ATE321561T1 - Azidoderivate von beta-l-2'-nukleosiden zur hiv- infektionsbehandlung - Google Patents
Azidoderivate von beta-l-2'-nukleosiden zur hiv- infektionsbehandlungInfo
- Publication number
- ATE321561T1 ATE321561T1 AT99971324T AT99971324T ATE321561T1 AT E321561 T1 ATE321561 T1 AT E321561T1 AT 99971324 T AT99971324 T AT 99971324T AT 99971324 T AT99971324 T AT 99971324T AT E321561 T1 ATE321561 T1 AT E321561T1
- Authority
- AT
- Austria
- Prior art keywords
- beta
- acido
- nucleosides
- derivatives
- hiv infection
- Prior art date
Links
- 208000031886 HIV Infections Diseases 0.000 title 1
- 208000037357 HIV infectious disease Diseases 0.000 title 1
- 208000033519 human immunodeficiency virus infectious disease Diseases 0.000 title 1
- 239000002777 nucleoside Substances 0.000 title 1
- 125000002252 acyl group Chemical group 0.000 abstract 2
- 241001465754 Metazoa Species 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000001177 diphosphate Substances 0.000 abstract 1
- XPPKVPWEQAFLFU-UHFFFAOYSA-J diphosphate(4-) Chemical compound [O-]P([O-])(=O)OP([O-])([O-])=O XPPKVPWEQAFLFU-UHFFFAOYSA-J 0.000 abstract 1
- 235000011180 diphosphates Nutrition 0.000 abstract 1
- 229960004413 flucytosine Drugs 0.000 abstract 1
- 208000002672 hepatitis B Diseases 0.000 abstract 1
- 150000004712 monophosphates Chemical class 0.000 abstract 1
- 239000002773 nucleotide Substances 0.000 abstract 1
- 125000003729 nucleotide group Chemical group 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003013 phosphoric acid derivatives Chemical class 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 239000001226 triphosphate Substances 0.000 abstract 1
- 235000011178 triphosphate Nutrition 0.000 abstract 1
- UNXRWKVEANCORM-UHFFFAOYSA-N triphosphoric acid Chemical compound OP(O)(=O)OP(O)(=O)OP(O)(O)=O UNXRWKVEANCORM-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Virology (AREA)
- Epidemiology (AREA)
- Communicable Diseases (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Tropical Medicine & Parasitology (AREA)
- AIDS & HIV (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10717898P | 1998-11-05 | 1998-11-05 | |
| US11586299P | 1999-01-13 | 1999-01-13 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE321561T1 true ATE321561T1 (de) | 2006-04-15 |
Family
ID=26804484
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT99971324T ATE321561T1 (de) | 1998-11-05 | 1999-11-05 | Azidoderivate von beta-l-2'-nukleosiden zur hiv- infektionsbehandlung |
Country Status (12)
| Country | Link |
|---|---|
| EP (1) | EP1124565B1 (de) |
| JP (2) | JP2002528510A (de) |
| KR (1) | KR100679239B1 (de) |
| AT (1) | ATE321561T1 (de) |
| AU (1) | AU768059B2 (de) |
| BR (1) | BR9915037A (de) |
| CA (1) | CA2348948C (de) |
| DE (1) | DE69930678T2 (de) |
| ES (1) | ES2262366T3 (de) |
| IL (2) | IL142982A0 (de) |
| MX (1) | MXPA01004505A (de) |
| WO (1) | WO2000025799A1 (de) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MY164523A (en) | 2000-05-23 | 2017-12-29 | Univ Degli Studi Cagliari | Methods and compositions for treating hepatitis c virus |
| BR0111196A (pt) | 2000-05-26 | 2004-04-06 | Idenix Cayman Ltd | Composições e uso das mesmas para tratamento de flavivìrus e pestivìrus |
| KR20050035194A (ko) | 2002-06-28 | 2005-04-15 | 이데닉스 (케이만) 리미티드 | 플라비비리다에 감염 치료용 2'-ｃ-메틸-3'-ｏ-ｌ-발린에스테르 리보푸라노실 사이티딘 |
| NZ537662A (en) | 2002-06-28 | 2007-10-26 | Idenix Cayman Ltd | 2'-C-methyl-3'-O-L-valine ester ribofuranosyl cytidine for treatment of flaviviridae infections |
| WO2004046331A2 (en) | 2002-11-15 | 2004-06-03 | Idenix (Cayman) Limited | 2’-branched nucleosides and flaviviridae mutation |
| CA2509687C (en) | 2002-12-12 | 2012-08-14 | Idenix (Cayman) Limited | Process for the production of 2'-branched nucleosides |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DD293498A5 (de) * | 1989-07-20 | 1991-09-05 | Zi Fuer Molekularbiologie Der Adw,De | Verfahren zur herstellung eines mittels fuer die behandlung oder prophylaxe von hepatits-infektionen bei mensch und tier |
| AU7954694A (en) * | 1993-09-10 | 1995-03-27 | Centre National De La Recherche Scientifique (Cnrs) | Nucleosides with anti-hepatitis b virus activity |
| JPH11512397A (ja) * | 1995-09-07 | 1999-10-26 | ユニバーシティー オブ ジョージア リサーチ ファウンデーション，インコーポレイテッド | 治療用アジド化合物 |
| ATE238328T1 (de) * | 1996-10-16 | 2003-05-15 | Ribapharm Inc | Monozyklische l-nukleoside, analoga und ihre anwendungen |
-
1999
- 1999-11-05 AU AU14691/00A patent/AU768059B2/en not_active Ceased
- 1999-11-05 BR BR9915037-9A patent/BR9915037A/pt not_active IP Right Cessation
- 1999-11-05 EP EP99971324A patent/EP1124565B1/de not_active Expired - Lifetime
- 1999-11-05 MX MXPA01004505A patent/MXPA01004505A/es active IP Right Grant
- 1999-11-05 IL IL14298299A patent/IL142982A0/xx unknown
- 1999-11-05 WO PCT/US1999/026156 patent/WO2000025799A1/en active IP Right Grant
- 1999-11-05 KR KR1020017005695A patent/KR100679239B1/ko not_active Expired - Fee Related
- 1999-11-05 AT AT99971324T patent/ATE321561T1/de not_active IP Right Cessation
- 1999-11-05 JP JP2000579239A patent/JP2002528510A/ja not_active Withdrawn
- 1999-11-05 CA CA002348948A patent/CA2348948C/en not_active Expired - Fee Related
- 1999-11-05 DE DE69930678T patent/DE69930678T2/de not_active Expired - Lifetime
- 1999-11-05 ES ES99971324T patent/ES2262366T3/es not_active Expired - Lifetime
-
2001
- 2001-05-04 IL IL142982A patent/IL142982A/en not_active IP Right Cessation
-
2011
- 2011-06-22 JP JP2011138608A patent/JP2011251968A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| JP2011251968A (ja) | 2011-12-15 |
| AU768059B2 (en) | 2003-12-04 |
| AU1469100A (en) | 2000-05-22 |
| JP2002528510A (ja) | 2002-09-03 |
| CA2348948A1 (en) | 2000-05-11 |
| KR20020013475A (ko) | 2002-02-20 |
| DE69930678D1 (de) | 2006-05-18 |
| IL142982A (en) | 2010-05-17 |
| CA2348948C (en) | 2007-09-18 |
| ES2262366T3 (es) | 2006-11-16 |
| DE69930678T2 (de) | 2006-09-21 |
| KR100679239B1 (ko) | 2007-02-07 |
| IL142982A0 (en) | 2002-04-21 |
| BR9915037A (pt) | 2001-11-20 |
| WO2000025799A1 (en) | 2000-05-11 |
| MXPA01004505A (es) | 2005-04-19 |
| EP1124565B1 (de) | 2006-03-29 |
| EP1124565A1 (de) | 2001-08-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |