Of Arkansas Capillary-column-based bioseparator/bioreactor with an optical/electrochemical detector for detection of microbial pathogens
JP2006508095A (ja) * 2002-05-07 2006-03-09 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 粒子の生物活性化
AU2003245302A1 (en) 2002-05-17 2003-12-02 Applera Corporation Apparatus and method for differentiating multiple fluorescence signals by excitation wavelength
AU2003243268A1 (en) 2002-05-17 2003-12-02 Applera Corporation Optical instrument including excitation source
US20040126773A1 (en) * 2002-05-23 2004-07-01 Beske Oren E. Assays with coded sensor particles to sense assay conditions
DE10224825A1 (de) * 2002-06-05 2003-12-24 Eppendorf Ag Verfahren zur Analyse von Biomolekülen
US6730515B2 (en) * 2002-06-11 2004-05-04 Eastman Kodak Company Micro-array calibration means
US20030232340A1 (en) * 2002-06-13 2003-12-18 David Anderson Nanoporous particle with a retained target
DE10231684A1 (de) * 2002-07-12 2004-02-12 Micronas Holding Gmbh Verfahren zur Bestimmung der Zahl von Rezeptoren auf einem Träger sowie Biosensor herstellbar nach diesem Verfahren
GB2391230A (en) * 2002-07-26 2004-02-04 Smartbead Technologies Ltd Multiparameter assays using coded supports
US7810380B2 (en) 2003-03-25 2010-10-12 Tearlab Research, Inc. Systems and methods for collecting tear film and measuring tear film osmolarity
US8020433B2 (en) * 2003-03-25 2011-09-20 Tearlab Research, Inc. Systems and methods for a sample fluid collection device
US20040105979A1 (en) * 2002-08-14 2004-06-03 Encap Technologies, Inc. Microencapsulated and nanoencapsulated particles, moisture barrier resins, and processes for manufacturing same
US7939170B2 (en) * 2002-08-15 2011-05-10 The Rockefeller University Water soluble metal and semiconductor nanoparticle complexes
WO2004035612A2 (en) * 2002-09-04 2004-04-29 Board Of Regents, University Of Texas System Composition, method and use of bi-functional biomaterials
AU2003268444A1 (en) * 2002-09-06 2004-03-29 Chiron Corporation Methods for verifying fluid movement
US7361821B2 (en) 2002-09-20 2008-04-22 Intel Corporation Controlled alignment of nanobarcodes encoding specific information for scanning probe microscopy (SPM) reading
US7176036B2 (en) * 2002-09-20 2007-02-13 Arrowhead Center, Inc. Electroactive microspheres and methods
JP4520857B2 (ja) 2002-09-20 2010-08-11 インテル・コーポレーション 走査型プローブ顕微鏡検査（ｓｐｍ）読取用の特定の情報をエンコードするナノバーコードの制御された整列
EP1552300B1 (de) * 2002-10-15 2011-07-20 Abmetrix, Inc. Sätze gegen kurze epitope gerichteter digitaler antikörper sowie diese verwendende verfahren
US9740817B1 (en) 2002-10-18 2017-08-22 Dennis Sunga Fernandez Apparatus for biological sensing and alerting of pharmaco-genomic mutation
US7192780B2 (en) * 2002-10-23 2007-03-20 Evident Technologies Fluorescent lifetime biological detection and imaging using water-stable semiconductor nanocrystals
US20040101822A1 (en) * 2002-11-26 2004-05-27 Ulrich Wiesner Fluorescent silica-based nanoparticles
JP2004184312A (ja) * 2002-12-05 2004-07-02 Yokogawa Electric Corp 生体高分子検出方法およびバイオチップ
WO2004065000A1 (en) 2003-01-21 2004-08-05 Illumina Inc. Chemical reaction monitor
WO2004065995A2 (en) * 2003-01-23 2004-08-05 Alpha Innotech Corporation Identifying indicia and focusing target
JP4073323B2 (ja) * 2003-01-23 2008-04-09 日立ソフトウエアエンジニアリング株式会社 機能性ビーズ、その読み取り方法および読み取り装置
US20040175843A1 (en) * 2003-03-04 2004-09-09 Roitman Daniel B. Near-field and far-field encoding and shaping of microbeads for bioassays
US20040175842A1 (en) * 2003-03-04 2004-09-09 Roitman Daniel B. Near-field and far-field encoding of microbeads for bioassays
US7917298B1 (en) 2003-04-17 2011-03-29 Nanosys, Inc. Nanocrystal taggants
US20050026181A1 (en) * 2003-04-29 2005-02-03 Genvault Corporation Bio bar-code
US20040219533A1 (en) * 2003-04-29 2004-11-04 Jim Davis Biological bar code
US8859000B2 (en) * 2003-05-05 2014-10-14 The Research Foundation Of State University Of New York Synthesis of nanoparticles by an emulsion-gas contacting process
US9063145B2 (en) 2003-07-23 2015-06-23 Cellular Technology Limited Multivalent opsonophagocytic assay using bead array and imaging
US7598093B2 (en) 2003-07-23 2009-10-06 Ctl Analyzers, Llc Nanoparticle and microparticle based detection of cellular products
EP1658506A2 (de) * 2003-08-18 2006-05-24 Tethys Bioscience, Inc. Verfahren zur verringerung der komplexität einer probe unter verwendung von antikörpern für kleine epitope
US8346482B2 (en) * 2003-08-22 2013-01-01 Fernandez Dennis S Integrated biosensor and simulation system for diagnosis and therapy
US7488451B2 (en) * 2003-09-15 2009-02-10 Millipore Corporation Systems for particle manipulation
US20050208468A1 (en) * 2003-09-15 2005-09-22 Beske Oren E Assays with primary cells
US20050069900A1 (en) * 2003-09-25 2005-03-31 Cytyc Corporation Analyte sample detection
CN101300026A (zh) 2003-10-15 2008-11-05 得克萨斯系统大学评议会 电子、光、磁、半导体和生物技术应用中作为支架的多功能生物材料
WO2005040755A2 (en) * 2003-10-20 2005-05-06 The Regents Of The University Of California Nanoscale transduction systems for detecting molecular interactions
WO2005046722A2 (en) * 2003-11-05 2005-05-26 The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Carbohydrate antigen-nanoparticle conjugates and uses thereof as antimetastatic agents in treating cancer
AU2003285133A1 (en) * 2003-11-05 2005-06-24 The Government Of The United States Of America As Represented By The Secretary Of Health And Human Services Biofunctionalized quantum dots for biological imaging
CA2549190A1 (en) 2003-12-11 2005-06-30 Board Of Regents, The University Of Texas System Method and system for the analysis of saliva using a sensor array
US20050147963A1 (en) * 2003-12-29 2005-07-07 Intel Corporation Composite organic-inorganic nanoparticles and methods for use thereof
US20050191665A1 (en) * 2003-12-29 2005-09-01 Xing Su Composite organic-inorganic nanoclusters
US8101431B2 (en) 2004-02-27 2012-01-24 Board Of Regents, The University Of Texas System Integration of fluids and reagents into self-contained cartridges containing sensor elements and reagent delivery systems
US8105849B2 (en) 2004-02-27 2012-01-31 Board Of Regents, The University Of Texas System Integration of fluids and reagents into self-contained cartridges containing sensor elements
US20050191687A1 (en) * 2004-02-27 2005-09-01 Tianxin Wang Method for multiplexed analyte detection
US7745001B2 (en) * 2004-03-23 2010-06-29 University Of New Orleans Research And Technology Foundation, Inc. Synthesis of nanoassemblies containing luminescent quantum dots and magnetic nanoparticles
US20080032420A1 (en) * 2004-03-30 2008-02-07 Lambert James L Surface Enhanced Raman Scattering and Multiplexed Diagnostic Assays
WO2006071247A2 (en) * 2004-03-30 2006-07-06 California Institute Of Technology Diagnostic assays including multiplexed lateral flow immunoassays with quantum dots
US7521259B2 (en) * 2004-04-01 2009-04-21 Alverix, Inc. Assay test strips with multiple labels and reading same
US20070185679A1 (en) * 2004-04-01 2007-08-09 Petruno Patrick T Indicating status of a diagnostic test system
US8128871B2 (en) * 2005-04-22 2012-03-06 Alverix, Inc. Lateral flow assay systems and methods
US20050221504A1 (en) * 2004-04-01 2005-10-06 Petruno Patrick T Optoelectronic rapid diagnostic test system
US20070143035A1 (en) * 2005-12-19 2007-06-21 Petruno Patrick T Diagnostic test reader with disabling unit
EP1584914A1 (de) * 2004-04-08 2005-10-12 Sony Deutschland GmbH Ellipsometrie-Verfahren zum Nachweis eines Substrat-gebundenden Hybrids aus mindestens zwei Spezies
WO2005098379A1 (en) * 2004-04-08 2005-10-20 Purdue Research Foundation Multi-spectral detector and analysis system
WO2006093516A2 (en) * 2004-06-22 2006-09-08 The Regents Of The University Of California Peptide-coated nanoparticles with graded shell compositions
US20060154380A1 (en) * 2004-06-23 2006-07-13 Shunji Egusa Synthesis of ordered arrays from gold clusters
US20060194198A1 (en) * 2004-06-29 2006-08-31 Carlo Licata Use of fibrous protein fibers for chemical sensing and radiation detection
KR100724314B1 (ko) 2004-07-22 2007-06-04 주식회사 엘지생명과학 생체감지물질이 고정된 광결정구 및 이의 제조방법 및이용방법
US7229690B2 (en) * 2004-07-26 2007-06-12 Massachusetts Institute Of Technology Microspheres including nanoparticles
US20060024744A1 (en) * 2004-07-28 2006-02-02 Mills Rhonda A Methods for substantially simultaneous evaluation of a sample containing a cellular target and a soluble analyte
EP1782320A2 (de) * 2004-07-29 2007-05-09 Kim Laboratories, Inc. Ultrasensibler sensor und schnelle detektion von analyten
US7405002B2 (en) 2004-08-04 2008-07-29 Agency For Science, Technology And Research Coated water-soluble nanoparticles comprising semiconductor core and silica coating
CA2520670A1 (en) * 2004-09-23 2006-03-23 National Research Council Of Canada Nanocrystal coated surfaces
US7534489B2 (en) * 2004-09-24 2009-05-19 Agency For Science, Technology And Research Coated composites of magnetic material and quantum dots
US7682782B2 (en) * 2004-10-29 2010-03-23 Affymetrix, Inc. System, method, and product for multiple wavelength detection using single source excitation
US8202479B1 (en) * 2004-11-09 2012-06-19 Applied Biosystems, Llc Light collection system
US20060240590A1 (en) * 2004-11-09 2006-10-26 The Research Foundation Of State University Of New York Controlled synthesis of nanowires, nanodiscs, and nanostructured materials using liquid crystalline templates
JP2008524600A (ja) * 2004-12-16 2008-07-10 インヴィトロジェン コーポレーション 多重化アッセイの較正及び定量化用の量子ドットコード化ビーズセット、及びその使用方法
US20060148103A1 (en) * 2004-12-30 2006-07-06 Yin-Peng Chen Highly sensitive biological assays
US8569042B2 (en) * 2005-02-23 2013-10-29 Alcatel Lucent DNA structures on ferroelectrics and semiconductors
EP1853732A2 (de) * 2005-02-28 2007-11-14 Gen-Probe Incorporated Präparate und verfahren zur probenmessung durch eine umschaltbare nukleinsäuren-sonde
EP1869451B1 (de) * 2005-03-08 2013-06-26 Life Technologies Corporation Überwachung und behandlung von zelltransmembranpotentialen mittels nanostrukturen
EP1861697A4 (de) * 2005-03-10 2010-11-03 Commercialisation Des Produits Quantenpunkt-matrize zum schnellen und gleichzeitigen nachweis unterschiedlicher infektiöser agentien
WO2006105102A2 (en) * 2005-03-28 2006-10-05 The Research Foundation Of State University Of New York Synthesis of nanostructured materials using liquid crystalline templates
US20080166706A1 (en) * 2005-03-30 2008-07-10 Jin Zhang Novel gold nanoparticle aggregates and their applications
US20070026391A1 (en) * 2005-04-11 2007-02-01 Ghc Technologies, Inc. Methods and compositions for identifying chemical or biological agents using multiplexed labeling and colocalization detection
US10041941B2 (en) * 2005-04-22 2018-08-07 Alverix, Inc. Assay test strips with multiple labels and reading same
EP1877101B1 (de) 2005-04-28 2016-11-16 Ventana Medical Systems, Inc. Mit antikörpern über einen heterobifuntionellen peg-linker konjugierte enzyme
JP2008541015A (ja) * 2005-04-28 2008-11-20 ベンタナ・メデイカル・システムズ・インコーポレーテツド ナノ粒子コンジュゲート
US8084001B2 (en) * 2005-05-02 2011-12-27 Cornell Research Foundation, Inc. Photoluminescent silica-based sensors and methods of use
