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ATE493136T1 - NEW ONE-STEP PROCESS FOR PRODUCING CROSS-LINKED POLY(ALLYLAMIN) POLYMERS - Google Patents

NEW ONE-STEP PROCESS FOR PRODUCING CROSS-LINKED POLY(ALLYLAMIN) POLYMERS

Info

Publication number
ATE493136T1
ATE493136T1 AT08775124T AT08775124T ATE493136T1 AT E493136 T1 ATE493136 T1 AT E493136T1 AT 08775124 T AT08775124 T AT 08775124T AT 08775124 T AT08775124 T AT 08775124T AT E493136 T1 ATE493136 T1 AT E493136T1
Authority
AT
Austria
Prior art keywords
polymers
linked poly
step process
allylamin
new
Prior art date
Application number
AT08775124T
Other languages
German (de)
Inventor
Sabrina Bianchi
Valter Castelvetro
Giovanni Marras
Sonja Bellomi
Graziano Castaldi
Gianpiero Ventimiglia
Original Assignee
Chemo Iberica Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chemo Iberica Sa filed Critical Chemo Iberica Sa
Application granted granted Critical
Publication of ATE493136T1 publication Critical patent/ATE493136T1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C215/04—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated
    • C07C215/06—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated and acyclic
    • C07C215/18—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated and acyclic with hydroxy groups and at least two amino groups bound to the carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/785—Polymers containing nitrogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F226/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen
    • C08F226/02—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen by a single or double bond to nitrogen
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F226/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen
    • C08F226/02—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen by a single or double bond to nitrogen
    • C08F226/04—Diallylamine

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Obesity (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Polymers & Plastics (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polymerisation Methods In General (AREA)
  • Processes Of Treating Macromolecular Substances (AREA)

Abstract

The present invention relates to a novel one step process for preparing cross-linked poly(allylamine) polymers or salts thereof using the novel cross-linking agent of Formula (IV). This invention also relates to the compound of Formula (IV) as well as to a process to obtain it. The cross-linked poly(allylamine) polymers of the invention are useful in medicine as substrate-binding polymers.
AT08775124T 2007-07-17 2008-07-16 NEW ONE-STEP PROCESS FOR PRODUCING CROSS-LINKED POLY(ALLYLAMIN) POLYMERS ATE493136T1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP07112604A EP2016947A1 (en) 2007-07-17 2007-07-17 Novel one step process for preparing cross-linked poly(allylamine) polymers
PCT/EP2008/059303 WO2009010531A1 (en) 2007-07-17 2008-07-16 Novel one step process for preparing cross-linked poly(allylamine) polymers

Publications (1)

Publication Number Publication Date
ATE493136T1 true ATE493136T1 (en) 2011-01-15

Family

ID=38921775

Family Applications (1)

Application Number Title Priority Date Filing Date
AT08775124T ATE493136T1 (en) 2007-07-17 2008-07-16 NEW ONE-STEP PROCESS FOR PRODUCING CROSS-LINKED POLY(ALLYLAMIN) POLYMERS

Country Status (17)

Country Link
US (1) US8394416B2 (en)
EP (2) EP2016947A1 (en)
JP (1) JP2010533758A (en)
KR (1) KR20100051616A (en)
CN (1) CN101743012B (en)
AT (1) ATE493136T1 (en)
BR (1) BRPI0813829A2 (en)
CA (1) CA2697130A1 (en)
DE (1) DE602008004259D1 (en)
DK (1) DK2175866T3 (en)
ES (1) ES2358381T3 (en)
HK (1) HK1140945A1 (en)
HR (1) HRP20110181T1 (en)
PL (1) PL2175866T3 (en)
PT (1) PT2175866E (en)
SI (1) SI2175866T1 (en)
WO (1) WO2009010531A1 (en)

Families Citing this family (21)

