ATE409697T1 - 1,1a,5,5a-tetrahydro-3-thia- cyclopropaäaüpentalene: trizyklische thiophenderivate als s1p1/edg1-rezeptor-agonisten - Google Patents
1,1a,5,5a-tetrahydro-3-thia- cyclopropaäaüpentalene: trizyklische thiophenderivate als s1p1/edg1-rezeptor-agonistenInfo
- Publication number
- ATE409697T1 ATE409697T1 AT05772622T AT05772622T ATE409697T1 AT E409697 T1 ATE409697 T1 AT E409697T1 AT 05772622 T AT05772622 T AT 05772622T AT 05772622 T AT05772622 T AT 05772622T AT E409697 T1 ATE409697 T1 AT E409697T1
- Authority
- AT
- Austria
- Prior art keywords
- cyclopropaäaüpentalene
- thia
- tetrahydro
- receptor agonists
- thiophene derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/78—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems condensed with rings other than six-membered or with ring systems containing such rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Immunology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Transplantation (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/EP2004/008501 WO2006010379A1 (en) | 2004-07-29 | 2004-07-29 | Novel thiophene derivatives as immunosuppressive agents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE409697T1 true ATE409697T1 (de) | 2008-10-15 |
Family
ID=34958296
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT05772622T ATE409697T1 (de) | 2004-07-29 | 2005-07-20 | 1,1a,5,5a-tetrahydro-3-thia- cyclopropaäaüpentalene: trizyklische thiophenderivate als s1p1/edg1-rezeptor-agonisten |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US7750040B2 (de) |
| EP (1) | EP1805163B1 (de) |
| JP (1) | JP4807884B2 (de) |
| KR (1) | KR20070046849A (de) |
| CN (1) | CN1993346B (de) |
| AR (1) | AR050273A1 (de) |
| AT (1) | ATE409697T1 (de) |
| AU (1) | AU2005266529A1 (de) |
| BR (1) | BRPI0513841A (de) |
| CA (1) | CA2574305A1 (de) |
| DE (1) | DE602005010109D1 (de) |
| DK (1) | DK1805163T3 (de) |
| ES (1) | ES2313391T3 (de) |
| IL (1) | IL180962A0 (de) |
| MX (1) | MX2007000972A (de) |
| NO (1) | NO20071095L (de) |
| PL (1) | PL1805163T3 (de) |
| PT (1) | PT1805163E (de) |
| RU (1) | RU2386626C2 (de) |
| SI (1) | SI1805163T1 (de) |
| TW (1) | TW200616994A (de) |
| WO (2) | WO2006010379A1 (de) |
| ZA (1) | ZA200700535B (de) |
Families Citing this family (50)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4678139B2 (ja) * | 2004-05-10 | 2011-04-27 | トヨタ自動車株式会社 | 自動車の暖房制御システム |
| WO2006010379A1 (en) | 2004-07-29 | 2006-02-02 | Actelion Pharmaceuticals Ltd. | Novel thiophene derivatives as immunosuppressive agents |
| KR20070058455A (ko) | 2004-08-13 | 2007-06-08 | 프래시스 파마슈티컬즈 인코포레이티드 | 스핑고신-1-포스페이트(ｓ1ｐ) 수용체 활성을 조절하기위한 방법 및 조성물 |
| US7846964B2 (en) * | 2005-03-23 | 2010-12-07 | Actelion Pharmaceuticals Ltd. | Thiophene derivatives as spingosine-1-phosphate-1 receptor agonists |
| WO2006100633A1 (en) * | 2005-03-23 | 2006-09-28 | Actelion Pharmaceuticals Ltd | NOVEL THIOPHENE DERIVATIVES AS SPHINGOSINE-l-PHOSPHATE-1 RECEPTOR AGONISTS |
| US7723378B2 (en) | 2005-03-23 | 2010-05-25 | Actelion Pharmaceuticals Ltd. | Hydrogenated benzo (C) thiophene derivatives as immunomodulators |
| WO2006137019A1 (en) | 2005-06-24 | 2006-12-28 | Actelion Pharmaceuticals Ltd | Novel thiophene derivatives |
| AR057894A1 (es) * | 2005-11-23 | 2007-12-26 | Actelion Pharmaceuticals Ltd | Derivados de tiofeno |
| TWI404706B (zh) * | 2006-01-11 | 2013-08-11 | Actelion Pharmaceuticals Ltd | 新穎噻吩衍生物 |
| KR20080092385A (ko) | 2006-01-24 | 2008-10-15 | 액테리온 파마슈티칼 리미티드 | 신규한 피리딘 유도체 |
| SI2069336T1 (sl) * | 2006-09-07 | 2013-03-29 | Actelion Pharmaceuticals Ltd. | Derivati piridin-4-ila kot imunomodulirna sredstva |
| AR061841A1 (es) * | 2006-09-07 | 2008-09-24 | Actelion Pharmaceuticals Ltd | Derivados de tiofen-oxadiazoles, agonistas del receptor s1p1/edg1, composiciones farmaceuticas que los contienen y usos como agentes inmunomoduladores. |
| CN101522670B (zh) * | 2006-09-08 | 2012-05-23 | 埃科特莱茵药品有限公司 | 作为免疫调制剂的吡啶-3-基衍生物 |
| DE102007019677A1 (de) | 2006-11-06 | 2008-05-08 | Carl Zeiss Surgical Gmbh | Operationsmikroskop mit OCT-System und Operationsmikroskop-Beleuchtungsmodul mit OCT-System |
| DE102007019679A1 (de) | 2006-11-06 | 2008-05-15 | Carl Zeiss Surgical Gmbh | Operationsmikroskop mit OCT-System |
| DE102007019680A1 (de) | 2006-11-06 | 2008-05-08 | Carl Zeiss Surgical Gmbh | Ophthalmo-Operationsmikroskop mit OCT-System |
| BRPI0808789A2 (pt) * | 2007-03-16 | 2014-08-12 | Actelion Pharmaceuticals Ltd | Compostos e composição farmacêutica de derivados aminopiridina e uso destes |
| US20090069288A1 (en) * | 2007-07-16 | 2009-03-12 | Breinlinger Eric C | Novel therapeutic compounds |
| BRPI0820868A2 (pt) * | 2007-12-10 | 2019-09-24 | Actelion Pharmaceuticals Ltd | composto de tiofeno fórmula(i), composição farmacêutica contendo o mesmo e uso deste para a prevenção ou tratamento de doenças ou disturbíos associados a um sistema imune ativado |
| WO2009074969A2 (en) * | 2007-12-12 | 2009-06-18 | University Of Lausanne | Sphingosine-1-phosphate, analogs and antagonists for use as medicaments |
| JP5411877B2 (ja) * | 2008-03-06 | 2014-02-12 | アクテリオン ファーマシューティカルズ リミテッド | ピリジン化合物 |
| MX2010009644A (es) * | 2008-03-07 | 2010-09-22 | Actelion Pharmaceuticals Ltd | Derivados piridin-2-ilo como agentes inmunomoduladores. |
| ES2617628T5 (es) | 2008-03-17 | 2020-06-01 | Actelion Pharmaceuticals Ltd | Régimen de dosificación para un agonista selectivo del receptor de S1P1 |
| RU2503680C2 (ru) | 2008-07-15 | 2014-01-10 | Санофи-Авентис | ОКСАЗОЛОПИРИМИДИНЫ КАК АГОНИСТЫ РЕЦЕПТОРА Edg-1 |
| AU2009274569C1 (en) | 2008-07-23 | 2015-06-25 | Arena Pharmaceuticals, Inc. | Substituted 1,2,3,4- tetrahydrocyclopenta[b]indol-3-yl) acetic acid derivatives useful in the treatment of autoimmune and inflammatory disorders |
| BRPI0917923B1 (pt) | 2008-08-27 | 2022-04-05 | Arena Pharmaceuticals Inc | Derivado de ácido tricíclico substituído, sua composição, seu uso e processo para preparar a referida composição |
| DE102009002514A1 (de) | 2009-04-21 | 2010-10-28 | Evonik Degussa Gmbh | Verfahren zur Herstellung von substituierten 1,4-Chinonmethiden |
| MX2012000414A (es) | 2009-07-16 | 2012-02-08 | Actelion Pharmaceuticals Ltd | Derivados piridin-4-ilo. |
| CA2770866C (en) * | 2009-08-28 | 2017-10-10 | Arena Pharmaceuticals, Inc. | Cannabinoid receptor modulators |
| ES2937386T3 (es) | 2010-01-27 | 2023-03-28 | Arena Pharm Inc | Procesos para la preparación de ácido (R)-2-(7-(4-ciclopentil-3-(trifluorometil)benciloxi)-1,2,3,4-tetrahidrociclopenta[b]indol-3-il)acético y sales del mismo |
| CN102884064B (zh) | 2010-03-03 | 2016-01-13 | 艾尼纳制药公司 | 制备s1p1受体调节剂及其晶体形式的方法 |
| SI2665720T1 (sl) | 2011-01-19 | 2015-08-31 | Actelion Pharmaceuticals Ltd. | Derivati 2-metoksi-piridin-4-ila |
| US9597340B2 (en) | 2011-02-25 | 2017-03-21 | Arena Pharmaceuticals, Inc. | Cannabinoid receptor modulators |
| MX350891B (es) | 2012-08-17 | 2017-09-22 | Actelion Pharmaceuticals Ltd | Proceso para la preparacion de (2z,5z)-5-(3-cloro-4-((r)-2,3-dihid roxipropoxi) bencilideno)-2-(propilimino)-3-(o-tolil) tiazolidin-4-ona y el intermediario usado en dicho proceso. |
| DE102013208091B4 (de) | 2013-05-02 | 2019-05-09 | Carl Zeiss Ag | Vorrichtung und Verfahren zum Vermessen einer Flächentopografie |
| DE102014222629A1 (de) | 2014-11-05 | 2016-05-12 | Carl Zeiss Meditec Ag | Untersuchen eines Objekts mit OCT-Abtastlichtstrahlen |
| DE202014011050U1 (de) | 2014-11-05 | 2017-07-26 | Carl Zeiss Meditec Ag | Vorrichtung für das Untersuchen eines Patientenauges |
| DE202014011051U1 (de) | 2014-11-05 | 2017-07-26 | Carl Zeiss Meditec Ag | Vorrichtung für das Untersuchen eines Patientenauges |
| US11007175B2 (en) | 2015-01-06 | 2021-05-18 | Arena Pharmaceuticals, Inc. | Methods of treating conditions related to the S1P1 receptor |
| KR20200044155A (ko) | 2015-05-20 | 2020-04-28 | 이도르시아 파마슈티컬스 리미티드 | 화합물 (s)-3-｛4-[5-(2-시클로펜틸-6-메톡시-피리딘-4-일)-[1,2,4]옥사디아졸-3-일]-2-에틸-6-메틸-페녹시｝-프로판-1,2-디올의 결정형 |
| US10111841B2 (en) | 2015-06-19 | 2018-10-30 | University Of South Florida | Stabilization of alcohol intoxication-induced cardiovascular instability |
| CN108349891B (zh) | 2015-06-22 | 2022-04-05 | 艾尼纳制药公司 | 用于s1p1受体相关病症的化合物的结晶l-精氨酸盐 |
| MX2019009841A (es) | 2017-02-16 | 2020-01-30 | Arena Pharm Inc | Compuestos y metodos para el tratamiento de la colangitis biliar primaria. |
| JP2020507610A (ja) | 2017-02-16 | 2020-03-12 | アリーナ ファーマシューティカルズ， インコーポレイテッド | 腸管外症状を伴う炎症性腸疾患の治療のための化合物および方法 |
| CN112955431A (zh) | 2018-09-06 | 2021-06-11 | 艾尼纳制药公司 | 可用于治疗自身免疫性病症和炎性病症的化合物 |
| US11013723B1 (en) | 2018-10-16 | 2021-05-25 | Celgene Corporation | Solid forms of a thiazolidinone compound, compositions and methods of use thereof |
| US11014940B1 (en) | 2018-10-16 | 2021-05-25 | Celgene Corporation | Thiazolidinone and oxazolidinone compounds and formulations |
| US11014897B1 (en) | 2018-10-16 | 2021-05-25 | Celgene Corporation | Solid forms comprising a thiazolidinone compound, compositions and methods of use thereof |
| US11186556B1 (en) | 2018-10-16 | 2021-11-30 | Celgene Corporation | Salts of a thiazolidinone compound, solid forms, compositions and methods of use thereof |
| CN113072519A (zh) * | 2021-04-01 | 2021-07-06 | 福建海西新药创制有限公司 | 一种利用微反应装置连续生产非布司他的方法 |