EP1910824A4 (de) 2005-05-31 2012-11-21 Labnow Inc Verfahren und zusammensetzungen in zusammenhang mit der erstellung und verwendung eines weissen blutbildes
EP2620510B2 (de) 2005-06-15 2020-02-19 Complete Genomics Inc. Einzelne Molekülarrays für genetische und chemische Analyse
US7858307B2 (en) * 2005-08-09 2010-12-28 Maxwell Sensors, Inc. Light transmitted assay beads
US8232092B2 (en) * 2005-08-09 2012-07-31 Maxwell Sensors, Inc. Apparatus and method for digital magnetic beads analysis
US7871770B2 (en) 2005-08-09 2011-01-18 Maxwell Sensors, Inc. Light transmitted assay beads
US20090201504A1 (en) * 2005-08-09 2009-08-13 Maxwell Sensors, Inc. Hydrodynamic focusing for analyzing rectangular microbeads
US20070043510A1 (en) * 2005-08-19 2007-02-22 Beckman Coulter, Inc. Assay system
WO2007133831A2 (en) 2006-02-24 2007-11-22 Callida Genomics, Inc. High throughput genome sequencing on dna arrays
WO2007044245A2 (en) 2005-10-07 2007-04-19 Callida Genomics, Inc. Self-assembled single molecule arrays and uses thereof
WO2007120265A2 (en) * 2005-11-14 2007-10-25 Applera Corporation Coded molecules for detecting target analytes
EP1948829A4 (de) * 2005-11-15 2009-08-26 Becton Dickinson Co Sers-basierte verfahren zur erkennung von biowirkstoffen
US7772009B2 (en) * 2005-11-22 2010-08-10 SCR Research, LLC Room temperature phosphorescence apparatus and methods
US8632730B2 (en) * 2005-11-22 2014-01-21 Alverix, Inc. Assaying test strips having different capture reagents
EP2963011B1 (de) * 2005-11-23 2018-05-09 Ventana Medical Systems, Inc. Molekulares konjugat
US20070122914A1 (en) * 2005-11-30 2007-05-31 Curry Bo U Obtaining measurements of light transmitted through an assay test strip
JP4654414B2 (ja) * 2005-12-01 2011-03-23 独立行政法人産業技術総合研究所 免疫化学的検出方法、及びその検出用試薬キット
US8409863B2 (en) 2005-12-14 2013-04-02 Becton, Dickinson And Company Nanoparticulate chemical sensors using SERS
WO2007076129A2 (en) 2005-12-23 2007-07-05 Nanostring Technologies, Inc. Nanoreporters and methods of manufacturing and use thereof
US7723100B2 (en) 2006-01-13 2010-05-25 Becton, Dickinson And Company Polymer coated SERS nanotag
US7226752B1 (en) 2006-01-19 2007-06-05 Avago Technologies General Ip (Singapore) Pte. Ltd. Methods for detecting an analyte in a sample
JP2009524834A (ja) * 2006-01-27 2009-07-02 オクソニカ・インコーポレーテッド 被包検出様式を用いた側方流動イムノアッセイ
WO2008085182A2 (en) * 2006-02-02 2008-07-17 University Of Wyoming Supra nanoparticle assemblies and methods of making and using the assemblies
US9274108B2 (en) 2006-02-06 2016-03-01 Massachusetts Institute Of Technology Self-assembly of macromolecules on multilayered polymer surfaces
WO2007095279A2 (en) * 2006-02-14 2007-08-23 University Of Florida Research Foundation, Inc. Dual nanoparticle assay for detection and separation of biological species
CA2571904A1 (en) * 2006-02-15 2007-08-15 Fio Corporation System and method of detecting pathogens
US20070188736A1 (en) * 2006-02-16 2007-08-16 Fouquet Julie E Obtaining measurement and baseline signals for evaluating assay test strips
US8492098B2 (en) 2006-02-21 2013-07-23 The Trustees Of Tufts College Methods and arrays for target analyte detection and determination of reaction components that affect a reaction
SG170028A1 (en) * 2006-02-24 2011-04-29 Callida Genomics Inc High throughput genome sequencing on dna arrays
US8097425B2 (en) * 2006-03-10 2012-01-17 Tethys Bioscience, Inc. Multiplex protein fractionation
US7807265B2 (en) * 2006-05-12 2010-10-05 University Of Central Florida Research Foundation, Inc. Partially passivated quantum dots, process for making, and sensors therefrom
JP2009537148A (ja) * 2006-05-16 2009-10-29 アプライド バイオシステムズ インコーポレイテッド 単分子配列のためのシステム、方法および装置
WO2007138851A1 (ja) * 2006-05-26 2007-12-06 Konica Minolta Medical & Graphic, Inc. III－Ｖ型半導体／ＳｉＯ2型ナノ粒子、及び生体物質標識剤
WO2008008349A2 (en) * 2006-07-11 2008-01-17 Drexel University Methods of quantitatively assessing inflammation with biosensing nanoparticles
JP5277165B2 (ja) * 2006-07-24 2013-08-28 ベクトン・ディキンソン・アンド・カンパニー 分析粒子凝集およびイメージング装置および方法
US7764361B2 (en) * 2006-07-27 2010-07-27 Northwestern University Systems and methods to analyze multiplexed bead-based assays using backscattered light
JPWO2008032534A1 (ja) * 2006-09-14 2010-01-21 コニカミノルタエムジー株式会社 蛍光半導体微粒子集合体、生体物質蛍光標識剤集合体、これらを用いたバイオイメージング法及び生体物質解析方法
US8219170B2 (en) * 2006-09-20 2012-07-10 Nellcor Puritan Bennett Llc System and method for practicing spectrophotometry using light emitting nanostructure devices
US7910302B2 (en) 2006-10-27 2011-03-22 Complete Genomics, Inc. Efficient arrays of amplified polynucleotides
ES2491743T3 (es) * 2006-11-01 2014-09-08 Ventana Medical Systems, Inc. Haptenos, conjugados de haptenos, composiciones de los mismos y método para su preparación y uso
US20090075343A1 (en) 2006-11-09 2009-03-19 Complete Genomics, Inc. Selection of dna adaptor orientation by nicking
CA2580589C (en) 2006-12-19 2016-08-09 Fio Corporation Microfluidic detection system
US8244021B2 (en) * 2006-12-20 2012-08-14 Ventana Medical Systems, Inc. Quantitative, multispectral image analysis of tissue specimens stained with quantum dots
US20080216894A1 (en) * 2007-01-08 2008-09-11 Plextronics, Inc. Quantum dot photovoltaic device
EP2126072A4 (de) * 2007-02-21 2011-07-13 Life Technologies Corp Materialien und verfahren zur einzelmolekülsequenzierung von nukleinsäuren
CA2682826C (en) 2007-04-02 2013-08-13 Fio Corporation System and method of deconvolving multiplexed fluorescence spectral signals generated by quantum dot optical coding technology
JP4357544B2 (ja) * 2007-05-15 2009-11-04 シャープ株式会社 １３族窒化物蛍光体およびその製造方法
US8597729B2 (en) 2007-06-22 2013-12-03 Fio Corporation Systems and methods for manufacturing quantum dot-doped polymer microbeads
CA2693055C (en) 2007-07-09 2012-02-21 Fio Corporation Systems and methods for enhancing fluorescent detection of target molecules in a test sample
US20090045360A1 (en) * 2007-08-13 2009-02-19 Xerox Corporation Quantum dot-based luminescent marking material
WO2009026105A1 (en) * 2007-08-17 2009-02-26 Massachusetts Institute Of Technology Light emitting material
US8551763B2 (en) 2007-10-12 2013-10-08 Fio Corporation Flow focusing method and system for forming concentrated volumes of microbeads, and microbeads formed further thereto
CA2740973A1 (en) * 2007-10-23 2009-04-30 Stratos Genomics Inc. High throughput nucleic acid sequencing by spacing
WO2009054244A1 (ja) * 2007-10-26 2009-04-30 Konica Minolta Medical & Graphic, Inc. 半導体ナノ粒子蛍光体の集合体および単一分子観察方法
JP2011504236A (ja) * 2007-11-20 2011-02-03 スリーエム イノベイティブ プロパティズ カンパニー ジアセチレンを含むポリマーセンサーを用いる細菌試料の分析方法
JP2009128136A (ja) * 2007-11-22 2009-06-11 Fujifilm Corp 蛍光検出方法
US20100304502A1 (en) * 2007-12-05 2010-12-02 Konica Minolta Medical & Graphic, Inc. Detection method and detection kit
KR101588736B1 (ko) 2008-01-10 2016-01-26 리서치 디벨롭먼트 파운데이션 얼리키아 샤피엔시스에 대한 백신 및 진단제
JP4980944B2 (ja) 2008-02-12 2012-07-18 富士フイルム株式会社 免疫学的測定方法
WO2009145813A1 (en) * 2008-03-04 2009-12-03 Qd Vision, Inc. Particles including nanoparticles, uses thereof, and methods
CN102084003A (zh) * 2008-04-04 2011-06-01 生命科技公司 用于成像和测序的扫描系统和方法
CN102119331A (zh) 2008-06-05 2011-07-06 生命科技公司 细胞跨膜电位的激活和监测
CA2729023C (en) 2008-06-25 2013-02-26 Fio Corporation Bio-threat alert system
US8747517B2 (en) * 2008-06-30 2014-06-10 Life Technologies Corporation Methods for isolating and purifying nanoparticles from a complex medium
EP2307309B1 (de) 2008-07-02 2015-11-11 Life Technologies Corporation VERFAHREN ZUR HERSTELLUNG VON STABILE InP/ZnS KERN/SCHICHT ARTIGE HALBLEITERNANOKRISTALLE UND DADURCH HERGESTELLTE PRODUKTEN
EP3162900B1 (de) 2008-08-14 2018-07-18 Nanostring Technologies, Inc Stabile nanoreporter
EP2329278A4 (de) 2008-08-29 2014-05-14 Fio Corp Tragbare diagnostische testvorrichtung zur einmaligen verwendung sowie zugehöriges system und verfahren zum testen biologischer und ökologischer proben
EP2356457B1 (de) * 2008-10-13 2018-05-16 Xeptagen SPA Verfahren zur herstellung von immunokonjugaten und verwendung davon
JP2012506556A (ja) * 2008-10-23 2012-03-15 コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ 生体サンプル用のカラーマネージメント
CA2749660C (en) 2009-01-13 2017-10-31 Fio Corporation A handheld diagnostic test device and method for use with an electronic device and a test cartridge in a rapid diagnostic test
US10290387B2 (en) * 2009-01-20 2019-05-14 University Of Utah Research Foundation Modification of colloidal nanocrystals
US20120068126A1 (en) * 2009-01-20 2012-03-22 University Of Utah Research Foundation Post-systhesis modification of colloidal nanocrystals
WO2010085658A1 (en) * 2009-01-23 2010-07-29 Drexel University Apparatus and methods for detecting inflammation using quantum dots
JP5744033B2 (ja) 2009-09-09 2015-07-01 キユーデイー・ビジヨン・インコーポレーテツド ナノ粒子を含む粒子、それの使用および方法
WO2011031876A1 (en) 2009-09-09 2011-03-17 Qd Vision, Inc. Formulations including nanoparticles
DE102009041967A1 (de) * 2009-09-17 2011-03-24 Lre Medical Gmbh Vorrichtung zur Analyse von Körperflüssigkeiten
WO2011047087A2 (en) 2009-10-13 2011-04-21 Nanostring Technologies, Inc. Protein detection via nanoreporters
WO2011072228A1 (en) * 2009-12-11 2011-06-16 Massachusetts Institute Of Technology Spectral imaging of photoluminescent materials
AU2010339464B2 (en) 2009-12-31 2014-10-09 Ventana Medical Systems, Inc. Methods for producing uniquely specific nucleic acid probes
WO2011100541A2 (en) 2010-02-11 2011-08-18 Nanostring Technologies, Inc. Compositions and methods for the detection of small rnas
AU2011220792A1 (en) 2010-02-26 2012-07-26 Ventana Medical Systems, Inc. Cytogenic analysis of metaphase chromosomes
CA2787487C (en) 2010-02-26 2018-07-24 Ventana Medical Systems, Inc. Polytag probes
CN103180463B (zh) 2010-10-22 2014-12-31 霍夫曼-拉罗奇有限公司 亲硫性固相以及包含硫代羰基核苷酸的寡核苷酸的缀合物
EP2670867B1 (de) 2011-02-04 2017-11-01 The Trustees Of The University Of Pennsylvania Verfahren zur gleichzeitigen erkennung einer chromosomenstruktur und einer genexpression in einzelzellen
CA2825453C (en) 2011-03-14 2016-05-10 Ventana Medical Systems, Inc. A method of analyzing chromosomal translocations and a system therefore
US9758834B2 (en) 2011-03-28 2017-09-12 Nanostring Technologies, Inc. Compositions and methods for diagnosing cancer
ES2597032T3 (es) 2011-05-04 2017-01-13 HTG Molecular Diagnostics, Inc Mejoras en un ensayo cuantitativo de protección contra la nucleasa (qNPA) y secuenciación (qNPS)
US9556281B2 (en) 2011-08-15 2017-01-31 The University Of Chicago Compositions and methods related to antibodies to staphylococcal protein A
WO2013057586A1 (en) 2011-10-19 2013-04-25 Oslo Universitetssykehus Hf Compositions and methods for producing soluble t - cell receptors
WO2013108126A2 (en) 2012-01-16 2013-07-25 University Of Oslo Methyltransferases and uses thereof
AU2013252888B2 (en) 2012-04-26 2018-06-14 University Of Chicago Compositions and methods related to antibodies that neutralize coagulase activity during Staphylococcus aureus disease
WO2013167387A1 (en) 2012-05-10 2013-11-14 Ventana Medical Systems, Inc. Uniquely specific probes for pten, pik3ca, met, top2a, and mdm2
NO2872646T3 (de) 2012-07-12 2018-01-27
WO2014048942A1 (en) 2012-09-25 2014-04-03 Ventana Medical Systems, Inc. Probes for pten, pik3ca, met, and top2a, and method for using the probes
CN107941706A (zh) 2012-12-17 2018-04-20 伦珂德克斯有限公司 用于测定化学状态的系统和方法
US10610861B2 (en) 2012-12-17 2020-04-07 Accellix Ltd. Systems, compositions and methods for detecting a biological condition
US9759722B2 (en) * 2012-12-17 2017-09-12 Leukodx Ltd. Systems and methods for determining a chemical state
US11366061B2 (en) 2013-01-24 2022-06-21 Grace Bio-Labs, Inc. Protein microarray assay imager
US20140246624A1 (en) * 2013-03-01 2014-09-04 Rarecyte, Inc. Monochromatic dot ensembles
EP4163387A1 (de) 2013-03-15 2023-04-12 The University of Chicago Verfahren und zusammensetzungen in zusammenhang mit t-zell-aktivität
WO2015036405A1 (en) 2013-09-10 2015-03-19 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for diagnosing and treating basal cell carcinoma
US10378044B1 (en) * 2013-10-01 2019-08-13 FemtoDx Methods for increasing the molecular specificity of a nanosensor
WO2015069787A1 (en) 2013-11-05 2015-05-14 Htg Molecular Diagnostics, Inc. Methods for detecting nucleic acids
AU2015220784B2 (en) 2014-02-24 2021-02-04 Ventana Medical Systems, Inc. Automated RNA detection using labeled 2'-O-methyl RNA oligonucleotide probes and signal amplification systems
US10323271B2 (en) * 2014-03-20 2019-06-18 Konica Minolta, Inc. Probe reagent and fish using probe reagent
AU2015320685B2 (en) 2014-09-23 2021-01-28 Tearlab Research, Inc. Systems and methods for integration of microfluidic tear collection and lateral flow analysis of analytes of interest
EP3009147A1 (de) 2014-10-16 2016-04-20 INSERM (Institut National de la Santé et de la Recherche Médicale) Verfahren zur Behandlung von resistenten Glioblastomen
WO2016113233A1 (en) 2015-01-12 2016-07-21 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for the diagnosis of pancreatic cancer
US9909972B2 (en) * 2016-02-08 2018-03-06 MANTA Instruments, Inc. Multi-camera apparatus for observation of microscopic movements and counting of particles in colloids and its calibration
EP3325649B1 (de) 2015-07-17 2024-01-03 Nanostring Technologies, Inc. Gleichzeitigen quantifizierung einer vielzahl von proteinen in einer benutzerdefinierten region eines gewebequerschnitts
SG10202107053QA (en) 2015-07-17 2021-08-30 Nanostring Technologies Inc Simultaneous quantification of gene expression in a user-defined region of a cross-sectioned tissue
WO2017029391A1 (en) 2015-08-20 2017-02-23 INSERM (Institut National de la Santé et de la Recherche Médicale) New method for treating cancer
WO2017055321A1 (en) 2015-09-29 2017-04-06 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for quantifying the population of fibroblasts in a tissue sample
WO2017055319A1 (en) 2015-09-29 2017-04-06 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for quantifying the population of b cells in a tissue sample
WO2017055327A1 (en) 2015-09-29 2017-04-06 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for quantifying the population of endothelial cells in a tissue sample
WO2017055320A1 (en) 2015-09-29 2017-04-06 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for quantifying the population of cytotoxic lymphocytes in a tissue sample
WO2017055326A1 (en) 2015-09-29 2017-04-06 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for quantifying the population of myeloid dendritic cells in a tissue sample
WO2017055325A1 (en) 2015-09-29 2017-04-06 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for quantifying the population of nk cells in a tissue sample
WO2017055324A1 (en) 2015-09-29 2017-04-06 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for quantifying the population of cells of monocytic origin in a tissue sample
WO2017055322A1 (en) 2015-09-29 2017-04-06 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for quantifying the population of neutrophils in a tissue sample
WO2017060397A1 (en) 2015-10-09 2017-04-13 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for predicting the survival time of subjects suffering from melanoma metastases
WO2017067944A1 (en) 2015-10-19 2017-04-27 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for predicting the survival time of subjects suffering from triple negative breast cancer
CN105353131B (zh) * 2015-10-23 2017-04-19 山东大学 基于双编码和单分子计数的细胞因子多重检测方法
WO2017079763A1 (en) 2015-11-06 2017-05-11 Ventana Medical Systems, Inc. Representative diagnostics
EP3374518B1 (de) 2015-11-10 2019-11-06 INSERM (Institut National de la Santé et de la Recherche Médicale) Verfahren zur vorhersage der überlebenszeit von patienten mit dekompensierter alkoholzirrhose
SG11201804648RA (en) 2015-12-04 2018-06-28 Univ Texas Slc45a2 peptides for immunotherapy
WO2017122039A1 (en) 2016-01-13 2017-07-20 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for predicting pancreatic cancer treatment response
WO2017182834A1 (en) 2016-04-19 2017-10-26 INSERM (Institut National de la Santé et de la Recherche Médicale) New method for treating resistant glioblastoma
US20190292259A1 (en) 2016-05-24 2019-09-26 Inserm (Institut National De La Sante Et De La Recherche Medicale) Methods and pharmaceutical compositions for the treatment of non small cell lung cancer (nsclc) that coexists with chronic obstructive pulmonary disease (copd)
EP3469098A1 (de) 2016-06-14 2019-04-17 INSERM - Institut National de la Santé et de la Recherche Médicale Verfahren zur vorhersage der reaktion auf die behandlung von akuter schwerer kolitis