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US8404784B2 (en) 2008-12-03 2013-03-26 Navinta Llc Manufacturing process of making polymeric amine salts
AU2010261339A1 (en) * 2009-06-16 2012-01-19 Watson Pharma Private Limited Processes for the preparation of sevelamer carbonate
IT1404163B1 (en) 2011-02-01 2013-11-15 Chemi Spa PROCESS FOR THE PREPARATION OF RETICULATED POLYALLYLAMINS OR THEIR PHARMACEUTICAL ACCEPTABLE SALTS
CN102796259B (en) * 2011-05-24 2014-11-12 北大方正集团有限公司 Method for preparing sevelamer carbonate
CN102796262B (en) * 2011-05-24 2014-11-12 北大方正集团有限公司 Method for preparing sevelamer carbonate
CN103012789B (en) * 2011-09-23 2015-02-25 北大方正集团有限公司 Preparation method of niacin sevelamer
CN102675510B (en) * 2012-05-28 2014-04-02 诚达药业股份有限公司 Synthesis process of Sevelamer
CN102942646B (en) * 2012-10-26 2016-06-29 青岛正大海尔制药有限公司 The synthesis of a kind of high molecular polymer and isolation and purification method
CN111671766B (en) 2013-06-05 2024-03-08 特里赛达公司 Proton-binding polymers for oral administration
CN104448139B (en) * 2014-11-21 2016-08-17 新发药业有限公司 A kind of preparation method of colesevelam hydrocholoride
PL3593808T3 (en) 2014-12-10 2021-06-14 Tricida Inc. Proton-binding polymers for oral administration
MA41202A (en) * 2014-12-18 2017-10-24 Genzyme Corp CROSS-LINKED POLYDIALLYMINE COPOLYMERS FOR THE TREATMENT OF TYPE 2 DIABETES
WO2017193024A1 (en) * 2016-05-06 2017-11-09 Tricida, Inc. Hcl-binding compositions for and method of treating acid-base disorders
CN106008813B (en) * 2016-06-15 2017-11-14 新发药业有限公司 The method that polymerisation in solution prepares colesevelam hydrocholoride
KR101853260B1 (en) * 2016-11-29 2018-06-14 주식회사 퍼슨 Process for preparation of sevelamer carbonate
KR20190084125A (en) 2016-12-28 2019-07-15 후지필름 가부시키가이샤 Emulsion of nitrogen atom-containing polymer or salt thereof, method for producing the same, and method for producing particles
KR102610953B1 (en) * 2017-07-05 2023-12-06 니토 보세키 가부시기가이샤 High-purity allylamine (co)polymer and method for producing the same
US10934380B1 (en) 2017-09-25 2021-03-02 Tricida, Inc. Crosslinked poly(allylamine) polymer pharmaceutical compositions
CN111225674A (en) 2017-10-16 2020-06-02 富士胶片株式会社 Therapeutic agent for hyperphosphatemia
CA3080651A1 (en) 2017-11-03 2019-05-09 Tricida, Inc. Compositions for and method of treating acid-base disorders
CN108751208B (en) * 2018-06-05 2020-06-30 山东师范大学 Monodisperse silicon dioxide nanospheres prepared from surfactant-free microemulsion and preparation method thereof

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BE757856A (en) * 1969-10-27 1971-04-22 Michelin & Cie SULFUR VULCANIZABLE POLYURETHANES IMPROVEMENTS
JPS6090243A (en) 1983-10-25 1985-05-21 Nitto Boseki Co Ltd Small spherical crosslinked monoallylamine polymer and its preparation
JP2862933B2 (en) * 1990-02-06 1999-03-03 東芝シリコーン株式会社 Method for producing N-alkenyl-N-glycidyl (meth) acrylamide compound
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TW474813B (en) * 1994-06-10 2002-02-01 Geltex Pharma Inc Alkylated composition for removing bile salts from a patient
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TW568788B (en) * 1998-10-12 2004-01-01 Chugai Pharmaceutical Co Ltd Polymer combining with phosphoric acid and preparation containing the same
JP3363143B2 (en) * 1998-10-12 2003-01-08 中外製薬株式会社 Phosphate binding polymer particles
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Also Published As

Publication number Publication date
CA2697130A1 (en) 2009-01-22
BRPI0813829A2 (en) 2015-01-06
DK2175866T3 (en) 2011-04-04
EP2175866B1 (en) 2010-12-29
KR20100051616A (en) 2010-05-17
ES2358381T3 (en) 2011-05-10
PL2175866T3 (en) 2011-05-31
HK1140945A1 (en) 2010-10-29
PT2175866E (en) 2011-04-01
WO2009010531A1 (en) 2009-01-22
DE602008004259D1 (en) 2011-02-10
US20100183732A1 (en) 2010-07-22
EP2016947A1 (en) 2009-01-21
US8394416B2 (en) 2013-03-12
CN101743012A (en) 2010-06-16
JP2010533758A (en) 2010-10-28
CN101743012B (en) 2012-07-04
EP2175866A1 (en) 2010-04-21
SI2175866T1 (en) 2011-04-29
HRP20110181T1 (en) 2011-04-30

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