Family Cites Families (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2599740B1 (fr) * | 1986-06-05 | 1988-08-12 | Rhone Poulenc Sante | Derives de benzo(b)thiophene de benzo(b)furannecarboxamides, leurs procedes de preparation et les medicaments les contenant |
| US4963557A (en) | 1987-09-28 | 1990-10-16 | Smithkline Beecham Corporation | Immunomodulatory azaspiranes |
| AU7686891A (en) | 1990-04-05 | 1991-10-30 | American National Red Cross, The | A protein family related to immediate-early protein expressed by human endothelial cells during differentiation |
| AU653957B2 (en) | 1990-09-20 | 1994-10-20 | Merrell Dow Pharmaceuticals Inc. | 1-aryl-3-pyridinyl-2-propene-1-ones |
| EP1070080A4 (de) | 1998-03-09 | 2004-12-29 | Smithkline Beecham Corp | MENSCHLICHE EDG-1c POLYNUCLEOTIDE UND POLYPEPTIDE SOWIE IHRE ANWENDUNGEN |
| GB9808665D0 (en) | 1998-04-23 | 1998-06-24 | Merck Sharp & Dohme | Therapeutic compounds |
| JP2005501841A (ja) | 2001-08-01 | 2005-01-20 | バセル ポリオレフィン ジーエムビーエイチ | 複素環式ペンタレン誘導体の製造方法 |
| DE60330047D1 (en) | 2002-01-18 | 2009-12-24 | Merck & Co Inc | "n-(benzyl)aminoalkyl carboxylate, phosphinate, phosphonate und tetrazole als edg rezeptoragonisten" |
| US20040058894A1 (en) * | 2002-01-18 | 2004-03-25 | Doherty George A. | Selective S1P1/Edg1 receptor agonists |
| US7199142B2 (en) | 2002-06-17 | 2007-04-03 | Merck & Co., Inc. | 1-((5-aryl-1,2,4-oxadiazol-3-yl) benzyl)azetidine-3-carboxylates and 1-((5-aryl-1,2,4-oxadiazol-3-yl)benzyl) pyrrolidine-3-carboxylates as edg receptor agonists |
| DE10231370B4 (de) * | 2002-07-11 | 2006-04-06 | Sanofi-Aventis Deutschland Gmbh | Thiophenglycosidderivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zur Herstellung dieser Arzneimittel |
| AU2003259296A1 (en) * | 2002-07-30 | 2004-02-16 | University Of Virginia Patent Foundation | Compounds active in spinigosine 1-phosphate signaling |
| WO2004035538A1 (en) | 2002-10-15 | 2004-04-29 | Merck & Co., Inc. | Process for making azetidine-3-carboxylic acid |
| CA2524867A1 (en) | 2003-05-15 | 2004-12-02 | Merck & Co., Inc. | 3-(2-amino-1-azacyclyl)-5-aryl-1,2,4-oxadiazoles as s1p receptor agonists |
| WO2005014525A2 (en) | 2003-08-12 | 2005-02-17 | Mitsubishi Pharma Corporation | Bi-aryl compound having immunosuppressive activity |
| US20070043014A1 (en) | 2003-10-01 | 2007-02-22 | Merck & Co., Inc. | 3,5-Aryl, heteroaryl or cycloalkyl substituted-1,2,4-oxadiazoles as s1p receptor agonists |
| WO2005058848A1 (en) | 2003-12-17 | 2005-06-30 | Merck & Co., Inc. | (3,4-disubstituted)propanoic carboxylates as s1p (edg) receptor agonists |
| WO2006010379A1 (en) | 2004-07-29 | 2006-02-02 | Actelion Pharmaceuticals Ltd. | Novel thiophene derivatives as immunosuppressive agents |
| WO2006100633A1 (en) * | 2005-03-23 | 2006-09-28 | Actelion Pharmaceuticals Ltd | NOVEL THIOPHENE DERIVATIVES AS SPHINGOSINE-l-PHOSPHATE-1 RECEPTOR AGONISTS |
| US7723378B2 (en) * | 2005-03-23 | 2010-05-25 | Actelion Pharmaceuticals Ltd. | Hydrogenated benzo (C) thiophene derivatives as immunomodulators |
| US7846964B2 (en) * | 2005-03-23 | 2010-12-07 | Actelion Pharmaceuticals Ltd. | Thiophene derivatives as spingosine-1-phosphate-1 receptor agonists |
| JP2008545767A (ja) | 2005-06-08 | 2008-12-18 | ノバルティス アクチエンゲゼルシャフト | 多環式オキサジアゾールまたはイソキサゾールおよびｓｉｐ受容体リガンドとしてのそれらの使用 |
| WO2006137019A1 (en) | 2005-06-24 | 2006-12-28 | Actelion Pharmaceuticals Ltd | Novel thiophene derivatives |
| AR057894A1 (es) * | 2005-11-23 | 2007-12-26 | Actelion Pharmaceuticals Ltd | Derivados de tiofeno |
| GB0601744D0 (en) | 2006-01-27 | 2006-03-08 | Novartis Ag | Organic compounds |
| US20080005421A1 (en) * | 2006-05-19 | 2008-01-03 | Chi-Tung Chang | Switching Device of Input and Output Interfaces of Computer Systems |
| CA2672616A1 (en) | 2006-12-15 | 2008-06-26 | Abbott Laboratories | Novel oxadiazole compounds |
| WO2008091967A1 (en) | 2007-01-26 | 2008-07-31 | Smithkline Beecham Corporation | Chemical compounds |
-
2004
- 2004-07-29 WO PCT/EP2004/008501 patent/WO2006010379A1/en active Application Filing
-
2005
- 2005-07-20 PL PL05772622T patent/PL1805163T3/pl unknown
- 2005-07-20 SI SI200530472T patent/SI1805163T1/sl unknown
- 2005-07-20 RU RU2007107164/04A patent/RU2386626C2/ru not_active IP Right Cessation
- 2005-07-20 WO PCT/EP2005/007892 patent/WO2006010544A2/en active IP Right Grant
- 2005-07-20 EP EP05772622A patent/EP1805163B1/de active Active
- 2005-07-20 DK DK05772622T patent/DK1805163T3/da active
- 2005-07-20 US US11/572,801 patent/US7750040B2/en not_active Expired - Fee Related
- 2005-07-20 DE DE602005010109T patent/DE602005010109D1/de active Active
- 2005-07-20 KR KR1020077003174A patent/KR20070046849A/ko not_active Application Discontinuation
- 2005-07-20 AU AU2005266529A patent/AU2005266529A1/en not_active Abandoned
- 2005-07-20 CN CN2005800255902A patent/CN1993346B/zh not_active Expired - Fee Related
- 2005-07-20 PT PT05772622T patent/PT1805163E/pt unknown
- 2005-07-20 BR BRPI0513841-8A patent/BRPI0513841A/pt not_active IP Right Cessation
- 2005-07-20 JP JP2007522982A patent/JP4807884B2/ja not_active Expired - Fee Related
- 2005-07-20 ES ES05772622T patent/ES2313391T3/es active Active
- 2005-07-20 CA CA002574305A patent/CA2574305A1/en not_active Abandoned
- 2005-07-20 AT AT05772622T patent/ATE409697T1/de not_active IP Right Cessation
- 2005-07-20 MX MX2007000972A patent/MX2007000972A/es active IP Right Grant
- 2005-07-28 AR ARP050103142A patent/AR050273A1/es not_active Application Discontinuation
- 2005-07-28 TW TW094125581A patent/TW200616994A/zh unknown
-
2007
- 2007-01-18 ZA ZA200700535A patent/ZA200700535B/en unknown
- 2007-01-25 IL IL180962A patent/IL180962A0/en unknown
- 2007-02-27 NO NO20071095A patent/NO20071095L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| NO20071095L (no) | 2007-02-27 |
| JP4807884B2 (ja) | 2011-11-02 |
| JP2008508210A (ja) | 2008-03-21 |
| WO2006010544A3 (en) | 2006-03-30 |
| TW200616994A (en) | 2006-06-01 |
| CN1993346A (zh) | 2007-07-04 |
| RU2007107164A (ru) | 2008-09-10 |
| DK1805163T3 (da) | 2008-12-15 |
| DE602005010109D1 (de) | 2008-11-13 |
| BRPI0513841A (pt) | 2008-05-20 |
| PT1805163E (pt) | 2008-12-05 |
| SI1805163T1 (sl) | 2009-02-28 |
| AU2005266529A1 (en) | 2006-02-02 |
| AR050273A1 (es) | 2006-10-11 |
| CA2574305A1 (en) | 2006-02-02 |
| EP1805163A2 (de) | 2007-07-11 |
| RU2386626C2 (ru) | 2010-04-20 |
| KR20070046849A (ko) | 2007-05-03 |
| IL180962A0 (en) | 2007-07-04 |
| ES2313391T3 (es) | 2009-03-01 |
| WO2006010544A2 (en) | 2006-02-02 |
| US7750040B2 (en) | 2010-07-06 |
| ZA200700535B (en) | 2008-10-29 |
| CN1993346B (zh) | 2011-04-27 |
| PL1805163T3 (pl) | 2009-04-30 |
| WO2006010379A1 (en) | 2006-02-02 |
| EP1805163B1 (de) | 2008-10-01 |
| MX2007000972A (es) | 2007-04-10 |
| US20080064740A1 (en) | 2008-03-13 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE409697T1 (de) | 1,1a,5,5a-tetrahydro-3-thia- cyclopropaäaüpentalene: trizyklische thiophenderivate als s1p1/edg1-rezeptor-agonisten | |
| DK1863474T3 (da) | Hidtil ukendte thiophenderivater som sphingosin-1-phosphat-1-receptoragonister | |
| MY149869A (en) | Thiophene derivatives as s1p1/edg1 receptor agonists | |
| IL192657A (en) | Theophenic history as 1edg / 1p1s receptor agonists | |
| DK1720836T3 (da) | 6-substituerede 2,3,4,5-tetrahydro-1h-benzo [d]azepiner som 5-ht2c-receptoragonister | |
| ZA200709086B (en) | Novel thiophene derivatives as sphingosine-1-phosphate-1 receptor agonists | |
| DE602006020447D1 (de) | Niacin-rezeptoragonisten, zusammensetzungen mit de | |
| LTC1725537I2 (lt) | Nauji junginiai, kaip opioido receptoriaus moduliatoriai | |
| DK2206710T3 (da) | Indolderivater som s1p1-receptor agonister | |
| IL177799A0 (en) | Substituted thiophene derivatives as anti-cancer agents | |
| EP1625123A4 (de) | 3-(2-amino-1-azacyclyl)-5-aryl-1,2,4-oxadiazole als s1p-rezeptoragonisten | |
| DK1668014T3 (da) | Kondenserede heterocykliske forbindelser som serotoninreceptormodulatorer | |
| DK1924561T3 (da) | 6-arylalkylamino-2,3,4,5-tetrahydro-1h-benzo[d]azepiner as 5-ht2c-receptor agonister | |
| DK1868999T3 (da) | Pyridin-3-carboxamidderivater som omvendte CB1-agonister | |
| NO20070494L (no) | Substituerte azepinderivater som serotoninreseptormodulatorer | |
| ATE465995T1 (de) | N-'(1,5-diphenyl-1h-pyrazol-3- yl)sulfonamidderivate mit affinität zum cb1- rezeptor | |
| DK1833791T3 (da) | 2,3,4,9-tetrahydor-1H-carbazolderivater som CRTH2 receptorantagonister | |
| DK2099784T3 (da) | 1,5-diphenyl-3-pyridinylamino-1,5-dihydrioyrrolidin-2-on som cb1-receptor-modulatorer | |
| ATE396724T1 (de) | 1h-thieno 2,3-c-pyrazol-derivate als kinase-i- hemmer | |
| DK1874761T3 (da) | 4h-1,2,4-triazin-5-on-derivater, fremstilling heraf og anvendelse heraf som alpha-7-nikotin-acetylcholin-receptorer | |
| DK1749001T3 (da) | 3-piperidinylisochroman-5-ol som dopaminagonister | |
| ATE445604T1 (de) | Neue 2,6-diaminopyridin-3-on-derivate | |
| FI20041512A0 (fi) | Luonnonmukainen puhdistusaine, jolla on antioksidanttinen koostumus | |
| ES1061924Y (es) | Lampara basculante empotrable, para balizamiento. |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 1805163 Country of ref document: EP |
|
| REN | Ceased due to non-payment of the annual fee |