WO2018011107A1 (en) 2016-07-11 2018-01-18 INSERM (Institut National de la Santé et de la Recherche Médicale) Use of er-alpha 46 in methods and kits for assessing the status of breast cancer
WO2018011166A2 (en) 2016-07-12 2018-01-18 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for quantifying the population of myeloid dendritic cells in a tissue sample
NL2017437B1 (en) * 2016-09-08 2018-03-27 Univ Amsterdam Multi-chromatic capped semiconductor nanocrystals
WO2018046736A1 (en) 2016-09-12 2018-03-15 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for predicting the survival time of patients suffering from cancer
WO2018046738A1 (en) 2016-09-12 2018-03-15 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for predicting the survival time of patients suffering from cancer
WO2018054960A1 (en) 2016-09-21 2018-03-29 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for predicting and treating resistance to chemotherapy in npm-alk(+) alcl
EP3515453A1 (de) 2016-09-22 2019-07-31 INSERM (Institut National de la Santé et de la Recherche Médicale) Verfahren und pharmazeutische zusammensetzungen zur neuprogrammierung der immunumgebung bei einer darauf angewiesenen person
US10241111B2 (en) 2016-10-21 2019-03-26 AhuraTech LLC Electroluminescent binding assays
US10415080B2 (en) 2016-11-21 2019-09-17 Nanostring Technologies, Inc. Chemical compositions and methods of using same
DE102016124692B4 (de) 2016-12-16 2019-05-16 Gna Biosolutions Gmbh Verfahren und System zum Vervielfältigen einer Nukleinsäure
WO2018122245A1 (en) 2016-12-28 2018-07-05 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods of predicting the survival time of patients suffering from cms3 colorectal cancer
WO2018122249A1 (en) 2016-12-28 2018-07-05 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for predicting the survival time of patients suffering from a microsatellite stable colorectal cancer
WO2018146239A1 (en) 2017-02-10 2018-08-16 INSERM (Institut National de la Santé et de la Recherche Médicale) Biomarker for outcome in aml patients
WO2018162404A1 (en) 2017-03-06 2018-09-13 INSERM (Institut National de la Santé et de la Recherche Médicale) Biomarker for outcome in aml patients
WO2018172540A1 (en) 2017-03-24 2018-09-27 INSERM (Institut National de la Santé et de la Recherche Médicale) Method to predict the progression of alzheimer's disease
US11230736B2 (en) 2017-03-29 2022-01-25 Inserm (Institut National De La Santé De La Recherche Médicale) Methods for assessing pregnancy outcome
WO2018189215A1 (en) 2017-04-12 2018-10-18 INSERM (Institut National de la Santé et de la Recherche Médicale) Method for predicting the survival time of a patient suffering from hepatocellular carcinoma
CN111051884A (zh) * 2017-05-18 2020-04-21 轨迹农业Ip有限责任公司 用于检测、定量和/或跟踪微生物及其他分析物的诊断测定法
WO2019038219A1 (en) 2017-08-21 2019-02-28 INSERM (Institut National de la Santé et de la Recherche Médicale) NEW PROGNOSTIC METHOD OF PANCREATIC CANCER
WO2019043138A1 (en) 2017-09-01 2019-03-07 INSERM (Institut National de la Santé et de la Recherche Médicale) METHOD FOR PREDICTING OUTCOME OF CANCER
WO2019092269A1 (en) 2017-11-13 2019-05-16 F. Hoffmann-La Roche Ag Devices for sample analysis using epitachophoresis
AU2019216973A1 (en) 2018-02-12 2020-08-27 Bruker Spatial Biology, Inc. Biomolecular probes and methods of detecting gene and protein expression
WO2019207030A1 (en) 2018-04-26 2019-10-31 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for predicting a response with an immune checkpoint inhibitor in a patient suffering from a lung cancer
WO2019222178A1 (en) 2018-05-14 2019-11-21 Nanostring Technologies, Inc. Chemical compositions and methods of using same
WO2019229489A1 (en) 2018-05-31 2019-12-05 INSERM (Institut National de la Santé et de la Recherche Médicale) Use of mir-146a-5p and mir-186 as biomarkers of osteoarthritis
US11460403B2 (en) 2018-07-05 2022-10-04 AhuraTech LLC Electroluminescent methods and devices for characterization of biological specimens
US11428656B2 (en) 2018-07-05 2022-08-30 AhuraTech LLC Electroluminescent methods and system for real-time measurements of physical properties
US11393387B2 (en) 2018-07-05 2022-07-19 AhuraTech LLC Open-circuit electroluminescence
CN109187484B (zh) * 2018-09-13 2020-12-04 广西师范大学 一种用亲和反应调控碳点催化sers检测生物素的方法
WO2020089432A1 (en) 2018-11-02 2020-05-07 INSERM (Institut National de la Santé et de la Recherche Médicale) New prognostic method of pancreatic cancer
WO2020089428A1 (en) 2018-11-02 2020-05-07 INSERM (Institut National de la Santé et de la Recherche Médicale) New prognostic method of pancreatic cancer
US20220073626A1 (en) 2019-01-03 2022-03-10 Institut National De La Santé Et De La Recheche Médicale (Inserm) Methods and pharmaceutical compositions for enhancing cd8+ t cell-dependent immune responses in subjects suffering from cancer
JP2022522265A (ja) 2019-01-16 2022-04-15 アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル エリスロフェロンの変異体及びその使用
EP3924520A1 (de) 2019-02-13 2021-12-22 INSERM (Institut National de la Santé et de la Recherche Médicale) Verfahren und zusammensetzungen zur behandlung von krebs bei einer krebskranken person
WO2020182932A1 (en) 2019-03-13 2020-09-17 INSERM (Institut National de la Santé et de la Recherche Médicale) New gene signatures for predicting survival time in patients suffering from renal cell carcinoma
WO2020193740A1 (en) 2019-03-28 2020-10-01 INSERM (Institut National de la Santé et de la Recherche Médicale) New strategy for treating pancreatic cancer
US11609233B2 (en) 2019-03-28 2023-03-21 Alentic Microscience Inc. Indicator-based analysis of a sample
US10684278B1 (en) * 2019-03-28 2020-06-16 Alentic Microscience Inc. Bead-based analysis of a sample
US11255850B2 (en) 2019-03-28 2022-02-22 Alentic Microscience Inc. Bead-based analysis of a sample
US11719700B2 (en) 2019-03-28 2023-08-08 Alentic Microscience Inc. Upconversion for microscopy
US20220177978A1 (en) 2019-04-02 2022-06-09 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods of predicting and preventing cancer in patients having premalignant lesions
WO2020212586A1 (en) 2019-04-18 2020-10-22 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for the treatment and prognosis of cancer
JP2022530390A (ja) 2019-04-24 2022-06-29 アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル 抗精神病剤の応答を予測するための方法
WO2020229521A1 (en) 2019-05-14 2020-11-19 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for inhibiting or reducing bacterial biofilms on a surface
WO2020229437A1 (en) 2019-05-14 2020-11-19 F. Hoffmann-La Roche Ag Devices and methods for sample analysis
WO2021001539A1 (en) 2019-07-04 2021-01-07 INSERM (Institut National de la Santé et de la Recherche Médicale) New strategy to detect and treat eosinophilic fasciitis
US11692989B2 (en) 2019-07-11 2023-07-04 Locus Solutions Ipco, Llc Use of soil and other environmental data to recommend customized agronomic programs
EP4025712A1 (de) 2019-09-05 2022-07-13 Institut National de la Santé et de la Recherche Médicale (INSERM) Verfahren zur behandlung und prognose akuter myeloischer leukämie
WO2021063968A1 (en) 2019-09-30 2021-04-08 INSERM (Institut National de la Santé et de la Recherche Médicale) Method and composition for diagnosing chronic obstructive pulmonary disease
WO2021074391A1 (en) 2019-10-17 2021-04-22 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for diagnosing nasal intestinal type adenocarcinomas
CN112925005B (zh) * 2019-12-05 2023-09-08 中核四0四有限公司 一种二氧化镎样品钚含量的测定方法
EP4110955A1 (de) 2020-02-28 2023-01-04 INSERM (Institut National de la Santé et de la Recherche Médicale) Verfahren zur diagnose, prognose und verwaltung der behandlung von brustkrebs
WO2021186014A1 (en) 2020-03-20 2021-09-23 INSERM (Institut National de la Santé et de la Recherche Médicale) Method for predicting the survival time of a patient suffering from a cancer
WO2021250106A1 (en) 2020-06-10 2021-12-16 INSERM (Institut National de la Santé et de la Recherche Médicale) Method for treating and prognosing cancer like glioblastoma
US20230218608A1 (en) 2020-06-18 2023-07-13 INSERM (Institut National de la Santé et de la Recherche Médicale) New strategy for treating pancreatic cancer
WO2022018163A1 (en) 2020-07-22 2022-01-27 INSERM (Institut National de la Santé et de la Recherche Médicale) Method for predicting survival time in patients suffering from cancer
WO2022064049A1 (en) 2020-09-28 2022-03-31 INSERM (Institut National de la Santé et de la Recherche Médicale) Method for diagnosing brucella infection
WO2022084327A1 (en) 2020-10-20 2022-04-28 INSERM (Institut National de la Santé et de la Recherche Médicale) Method for predicting the response to tnf inhibitors
US20240011094A1 (en) 2020-11-06 2024-01-11 Institut National de la Santé et de la Recherche Médicale Methods for diagnosis and treating polycystic ovary syndrome (pcos)
WO2022135753A1 (en) 2020-12-21 2022-06-30 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for prognosis the humoral response of a subject prior to vaccination
WO2022136252A1 (en) 2020-12-21 2022-06-30 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for prognosis the humoral response of a subject prior to vaccination
WO2022152698A1 (en) 2021-01-12 2022-07-21 INSERM (Institut National de la Santé et de la Recherche Médicale) Use of npdk-d to evaluate cancer prognosis
EP4291897A1 (de) 2021-02-09 2023-12-20 Institut National de la Santé et de la Recherche Médicale (INSERM) Neues verfahren zur prognose von lungenkrebs
EP4308934A1 (de) 2021-03-17 2024-01-24 INSERM (Institut National de la Santé et de la Recherche Médicale) Verfahren zur diagnose von bauchspeicheldrüsenkrebs
WO2022207566A1 (en) 2021-03-29 2022-10-06 INSERM (Institut National de la Santé et de la Recherche Médicale) New method to evaluate pancreatic cancer prognosis
WO2022223791A1 (en) 2021-04-23 2022-10-27 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and compositions for treating cell senescence accumulation related disease
EP4367269A1 (de) 2021-07-05 2024-05-15 Inserm (Institut National De La Sante Et De La Recherche Medicale) Gensignaturen zur vorhersage der überlebenszeit bei patienten mit nierenzellkarzinom
WO2023089159A1 (en) 2021-11-22 2023-05-25 INSERM (Institut National de la Santé et de la Recherche Médicale) New strategy targeting stroma/tumor cell crosstalk to treat a cancer
WO2023144303A1 (en) 2022-01-31 2023-08-03 INSERM (Institut National de la Santé et de la Recherche Médicale) Cd38 as a biomarker and biotarget in t-cell lymphomas
WO2023152133A1 (en) 2022-02-08 2023-08-17 INSERM (Institut National de la Santé et de la Recherche Médicale) Method for diagnosing colorectal cancer
WO2024061930A1 (en) 2022-09-22 2024-03-28 Institut National de la Santé et de la Recherche Médicale New method to treat and diagnose peripheral t-cell lymphoma (ptcl)
WO2024115935A1 (en) 2022-11-29 2024-06-06 Inserm Methods for the treatment of b-cell lymphoma using cd39 inhibitors

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4868105A (en) * 1985-12-11 1989-09-19 Chiron Corporation Solution phase nucleic acid sandwich assay
JPH03279860A (ja) * 1990-03-29 1991-12-11 Mitsui Petrochem Ind Ltd 検査方法及び検査試薬
US5665582A (en) * 1990-10-29 1997-09-09 Dekalb Genetics Corp. Isolation of biological materials
US5505928A (en) 1991-11-22 1996-04-09 The Regents Of University Of California Preparation of III-V semiconductor nanocrystals
US5674698A (en) * 1992-09-14 1997-10-07 Sri International Up-converting reporters for biological and other assays using laser excitation techniques
JP3410777B2 (ja) * 1993-09-13 2003-05-26 株式会社東芝 超微粒子無機蛍光体標識特異的結合物質およびこれを用いた検出方法
JP3517031B2 (ja) * 1995-06-09 2004-04-05 日清紡績株式会社 生物学的活性物質の分析法
US5690807A (en) 1995-08-03 1997-11-25 Massachusetts Institute Of Technology Method for producing semiconductor particles
US5861279A (en) * 1996-01-17 1999-01-19 Schering Corporation Baculovirus expression system for human interleukin 5 receptor and method of screening for interleukin 5 antagonists
DE19627290A1 (de) * 1996-07-06 1998-01-08 Boehringer Mannheim Gmbh Bestimmung von Analyten unter Verwendung zweier Markierungen
CA2262018C (en) * 1996-07-29 2007-10-02 Nanosphere Llc Nanoparticles having oligonucleotides attached thereto and uses therefor
US5739001A (en) * 1996-10-29 1998-04-14 E. I. Du Pont De Nemours And Company Solid phase cell-based assay
JPH1151935A (ja) * 1997-08-06 1999-02-26 Aisin Seiki Co Ltd 複数種類のターゲット分子の同時検出方法
US6322901B1 (en) 1997-11-13 2001-11-27 Massachusetts Institute Of Technology Highly luminescent color-selective nano-crystalline materials
US6207392B1 (en) * 1997-11-25 2001-03-27 The Regents Of The University Of California Semiconductor nanocrystal probes for biological applications and process for making and using such probes
US5990479A (en) 1997-11-25 1999-11-23 Regents Of The University Of California Organo Luminescent semiconductor nanocrystal probes for biological applications and process for making and using such probes
EP0990903B1 (de) * 1998-09-18 2003-03-12 Massachusetts Institute Of Technology Biologische Verwendungen von halbleitenden Nanokristallen
EP1113986A2 (de) 1998-09-18 2001-07-11 Massachusetts Institute Of Technology Regelsystem des bestandes
US6306610B1 (en) * 1998-09-18 2001-10-23 Massachusetts Institute Of Technology Biological applications of quantum dots
DE19905277A1 (de) * 1999-02-09 2000-08-10 Bayer Ag Verfahren zur Herstellung von 2-Aminomethyl-1,5-pentandiamin
US20010055764A1 (en) * 1999-05-07 2001-12-27 Empedocles Stephen A. Microarray methods utilizing semiconductor nanocrystals
ATE439452T1 (de) * 1999-05-07 2009-08-15 Life Technologies Corp Verfahren zum nachweis von analyten mit hilfe von halbleiternanokrystallen

Also Published As

Publication number Publication date
AU4701200A (en) 2000-11-21
US6630307B2 (en) 2003-10-07
DE60042738D1 (de) 2009-09-24
WO2000068692A1 (en) 2000-11-16
EP1179185B1 (de) 2009-08-12
US20090176221A1 (en) 2009-07-09
US20010034034A1 (en) 2001-10-25
CA2373146A1 (en) 2000-11-16
EP1179185A1 (de) 2002-02-13
JP2002544488A (ja) 2002-12-24
US20040166505A1 (en) 2004-08-26
US20120252018A1 (en) 2012-10-04
US6274323B1 (en) 2001-08-14

Similar Documents

Publication Publication Date Title
ATE439452T1 (de) Verfahren zum nachweis von analyten mit hilfe von halbleiternanokrystallen
WO2001057522A3 (en) Immunochromatographic methods which employ semiconductor nanocrystals
DE60223635D1 (de) Reagenzien, Verfahren und Vorrichtungen zum Nachweis von Analyten
DE69938662D1 (de) Spurendetektion von analyten mit hilfe artifizieller olfaktometrie
ATE431427T1 (de) Verbessertes verfahren zum nachweis von atp
DK0699768T3 (da) Fremgangsmåder til quenching i opløsning af fluorescens-mærkede oligonnukleotidprober
CY1109554T1 (el) Μεθοδοι και αντιδραστηρια για την ανιχνευση ενδοτοξινης
ATE204333T1 (de) Verfahren zur dämpfung der fluoreszenz von fluoreszenzmarkierten oligonukleotiden in lösung
AR053251A1 (es) Estrategias nuevas de etiquetado para la deteccion sensible de analitos
ATE509120T1 (de) Fusionsproteine zur detektion von analyten
DE69732667D1 (de) Vorrichtung und verfahren zum nachweis und identifizieren von infektiösen wirkstoffen
ES2081991T3 (es) Deteccion o cuantificacion de varios analitos utilizando tecnicas de marcacion.
ATE239912T1 (de) Verfahren und vorrichtung zur referenzierung von fluoreszenzintensitätssignalen
DE69811067D1 (de) Anzeigeverwaltungsverfahren, vorrichtung und hergestellter gegenstand zur verwaltung von ikonen, etiketten und führungslinien
FI900602A0 (fi) Bestaemning.
ATE236996T1 (de) Sätze von, mit fluoreszierenden energieübertragungsverbindungen, markierten primern und deren verwendung in mehrkomponentenanalyse
DE602004001227D1 (de) Nukleinsäure-biosensor
DE69401717D1 (de) Verfahren zur Aktivierung von polyanionischen,fluoreszierenden Farbstoffen in schwach dielektrischen Medien mit quaternären Oniumverbindungen
DE60143888D1 (de) Methode um die sensitivität einer luminesenz assay zu erhöhen
DE60332382D1 (de) Zentrifugalvorrichtung und verfahren zur durchführung von bindungsversuchen
WO2003054225A3 (de) Verfahren zur bestimmung von nukleinsäureanalyten
DE502004010078D1 (de) Verfahren zur anzeige von zeitabhängigen vorgängen
DE60043618D1 (de) Verfahren zum nachweis einer reaktion zur molekularen erkennung
ES542287A0 (es) Un metodo para detectar una secuencia de polinucleotidos en un analito
DE60130970D1 (de) Reagenziensatz zur detektion von mikroorganismen, vorrichtung zur quantifizierungvon mikroorganismen und verfahren zur quantifizierung von mikroorganismen

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties