Nothing Special   »   [go: up one dir, main page]

ATE303792T1 - Implantierbares system mit verzögerter wirkstofffreisetzung - Google Patents

Implantierbares system mit verzögerter wirkstofffreisetzung

Info

Publication number
ATE303792T1
ATE303792T1 AT02076869T AT02076869T ATE303792T1 AT E303792 T1 ATE303792 T1 AT E303792T1 AT 02076869 T AT02076869 T AT 02076869T AT 02076869 T AT02076869 T AT 02076869T AT E303792 T1 ATE303792 T1 AT E303792T1
Authority
AT
Austria
Prior art keywords
implantable
delayed release
release system
delayed
release
Prior art date
Application number
AT02076869T
Other languages
English (en)
Inventor
Bonnie J Eckenhoff
John R Peery
Keith E Dionne
Felix A Landrau
Scott D Lautenbach
Judy A Magruder
Jeremy C Wright
Original Assignee
Alza Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=24384575&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE303792(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Alza Corp filed Critical Alza Corp
Application granted granted Critical
Publication of ATE303792T1 publication Critical patent/ATE303792T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0004—Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • A61K38/09—Luteinising hormone-releasing hormone [LHRH], i.e. Gonadotropin-releasing hormone [GnRH]; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/145—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
    • A61M5/1452—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by means of pistons
    • A61M5/14526—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by means of pistons the piston being actuated by fluid pressure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/145—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
    • A61M2005/14513—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons with secondary fluid driving or regulating the infusion
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2206/00—Characteristics of a physical parameter; associated device therefor
    • A61M2206/10—Flow characteristics

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Anesthesiology (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Fluid Mechanics (AREA)
  • Vascular Medicine (AREA)
  • Endocrinology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Reproductive Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurosurgery (AREA)
  • Dermatology (AREA)
  • Medicinal Preparation (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Media Introduction/Drainage Providing Device (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT02076869T 1996-02-02 1997-01-15 Implantierbares system mit verzögerter wirkstofffreisetzung ATE303792T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US59576196A 1996-02-02 1996-02-02

Publications (1)

Publication Number Publication Date
ATE303792T1 true ATE303792T1 (de) 2005-09-15

Family

ID=24384575

Family Applications (5)

Application Number Title Priority Date Filing Date
AT02076869T ATE303792T1 (de) 1996-02-02 1997-01-15 Implantierbares system mit verzögerter wirkstofffreisetzung
AT02076867T ATE284202T1 (de) 1996-02-02 1997-01-15 Implantierbares system mit verzögerter wirkstofffreisetzung
AT02076866T ATE281153T1 (de) 1996-02-02 1997-01-15 Implantierbares system mit verzögerter wirkstofffreisetzung
AT02076868T ATE277595T1 (de) 1996-02-02 1997-01-15 Implantierbares system mit verzögerter wirkstofffreisetzung
AT97902971T ATE235224T1 (de) 1996-02-02 1997-01-15 Implantierbares system mit verzögerter freisetzung von leuprolid

Family Applications After (4)

Application Number Title Priority Date Filing Date
AT02076867T ATE284202T1 (de) 1996-02-02 1997-01-15 Implantierbares system mit verzögerter wirkstofffreisetzung
AT02076866T ATE281153T1 (de) 1996-02-02 1997-01-15 Implantierbares system mit verzögerter wirkstofffreisetzung
AT02076868T ATE277595T1 (de) 1996-02-02 1997-01-15 Implantierbares system mit verzögerter wirkstofffreisetzung
AT97902971T ATE235224T1 (de) 1996-02-02 1997-01-15 Implantierbares system mit verzögerter freisetzung von leuprolid

Country Status (28)

Country Link
US (2) US5728396A (de)
EP (7) EP1238656A1 (de)
JP (1) JP4176832B2 (de)
KR (1) KR100540090B1 (de)
CN (3) CN1146403C (de)
AR (1) AR006079A1 (de)
AT (5) ATE303792T1 (de)
BR (1) BR9707336B1 (de)
CO (1) CO4761076A1 (de)
CZ (2) CZ300994B6 (de)
DE (5) DE69720190T2 (de)
DK (5) DK1238659T3 (de)
ES (5) ES2233768T3 (de)
HK (3) HK1018396A1 (de)
HU (1) HU221919B1 (de)
ID (1) ID17704A (de)
IL (2) IL125596A (de)
MY (1) MY122081A (de)
NO (1) NO327194B1 (de)
NZ (1) NZ331186A (de)
PL (2) PL189137B1 (de)
PT (5) PT1238658E (de)
RO (1) RO119929B1 (de)
RU (1) RU2189221C2 (de)
SK (2) SK284136B6 (de)
TW (1) TW466121B (de)
WO (1) WO1997027840A1 (de)
ZA (1) ZA97831B (de)

Families Citing this family (334)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6132420A (en) * 1996-02-02 2000-10-17 Alza Corporation Osmotic delivery system and method for enhancing start-up and performance of osmotic delivery systems
US6156331A (en) * 1996-02-02 2000-12-05 Alza Corporation Sustained delivery of an active agent using an implantable system
US6395292B2 (en) * 1996-02-02 2002-05-28 Alza Corporation Sustained delivery of an active agent using an implantable system
US5932547A (en) * 1996-07-03 1999-08-03 Alza Corporation Non-aqueous polar aprotic peptide formulations
US5916582A (en) * 1996-07-03 1999-06-29 Alza Corporation Aqueous formulations of peptides
US5981489A (en) * 1996-07-18 1999-11-09 Alza Corporation Non-aqueous protic peptide formulations
US6676127B2 (en) 1997-03-13 2004-01-13 Shuffle Master, Inc. Collating and sorting apparatus
ZA981610B (en) * 1997-03-24 1999-08-26 Alza Corp Self adjustable exit port.
JP2001518880A (ja) * 1997-03-31 2001-10-16 アルザ・コーポレイション 拡散注入供給システム
JPH10279499A (ja) * 1997-04-04 1998-10-20 Takeda Chem Ind Ltd 子宮粘膜適用製剤
CA2291659A1 (fr) * 1997-06-04 1998-12-10 Debio Recherche Pharmaceutique S.A. Implants pour la liberation controlee de principes pharmaceutiquement actifs et procede pour leur fabrication
MY125849A (en) 1997-07-25 2006-08-30 Alza Corp Osmotic delivery system, osmotic delivery system semipermeable body assembly, and method for controlling delivery rate of beneficial agents from osmotic delivery systems
EP1779847B1 (de) * 1997-07-25 2009-03-18 Intarcia Therapeutics, Inc. Osmotisches Abgabesystem mit halbdurchlässigem Stöpsel
MY125870A (en) * 1997-07-25 2006-08-30 Alza Corp Osmotic delivery system flow modulator apparatus and method
ATE223208T1 (de) 1997-12-22 2002-09-15 Alza Corp Membranen zur steuerung des durchflusses in vorrichtungen mit kontrollierter wirkstoffabgabe
JP4173635B2 (ja) 1997-12-29 2008-10-29 インターシア セラピューティクス，インコーポレイティド 膜プラグ保持機構を有する浸透供給装置
JP4494629B2 (ja) * 1997-12-30 2010-06-30 インターシア セラピューティクス，インコーポレイティド メンブレンプラグを備えた有益な作用剤の供給システム
DE69834213T2 (de) 1997-12-31 2007-01-25 Alza Corp., Mountain View Osmotisches Abgabesystem für ein nützliches Mittel
US6183461B1 (en) 1998-03-11 2001-02-06 Situs Corporation Method for delivering a medication
US6254096B1 (en) 1998-04-15 2001-07-03 Shuffle Master, Inc. Device and method for continuously shuffling cards
US6655684B2 (en) 1998-04-15 2003-12-02 Shuffle Master, Inc. Device and method for forming and delivering hands from randomly arranged decks of playing cards
US7890176B2 (en) * 1998-07-06 2011-02-15 Boston Scientific Neuromodulation Corporation Methods and systems for treating chronic pelvic pain
US6565874B1 (en) * 1998-10-28 2003-05-20 Atrix Laboratories Polymeric delivery formulations of leuprolide with improved efficacy
CA2356860C (en) * 1998-12-31 2006-11-07 Alza Corporation Osmotic delivery system having space efficient piston
US7258869B1 (en) 1999-02-08 2007-08-21 Alza Corporation Stable non-aqueous single phase viscous vehicles and formulations utilizing such vehicle
US7919109B2 (en) 1999-02-08 2011-04-05 Intarcia Therapeutics, Inc. Stable non-aqueous single phase viscous vehicles and formulations utilizing such vehicles
US6835194B2 (en) 1999-03-18 2004-12-28 Durect Corporation Implantable devices and methods for treatment of pain by delivery of fentanyl and fentanyl congeners
US6541021B1 (en) * 1999-03-18 2003-04-01 Durect Corporation Devices and methods for pain management
US6139535A (en) * 1999-05-27 2000-10-31 Situs Corporation Method and apparatus for placement and activation of a medical device within a body cavity
US6468264B1 (en) 1999-10-12 2002-10-22 Durect Corporation Closed exchange system
US6436091B1 (en) * 1999-11-16 2002-08-20 Microsolutions, Inc. Methods and implantable devices and systems for long term delivery of a pharmaceutical agent
AU1958301A (en) 1999-12-08 2001-06-18 Durect Corporation Catheter with stylet lumen
EP1328256B1 (de) 1999-12-21 2005-10-19 Alza Corporation Ventil für osmotische vorrichtungen
WO2001047595A1 (en) * 1999-12-27 2001-07-05 Alza Corporation Osmotic beneficial agent delivery system
US6471688B1 (en) 2000-02-15 2002-10-29 Microsolutions, Inc. Osmotic pump drug delivery systems and methods
US6464688B1 (en) 2000-02-15 2002-10-15 Microsolutions, Inc. Osmotic pump delivery system with flexible drug compartment
US6616652B1 (en) 2000-02-15 2003-09-09 Microsolutions, Inc. Osmotic pump delivery system with pre-hydrated membrane(s) and/or primable catheter
US6582441B1 (en) 2000-02-24 2003-06-24 Advanced Bionics Corporation Surgical insertion tool
US7074803B2 (en) * 2001-03-02 2006-07-11 Durect Corporation Opioid formulations
US8024048B2 (en) * 2000-03-13 2011-09-20 Ionix Medical Inc. Method and device for treating cancer with electrical therapy in conjunction with chemotherapeutic agents and radiation therapy
US7742811B2 (en) * 2000-03-13 2010-06-22 Onco Stim Implantable device and method for the electrical treatment of cancer
US8511684B2 (en) 2004-10-04 2013-08-20 Shfl Entertainment, Inc. Card-reading shoe with inventory correction feature and methods of correcting inventory
US8590896B2 (en) 2000-04-12 2013-11-26 Shuffle Master Gmbh & Co Kg Card-handling devices and systems
US7179483B2 (en) 2000-04-26 2007-02-20 Watson Pharmaceuticals, Inc. Compositions and methods for transdermal oxybutynin therapy
AU5378201A (en) 2000-04-26 2001-11-07 Watson Pharmaceuticals Inc Minimizing adverse experience associated with oxybutynin therapy
US20030124177A1 (en) * 2000-04-26 2003-07-03 Watson Pharmaceuticals, Inc. Compositions and methods for transdermal oxybutynin therapy
US7029694B2 (en) 2000-04-26 2006-04-18 Watson Laboratories, Inc. Compositions and methods for transdermal oxybutynin therapy
US20060034828A1 (en) * 2000-06-28 2006-02-16 Gerngross Tillman U Immunoglobulins comprising predominantly a GlcNAcMAN5GLCNAC2 glycoform
JP2002089978A (ja) 2000-09-11 2002-03-27 Daikin Ind Ltd ペア型の冷凍装置およびマルチ型の冷凍装置
KR20040007413A (ko) * 2000-11-03 2004-01-24 바이오메디신즈 인코포레이티드 단기 및 장기 약물 약량측정 방법
US8470359B2 (en) 2000-11-13 2013-06-25 Qlt Usa, Inc. Sustained release polymer
US20050070883A1 (en) * 2000-11-29 2005-03-31 Brown James E Devices and methods for controlled delivery from a drug delivery device
US20050143789A1 (en) * 2001-01-30 2005-06-30 Whitehurst Todd K. Methods and systems for stimulating a peripheral nerve to treat chronic pain
US7776029B2 (en) * 2001-01-30 2010-08-17 The Alfred E. Mann Foundation For Scientific Research Microminiature infusion pump
US20060064140A1 (en) * 2001-01-30 2006-03-23 Whitehurst Todd K Methods and systems for stimulating a trigeminal nerve to treat a psychiatric disorder
US7493172B2 (en) * 2001-01-30 2009-02-17 Boston Scientific Neuromodulation Corp. Methods and systems for stimulating a nerve originating in an upper cervical spine area to treat a medical condition
EP1365770A2 (de) * 2001-02-07 2003-12-03 Durect Corporation Vorrichtungen und verfahren zur erhaltung der knochendichte
US20030009145A1 (en) * 2001-03-23 2003-01-09 Struijker-Boudier Harry A.J. Delivery of drugs from sustained release devices implanted in myocardial tissue or in the pericardial space
US6632217B2 (en) * 2001-04-19 2003-10-14 Microsolutions, Inc. Implantable osmotic pump
US7163688B2 (en) * 2001-06-22 2007-01-16 Alza Corporation Osmotic implant with membrane and membrane retention means
GB0121709D0 (en) * 2001-09-07 2001-10-31 Imp College Innovations Ltd Food inhibition agent
ATE443513T1 (de) 2001-09-17 2009-10-15 Durect Corp Vorrichtung und verfahren zur genauen abgabe eines wirkstoffs
BR0212985A (pt) 2001-09-24 2005-08-30 Imp College Innovations Ltd Uso de pyy ou de um agonista do mesmo na preparação de medicamentos para tratamento de distúrbios associados com excesso de peso
US7753373B2 (en) 2001-09-28 2010-07-13 Shuffle Master, Inc. Multiple mode card shuffler and card reading device
US8337296B2 (en) 2001-09-28 2012-12-25 SHFL entertaiment, Inc. Method and apparatus for using upstream communication in a card shuffler
US7677565B2 (en) 2001-09-28 2010-03-16 Shuffle Master, Inc Card shuffler with card rank and value reading capability
US20080111300A1 (en) * 2006-11-10 2008-05-15 Zbigniew Czyzewski Casino card shoes, systems, and methods for a no peek feature
US8616552B2 (en) 2001-09-28 2013-12-31 Shfl Entertainment, Inc. Methods and apparatuses for an automatic card handling device and communication networks including same
US8011661B2 (en) 2001-09-28 2011-09-06 Shuffle Master, Inc. Shuffler with shuffling completion indicator
EP1536839B1 (de) * 2001-11-09 2010-09-15 Intarcia Therapeutics, Inc Kombinationstherapie mit omega-interferon zur behandlung von hepatitis c virus oder gelbfieber virus infektionen
AU2003201998C1 (en) 2002-01-10 2012-10-25 Imperial Innovations Limited Modification of feeding behavior
US8058233B2 (en) * 2002-01-10 2011-11-15 Oregon Health And Science University Modification of feeding behavior using PYY and GLP-1
US6886829B2 (en) 2002-02-08 2005-05-03 Vendingdata Corporation Image capturing card shuffler
US8150519B2 (en) 2002-04-08 2012-04-03 Ardian, Inc. Methods and apparatus for bilateral renal neuromodulation
US9308044B2 (en) 2002-04-08 2016-04-12 Medtronic Ardian Luxembourg S.A.R.L. Methods for therapeutic renal neuromodulation
US7756583B2 (en) 2002-04-08 2010-07-13 Ardian, Inc. Methods and apparatus for intravascularly-induced neuromodulation
US20080213331A1 (en) 2002-04-08 2008-09-04 Ardian, Inc. Methods and devices for renal nerve blocking
US9636174B2 (en) 2002-04-08 2017-05-02 Medtronic Ardian Luxembourg S.A.R.L. Methods for therapeutic renal neuromodulation
US7617005B2 (en) 2002-04-08 2009-11-10 Ardian, Inc. Methods and apparatus for thermally-induced renal neuromodulation
US20070135875A1 (en) 2002-04-08 2007-06-14 Ardian, Inc. Methods and apparatus for thermally-induced renal neuromodulation
US7853333B2 (en) 2002-04-08 2010-12-14 Ardian, Inc. Methods and apparatus for multi-vessel renal neuromodulation
US8131371B2 (en) 2002-04-08 2012-03-06 Ardian, Inc. Methods and apparatus for monopolar renal neuromodulation
US8774913B2 (en) 2002-04-08 2014-07-08 Medtronic Ardian Luxembourg S.A.R.L. Methods and apparatus for intravasculary-induced neuromodulation
US9308043B2 (en) 2002-04-08 2016-04-12 Medtronic Ardian Luxembourg S.A.R.L. Methods for monopolar renal neuromodulation
US8145317B2 (en) 2002-04-08 2012-03-27 Ardian, Inc. Methods for renal neuromodulation
US6978174B2 (en) 2002-04-08 2005-12-20 Ardian, Inc. Methods and devices for renal nerve blocking
US7162303B2 (en) 2002-04-08 2007-01-09 Ardian, Inc. Renal nerve stimulation method and apparatus for treatment of patients
US20070129761A1 (en) 2002-04-08 2007-06-07 Ardian, Inc. Methods for treating heart arrhythmia
US8774922B2 (en) 2002-04-08 2014-07-08 Medtronic Ardian Luxembourg S.A.R.L. Catheter apparatuses having expandable balloons for renal neuromodulation and associated systems and methods
US7620451B2 (en) 2005-12-29 2009-11-17 Ardian, Inc. Methods and apparatus for pulsed electric field neuromodulation via an intra-to-extravascular approach
US7653438B2 (en) 2002-04-08 2010-01-26 Ardian, Inc. Methods and apparatus for renal neuromodulation
US8145316B2 (en) 2002-04-08 2012-03-27 Ardian, Inc. Methods and apparatus for renal neuromodulation
US8175711B2 (en) 2002-04-08 2012-05-08 Ardian, Inc. Methods for treating a condition or disease associated with cardio-renal function
US20140018880A1 (en) 2002-04-08 2014-01-16 Medtronic Ardian Luxembourg S.A.R.L. Methods for monopolar renal neuromodulation
US8347891B2 (en) 2002-04-08 2013-01-08 Medtronic Ardian Luxembourg S.A.R.L. Methods and apparatus for performing a non-continuous circumferential treatment of a body lumen
WO2004037341A2 (en) * 2002-05-07 2004-05-06 Schroeppel Edward A Method and device for treating concer with electrical therapy in conjunction with chemotherapeutic agents and radiation therapy
EP1536767B1 (de) * 2002-06-17 2007-08-08 Alza Corporation Osmotisches abgabesystem mit schubmotor früher nullter ordnung mit einem osmotischen mittel, das in dem flüssigen vehikel dispergiert ist
US20040001889A1 (en) 2002-06-25 2004-01-01 Guohua Chen Short duration depot formulations
BR0312429A (pt) * 2002-06-26 2005-04-19 Alza Corp Pistão de deformidade mìnima e de volume eficiente para sistemas de distribuição de drogas por osmose
US7254449B2 (en) * 2002-07-31 2007-08-07 Advanced Bionics Corp Systems and methods for providing power to one or more implantable devices
CA2497867A1 (en) 2002-09-06 2004-03-18 Durect Corporation Delivery of modulators of glutamate-mediated neurotransmission to the inner ear
US20060009739A1 (en) * 2002-09-06 2006-01-12 Durect Corporation Implantable flow regulator with failsafe mode and reserve drug supply
WO2004039392A2 (en) * 2002-10-29 2004-05-13 Alza Corporation Stabilized, solid-state polypeptide particles
US7014636B2 (en) * 2002-11-21 2006-03-21 Alza Corporation Osmotic delivery device having a two-way valve and a dynamically self-adjusting flow channel
US20040102476A1 (en) * 2002-11-25 2004-05-27 Chan Tai Wah High concentration formulations of opioids and opioid derivatives
PT2218448E (pt) 2002-12-13 2016-01-26 Durect Corp Sistema oral de entrega de fármaco que compreende materiais transportadores líquidos de alta viscosidade
KR20050088196A (ko) * 2002-12-19 2005-09-02 알자 코포레이션 안정한 비수성 단일 상 겔 및 이식가능한 장치로부터전달하기 위한 이의 제형
US7731947B2 (en) 2003-11-17 2010-06-08 Intarcia Therapeutics, Inc. Composition and dosage form comprising an interferon particle formulation and suspending vehicle
GB0300571D0 (en) * 2003-01-10 2003-02-12 Imp College Innovations Ltd Modification of feeding behaviour
US7207982B2 (en) 2003-03-31 2007-04-24 Alza Corporation Osmotic pump with means for dissipating internal pressure
DE602004015755D1 (de) * 2003-03-31 2008-09-25 Alza Corp Nicht wässrige einphasige visköse vehikel und formulierungen die diese vehikel verwenden
WO2004089334A2 (en) * 2003-03-31 2004-10-21 Alza Corporation Osmotic delivery system and method for decreasing start-up times for osmotic delivery systems
WO2004098513A2 (en) * 2003-05-01 2004-11-18 West Pharmaceutical Services Drug Delivery & Clinical Research Centre Limited Nasal administration of the lh-rh analog leuprolide
US20070083240A1 (en) * 2003-05-08 2007-04-12 Peterson David K L Methods and systems for applying stimulation and sensing one or more indicators of cardiac activity with an implantable stimulator
US7344716B2 (en) * 2003-05-13 2008-03-18 Depuy Spine, Inc. Transdiscal administration of specific inhibitors of pro-inflammatory cytokines
US20040229878A1 (en) * 2003-05-13 2004-11-18 Depuy Spine, Inc. Transdiscal administration of specific inhibitors of P38 kinase
US7429378B2 (en) * 2003-05-13 2008-09-30 Depuy Spine, Inc. Transdiscal administration of high affinity anti-MMP inhibitors
EP2286804A1 (de) 2003-05-13 2011-02-23 DePuy Spine, Inc. Verfahren zur Behandlung von degenerativer Bandscheibenerkrankung
US8273347B2 (en) 2003-05-13 2012-09-25 Depuy Spine, Inc. Autologous treatment of degenerated disc with cells
US7553827B2 (en) * 2003-08-13 2009-06-30 Depuy Spine, Inc. Transdiscal administration of cycline compounds
EP1633317A4 (de) 2003-05-16 2008-08-20 Intermune Inc Synthetische chemokin-rezeptor-liganden und anwendungsverfahren dafür
US7678103B2 (en) * 2003-06-12 2010-03-16 Cordis Corporation Orifice device for delivering drugs at low fluid flow rates
US8109922B2 (en) * 2003-06-12 2012-02-07 Cordis Corporation Orifice device having multiple channels and multiple layers for drug delivery
US7108762B2 (en) * 2003-06-12 2006-09-19 Cordis Corporation Method for manufacturing an orifice mechanism capable of low fluid flow rates
US8491571B2 (en) * 2003-06-12 2013-07-23 Cordis Corporation Orifice device having multiple channels with varying flow rates for drug delivery
US7211076B2 (en) * 2003-06-12 2007-05-01 Cordis Corporation Medical device for fluid delivery having low fluid flow rate
US6976983B2 (en) 2003-06-12 2005-12-20 Cordis Corporation Implantable device for delivering drugs using orifice mechanism capable of low fluid flow rates
US8361467B2 (en) * 2003-07-30 2013-01-29 Depuy Spine, Inc. Trans-capsular administration of high specificity cytokine inhibitors into orthopedic joints
US7858110B2 (en) * 2003-08-11 2010-12-28 Endo Pharmaceuticals Solutions, Inc. Long term drug delivery devices with polyurethane based polymers and their manufacture
CA2437639C (en) 2003-08-11 2016-07-05 Valera Pharmaceuticals, Inc. Long term drug delivery devices with polyurethane based polymers and their manufacture
JP2007507513A (ja) 2003-09-30 2007-03-29 アルザ・コーポレーション 上昇傾向のレリース特性を生ずる浸透圧駆動活性剤供給装置
WO2005040758A2 (en) * 2003-10-24 2005-05-06 Intermune, Inc. Use of pirfenidone in therapeutic regimens
JP2007509703A (ja) * 2003-10-31 2007-04-19 アルザ・コーポレーシヨン 自己保持性、迅速スタート膜プラグを有する浸透式ポンプ
EP1694310A2 (de) * 2003-11-06 2006-08-30 Alza Corporation Modularer imbibitionsratenreduzierer zur verwendung mit einer implantierbaren osmotischen pumpe
US8895540B2 (en) * 2003-11-26 2014-11-25 DePuy Synthes Products, LLC Local intraosseous administration of bone forming agents and anti-resorptive agents, and devices therefor
US7769461B2 (en) * 2003-12-19 2010-08-03 Boston Scientific Neuromodulation Corporation Skull-mounted electrical stimulation system and method for treating patients
EP1703915A2 (de) * 2004-01-13 2006-09-27 Vasogenix Pharmaceuticals, Inc. Verfahren zur verwendung von cgrp für kardiovaskuläre und renale indikationen
JP2007517913A (ja) * 2004-01-13 2007-07-05 バソジェニックス ファーマシューティカルズ， インコーポレイテッド カルシトニン遺伝子関連ペプチドを投与することによって急性心筋梗塞を処置するための方法およびカルシトニン遺伝子関連ペプチドを含有する組成物
JP2007517912A (ja) * 2004-01-13 2007-07-05 バソジェニックス ファーマシューティカルズ， インコーポレイテッド 心脈管および腎臓の適応症のための制御放出ｃｇｒｐ送達組成物
US20050175701A1 (en) * 2004-02-10 2005-08-11 Alza Corporation Capillary moderator for osmotic delivery system
US7720549B2 (en) * 2004-04-06 2010-05-18 Oncostim, Inc. Partially implantable system for the electrical treatment of abnormal tissue growth
US20050222646A1 (en) * 2004-04-06 2005-10-06 Kai Kroll Method and device for treating cancer with modified output electrical therapy
US20050240166A1 (en) * 2004-04-26 2005-10-27 Microsolutions, Inc. Implantable device, formulation and method for anti-psychotic therapy using risperidone
WO2005107811A2 (en) * 2004-05-04 2005-11-17 Perry Victor A Drug delivery device
US20050266087A1 (en) * 2004-05-25 2005-12-01 Gunjan Junnarkar Formulations having increased stability during transition from hydrophobic vehicle to hydrophilic medium
US20050267555A1 (en) * 2004-05-28 2005-12-01 Marnfeldt Goran N Engagement tool for implantable medical devices
US20080027513A1 (en) * 2004-07-09 2008-01-31 Advanced Bionics Corporation Systems And Methods For Using A Butterfly Coil To Communicate With Or Transfer Power To An Implantable Medical Device
EP3417895A1 (de) 2004-07-28 2018-12-26 Medtronic Ardian Luxembourg S.à.r.l. Verfahren und vorrichtungen für die nierennervenblockade
CA2575988C (en) 2004-08-04 2014-02-18 Brookwood Pharmaceuticals, Inc. Methods for manufacturing delivery devices and devices thereof
US8452407B2 (en) * 2004-08-16 2013-05-28 Boston Scientific Neuromodulation Corporation Methods for treating gastrointestinal disorders
US20060045891A1 (en) * 2004-08-24 2006-03-02 Lovalenti Phillip M Density-matched suspension vehicles and pharmaceutical suspensions
US8821559B2 (en) * 2004-08-27 2014-09-02 Codman & Shurtleff, Inc. Light-based implants for treating Alzheimer's disease
US20060066048A1 (en) 2004-09-14 2006-03-30 Shuffle Master, Inc. Magnetic jam detection in a card shuffler
DK1809329T3 (da) * 2004-09-17 2012-04-02 Durect Corp Vedvarende lokalanæstesisammensætning indeholdende saib
US7766332B2 (en) 2006-07-05 2010-08-03 Shuffle Master, Inc. Card handling devices and methods of using the same
US20070083239A1 (en) * 2005-09-23 2007-04-12 Denise Demarais Methods and apparatus for inducing, monitoring and controlling renal neuromodulation
US7937143B2 (en) * 2004-11-02 2011-05-03 Ardian, Inc. Methods and apparatus for inducing controlled renal neuromodulation
US9358393B1 (en) 2004-11-09 2016-06-07 Andres M. Lozano Stimulation methods and systems for treating an auditory dysfunction
US7483746B2 (en) * 2004-12-06 2009-01-27 Boston Scientific Neuromodulation Corp. Stimulation of the stomach in response to sensed parameters to treat obesity
US20060161217A1 (en) * 2004-12-21 2006-07-20 Jaax Kristen N Methods and systems for treating obesity
US9327069B2 (en) 2004-12-21 2016-05-03 Boston Scientific Neuromodulation Corporation Methods and systems for treating a medical condition by promoting neural remodeling within the brain
US20070038264A1 (en) * 2004-12-21 2007-02-15 Jaax Kristen N Methods and systems for treating autism
US9095713B2 (en) * 2004-12-21 2015-08-04 Allison M. Foster Methods and systems for treating autism by decreasing neural activity within the brain
US8515541B1 (en) 2004-12-22 2013-08-20 Boston Scientific Neuromodulation Corporation Methods and systems for treating post-stroke disorders
US9352145B2 (en) * 2004-12-22 2016-05-31 Boston Scientific Neuromodulation Corporation Methods and systems for treating a psychotic disorder
JP2008537684A (ja) * 2005-01-24 2008-09-25 ニューロシステック コーポレイション 内耳およびその他の組織へ治療薬および／またはその他の薬剤を送達するための装置および方法
US20060216242A1 (en) * 2005-02-03 2006-09-28 Rohloff Catherine M Suspending vehicles and pharmaceutical suspensions for drug dosage forms
WO2006083761A2 (en) 2005-02-03 2006-08-10 Alza Corporation Solvent/polymer solutions as suspension vehicles
US11246913B2 (en) 2005-02-03 2022-02-15 Intarcia Therapeutics, Inc. Suspension formulation comprising an insulinotropic peptide
EP1877077A2 (de) * 2005-02-03 2008-01-16 Intarcia Therapeutics, Inc. Implantierbare interferonhaltige vorrichtung
US20060194724A1 (en) * 2005-02-25 2006-08-31 Whitehurst Todd K Methods and systems for nerve regeneration
US20060200205A1 (en) * 2005-03-01 2006-09-07 Haller Matthew I Systems and methods for treating a patient with multiple stimulation therapies
US7288108B2 (en) * 2005-03-14 2007-10-30 Codman & Shurtleff, Inc. Red light implant for treating Parkinson's disease
USRE47266E1 (en) 2005-03-14 2019-03-05 DePuy Synthes Products, Inc. Light-based implants for treating Alzheimer's disease
US7848803B1 (en) 2005-03-14 2010-12-07 Boston Scientific Neuromodulation Corporation Methods and systems for facilitating stimulation of one or more stimulation sites
US7702385B2 (en) * 2005-11-16 2010-04-20 Boston Scientific Neuromodulation Corporation Electrode contact configurations for an implantable stimulator
US8423155B1 (en) 2005-03-14 2013-04-16 Boston Scientific Neuromodulation Corporation Methods and systems for facilitating stimulation of one or more stimulation sites
US7853321B2 (en) * 2005-03-14 2010-12-14 Boston Scientific Neuromodulation Corporation Stimulation of a stimulation site within the neck or head
US7627383B2 (en) * 2005-03-15 2009-12-01 Boston Scientific Neuromodulation Corporation Implantable stimulator
US7959938B2 (en) * 2005-03-15 2011-06-14 Intarcia Therapeutics, Inc. Polyoxaester suspending vehicles for use with implantable delivery systems
US20110077579A1 (en) * 2005-03-24 2011-03-31 Harrison William V Cochlear implant with localized fluid transport
US7200504B1 (en) 2005-05-16 2007-04-03 Advanced Bionics Corporation Measuring temperature change in an electronic biomedical implant
US7764836B2 (en) 2005-06-13 2010-07-27 Shuffle Master, Inc. Card shuffler with card rank and value reading capability using CMOS sensor
GB0511986D0 (en) * 2005-06-13 2005-07-20 Imp College Innovations Ltd Novel compounds and their effects on feeding behaviour
US7351253B2 (en) * 2005-06-16 2008-04-01 Codman & Shurtleff, Inc. Intranasal red light probe for treating Alzheimer's disease
US20070015689A1 (en) 2005-06-23 2007-01-18 Alza Corporation Complexation of metal ions with polypeptides
US20070027105A1 (en) * 2005-07-26 2007-02-01 Alza Corporation Peroxide removal from drug delivery vehicle
US20070031341A1 (en) * 2005-08-08 2007-02-08 Dimauro Thomas M Methods of delivering therapeutics to the brain
US7684858B2 (en) * 2005-09-21 2010-03-23 Boston Scientific Neuromodulation Corporation Methods and systems for placing an implanted stimulator for stimulating tissue
US7790671B2 (en) * 2005-10-07 2010-09-07 Codman & Shurtleff, Inc. Implantable pump for protein delivery for obesity control by drug infusion into the brain
US7819907B2 (en) * 2005-10-31 2010-10-26 Codman & Shurtleff, Inc. Device and method for fixing adjacent bone plates
CN101563097A (zh) 2005-11-14 2009-10-21 企业合伙人风险资本公司 用于组织损伤的干细胞生长因子疗法
US7729758B2 (en) * 2005-11-30 2010-06-01 Boston Scientific Neuromodulation Corporation Magnetically coupled microstimulators
US7610100B2 (en) * 2005-12-30 2009-10-27 Boston Scientific Neuromodulation Corporation Methods and systems for treating osteoarthritis
US7835803B1 (en) 2006-01-17 2010-11-16 Boston Scientific Neuromodulation Corporation Lead assemblies with one or more switching networks
US8175710B2 (en) * 2006-03-14 2012-05-08 Boston Scientific Neuromodulation Corporation Stimulator system with electrode array and the method of making the same
US7556266B2 (en) 2006-03-24 2009-07-07 Shuffle Master Gmbh & Co Kg Card shuffler with gravity feed system for playing cards
US7777641B2 (en) * 2006-03-29 2010-08-17 Advanced Bionics, Llc Systems and methods of facilitating communication between a first and second device
US20070232660A1 (en) * 2006-04-04 2007-10-04 Allergan, Inc. Therapeutic and delivery methods of prostaglandin ep4 agonists
US8267905B2 (en) 2006-05-01 2012-09-18 Neurosystec Corporation Apparatus and method for delivery of therapeutic and other types of agents
CN101453982B (zh) 2006-05-30 2011-05-04 精达制药公司 两件式内部通道渗透递送系统流动调节器
US8342525B2 (en) 2006-07-05 2013-01-01 Shfl Entertainment, Inc. Card shuffler with adjacent card infeed and card output compartments
US8353513B2 (en) 2006-05-31 2013-01-15 Shfl Entertainment, Inc. Card weight for gravity feed input for playing card shuffler
US8579289B2 (en) 2006-05-31 2013-11-12 Shfl Entertainment, Inc. Automatic system and methods for accurate card handling
US7803148B2 (en) * 2006-06-09 2010-09-28 Neurosystec Corporation Flow-induced delivery from a drug mass
RU2009101475A (ru) * 2006-06-20 2010-07-27 Конинклейке Филипс Электроникс, Н.В. (Nl) Электронная капсула и способ для лечения желудочно-кишечного заболевания
US8401654B1 (en) 2006-06-30 2013-03-19 Boston Scientific Neuromodulation Corporation Methods and systems for treating one or more effects of deafferentation
US8504163B1 (en) 2006-06-30 2013-08-06 Boston Scientific Neuromodulation Corporation Cranially mounted stimulation systems and methods
US8070574B2 (en) 2007-06-06 2011-12-06 Shuffle Master, Inc. Apparatus, system, method, and computer-readable medium for casino card handling with multiple hand recall feature
EP2046437A2 (de) * 2006-07-20 2009-04-15 Neurosystec Corporation Vorrichtungen, systeme und verfahren zur verabreichung von augenmedikamenten
WO2008016602A2 (en) * 2006-07-31 2008-02-07 Neurosystec Corporation Free base gacyclidine nanoparticles
EP3421031A1 (de) 2006-08-09 2019-01-02 Intarcia Therapeutics, Inc Osmotisches verabreichungssystem mit kolbenanordnung
DE102006038940A1 (de) * 2006-08-18 2008-02-21 Bayer Materialscience Ag Dispersionen von Nanoharnstoffen, enthaltend Wirkstoffe
EP2054076A2 (de) * 2006-08-21 2009-05-06 United Therapeutics Corporation Kombinationstherapie zur behandlung von virusinfektionen
US20080065002A1 (en) * 2006-09-07 2008-03-13 Neurosystec Corporation Catheter for Localized Drug Delivery and/or Electrical Stimulation
US7445528B1 (en) 2006-09-29 2008-11-04 Boston Scientific Neuromodulation Corporation Connector assemblies
CA3163418A1 (en) 2006-10-06 2008-05-22 Jeffrey S. Isenberg Prevention of tissue ischemia, related methods and compositions
US7347746B1 (en) 2006-10-27 2008-03-25 Boston Scientific Neuromodulation Corporation Receptacle connector assembly
RU2009120512A (ru) * 2006-10-31 2010-12-10 Конинклейке Филипс Электроникс Н.В. (Nl) Конструкция глотаемого дозирующего устройства с множеством форсунок для выпуска лекарств в желудочно-кишечный тракт
AU2007325918B2 (en) 2006-11-03 2013-10-17 Durect Corporation Transdermal delivery systems comprising bupivacaine
US8919775B2 (en) 2006-11-10 2014-12-30 Bally Gaming, Inc. System for billing usage of an automatic card handling device
TWI428346B (zh) * 2006-12-13 2014-03-01 Imp Innovations Ltd 新穎化合物及其等對進食行為影響
DK2157967T3 (da) 2007-04-23 2013-04-08 Intarcia Therapeutics Inc Suspensionsformuleringer af insulinotropiske peptider og anvendelser deraf
JP2011506318A (ja) 2007-12-06 2011-03-03 デュレクト コーポレーション 経口医薬製剤
WO2009085952A1 (en) 2007-12-20 2009-07-09 Brookwood Pharmaceuticals, Inc. Process for preparing microparticles having a low residual solvent volume
US20090162351A1 (en) * 2007-12-21 2009-06-25 Depuy Spine, Inc. Transdiscal administration of inhibitors of p38 MAP kinase
US8986696B2 (en) * 2007-12-21 2015-03-24 Depuy Mitek, Inc. Trans-capsular administration of p38 map kinase inhibitors into orthopedic joints
US8986253B2 (en) 2008-01-25 2015-03-24 Tandem Diabetes Care, Inc. Two chamber pumps and related methods
CA2726861C (en) 2008-02-13 2014-05-27 Intarcia Therapeutics, Inc. Devices, formulations, and methods for delivery of multiple beneficial agents
US9320914B2 (en) 2008-03-03 2016-04-26 DePuy Synthes Products, Inc. Endoscopic delivery of red/NIR light to the subventricular zone
US20090259214A1 (en) * 2008-04-09 2009-10-15 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Agent delivery device
US20090259217A1 (en) * 2008-04-09 2009-10-15 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Methods and systems associated with delivery of one or more agents to an individual
JP5670326B2 (ja) * 2008-06-25 2015-02-18 メディメトリクス ペルソナリズド ドルグ デリヴェリー ベー ヴェ 複数の薬剤リザーバを有する電子ピル
US9211155B2 (en) 2008-08-20 2015-12-15 Prostacare Pty Ltd. Non-thermal ablation system for treating BPH and other growths
US8408421B2 (en) 2008-09-16 2013-04-02 Tandem Diabetes Care, Inc. Flow regulating stopcocks and related methods
EP2334234A4 (de) 2008-09-19 2013-03-20 Tandem Diabetes Care Inc Vorrichtung zur messung der konzentration eines gelösten stoffs und entsprechende verfahren
BRPI0919465A2 (pt) * 2008-09-30 2015-12-01 Endo Pharmaceuticals Solutions dispositivo implantável para a liberação de risperidona e métodos de uso do mesmo
EP2341924A4 (de) 2008-10-02 2013-01-23 David Gladstone Inst Verfahren zur behandlung von hepatitis-c-virusinfektionen
CN102281865B (zh) * 2008-10-15 2017-04-05 精达制药公司 高浓缩药物颗粒、制剂、混悬剂及其应用
US20100260844A1 (en) 2008-11-03 2010-10-14 Scicinski Jan J Oral pharmaceutical dosage forms
CA2743772C (en) 2008-11-14 2015-06-30 The Board Of Regents Of The University Of Texas System Nanochanneled device and related methods
WO2010120817A2 (en) 2009-04-13 2010-10-21 The Board Of Regents Of The University Of Texas System Nanochanneled device and related methods
US8652129B2 (en) 2008-12-31 2014-02-18 Medtronic Ardian Luxembourg S.A.R.L. Apparatus, systems, and methods for achieving intravascular, thermally-induced renal neuromodulation
EP2405967B1 (de) 2009-03-12 2020-09-23 Delpor, Inc. Implantierbare vorrichtung zur langzeitverabreichung von arzneimitteln
US8975247B2 (en) 2009-03-18 2015-03-10 The Board Of Trustees Of The Leland Stanford Junion University Methods and compositions of treating a flaviviridae family viral infection
US7988152B2 (en) 2009-04-07 2011-08-02 Shuffle Master, Inc. Playing card shuffler
US20120143171A1 (en) * 2009-04-07 2012-06-07 Koninklijke Philips Electronics N.V. Valveless drug delivery device
US8967621B2 (en) 2009-04-07 2015-03-03 Bally Gaming, Inc. Card shuffling apparatuses and related methods
CA2769030C (en) 2009-07-30 2016-05-10 Tandem Diabetes Care, Inc. Infusion pump system with disposable cartridge having pressure venting and pressure feedback
JP5497176B2 (ja) 2009-08-12 2014-05-21 コーニンクレッカ フィリップス エヌ ヴェ 圧縮可能な薬品貯槽を備える薬品送出装置
KR102093612B1 (ko) 2009-09-28 2020-03-26 인타르시아 세라퓨틱스 인코포레이티드 실질 항정상태 약물 전달의 신속 확립 및/또는 종결
US9327015B2 (en) * 2009-10-23 2016-05-03 DePuy Synthes Products, Inc. Methods and devices for correcting spinal deformity with pharmaceutical-eluting pedicle screws
US8916186B2 (en) * 2009-10-23 2014-12-23 DePuy Synthes Products, LLC Methods and devices for correcting spinal deformity with pharmaceutical-eluting pedicle screws
AU2010313456A1 (en) 2009-10-30 2012-05-17 Ntf Therapeutics, Inc. Improved neurturin molecules
EP2563380B1 (de) 2010-04-26 2018-05-30 aTyr Pharma, Inc. Innovative entdeckung therapeutischer, diagnostischer und antikörperhaltiger zusammensetzungen im zusammenhang mit proteinfragmenten der cysteinyl-trna-synthetase
US8961960B2 (en) 2010-04-27 2015-02-24 Atyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of isoleucyl tRNA synthetases
US8993723B2 (en) 2010-04-28 2015-03-31 Atyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of alanyl-tRNA synthetases
US9034320B2 (en) 2010-04-29 2015-05-19 Atyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of Valyl-tRNA synthetases
AU2011248490B2 (en) 2010-04-29 2016-11-10 Pangu Biopharma Limited Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of Asparaginyl tRNA synthetases
CA2797978C (en) 2010-05-03 2019-12-03 Atyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of methionyl-trna synthetases
EP2566495B1 (de) 2010-05-03 2017-03-01 aTyr Pharma, Inc. Innovative entdeckung therapeutischer, diagnostischer und antikörperhaltiger zusammensetzungen im zusammenhang mit proteinfragmenten von phenylalanyl-alpha-trna-synthetasen
CA2797277C (en) 2010-05-03 2021-02-23 Atyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of arginyl-trna synthetases
US9062302B2 (en) 2010-05-04 2015-06-23 Atyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of p38 multi-tRNA synthetase complex
EP2568996B1 (de) 2010-05-14 2017-10-04 aTyr Pharma, Inc. Therapeutische, diagnostische und antikörperhaltige zusammensetzungen im zusammenhang mit proteinfragmenten von phenylalanyl-beta-trna-synthetasen
AU2011256366C1 (en) 2010-05-17 2017-06-15 Pangu Biopharma Limited Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of leucyl-tRNA synthetases
US20110288497A1 (en) 2010-05-19 2011-11-24 Nanomedical Systems, Inc. Nano-Scale Coatings and Related Methods Suitable for In-Vivo Use
EP2575856B1 (de) 2010-05-27 2017-08-16 aTyr Pharma, Inc. Therapeutische, diagnostische und antikörperhaltige zusammensetzungen in zusammenhang mit proteinfragmenten von glutaminyl-trna-synthetasen
CA2800281C (en) 2010-06-01 2021-01-12 Atyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of lysyl-trna synthetases
CA2804416C (en) 2010-07-12 2020-04-28 Atyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of glycyl-trna synthetases
CN103108650A (zh) 2010-08-25 2013-05-15 Atyr医药公司 与酪氨酰-tRNA合成酶的蛋白片段相关的治疗、诊断和抗体组合物的创新发现
WO2012030673A2 (en) 2010-08-30 2012-03-08 SinuSys Corporation Devices and methods for dilating a paranasal sinus opening and for treating sinusitis
US8800993B2 (en) 2010-10-14 2014-08-12 Shuffle Master Gmbh & Co Kg Card handling systems, devices for use in card handling systems and related methods
CN103313671B (zh) 2010-10-25 2017-06-06 美敦力Af卢森堡有限责任公司 用于神经调节治疗的估算及反馈的装置、系统及方法
US8801768B2 (en) * 2011-01-21 2014-08-12 Endologix, Inc. Graft systems having semi-permeable filling structures and methods for their use
US20120208755A1 (en) 2011-02-16 2012-08-16 Intarcia Therapeutics, Inc. Compositions, Devices and Methods of Use Thereof for the Treatment of Cancers
AU2011364973A1 (en) 2011-04-07 2013-11-07 Allergan, Inc. Devices, compositions and methods utilizing EP4 and EP2 receptor agonists for preventing, reducing or treating capsular contracture
WO2012175698A1 (en) 2011-06-23 2012-12-27 Université Libre de Bruxelles Therapeutic use of all-trans retinoic acid (atra) in patients suffering from alcoholic liver disease
US9731190B2 (en) 2011-07-29 2017-08-15 Bally Gaming, Inc. Method and apparatus for shuffling and handling cards
US8485527B2 (en) 2011-07-29 2013-07-16 Savant Shuffler LLC Card shuffler
EP2751291B1 (de) 2011-09-01 2018-08-15 University of Southern California Verfahren zur herstellung von peptidomimetika mit hohem durchsatz, oral bioverfügbaren wirkstoffen und zusammensetzungen damit
CN104066432B (zh) 2011-12-06 2017-06-13 小利兰·斯坦福大学董事会 用于治疗病毒性疾病的方法和组合物
US9138569B2 (en) 2012-02-29 2015-09-22 SinuSys Corporation Devices and methods for dilating a paranasal sinus opening and for treating sinusitis
US9597018B2 (en) 2012-03-08 2017-03-21 Medtronic Ardian Luxembourg S.A.R.L. Biomarker sampling in the context of neuromodulation devices, systems, and methods
AU2013230781B2 (en) 2012-03-08 2015-12-03 Medtronic Af Luxembourg S.A.R.L. Ovarian neuromodulation and associated systems and methods
US9335910B2 (en) 2012-04-23 2016-05-10 Tandem Diabetes Care, Inc. System and method for reduction of inadvertent activation of medical device during manipulation
US9180242B2 (en) 2012-05-17 2015-11-10 Tandem Diabetes Care, Inc. Methods and devices for multiple fluid transfer
US9238100B2 (en) 2012-06-07 2016-01-19 Tandem Diabetes Care, Inc. Device and method for training users of ambulatory medical devices
US9715327B2 (en) 2012-06-07 2017-07-25 Tandem Diabetes Care, Inc. Preventing inadvertent changes in ambulatory medical devices
US8960674B2 (en) 2012-07-27 2015-02-24 Bally Gaming, Inc. Batch card shuffling apparatuses including multi-card storage compartments, and related methods
US9378766B2 (en) 2012-09-28 2016-06-28 Bally Gaming, Inc. Card recognition system, card handling device, and method for tuning a card handling device
US9511274B2 (en) 2012-09-28 2016-12-06 Bally Gaming Inc. Methods for automatically generating a card deck library and master images for a deck of cards, and a related card processing apparatus
US20140110296A1 (en) 2012-10-19 2014-04-24 Medtronic Ardian Luxembourg S.A.R.L. Packaging for Catheter Treatment Devices and Associated Devices, Systems, and Methods
CN104001261A (zh) * 2013-02-27 2014-08-27 重庆市北碚区精神卫生中心 一种皮下给药装置
EP2968536B1 (de) 2013-03-13 2023-06-28 The United States of America, as represented by The Secretary, Department of Health and Human Services Verfahren zur modulierung von chemotherapeutischer zytotoxizität
US9173998B2 (en) 2013-03-14 2015-11-03 Tandem Diabetes Care, Inc. System and method for detecting occlusions in an infusion pump
AU2014233453A1 (en) 2013-03-15 2015-10-01 Durect Corporation Compositions with a rheological modifier to reduce dissolution variability
US9687263B2 (en) 2013-05-30 2017-06-27 SinuSys Corporation Devices and methods for inserting a sinus dilator
KR102503010B1 (ko) 2013-08-19 2023-02-24 타리스 바이오메디컬 엘엘씨 다중 유닛 약물 전달 장치 및 방법
JP7064285B2 (ja) * 2013-12-06 2022-05-10 デュレクト コーポレーション 抗酸化剤を含む組成物、流体分注器、及びそれらに関わる方法
US20160303242A1 (en) 2013-12-09 2016-10-20 Durect Corporation Pharmaceutically Active Agent Complexes, Polymer Complexes, and Compositions and Methods Involving the Same
US10194980B1 (en) 2014-03-28 2019-02-05 Medtronic Ardian Luxembourg S.A.R.L. Methods for catheter-based renal neuromodulation
US9980766B1 (en) 2014-03-28 2018-05-29 Medtronic Ardian Luxembourg S.A.R.L. Methods and systems for renal neuromodulation
US10194979B1 (en) 2014-03-28 2019-02-05 Medtronic Ardian Luxembourg S.A.R.L. Methods for catheter-based renal neuromodulation
US9474957B2 (en) 2014-05-15 2016-10-25 Bally Gaming, Inc. Playing card handling devices, systems, and methods for verifying sets of cards
USD764599S1 (en) 2014-08-01 2016-08-23 Bally Gaming, Inc. Card shuffler device
US9566501B2 (en) 2014-08-01 2017-02-14 Bally Gaming, Inc. Hand-forming card shuffling apparatuses including multi-card storage compartments, and related methods
US9504905B2 (en) 2014-09-19 2016-11-29 Bally Gaming, Inc. Card shuffling device and calibration method
US9889085B1 (en) 2014-09-30 2018-02-13 Intarcia Therapeutics, Inc. Therapeutic methods for the treatment of diabetes and related conditions for patients with high baseline HbA1c
US20160243288A1 (en) * 2015-02-23 2016-08-25 Tissuetech, Inc. Apparatuses and methods for treating ophthalmic diseases and disorders
US20180104251A1 (en) 2015-03-09 2018-04-19 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Compositions and methods for the treatment of glioblastoma
WO2016164412A1 (en) 2015-04-07 2016-10-13 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Hypoxia-inducible factor 1 (hif-1) inhibitors
KR102650751B1 (ko) 2015-06-03 2024-03-22 인타르시아 세라퓨틱스 인코포레이티드 임플란트 배치 및 제거 시스템들
JP2018528763A (ja) 2015-07-31 2018-10-04 リサーチ インスティチュート アット ネイションワイド チルドレンズ ホスピタル バイオフィルムの除去のためのペプチドおよび抗体
WO2017066719A2 (en) 2015-10-14 2017-04-20 Research Institute At Nationwide Children's Hospital Hu specific interfering agents
EP4066862A1 (de) 2015-11-05 2022-10-05 The General Hospital Corporation Intrathekale verabreichung von nukleinsäuresequenzen zur codierung von abcd1 zur behandlung von adrenomyeloneuropathie
US10501517B2 (en) 2016-05-16 2019-12-10 Intarcia Therapeutics, Inc. Glucagon-receptor selective polypeptides and methods of use thereof
USD840030S1 (en) 2016-06-02 2019-02-05 Intarcia Therapeutics, Inc. Implant placement guide
USD860451S1 (en) 2016-06-02 2019-09-17 Intarcia Therapeutics, Inc. Implant removal tool
CN110191717A (zh) 2016-10-20 2019-08-30 佩特通公司 向中枢神经系统递送神经保护性多肽的方法
IL307966A (en) 2017-01-03 2023-12-01 Intarcia Therapeutics Inc Methods involving continuous administration of a GLP-1 receptor agonist and co-administration of a drug
CA3049114A1 (en) 2017-01-04 2018-07-12 Lauren O. Bakaletz Antibody fragments for the treatment of biofilm-related disorders
CA3049105A1 (en) 2017-01-04 2018-07-12 Lauren O. Bakaletz Dnabii vaccines and antibodies with enhanced activity
CA3055759A1 (en) 2017-03-08 2018-09-13 Intarcia Therapeutics, Inc. Apparatus and methods for administration of a nauseogenic compound from a drug delivery device
US11541015B2 (en) 2017-05-17 2023-01-03 Massachusetts Institute Of Technology Self-righting systems, methods, and related components
CN110891635B (zh) 2017-05-17 2023-07-04 麻省理工学院 自致动制品
WO2019104326A1 (en) 2017-11-27 2019-05-31 Prostacare Pty Ltd An apparatus and a method for the treatment of a prostatic disease
WO2019168949A1 (en) 2018-02-28 2019-09-06 Prostacare Pty Ltd System for managing high impedance changes in a non-thermal ablation system for bph
AU2019269636A1 (en) 2018-05-17 2020-11-19 Massachusetts Institute Of Technology Systems for electrical stimulation
USD933219S1 (en) 2018-07-13 2021-10-12 Intarcia Therapeutics, Inc. Implant removal tool and assembly
JP2022504596A (ja) 2018-10-11 2022-01-13 インターシア セラピューティクス，インコーポレイティド ヒトアミリンアナログペプチド及び使用方法
CN109045454B (zh) * 2018-10-25 2021-02-02 北京光捷扬基健康科技有限公司 一种中耳重复给药装置及人工耳蜗植入电极
EP3997120A4 (de) 2019-07-08 2023-11-22 Research Institute at Nationwide Children's Hospital Antikörperzusammensetzungen zur unterbrechung von biofilmen
CN115666621A (zh) 2020-01-13 2023-01-31 度勒科特公司 具有减少的杂质的持续释放药物递送系统及相关方法
CN112107742B (zh) * 2020-10-22 2024-05-14 南京佑羲医药科技有限公司 一种长效智能植入式载药装置及其制造方法

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3987790A (en) * 1975-10-01 1976-10-26 Alza Corporation Osmotically driven fluid dispenser
US4865845A (en) * 1986-03-21 1989-09-12 Alza Corporation Release rate adjustment of osmotic or diffusional delivery devices
US5034229A (en) * 1988-12-13 1991-07-23 Alza Corporation Dispenser for increasing feed conversion of hog
US5059423A (en) * 1988-12-13 1991-10-22 Alza Corporation Delivery system comprising biocompatible beneficial agent formulation
US5057318A (en) * 1988-12-13 1991-10-15 Alza Corporation Delivery system for beneficial agent over a broad range of rates
US5112614A (en) * 1989-09-14 1992-05-12 Alza Corporation Implantable delivery dispenser
US5213809A (en) * 1990-01-24 1993-05-25 Alza Corporation Delivery system comprising means for controlling internal pressure
US5324280A (en) * 1990-04-02 1994-06-28 Alza Corporation Osmotic dosage system for delivering a formulation comprising liquid carrier and drug
US5234692A (en) * 1990-07-11 1993-08-10 Alza Corporation Delivery device with a protective sleeve
US5234693A (en) * 1990-07-11 1993-08-10 Alza Corporation Delivery device with a protective sleeve
US5137727A (en) * 1991-06-12 1992-08-11 Alza Corporation Delivery device providing beneficial agent stability
US5308348A (en) * 1992-02-18 1994-05-03 Alza Corporation Delivery devices with pulsatile effect
US5540665A (en) * 1994-01-31 1996-07-30 Alza Corporation Gas driven dispensing device and gas generating engine therefor
CN2230173Y (zh) * 1995-08-18 1996-07-03 赵先鲁 鼻腔给药装置

Also Published As

Publication number Publication date
EP1249229A2 (de) 2002-10-16
PL189137B1 (pl) 2005-06-30
JP4176832B2 (ja) 2008-11-05
DE69720190D1 (de) 2003-04-30
ES2233768T3 (es) 2005-06-16
SK104098A3 (en) 1998-12-02
DK1238658T3 (da) 2005-04-04
ES2232713T3 (es) 2005-06-01
NO983544L (no) 1998-09-28
IL125596A (en) 2004-07-25
DE69731902D1 (de) 2005-01-13
PT1238657E (pt) 2005-01-31
DE69734168T2 (de) 2006-01-19
DK1238657T3 (da) 2005-01-17
DE69734168D1 (de) 2005-10-13
HUP9902477A2 (hu) 1999-11-29
ATE277595T1 (de) 2004-10-15
NZ331186A (en) 2000-04-28
CN1210459A (zh) 1999-03-10
EP1238660A1 (de) 2002-09-11
IL156090A (en) 2011-12-29
PL328202A1 (en) 1999-01-18
HUP9902477A3 (en) 2001-02-28
HK1018396A1 (en) 1999-12-24
PT1238660E (pt) 2005-10-31
PT1238658E (pt) 2005-04-29
DE69731013D1 (de) 2004-11-04
EP1238658A1 (de) 2002-09-11
HU221919B1 (hu) 2003-02-28
BR9707336B1 (pt) 2009-01-13
DK1238659T3 (da) 2005-01-24
ATE284202T1 (de) 2004-12-15
CN100506311C (zh) 2009-07-01
RO119929B1 (ro) 2005-06-30
HK1093449A1 (en) 2007-03-02
KR19990082193A (ko) 1999-11-25
EP1238659A1 (de) 2002-09-11
AU1701797A (en) 1997-08-22
DE69731013T2 (de) 2005-11-17
CO4761076A1 (es) 1999-04-27
ATE235224T1 (de) 2003-04-15
US5728396A (en) 1998-03-17
EP1249229A3 (de) 2005-02-02
EP1238659B1 (de) 2004-09-29
ES2191165T3 (es) 2003-09-01
ES2229051T3 (es) 2005-04-16
RU2189221C2 (ru) 2002-09-20
EP0877599A1 (de) 1998-11-18
EP1238658B1 (de) 2004-12-08
SK284136B6 (sk) 2004-09-08
CN1520895A (zh) 2004-08-18
EP1238660B1 (de) 2005-09-07
ID17704A (id) 1998-01-22
US5985305A (en) 1999-11-16
DE69720190T2 (de) 2003-12-11
DE69731902T2 (de) 2005-12-22
PT1238659E (pt) 2005-01-31
EP0877599B1 (de) 2003-03-26
TW466121B (en) 2001-12-01
NO327194B1 (no) 2009-05-11
CN100493647C (zh) 2009-06-03
MY122081A (en) 2006-03-31
DE69731498T2 (de) 2005-11-03
DE69731498D1 (de) 2004-12-09
PT877599E (pt) 2003-08-29
ATE281153T1 (de) 2004-11-15
ZA97831B (en) 1997-10-31
ES2246004T3 (es) 2006-02-01
EP1238656A1 (de) 2002-09-11
AU724061B2 (en) 2000-09-14
NO983544D0 (no) 1998-07-31
KR100540090B1 (ko) 2006-03-23
SK285803B6 (sk) 2007-08-02
CN1146403C (zh) 2004-04-21
WO1997027840A1 (en) 1997-08-07
JP2000504011A (ja) 2000-04-04
DK0877599T3 (da) 2003-07-21
DK1238660T3 (da) 2006-01-16
EP1238657B1 (de) 2004-11-03
CZ293808B6 (cs) 2004-08-18
PL189289B1 (pl) 2005-07-29
CN1795940A (zh) 2006-07-05
CZ300994B6 (cs) 2009-10-07
AR006079A1 (es) 1999-08-11
BR9707336A (pt) 1999-07-20
IL125596A0 (en) 1999-03-12
CZ236598A3 (cs) 1998-10-14
HK1068821A1 (en) 2005-05-06
EP1238657A1 (de) 2002-09-11

Similar Documents

Publication Publication Date Title
ATE277595T1 (de) Implantierbares system mit verzögerter wirkstofffreisetzung
DE69728173D1 (de) Selbsteinstellendes cochleares implantatsystem
DE69839063D1 (de) Einstufiges Implantatsystem
DE69729472D1 (de) Phonopneumograph system
DE69713466D1 (de) Aktionsanalyse-/-aufnahmesystem
DE69726292D1 (de) Erdnahen-orbit-startsystem
DE69733624D1 (de) Bildgesteuertes chirurgisches System
NO985854D0 (no) Sammenkoblende stroppefestesystem
DE69720150D1 (de) Bildschirmgesteuertes chirurgisches system
DE69729021D1 (de) Flächiges Implantat
FI20095582A (fi) Röntgenkuvauslaitteisto
ATE214729T1 (de) Freisetzungssysteme
DE59710859D1 (de) Implantat
ID17405A (id) Sistim elektrokromik
FI974420A (fi) Röntgenkuvauslaitteisto
NO983086D0 (no) Fjernstyringssystem
NO983743L (no) Forankringssystem
DE59702083D1 (de) Elektronisch steuerbare bremsanlage
DE69735222D1 (de) Bremsanlage
FR2767394B3 (fr) Systeme porte-montre
DE69735754D1 (de) Impedanz-abhängiger implantierbarer kardiovertierer defribillator
NO985866L (no) Fortoejnings-system
ATE293931T1 (de) Implantsystem
NO973425D0 (no) Ankersystem
DE69710621D1 (de) Gesichertes automatisches System

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 1238660

Country of ref document: EP